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Neural Regeneration Research 2018年第3期13卷 402-405页

作者： Marius Nistor martin schmidt René Schiffner Department of Neurology Jena University Hospital Friedrich Schiller University Jena Germany Orthopaedic Department Jena University Hospital Friedrich Schiller University Jena Germany Institute for Biochemistry II Jena University Hospital Friedrich Schiller University Jena Germany

Since its discovery in the 1920’s the relaxin peptide hormone family has not only grown in number to now seven members （relaxin-1, relaxin-2, relaxin-3, insulin-like peptide （INSL） 3, INSL4, INSL5 and INSL6）, but ever more effects, suchs as vasodilatory, angiogenic, anti-apoptopic, anti-fibriotic and anti-inflammatory, have been linked to them. While relaxin-2 has mainly been investigated in the context of cardiac protection, most comprehensively in the RELAX-AHF and RELAX AHF2 studies, a small number of studies have furthermore assessed the potential neuroprotective effects of especially relaxin-2 and other members of the relaxin family. In this short review we summarise and discuss recent efforts to utilize relaxin hormones for neuroprotection and point out potential future fields of research and translational applications. While many questions still need to be answered, the promising results of the available studies definitely warrant future well-designed studies on neuroprotection by relaxin peptides.

关键词： relaxin relaxin-2 neuroprotection stroke hemorrhagic shock cerebral

counting and measuring particles sized from soot to pollen

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china Particuology 2007年第5期5卷 359-361页

作者： martin schmidt Sven Schütz Leander Mlter Palas GmbH Greschbachstr. 3b76229 KarlsruheGermany

For number concentration measurements of superfine particles a condensation nucleus counter （cNc） is frequently used. The combination of a new cNc module with a white light aerosol spectrometer and a passive collector makes possible accurate time-resolved determination of particle number within the overall size range of 10 nm to 40 μm and at concentrations up to 10^5 particles/cm^3. With the aerosol spectrometer a high time-resolved particle size determination is also possible in the size range of 0.3-40 μm up to the same high number concentrations of 10^5 particles/cm^3.

关键词： cNc Particles Size

Molecular level simulations on multi-component systems --a morphology prediction method

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Frontiers of chemical Science and Engineering 2013年第1期7卷 49-54页

作者： c. schmidt J. ULRIcH center for Engineering Science Thermal Process Engineering Martin Luther University Halle-Wittenberg D-06099 Halle (Saale) Germany

The crystal morphology grown from a solution composed of an organic solvent, solute and additive can be predicted reliably by a computational method. Modeling the supersaturated solution as liquid phase is achieved by employing commercial software. The molecular composition of this solution is a required input parameter. The face specific diffusion coefficient of the solid （crystal surface） and liquid （solution） system is determined using the molecular dynamics procedure. The obtained diffusion coefficient is related to the specific face growth rate via the attachment energy of the pure morphology. The significant improvements are achieved in the morphology prediction because the investigation on the face growth rates in a complex growth environment （as multi-component solutions with additives） can be carried out based on the diffusion coefficients.

关键词： crystallization morphology molecular dynamics solution

chapter model systems in heterogeneous catalysis at the atomic level: a personal view

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Science china chemistry 2020年第4期63卷 426-447页

作者： Hans-Joachim Freund Markus Heyde Helmut Kuhlenbeck Niklas Nilius Thomas Risse Thomas schmidt Shamil Shaikhutdinov martin Sterrer Fritz Haber Institute of the Max Planck Society Faradayweg 4-6Berlin D-14195Germany Fakultat V-Mathematik und Naturwissenschaften Carl von Ossietzky Universitat OldenburgGermany Institut fur chemie und Biochemie Freie UniversitatBerlinGermany Institute of Physics University of GrazGrazAustria

The review presents an overview of studies in the surface science of oxide and related surfaces with an emphasis of the studies performed in the authors’ group. Novel instruments and technique developments, as well as their applications are reported, in an attempt to cover studies on model systems of increasing complexity, including some of the key ingredients of an industrially applied heterogeneous catalyst and its fabrication. The review is intended to demonstrate the power of model studies in understanding heterogeneous catalysis at the atomic level. The studies include those on supported nano-particles, both, prepared in vacuum and from solution, interaction of surfaces and the underlying bulk with molecules from the gas phase, strong metal support interaction, as well as the first attempt to include studies on reactions in confined spaces.

关键词： model catalysts oxide surfaces structure and spectroscopy supported nanoparticles reactions in the confined space

Estimating the size and travel distance of Klapperhorn Mountain debris flows for risk analysis along railway, canada

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International Journal of Sediment Research 2008年第3期23卷 275-282页

作者： c. Derek martin Dept. civil and Environmental Engineering University of Alberta Edmonton Alberta Canada T6G 2W2Drs.

Debris flows occurring on Klapperhorn Mountain in the Yellowhead Pass in the canadian Rocky Mountains pose a significant hazard to railway operations at the base of the mountain. The size (volume) and travel distance of these debris flows play an important role in assessing the risk to the railway. GIS analysis, airphoto interpretation together with field work were undertaken on two debris flows located at track mileage 54.0 and 54.3. characteristics of these two debris flow events were analyzed, including debris flow path morphology and event behavior. Their sizes and travel distances were estimated using an empirical-statistical model (UBcDFLOW) under different initiation conditions. Their potential impact on the railway bridge was evaluated using a bridge blockage ratio.

关键词： Debris flow Size Travel distance Railway

Factor of safety of strain-softening slopes

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Journal of Rock Mechanics and Geotechnical Engineering 2020年第3期12卷 473-483页

作者： Hossein Rafiei Renani c.Derek martin Klohn crippen Berger Ltd. VancouverCanada Department of civil and Environmental Engineering University of AlbertaEdmontonCanada

Stability analysis of strain-softening slopes is carried out using the shear strength reduction method and Mohr-coulomb model with degrading cohesion and friction *** e ffect of strain-softening behavior on the slope factor of safety is investigated by performing a series of analyses for various slope geometries and strength *** charts and equations are developed to estimate the factor of safety of strain-softe ning slopes from the results of traditional stability analysis based on perfectly-plastic *** example applications including an open pit mine in weak rock and clay shale slope with daylighting bedding planes are *** results of limit equilibrium analysis and shear strength reduction method with perfectly-plastic models were in close *** perfectly-plastic models with peak strength properties led to overly optimistic results while adopting residual strength properties gave excessively conservative *** shear strength reduction method with a strain-softening model gave realistic factors of safety while accounting for the process of strength degradation.

关键词： Slope stability analysis Factor of safety ratio Shear strength reduction Perfectly-plastic behavior Open pit slope clay shale slope

Output digitization of simple measure-preserving linear systems

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control Theory and Technology 2021年第4期19卷 430-443页

作者： A.DeStefano M.Thitsa c.martin Department of Mathematics and computer Science College of the Holy CrossWorcesterMA 01610USA Department of Electrical and computer Engineering Mercer UniversityMaconGA 31207USA Department of Mathematics and Statistics Texas Tech UniversityLubbockTX 79430USA

We examine three simple linear systems from the viewpoint of ergodic *** digitize the output and record only the sign of the output at integer *** show that even with this minimal output we can recover important information about the *** particular,for a two-dimensional system viewed as a fow on the circle,we can determine the rate of *** then use these results to determine the slope of the trajectories for constant irrational fow on the two-dimensional *** achieve this,we randomize the system by partitioning the state space and only recording which partition the state is in at each integer *** show directly that these systems have entropy ***,we examine two four-dimensional systems and reduce them to the study of linear fows on the two-dimensional torus.

关键词： Ergodic Linear system Observability cantor set

Split liver transplantation: current developments

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World Journal of Gastroenterology 2018年第47期24卷 5312-5321页

作者： christina Hackl Katharina M schmidt caner Süsal Bernd Dohler martin Zidek Hans J Schlitt Department of Surgery University Hospital RegensburgRegensburg 93053Germany collaborative Transplant Study (cTS) Institute of ImmunologyHeidelberg UniversityHeidelberg 69120Germany

In 1988, Rudolf Pichlmayr pioneered split liver transplantation(SLT), enabling the transplantation of one donor liver into two recipients-one pediatric and one adult patient. In the same year, Henri Bismuth and colleagues performed the first full right/full left split procedure with two adult recipients. Both splitting techniques were rapidly adopted within the transplant community. However, a SLT is technically demanding, may cause increased perioperative complications, and may potentially transform an excellent deceased donor organ into two marginal quality grafts. Thus, crucial evaluation of donor organs suitable for splitting and careful screening of potential SLT recipients is warranted. Furthermore, the logistic background of the splitting procedure as well as the organ allocation policy must be adapted to further increase the number and the safety of SLT. Under defined circumstances, in selected patients and at experienced transplant centers, SLT outcomes can be similar to those obtained in full organ LT. Thus, SLT is an important tool to reduce the donor organ shortage and waitlist mortality, especially for pediatric patients and small adults. The present review gives an overview of technical aspects, current developments, and clinical outcomes of SLT.

关键词： Liver transplantation organ shortage in situ split extended right lobe left lateral lobe living donor

Four-dimensional light shaping: manipulating ultrafast spatiotemporal foci in space and time

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Light(Science & Applications) 2017年第1期6卷 293-299页

作者： Bangshan Sun Patrick S Salter clemens Roider Alexander Jesacher Johannes Strauss Johannes Heberle Michael schmidt martin J Booth Department of Engineering Science University of OxfordParks RoadOxford OX13PJUK Institute of Photonic Technologies Friedrich-Alexander-University Erlangen-NurembergKonrad-Zuse-Strasse 3/5Erlangen 91052Germany Division of Biomedical Physics Innsbruck Medical UniversityMullerstrasse 44Innsbruck 6020Austria Graduate School in Advanced Optical Technologies(SAOT) Friedrich-Alexander University Erlangen-NurembergPaul-Gordan-Strasse 6Erlangen 91052Germany centre for Neural circuits and Behaviour University of OxfordMansfield RoadOxford OX13SRUK

The spectral dispersion of ultrashort pulses allows the simultaneous focusing of light in both space and time,which creates socalled spatiotemporal *** space–time coupling may be combined with the existing holographic techniques to give a further dimension of control when generating focal light *** the present study,it is shown that a phase-only hologram placed in the pupil plane of an objective and illuminated by a spatially chirped ultrashort pulse can be used to generate threedimensional arrays of spatio-temporally focused *** exploiting the pulse front tilt generated at focus when applying simultaneous spatial and temporal focusing(SSTF),it is possible to overlap neighboring foci in time to create a smooth intensity *** resulting light field displays a high level of axial confinement,with experimental demonstrations given through two-photon microscopy and the non-linear laser fabrication of glass.

关键词： laser material processing light shaping spatiotemporal focusing ultrafast lasers