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Current strategies to induce liver remnant hypertrophy before major liver resection

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World Journal of Hepatology 2021年第11期13卷 1629-1641页

作者： Celeste Del Basso martin gaillard Panagiotis Lainas Stella Zervaki Gabriel Perlemuter Pierre Chagué Laurence Rocher Cosmin Sebastian Voican Ibrahim Dagher Hadrien Tranchart Department of Minimally Invasive Digestive Surgery Antoine Béclère HospitalClamart 92140France Department of Hepato-Gastroenterology and Nutrition Antoine Béclère HospitalClamart 92140France Department of Radiology Antoine Béclère HospitalClamart 92140France

Hepatic resection is the gold standard for patients affected by primary or metastatic liver tumors but is hampered by the risk of post-hepatectomy liver *** recent impro-vements,liver surgery still requires excellent clinical judgement in selecting patients for surgery and,above all,efficient pre-operative strategies to provide adequate future liver *** aim of this article is to review the literature on the rational,the preliminary assessment,the advantages as well as the limits of each existing technique for preparing the liver for major hepatectomy.

关键词： Liver regeneration Major hepatectomy Liver insufficiency Future liver remnant Portal vein embolization

New minimally invasive approaches for cholecystectomy: Review of literature

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World Journal of Gastrointestinal Surgery 2015年第10期7卷 243-248页

作者： martin gaillard Hadrien Tranchart Panagiotis Lainas Ibrahim Dagher Department of Digestive Minimally Invasive Surgery Antoine-Beclere Hospital Faculté de Médecine Paris-Sud University

Laparoscopic cholecystectomy is the most commonlyperformed abdominal intervention in Western countries. In an attempt to reduce the invasiveness of the procedure, surgeons have developed single-incision laparoscopic cholecystectomy(SILC), minilaparoscopic cholecystectomy(MLC) and natural orifice transluminal endoscopic surgery(NOTES). The aim of this review was to determine the role of these new minimally invasive approaches for elective laparoscopic cholecystectomy in the treatment of gallstone related disease. Current literature remains insufficient for the correct assessment of emerging techniques for laparoscopic cholecystectomy. None of these procedures has demonstrated clear benefits over conventional laparoscopic cholecystectomy. SILC cannot be currently recommended as it can be associated with an increased risk of bile duct injury and incisional hernia incidence. NOTES cholecystectomy is still experimental, although hybrid transvaginal cholecystectomy is gaining popularity in clinical practice. As it is standardized and almost identical to the standard laparoscopic technique, MLC could lead to limited benefits without exposing patients to increased postoperative complications, being therefore adoptable for routine elective cholecystectomy. Technical challenges of SILC and NOTES cholecystectomy could be addressed with the evolution of new surgical tools that need to catch up with the innovative minds of surgeons. Regardless the place of these approaches in the future, robotization may be necessary to impose them as standard treatment.

关键词： Cholecystectomy Laparoscopy Singleincision laparos

Scalable and automated CRISPR-based strain engineering using droplet microfluidics

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Microsystems & Nanoengineering 2022年第2期8卷 227-236页

作者： Kosuke Iwai Maren Wehrs Megan Garber Jess Sustarich Lauren Washburn Zachary Costello Peter W.Kim David Ando William R.gaillard Nathan J.Hillson Paul D.Adams Aindrila Mukhopadhyay Hector Garcia martin Anup K.Singh Technology Division DOE Joint BioEnergy InstituteEmeryvilleCA 94608USA Biotechnology and Bioengineering Department Sandia National LaboratoriesLivermoreCA 94550USA Biofuels and Bioproducts Division DOE Joint BioEnergy InstituteEmeryvilleCA 94608USA Biological Systems and Engineering Division Lawrence Berkeley National LaboratoryBerkeleyCA 94720USA Molecular Biophysics and Integrated Bioimaging Division Lawrence Berkeley National LaboratoryBerkeleyCA 94720USA Department of Bioengineering University of CaliforniaBerkeleyCA 94720USA BCAM Basque Center for Applied MathematicsBilbao 48009Spain

We present a droplet-based microfluidic system that enables CRISPR-based gene editing and high-throughput screening on a *** microfluidic device contains a 10x10 element array,and each element contains sets of electrodes for two electric field-actuated operations:electrowetting for merging droplets to mix reagents and electroporation for *** device can perform up to 100 genetic modification reactions in parallel,providing a scalable platform for generating the large number of engineered strains required for the combinatorial optimization of genetic pathways and predictable *** demonstrate the system's capabilities through the CRISPR-based engineering of two test cases:(1)disruption of the function of the enzyme galactokinase(galK)in£coli and(2)targeted engineering of the glutamine synthetase gene(glnA)and the blue-pigment synthetase gene(bpsA)to improve indigoidine production in£coli.

关键词： operations generating fluid

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西普瑞安·盖拉德被图像冲散的历史

艺术界 2016年第1期 30-33页

作者：贺婧 Orion martin

将＂废墟＂作为萦绕不去的母题使得法国艺术家西普瑞安·盖拉德的影像作品像是一个穿梭于经典脚本与当代文化之间的图像枢纽,它四通八达地牵引着多条跨越了不同历史范畴和美学传统的线索,在错综的轨道上接踵和融汇：西欧古典绘画里的＂... 详细信息

将＂废墟＂作为萦绕不去的母题使得法国艺术家西普瑞安·盖拉德的影像作品像是一个穿梭于经典脚本与当代文化之间的图像枢纽,它四通八达地牵引着多条跨越了不同历史范畴和美学传统的线索,在错综的轨道上接踵和融汇：西欧古典绘画里的＂崇高＂图式、MTV流行音乐、大地艺术中的美学观念、乌托邦的重建与毁灭,甚至于浪漫主义和暴力革命问的矛盾渊源……这些线索并不难分辨,耐人寻味的是它们在影片中彼此搭配和嵌入的方式。

关键词：普瑞影像作品拉德大地艺术古典绘画美学传统暴力革命历史范畴母题 revolution