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Portal vein thrombosis:Prevalence,patient characteristics and lifetime risk:A population study based on 23796 consecutive autopsies

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World Journal of Gastroenterology 2006年第13期12卷 2115-2119页

作者： Mats gren David Bergqvist martin bjrck Stefan Acosta Henry Eriksson Nils H Sternby Department of Vascular Surgery Uppsala University Hospital UppsalaSweden Departments of Vascular Diseases and Pathology Lund University Malm University HospitalMalmSweden Department of Medicine Sahlgrenska University Hospital/stra GteborgSweden Departments of Vascular Diseases and Pathology Lund University MalmUniversity HospitalMalmSweden

AIM： TO assess the lifetime cumulative incidence of portal venous thrombosis （PVT） in the general population. METHODS： Between 1970 and 1982, 23 796 autopsies, representing 84% of all in-hospital deaths in the Malmo city population, were performed, using a standardised protocol including examination of the portal vein. PVT patients were characterised and the PVT prevalence at autopsy, an expression of life-time cumulative incidence, assessed in high-risk disease categories and expressed in terms of odds ratios and 95% CI. RESULTS： The population prevalence of PVT was 1.0%. Of the 254 patients with PVT 28% had cirrhosis, 23% primary and 44% secondary hepatobiliary malignancy, 10% major abdominal infectious or inflammatory disease and 3% had a myeloproliferative disorder. Patients with both cirrhosis and hepatic carcinoma had the highest PVT risk, OR 17.1 （95% CI 11.1-26.4）. In 14% no cause was found; only a minority of them had developed portal-hypertension-related complications. CONCLUSION： In this population-based study, PVT was found to be more common than indicated by previous clinical series. The markedly excess risk in cirrhosis and hepatic carcinoma should warrant an increased awareness in these patients for whom prospective studies of directed intervention might be considered.

关键词： Epidemiology Venous thrombosis Portal hypertension Cirrhosis Gastrointestinal cancer

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Emerging insights into the function of very long chain fatty acids at cerebellar synapses

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Neural Regeneration Research 2025年第6期20卷 1709-1710页

作者： martin-Paul Agbaga Mohiuddin Ahmad Department of Cell Biology and Ophthalmology University of Oklahoma Health Sciences Centerand Dean McGee Eye InstituteOklahoma CityOKUSA

Very long chain-saturated and-polyunsaturated fatty acids(VLC-SFA and VLC-PUFA, respectively) are a functionally important class of fatty acids containing 28 carbons or more in their acyl chain. They are synthesized by the elongation of very long fatty acids-4(ELOVL4) enzyme, expressed mainly in the brain, retina, skin, testes, and meibomian gland, where these fatty acids are found(Agbaga et al., 2008). Further, these organs exhibit tissuespecific VLC-PUFA and VLC-SFA biosynthesis and incorporation into complex lipids for specific functions. In the brain, skin, and Meibomian glands, the ELOVL4 mainly makes VLC-SFA, which are incorporated into complex sphingolipids. In the retina, the ELOVL4 makes VLC-PUFA that are incorporated into phosphatidylcholine, that are critical for visual function, while in testes and sperm, the VLC-PUFA are incorporated into sphingolipids that are critical for fertility(Yeboah et al., 2021).

关键词： functions function insight

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Surface sediment diatoms from the western Pacific marginal seas and their correlation to environmental variables

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Chinese Journal of Oceanology and Limnology 2009年第3期27卷 674-682页

作者：黄玥蒋辉 Svante bjrck 李铁刚吕厚远冉莉华 Key Laboratory of Geographic Information Science East China Normal University GeoBiosphere Science Centre Quaternary SciencesLund University Key Laboratory of Marine Geology and Environment Institute of OceanologyChinese Academy of Sciences Institute of Geology and Geophysics Chinese Academy of Sciences

Diatom data of 192 surface sediment samples from the marginal seas in the western Pacific together with modern summer and winter sea surface temperature and salinity data were *** results of canonical correspondence analysis show that summer sea-surface salinity(SSS) is highly positively correlated with winter SSS and so is summer sea-surface temperature(SST) with winter *** correlations between SSSs and SSTs are less positively correlated,which may be due to interactions of regional current pattern and monsoon *** correlations between diatom species,sample sites and environmental variables concur with known diatom ecology and regional oceanographic *** results of forward selection of the environmental variables and associated Monte Carlo permutation tests of the statistical significance of each variable suggest that summer SSS and winter SST are the main environmental factors affecting the diatom distribution in the area and therefore preserved diatom data from down core could be used for reconstructions of summer SSS and winter SST in the region.

关键词： diatoms the western Pacific marginal seas environmental variables summer sea surface salinity winter sea surface temperature

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Development of Caenorhabditis elegans pharynx,with emphasis on its nervous system

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Acta Pharmacologica Sinica 2005年第4期26卷 396-404页

作者： Marc PILON Catarina M rck Lundberg Laboratory Chalmers University G teborg S-405 30 Sweden Lundberg Laboratory Chalmers University G teborg S-405 30 Sweden

The Caenorhabditis elegans pharynx is a neuromuscular tube of which the func-tion is to pump and crush bacteria,and inject them into the *** 80-cellpharynx develops via the morphogenesis and differentiation of the ceils that com-pose its semi-spherical primordiurn,and requires the activity of several evolution-arily conserved genes,such as pha-4 (the homolog to the Drosophilaforkheadand vertebrate FoxA),ceh-22 (the homolog to the Drosophila tinman and verte-brate Nkx2.5),and pha-2 (the homolog to the vertebrate Hex).There are 20 neu-rons in the pharynx,each with a reproducible unique *** analysis of axon guidance in the pharynx indicates that some axon trajec-tories are in part established without growth cones,whereas other parts necessi-tate growth cone function and *** we provide an overview of thedevelopmental genetics of the Caenorhabditis elegans pharynx,with an empha-sis on its nervous system.

关键词： Caenorhabditis elegans pharynx axon growth cones morphogenesis heart

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Alternative Strategy for Development of Dielectric Calcium Copper Titanate‑Based Electrolytes for Low‑Temperature Solid Oxide Fuel Cells

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Nano-Micro Letters 2025年第1期17卷 310-332页

作者： Sajid Rauf Muhammad Bilal Hanif Zuhra Tayyab Matej Veis MAKYousaf Shah Naveed Mushtaq Dmitry Medvedev Yibin Tian Chen Xia martin Motola Bin Zhu College of Mechatronics and Control Engineering Shenzhen UniversityShenzhen 518060People’s Republic of China Department of Inorganic Chemistry Faculty of Natural SciencesComenius University BratislavaIlkovicova684215 BratislavaSlovakia Energy Storage Joint Research Center School of Energy and EnvironmentSoutheast UniversityNanjing 210096People’s Republic of China Hydrogen Energy Laboratory Ural Federal University620002 EkaterinburgRussia Laboratory of Electrochemical Devices Based on Solid Oxide Proton Electrolytes Institute of High Temperature Electrochemistry620066 EkaterinburgRussia School of Microelectronics Hubei UniversityWuhan 430062People’s Republic of China

The development of low-temperature solid oxide fuel cells(LT-SOFCs)is of significant importance for realizing the widespread application of *** has stimulated a substantial materials research effort in developing high oxide-ion conductivity in the electrolyte layer of *** this context,for the first time,a dielectric material,CaCu_(3)Ti_(4)O_(12)(CCTO)is designed for LT-SOFCs electrolyte application in this *** individual CCTO and its heterostructure materials with a p-type Ni_(0.8)Co_(0.15)Al_(0.05)LiO_(2−δ)(NCAL)semiconductor are evaluated as alternative electrolytes in LT-SOFC at 450–550℃.The single cell with the individual CCTO electrolyte exhibits a power output of approximately 263 mW cm^(-2) and an open-circuit voltage(OCV)of 0.95 V at 550℃,while the cell with the CCTO–NCAL heterostructure electrolyte capably delivers an improved power output of approximately 605 mW cm^(-2) along with a higher OCV over 1.0 V,which indicates the introduction of high hole-conducting NCAL into the CCTO could enhance the cell performance rather than inducing any potential short-circuiting *** is found that these promising outcomes are due to the interplay of the dielectric material,its structure,and overall properties that led to improve electrochemical mechanism in CCTO–***,density functional theory calculations provide the detailed information about the electronic and structural properties of the CCTO and NCAL and their heterostructure CCTO–*** study thus provides a new approach for developing new advanced electrolytes for LT-SOFCs.

关键词： LT-SOFCs Dielectric CaCu_(3)Ti_(4)O_(12) Semiconductor Ni_(0.8)Co_(0.15)Al_(0.05)LiO_(2−δ) Ionic conductivity Heterostructure electrolyte

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Movement analysis in the diagnosis and management of Parkinson’s disease

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Neural Regeneration Research 2025年第2期20卷 485-486页

作者： Johannes Burtscher Nicolas Bourdillon Jules MJanssen Daalen Aurélien Patoz Julien FBally martin Kopp Davide Malatesta Bastiaan RBloem Institute of Sport Sciences University of LausanneLausanneSwitzerland Radboud University Medical Center Department of NeurologyDonders Institute for BrainCognition and BehaviorCenter of Expertise for Parkinson and Movement DisordersNijmegenThe Netherlands Radboud University Medical Center Department of Medical BioSciencesNijmegenThe Netherlands Research and Development Department Volodalen Swiss Sport LabAigleSwitzerland Service of Neurology Department of Clinical NeurosciencesLausanne University Hospital(CHUV)and University of Lausanne(UNIL)LausanneSwitzerland Department of Sport Science University of InnsbruckInnsbruckAustria

Challenges in the diagnosis and treatment of Parkinson’s disease:Parkinson’s disease(PD)is an increasingly prevalent neurodegenerative disease,at first sight primarily characterized by motor symptoms,although non-motor symptoms also constitute a major part of the overall ***,this disease cannot be diagnosed reliably until a large part of the vulnerable dopaminergic neurons has been irretrievably lost,and the disease progresses *** biological criteria for PD have been proposed recently and might eventually improve early diagnosis,but they require further validation,and their use will initially be restricted to a research environment(Darweesh et al.,2024).

关键词： diagnosis Clinical eventually

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Getting physical with medical education:Exercise based virtual anatomy review classes for medical students

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World Journal of Methodology 2025年第1期15卷 20-25页

作者： Nadeesha R Samarasinghe Taniya S Nagpal Michele L Barbeau Charys M martin Division of General Surgery Faculty of MedicineUniversity of British ColumbiaVancouver V6T 1Z3BCCanada Faculty of Kinesiology Sport and RecreationUniversity of AlbertaEdmonton T6G 2R3ABCanada Anatomy and Cell Biology University of Western OntarioLondon N6A 3K7ONCanada Department of Anatomy and Cell Biology Schulich School of Medicine and DentistryThe University of Western OntarioLondon N6A 3K7ONCanada

The benefits of regular physical activity are well ***,few studies have examined the effectiveness of integrating physical activity(PA)into curricula within a post-secondary *** investigate the incorporation of PA into medical curriculum,we developed a series of optional exercise-based review sessions designed to reinforce musculoskeletal(MSK)anatomy course *** synchronous sessions were co-taught by a group fitness instructor and an anatomy *** fitness instructor would lead students through both strength and yoga style exercises,while the anatomy instructor asked questions about relevant anatomical structures related to course material previously *** the sessions,participants were asked to evaluate the classes on their self-reported exam preparedness in improving MSK anatomy knowledge,PA levels,and mental *** participants completed surveys;a majority agreed that the classes increased understanding of MSK concepts(90.0%)and activity levels(97.7%).Many(70.0%)felt that the classes helped reduce *** majority of respondents(90.0%)agreed that the classes contributed to increased feelings of social ***,medical students saw benefit in PA based interventions to supplement MSK course *** with increasing activity levels and promoting health behaviours,integrating PA into medical curriculum may improve comprehension of learning material,alleviate stress and foster social connectivity among medical students.

关键词： Medical education Musculoskeletal Anatomy Exercise Online learning

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Violent collisions can reveal hexadecapole deformation of nuclei

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Nuclear Science and Techniques 2024年第7期35卷 1-3页

作者： björn Schenke Physics Department Brookhaven National LaboratoryUptonNY 11973USA

A new observable in heavy ion collision experiments was identified to be sensitive to the hexadecapole deformation of the colliding *** deformation is difficult to measure in traditional nuclear electric transition measurements,as it is often overwhelmed by the nuclear quadrupole *** opens the door to gain new insight into nuclear structure with experiments that were designed to study hot and dense nuclear matter.

关键词： deformation collision insight

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Norwegian oil and gas storage in rock caverns-Technology based on experience from hydropower development

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Journal of Rock Mechanics and Geotechnical Engineering 2021年第2期13卷 479-486页

作者： bjørn Nilsen Department of Geoscience and Petroleum Norwegian University of Science and Technology(NTNU)TrondheimNorway

Underground storage in rock caverns is widely used in Norway for many different petroleum products,such as crude oil,fuel,propane and ***,the caverns for such storages are unlined,*** is ensured without using any steel lining or *** main basis for the storage technology originates from the extensive hydropower development in *** part of this activity,about 4500 km of tunnels and shafts have been excavated,and around 200 large powerhouse caverns have been *** hydropower tunnels are mainly unlined,with hydrostatic water pressure on unlined rock of up to 1000 *** of the projects also include air cushion chambers with volumes of up to 1×10^(5)m^(3)and air pressure up to 7.7 *** lessons which are valuable also for underground oil and gas storage have been learnt from these *** a storage project to become successful,systematic,well planned design and ground investigation procedures are *** main steps of the design procedure are first to define the optimum location of the project,and then to optimize orientation,shape/geometry and dimensions of caverns and *** part of the procedure,ground investigations have to be carried out at several steps integrated with the progress of *** investigation and design procedures,and the great significance of these for the project to become successful will be *** examples of oil and gas storage in unlined rock caverns are given,illustrating the relevancy of experience from high-pressure hydropower projects for planning and design of unlined caverns for oil and gas storage.

关键词： Underground storage Oil Gas Liquefied petroleum gas(LPG) Hydropower Air cushion chamber

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What is required for better progress in clinical and scientific andrology involving sperm assessments?

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Asian Journal of Andrology 2024年第3期26卷 229-232页

作者： Lars björndahl ANOVA Karolinska University Hospital and Karolinska Institutet Sweden Stockholm S-113 64

In scientific publications based on basicsemen examination,there is a generallack of consistency and transparencyregarding laboratory techniques *** support improvements in clinicaland scientific andrology,it is essential toincrease understanding of basic physiologyand biology,and enhance compliancewith existing recommendations andinternational *** designsneed to be improved as well as transparencyof laboratory methods used and openpublication of data obtained.

关键词： transparency consistency clinical

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