检索结果-南通市图书馆

Quantitative and qualitative subgenomic RNA profiles of sARs-CoV-2 in respiratory samples: A comparison between Omicron BA.2 and non-VOC-D614G

引用

Virologica sinica 2024年第2期39卷 218-227页

作者： Zigui Chen Rita Way Yin Ng Grace Lui Lowell Ling Agnes s.Y.Leung Chit Chow siaw shi Boon Wendy C.s.ho Maggie Haitian Wang Renee Wan Yi Chan Albert martin Li David shu Cheong Hui Paul Kay sheung Chan Department of Microbiology Faculty of MedicineThe Chinese University of Hong KongHong KongChina Department of Medicine and Therapeutics Faculty of MedicineThe Chinese University of Hong KongHong KongChina Department of Anaesthesia and Intensive Care Faculty of MedicineThe Chinese University of Hong KongHong KongChina Department of Paediatrics Faculty of MedicineThe Chinese University of Hong KongHong KongChina Department of Anatomical and Cellular Pathology Faculty of MedicineThe Chinese University of Hong KongHong KongChina Jockey Club school of Public Health and Primary Care Faculty of MedicineThe Chinese University of Hong KongHong KongChina stanley ho Centre for Emerging Infectious Diseases Faculty of MedicineThe Chinese University of Hong KongHong KongChina

The sARs-CoV-2 Omicron variants are notorious for their transmissibility,but little is known about their subgenomic RNA(sgRNA)*** study applied RNA-seq to delineate the quantitative and qualitative profiles of canonical sgRNA of 118 respiratory samples collected from patients infected with Omicron BA.2 and compared with 338 patients infected with non-variant of concern(non-VOC)-D614G.A unique characteristic profile depicted by the relative abundance of 9 canonical sgRNAs was reproduced by both BA.2 and non-VOCD614G regardless of host gender,age and presence of ***,such profile was lost in samples with low viral load,suggesting a potential application of sgRNA pattern to indicate viral activity of individual patient at a specific time point.A characteristic qualitative profile of canonical sgRNAs was also reproduced by both BA.2 and *** presence of a full set of canonical sgRNAs carried a coherent correlation with crude viral load(AuC¼0.91,95%CI 0.88–0.94),and sgRNA ORF7b was identified to be the best surrogate marker allowing feasible routine application in characterizing the infection status of individual *** potentials in using sgRNA as a target for vaccine and antiviral development are worth pursuing.

关键词： Coronavirus sARs-CoV-2 Omicron BA.2 Non-VOC-D614G RNA-seq subgenomic RNA(sgRNA)

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Current and further trajectories in designing functional materials for solid oxide electrochemical cells:A review of other reviews

引用

Journal of Energy Chemistry 2024年第7期94卷 302-331页

作者： stanislav Baratov Elena Filonova Anastasiya Ivanova Muhammad Bilal Hanif Muneeb Irshad Muhammad Zubair Khan martin Motola sajid Rauf Dmitry Medvedev Hydrogen Energy Laboratory Ural Federal University620002 EkaterinburgRussia Institute of Natural sciences and Mathematics Ural Federal University620002 EkaterinburgRussia Department of Inorganic Chemistry Faculty of Natural SciencesComenius University BratislavaIlkovicova 6Mlynska Dolina84215 BratislavaSlovakia state Key Laboratory for Mechanical Behavior of Materials School of Materials Science and EngineeringXi'an Jiaotong UniversityXi'an 710049ShaanxiChina Department of Physics University of Engineering and TechnologyLahore 54890Pakistan Pak-Austria Fachhochschule:Institute of Applied sciences and Technology Mang Haripur 22621Khyber PakhtunkhwaPakistan College of Mechatronics and Control Engineering Shenzhen UniversityShenzhen 518000GuangdongChina Laboratory of Electrochemical Devices Based on solid Oxide Proton Electrolytes Institute of High Temperature Electrochemistry620066 EkaterinburgRussia

Complex oxides are an important class of materials with enormous potential for electrochemical *** on their composition and structure,such complex oxides can exhibit either a single conductivity(oxygen-ionic or protonic,or n-type,or p-type electronic)or a combination thereof gener-ating distinct dual-conducting or even triple-conducting *** properties enable their use as diverse functional materials for solid oxide fuel cells,solid oxide electrolysis cells,permeable membranes,and gas *** literature review shows that the field of solid oxide materials and related electro-chemical cells has a significant level of research engagement,with over 8,000 publications published since *** manual analysis of such a large volume of material is ***,by examining the review articles,it is possible to identify key patterns,recent achievements,prospects,and remaining *** perform such an analysis,the present article provides,for the first time,a comprehensive summary of previous review publications that have been published since 2020,with a special focus on solid oxide materials and electrochemical ***,this study provides an important reference for researchers specializing in the fields of solid state ionics,high-temperature electrochemistry,and energyconversiontechnologies.

关键词： sOFCs sOECs PCFCs Electrochemistry Energy conversion Hydrogen energy,Carbon neutrality

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Polarity-controllable magnetic skyrmion filter

引用

Chinese Physics B 2024年第10期33卷 400-404页

作者： Xiao-Lin Ai Hui-Ting Li Xue-Feng Zhang Chang-Feng Li Je-ho shim Xiao-Ping Ma hong-Guang Piao Hubei Engineering Research Center of Weak Magnetic-Field Detection College of ScienceChina Three Gorges UniversityYichang 443002China Department of Physics College of ScienceYanbian UniversityYanji 133002China

The skyrmion generator is one of the indispensable components for the future functional skyrmion devices,but the process of generating skyrmion cannot avoid mixing with other magnetic textures,such as skyrmionium and nested skyrmion *** mixed magnetic textures will inevitably lead to the blockage of skyrmion transport and even the distortion of data ***,the design of an efficient skyrmion filter is of great significance for the development of skyrmion-based spintronic *** this work,a skyrmion filter scheme is proposed,and the high-efficiency filtering function is demonstrated by micromagnetic *** results show that the filtering effect of the scheme depends on the structure geometry and the spin current density that drives the *** on this scheme,the polarity of the filtered skyrmion can be controlled by switching the magnetization state at the output end,and the“cloning”of the skyrmion can be realized by geometric optimization of the *** believe that in the near future,the skyrmion filter will become one of the important components of skyrmion-based spintronic devices in the future.

关键词： spintronics skyrmions skyrmion filter skyrmion polarity skyrmion clone

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Concept study of measuring gravitational constant using superconducting gravity gradiometer

引用

Chinese Physics B 2018年第8期27卷 130-135页

作者： Xing Bian ho Jung Paik martin Vol Moody university of Chinese Academy of sciences Beijing 100049China Technical Institute of Physics and Chemistry Chinese Academy of SciencesBeijing 100190China Department of Physics University of MarylandCollege ParkMaryland 20742USA

Newton＇s gravitational constant G is the least known fundamental constant of nature. since Cavendish made the first measurement of G with a torsion balance over two hundred years ago, the best results of G have been obtained by using torsion balances. however, the uncorrected anelasticity of torsion fibers makes the results questionable. We present a new method of G measurement by using a superconducting gravity gradiometer constructed with levitated test masses, which is free from the irregularities of mechanical suspension. The superconducting gravity gradiometer is rotated to generate a centrifugal acceleration that nulls the gravity field of the source mass, forming an artificial planetary system. This experiment has a potential accuracy of G better than 10 ppm.

关键词： gravitational constant superconducting gravity gradiometer artificial planetary system

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effect of asphalt thin beams mixed with three nominal maximum aggregate sizes in the bending beam rheometer on the prediction of thermal properties of bituminous material

引用

Frontiers of structural and Civil Engineering 2017年第1期11卷 1-7页

作者： Chun-Hsing ho Maria Francisca martinez GONZALEZ Cristina Pilar martin LINAREs Department of Civil Engineering Construction Management and Environmental Engineering Northern Arizona UniversityFlagstaff Arizona 86001 USA

The objective of this research is to evaluate an impact of asphalt mixture beams with varying sizes of aggregate in the Bending Beam Rheometer （BBR） for testing/predicting thermal cracking properties of asphalt pavements. The BBR test has following benefits： the equipment is cheaper, it uses smaller specimens, faster conditioning, easier availability for quality control, easier to manage, etc. however some concerns have been raised： some consider that the size of the aggregate may affect the test＇s results; the other concern is that such small beams cannot represent the whole properties of the asphalt pavement. To address these criticisms, imaging techniques, statistical analysis, and viscoelastic modeling are used. Asphalt thin beams prepared with three different nominal maximum aggregate size （NMAs）（12.5mm, 9.5 mm, and 4.75 mm） were tested at three different temperatures （-18℃, -24℃, and -30℃）. Based on results from statistical analyses and viscoelasticity, the ratio of asphalt binders and voids and stiffness differences among the three NMAs specimens are not significant, meaning that the impact of asphalt thin beams prepared with the three NMAs on the prediction of thermal cracking is minimal and can be neglected.

关键词： bending beam rheometer thin beams thermal cracking

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Plasma monocyte chemotactic protein-1 remains elevated after minimally invasive colorectal cancer resection

引用

World Journal of Gastrointestinal Oncology 2014年第10期6卷 413-419页

作者： HMC shantha Kumara Elizabeth A Myers sonali AC Herath Joon ho Jang Linda Njoh Xiaohong Yan Daniel Kirchoff Vesna Cekic martin Luchtefeld Richard L Whelan Division of Colon and Rectal surgery Department of Surgery Mount Sinai-Roosevelt Hospital Center New York NY 10019 United States Division of Colon and Rectal surgery Fer-guson Clinic Grand Rapids MI 49546 United States Icahn school of Medicine at-Mount sinai New York NY 10029 United States surgical Oncology Department of Surgery College of Physicians and Surgeons Columbia University New York NY 10032 United States

AIM: To investigate plasma Monocyte Chemotactic Protein-1 levels preoperatively in colorectal cancer(CRC) and benign patients and postoperatively after CRC ***: A plasma bank was screened for minimally invasive colorectal cancer resection(MICR) for CRC and benign disease(BEN) patients for whom preoperative, early postoperative, and 1 or more late postoperative samples(postoperative day 7-27) were available. Monocyte chemotactic protein-1(MCP-1) levels(pg/mL) were determined via enzyme linked immuno-absorbent assay. REsuLTs: One hundred and two CRC and 86 BEN patients were studied. The CRC patient's median preoperative MCP-1 level(283.1, CI: 256.0, 294.3) was higher than the BEN group level(227.5, CI: 200.2, 245.2; P = 0.0004). Vs CRC preoperative levels, elevated MCP-1 plasma levels were found on postoperative day 1(446.3, CI: 418.0, 520.1), postoperative day 3(342.7, CI: 320.4, 377.4), postoperative day 7-13(326.5, CI: 299.4, 354.1), postoperative day 14-20(361.6, CI: 287.8, 407.9), and postoperative day 21-27(318.1, CI: 287.2, 371.6; P usION: Preoperative MCP-1 levels were higher in CRC patients(vs BEN). After MICR for CRC, MCP-1 levels were elevated for 1 mo and may promote angiogenesis, cancer recurrence and metastasis.

关键词： Colorectal cancer Monocyte chemotactic protein-1 Minimally invasive colorectal resection angio-genesis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Multi-tissue transcriptomics of a unique monozygotic discordant twin case of severe progressive osseous heteroplasia

引用

Genes & Diseases 2024年第3期11卷 22-25页

作者： Alberto Gomez-Carballa Maria Jose Curras-Tuala sara Pischedda Miriam Cebey-Lopez Jose Gomez-Rial Irene Rivero-Cale Jacobo Pardo-seco Xabier Bello sandra Viz-Lasheras Antonio Justicia-Grande Julian Montoto-Louzao Alba Camino-Mera Isabel Ferreiros-Vidal Maximo Fraga Jose RAntunez Rodolfo Gomez Federico martinon-Torres Antonio salas Genetics Vaccines and Infections Research Group(GENVIP)Instituto de Investigacion Sanitaria de SantiagoSantiagode CompostelaGalicia 15706Spain Translational Pediatrics and Infectious Diseases Department of PediatricsHospital Clinico Universitario de Santiago de CompostelaServicio Galego de Saude(SERGAS)Galicia 15706Spain Laboratorio de Inmunologia Servicio de Andlisis ClinicosHospital Clinico Universitario de Santiago de CompostelaServicio Galego de Saude(SERGAS)Galicia 15706Spain unidade de Xenetica Instituto de Ciencias Forenses(INCIFOR)Facultade de MedicinaUniversidade de Santiago de Compostelaand GenPoB Research GroupInstituto de Investigacion SanitariaHospital Clinico Universitario de Santiago de CompostelaServicio Galego de Saude(SERGAS)Galicia 15706Spain Musculoskeletal Pathology Group Instituto de Investigacion Sanitaria de SantiagoServicio Galego de Saude(SERGAS)Santiago de CompostelaGalicia 15706Spain Department of Pathology Hospital Clinico Universitario de Santiago de Compostela(SERGAS)Galicia 15706Spain Unidad Integrada de BiobancosBiomodelos 3D y Modelos Animales IDIS(lnstituto de Investigacion Sanitaria de Santiagode Compostela)Galicia15706Spain Centro de Investigacion Biomedica en Red de Enfermedades Respiratorias(CIBER-Es) MadridSpain

Progressive osseous heteroplasia(POH)is an ultra-rare autosomal dominant disabling disorder characterized by heterotopic ossification(ho).It is caused by heterozygous inactivating mutations in the GNAs(guanine nucleotide-binding protein alpha-stimulating activity polypeptide)***,the molecular mechanisms underlying ho remain poorly *** a treatment for POH is not yet available,the identification of the mechanisms driving POH in affected tissues using gene expression may be of great help to underestand the molecular basis of POH and develop new therapeutic approaches.

关键词： stimulating driving asi

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Functionalized Hydrogels for Articular Cartilage Tissue Engineering

引用

Engineering 2022年第6期8卷 71-90页

作者： Liangbin Zhou Peng Guo Matteo D’Este Wenxue Tong Jiankun Xu Hao Yao martin J.stoddart Gerjo J.V.M.van Osch Kevin Ki-Wai ho Zhen Li Ling Qin Musculoskeletal Research Laboratory of Department of Orthopaedics&Traumatology Faculty of MedicineThe Chinese University of Hong KongHong Kong 999077China Innovative Orthopaedic Biomaterials and Drug Translational Research Laboratory Li Ka Shing Institute of Health SciencesFaculty of MedicineThe Chinese University of Hong KongHong Kong 999077China AO Research Institute Davos DavosCH 7270Switzerland Innovation Platform of Regeneration and Repair of spinal Cord and Nerve Injury Department of Orthopaedic SurgeryThe Seventh Affiliated Hospital of Sun Yat-sen UniversityShenzhen 518000China Department of Orthopaedics and sports Medicine&Department of Otorhinolaryngology Erasmus MCUniversity Medical CenterRotterdam 3000 CAthe Netherlands f Department of Biomechanical EngineeringDelft University of TechnologyDelft 2600 AAthe Netherlands Centre for Translational Medicine Research and Development Shenzhen Institute of Advanced TechnologyThe Chinese Academy of SciencesShenzhen 518000China

Articular cartilage(AC)is an avascular and flexible connective tissue located on the bone surface in the diarthrodial *** defects are common in the knees of young and physically active *** of the lack of suitable tissue-engineered artificial matrices,current therapies for AC defects,espe-cially full-thickness AC defects and osteochondral interfaces,fail to replace or regenerate damaged carti-lage *** rapid research and development advancements in AC tissue engineering(ACTE),functionalized hydrogels have emerged as promising cartilage matrix substitutes because of their favor-able biomechanical properties,water content,swelling ability,cytocompatibility,biodegradability,and lubricating *** can be rationally designed and conveniently tuned to simulate the extracel-lular matrix of *** article briefly introduces the composition,structure,and function of AC and its defects,followed by a comprehensive review of the exquisite(bio)design and(bio)fabrication of func-tionalized hydrogels for AC ***,we summarize the challenges encountered in functionalized hydrogel-based strategies for ACTE both in vivo and in vitro and the future directions for clinical translation.

关键词： Articular cartilage Functionalized hydrogels Cartilage repair Cartilage tissue engineering Clinical translation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Deep reinforcement learning for the optimized operation of large amounts of distributed renewable energy assets

引用

能源与人工智能(英文) 2023年第1期11卷 106-117页

作者： Jan martin specht Reinhard Madlener Institute for Future Energy Consumer Needs and Behavior(FCN) School of Business and Economics/E.ON Energy Research CenterRWTH Aachen UniversityMathieustraße 1052074AachenGermany Department of Industrial Economics and Technology Management Norwegian University of Science and Technology(NTNU)Sentralbygg 17491GløshaugenTrondheimNorway

This study utilizes machine learning and,more specifically,reinforcement learning(RL)to allow for an optimized,real-time operation of large numbers of decentral flexible assets on private household scale in the electricity *** potential and current obstacles of RL are demonstrated and a guide for interested practitioners is provided on how to tackle similar tasks without advanced skills in neural network *** the application in the energy domain it is demonstrated that state-of-the-art RL algorithms can be trained to control potentially millions of small-scale assets in private *** detail,the applied RL algorithm outperforms common heuristic algorithms and only falls slightly short of the results provided by linear optimization,but at less than a thousandth of the simulation ***,RL paves the way for aggregators of flexible energy assets to optimize profit over multiple use cases in a smart energy grid and thus also provide valuable grid services and a more sustainable operation of private energy assets.

关键词： Reinforcement learning Virtual power plant Aggregation of energy Value stacking Flexibility of decentral energy assets

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

12 W high power InGaAsP/AlGaInP 755 nm quantum well laser

引用

Chinese Optics Letters 2019年第6期17卷 49-53页

作者： H. martin Hu Jianyang Zhao Weimin Wang James ho Langxing Kuang Wenbin Liu Research Institute of Tsinghua university in shenzhen Shenzhen 518057China Guangdong Provincial Key Laboratory of Optomechatronics Shenzhen 518057China shenzhen Raybow Optoelectronics Co. Ltd.Shenzhen 518055China

High power laser diodes(LDs)with a lasing wavelength between 700 and 780 nm have great potential in various medical ***,we report our recent efforts in developing an InGaAsP/AlGaInP-based commercial high power edge-emitting LD,which has 755 nm emission peak with a world-record continuous wave output power of 12.7 W,the highest reported so *** lack of Al atoms in the active region significantly lowers the chance of catastrophic optical damage during high power laser ***,with an accumulated 3800 h running time,our ongoing aging tests reveal excellent reliability of our devices.

关键词： High power laser wavelength between

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：