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Heart rate response and recovery during exercise predict future delirium risk——A prospective cohort study in middle-to older-aged adults

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journal of Sport and Health Science 2023年第3期12卷 312-323页

作者： Lei Gao Aden Gaba Peng Li Richa Saxena Frank a.j.LScheer Oluwaseun Akeju martin K.Rutter Kun Hu Department of Anesthesia Critical Care and Pain MedicineMassachusetts General HospitalHarvard Medical SchoolBostonMA 02114USA Medical Biodynamics Program Brigham and Women's HospitalBostonMA 02115USA Division of Sleep Medicine Harvard Medical SchoolBostonMA 02115USA Broad Institute of Massachusetts Institute of Technology and Harvard CambridgeMA 02142USA Center for Genomic Medicine Massachusetts General HospitalBostonMA 02114USA Division of Diabetes Endocrinology and GastroenterologySchool of Medical SciencesFaculty of BiologyMedicine and HealthManchester Academic Health Science CentreUniversity of ManchesterManchester M139PLUK Diabetes Endocrinology and Metabolism CentreManchester University National Health Service Foundation TrustManchester M139WLUK

Background:Delirium is a neurocognitive disorder characterized by an abrupt decline in attention,awareness,and cognition after surgical/illness-induced stressors on the *** is now an increasing focus on how cardiovascular health interacts with neurocognitive disorders given their overlapping risk factors and links to subsequent dementia and *** common indicator for cardiovascular health is the heart rate response/recovery(HRR)to exercise,but how this relates to future delirium is ***:Electrocardiogram data were examined in 38,740 middle-to older-aged UK Biobank participants(mean age=58.1 years,range:40-72 years;47.3%males)who completed a standardized submaximal exercise stress test(15-s baseline,6-min exercise,and 1-min recovery)and required hospitalization during *** HRR index was derived as the product of the heart rate(HR)responses during exercise(peak/resting HRs)and recovery(peak/recovery HRs)and categorized into low/average/high groups as the bottom quartile/middle 2 quartiles/top quartile,*** between 3 HRR groups and new-onset delirium were investigated using Cox proportional hazards models and a2-year landmark analysis to minimize reverse *** factors,lifestyle factors/physical activity,cardiovascular risk,comorbidities,cognition,and maximal workload achieved were included as ***:During a median follow-up period of 11 years,348 participants(9/1000)newly developed *** with the high HRR group(16/1000),the risk for delirium was almost doubled in those with low HRR(hazard ratio=1.90,95%)confidence interval(95%CI):1.30-2.79,p=0.001)and average HRR(hazard ratio=1.54,95%CI:1.07-2.22,p=0.020)).Low HRR was equivalent to being 6 years older,a current smoker,or>3 additional cardiovascular disease *** were robust in sensitivity analysis,but the risk appeared larger in those with better cognition and when only postoperative delirium was considered(n=1

关键词： Brain health Delirium Exercise stress test UK Biobank

Precise Orientational Control of Electroactive Units Using a Tripodal Triptycene Scaffold to Direct Noncovalent Pairing at the Single Molecular Level

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Precision Chemistry 2023年第6期1卷 388-394页

作者： Colin j.martin Tomoya Fukui Ryosuke Takehara Shintaro Fujii Takanori Fukushima Laboratory for Chemistry and Life Science Institute of Innovative ResearchTokyo Institute of TechnologyYokohama 226-8503Japan Department of Chemistry School of ScienceTokyo Institute of TechnologyTokyo 152-8551Japan

A break junction technique has been established to explore conductive behavior at the single molecular level,and recent interest has shifted toward the evaluation of bimolecular systems interacting through noncovalent intermolecular *** requires precise control over the orientation of the two molecules so that they can adapt an appropriate face-to-face arrangement between two ***,we present an approach using a tripodal triptycene scaffold that allows for accurate positioning of electroactive subunits with an upright configuration on substrate *** incorporated electron-donating tetrathiafulvalene or electron-accepting anthraquinone into the molecular scaffold and confirmed that the resulting molecules retain the electronic properties particular to their attached ***-assembled monolayers(SAMs)of these molecules were prepared on Au(111)and characterized by XPS and *** break junction techniques were applied to the SAMs,revealing two electrical conduction regimes;one arises from single-molecules sandwiched between two electrodes,and the second from intermolecularly interacting homodimers that bridge between *** observation demonstrates the validity of the approach of using tripodal triptycene scaffolds to precisely direct electroactive subunits to undergo intermolecular *** believe that the present work will provide a new avenue for evaluating the heterodimers at the single molecular level.

关键词： STM break junction self-assembled monolayers supramolecular scaffold noncovalent interactions triptycene

A global synthesis of the effectiveness and ecological impacts of management interventions for Spartina species

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Frontiers of Environmental Science & Engineering 2023年第11期17卷 263-272页

作者： Shengyu Wang Philip A.martin Yan Hao William j.Sutherland Gorm E.Shackelford jihua Wu Ruiting ju Wenneng Zhou Bo Li Ministry of Education Key Laboratory for Biodiversity Science and Ecological Engineering National Observations and Research Station of Wetland Ecosystems of the Yangtze EstuaryInstitute of Biodiversity Science and Institute of Eco-ChongmingSchool of Life SciencesFudan UniversityShanghai 200438China Biosecurity Research Initiative at St Catharine’s(BioRISC) St Catharine’s CollegeUniversity of CambridgeCambridgeCB21RLUK Conservation Science Group Department of ZoologyUniversity of CambridgeCambridgeCB23QZUK State Key Laboratory of Grassland Agro-Ecosystems and College of Ecology Lanzhou UniversityLanzhou 730000China Guangdong Provincial Key Laboratory of Water Quality Improvement and Ecological Restoration for Watersheds School of EcologyEnvironment and ResourcesGuangdong University of TechnologyGuangzhou 510006China Ministry of Education Key Laboratory for Transboundary Ecosecurity of Southwest China Yunnan Key Laboratory of Plant Reproductive AdaptationEvolutionary Ecology and Centre for Invasion BiologyInstitute of BiodiversitySchool of Ecology and Environmental ScienceYunnan UniversityKunming 650504China

Invasions by Spartina species pose serious threats to global coastal *** many studies have examined the effectiveness and ecological impacts of invasive Spartina management,no comprehensive global synthesis has been conducted to assess the effects of management on Spartina per se and on wider ***,we conducted a global meta-analysis of 3,459 observations from 102 studies to quantify the effects of different management interventions(physical,chemical,biological,and integrated control)on Spartina per se and native biodiversity and *** found that physical measures quickly suppressed Spartina but that their effectiveness declined over *** contrast,chemical measures decreased the abundance and growth of Spartina to a lesser degree in the early stage,but the effectiveness increased over *** management measures did not significantly decrease the diversity of native biota on the whole,but native-plant diversity significantly decreased with time after physical *** management measures did not affect abiotic factors *** results support the use of chemical measures to control invasive Spartina,although their effectiveness would depend on the time since the management *** the problem of Spartina regrowth following physical control requires improved *** hold that initial states of invaders and subsequent environmental changes after management interventions should be weighed in evaluating control efficacy.

关键词： Plant invasion Biodiversity Meta-analysis Restoration Salt marshes Treatment timing

两类层次模糊Mass-Assignment系统是全局逼近器(英文)

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软件学报 2002年第10期13卷 1943-1951页

作者：王士同 j.F.Baldwin T.P.martin 英国Bristol大学先进计算研究中心

基于mass assignment 理论,提出了两类层次模糊mass assignment系统,并运用构造性证明过程证明了其全局逼近性质.由于类型1层次模糊系统的规则数与输入变量数呈线性关系,类型2层次模糊系统按逼近精度要求引入子模糊系统,因此,此两类层... 详细信息

基于mass assignment 理论,提出了两类层次模糊mass assignment系统,并运用构造性证明过程证明了其全局逼近性质.由于类型1层次模糊系统的规则数与输入变量数呈线性关系,类型2层次模糊系统按逼近精度要求引入子模糊系统,因此,此两类层次模糊mass assignment系统可被用来有效地克服模糊规则爆炸问题,即所谓的规则数与输入变量数呈指数关系问题.

关键词：层次模糊Mass-Assignment系统全局逼近器人工智 mass-assignment理论

Spontaneous liver rupture following SARS-CoV-2 infection in late pregnancy:A case report

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World journal of Clinical Cases 2022年第15期10卷 5042-5050页

作者： Radek Ambroz martin Stasek ján Molnár Petr Spicka Dusan Klos jozef Hambálek Daniela Skanderová Department of Surgery I University Hospital Olomouc and Faculty of Medicine and DentistryPalacky UniversityOlomouc 77900Czech Republic Department of Obstetrics and Gynecology University Hospital Olomouc and Faculty of Medicine and DentistryPalacky UniversityOlomouc 77900Czech Republic Department of Pathology University Hospital Olomouc and Faculty of Medicine and DentistryPalackýUniversityOlomouc 77900Czech Republic

BACKGROUND Coronavirus disease-2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is characterized by systemic inflammatory response syndrome and ***-CoV-2 associated mortality ranges from 2%to 6%.Liver dysfunction was observed in 14%-53%of COVID-19 cases,especially in moderate severe ***,no cases of spontaneous hepatic rupture in pregnant women with SARS-CoV-2 have been *** SUMMARY A 32-year-old pregnant patient(gestational age:32 wk+4 d)without any remarkable medical history or long-term medication presented with ***,non-infectious,and pregnancy-related hepatopathies were *** onset of right subcostal pain with D-dimer and liver enzyme elevation was followed by shock with *** performing an emergency cesarean section,hemoperitoneum was observed,and the patient delivered a stillbirth.A 6-cm liver rupture at the edges of segments V and VI had occurred,which was sutured and ***-CoV-2 positivity on reverse transcriptionpolymerase chain reaction was *** revisions for intrahepatic hematoma with hemorrhagic shock and abdominal compartment syndrome were ***,the patient developed hemoptysis,which was treated using bronchoscopic therapy and non-invasive *** tissue biopsy revealed hemorrhagic foci and necrosis with an irregular centrilobular *** syndrome and autoimmune hepatitis were also ruled *** death was caused by acute intrauterine *** This case reveals that pregnant women with SARS-CoV-2 infection may be predisposed to liver parenchyma disease with liver rupture.

关键词： Liver rupture SARS-CoV-2 Pregnancy Abortion HELLP Case report

A culture model to analyze the acute biomaterial-dependent reaction of human primary neutrophils in vitro

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生物活性材料(英文) 2023年第2期20卷 627-637页

作者： Marinus A.Wesdorp Andrea Schwab Ezgi Irem Bektas Roberto Narcisi David Eglin martin j.Stoddart Gerjo j.V.M.Van Osch Matteo D’Este AO Research Institute Davos AO FoundationDavos PlatzSwitzerland Department of Orthopaedics and Sports Medicine Erasmus MCUniversity Medical Center Rotterdamthe Netherlands Mines Saint-Étienne Univ LyonUniv Jean MonnetINSERMU1059 SainbioseSaint-ÉtienneFrance Department of Biomaterials Science and Technology University of TwenteEnschedethe Netherlands Department of Otorhinolaryngology Erasmus MCUniversity Medical Center Rotterdamthe Netherlands Department of Biomechanical Engineering Faculty of MechanicalMaritimeand Materials EngineeringDelft University of Technologythe Netherlands Department of Oral and Maxillofacial Surgery Erasmus MCUniversity Medical Center Rotterdamthe Netherlands

Neutrophils play a pivotal role in orchestrating the immune system response to biomaterials,the onset and resolution of chronic inflammation,and macrophage ***,the neutrophil response to biomaterials and the consequent impact on tissue engineering approaches is still scarcely ***,we report an in vitro culture model that comprehensively describes the most important neutrophil functions in the light of tissue *** isolated human primary neutrophils from peripheral blood and exposed them to a panel of hard,soft,naturally-and synthetically-derived *** overall trend showed increased neutrophil survival on naturally derived constructs,together with higher oxidative burst,decreased myeloperoxidase and neutrophil elastase and decreased cytokine secretion compared to neutrophils on synthetic *** culture model is a step to better understand the immune modulation elicited by *** studies are needed to correlate the neutrophil response to tissue healing and to elucidate the mechanism triggering the cell response and their consequences in determining inflammation onset and resolution.

关键词： inflammation healing culture

pH-dependent leaching mechanism of carbonatitic chalcopyrite in ferric sulfate solution

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Transactions of Nonferrous Metals Society of China 2021年第7期31卷 2139-2152页

作者： Kolela.j.NYEMBWE Elvis FOSSO-KANKEU Frans WAANDERS martin MKANDAWIRE Water Pollution Monitoring and Remediation Initiatives Research Group School of Chemical and Minerals EngineeringFaculty of EngineeringNorth-West UniversitySouth Africa Department of Chemistry School of Science and TechnologyCape Breton UniversityCanada

The dissolution of a carbonatitic chalcopyrite(CuFeS2)was studied in H_(2)SO_(4)−Fe_(2)(SO_(4))_(3)−FeSO_(4)−H_(2)O at varying pH values(0.5−2.5)and 25℃ for 12 *** were conducted with a size fraction of 53−75μ*** Cu recoveries,below 15%,were observed in all pH *** results from the XRD,SEM−EDS,and optical microscopic(OM)analyses of the residues indicated that the dissolution proceeded through the formation of transient ***_(3.39)Fe_(0.61)S_(4) and Cu_(2)S were the intermediate phases at pH 0.5 and 1.0,respectively,whereas Cu_(5)FeS_(4) was the major mineral at pH 1.5 and *** thermodynamic modelling predicted the sequential formation of CuFeS_(2)→Cu_(5)FeS_(4)→Cu_(2)S→*** soluble intermediates were Cu_(5)FeS_(4) and Cu2S,whilst,CuS and Cu_(3.39)Fe_(0.61)S_(4) were the refractory phases,supporting their cumulating behaviour throughout the *** obtained results suggest that the formation of CuS and Cu_(3.39)Fe_(0.61)S_(4) could contribute to the passive film formed during CuFeS_(2) leaching.

关键词： chalcopyrite carbonatite chemical leaching leaching mechanism intermediate phase thermodynamic behavior

Increased hepcidin expression in colorectal carcinogenesis

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World journal of Gastroenterology 2008年第9期14卷 1339-1345页

作者： Douglas G Ward Keith Roberts Matthew j Brookes Howard joy Ashley martin Tariq Ismail Robert Spychal Tariq Iqbal Chris Tselepis CRUK Institute for Cancer Studies University of Birmingham Birmingham B15 2THUnited Kingdom

AIM:To investigate whether the iron stores regulator hepcidin is implicated in colon cancer-associated anae- mia and whether it might have a role in colorectal car- cinogenesis. METHODS: Mass spectrometry (MALDI-TOF MS and SELDI-TOF MS) was employed to measure hepcidin in urine collected from 56 patients with colorectal cancer. Quantitative Real Time RT-PCR was utilised to determine hepcidin mRNA expression in colorectal cancer tissue. Hepcidin cellular localisation was determined using im- munohistochemistry. RESULTS: We demonstrate that whilst urinary hepcidin expression was not correlated with anaemia it was posi- tively associated with increasing T-stage of colorectal cancer (P < 0.05). Furthermore, we report that hepcidin mRNA is expressed in 34% of colorectal cancer tissue specimens and was correlated with ferroportin repres- sion. This was supported by hepcidin immunoreactivity in colorectal cancer tissue. CONCLUSION: We demonstrate that systemic hepcidin expression is unlikely to be the cause of the systemic anaemia associated with colorectal cancer. However, we demonstrate for the first time that hepcidin is expressed by colorectal cancer tissue and that this may represent a novel oncogenic signalling mechanism.

关键词： Iron Hepcidin Colon Cancer Anaemia Mass spectrometry

Lack of support for Rensch＇s rule in an intraspecific test using red flour beetle （Tribo/ium castaneum） populations

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Insect Science 2017年第1期24卷 133-140页

作者： Oliver Y. martin Lukasz Michalczyk Anna L. Millard Brent C. Emerson Matthew j. G. Gage School of Biological Sciences University of East Anglia Norwich Research Park Norwich NR4 7T J United Kingdom ETH Zurich Experimental Ecology Institute of Integrative Biology D-USYS Universitatsstrasse 16 CH-8092 Zurich Switzerland Department of Entomology Institute of Zoology Jagiellonian University Gronostajowa 9 30-387 Krakow Poland Island Ecology and Evolution Research Group (IPNA-CSIC) CIAstrofisico Francisco Sanchez 3 38206 La Laguna Tenerife Canary Islands Spain

Rensch＇s rule proposes a universal allometric scaling phenomenon across species where sexual size dimorphism （SSD） has evolved： in taxa with male-biased dimorphism, degree of SSD should increase with overall body size, and in taxa with female-biased dimorphism, degree of SSD should decrease with increasing average body size. Rensch＇s rule appears to hold widely across taxa where SSD is male-biased, but not consistently when SSD is female-biased. Furthermore, studies addressing this question within species are rare, so it remains unclear whether this rule applies at the intraspecific level. We assess body size and SSD within Tribolium castaneum （Herbst）, a species where females are larger than males, using 21 populations derived from separate locations across the world, and maintained in isolated laboratory culture for at least 20 years. Body size, and hence SSD patterns, are highly susceptible to variations in temperature, diet quality and other environmental factors. Crucially, here we nullify interference of such confounds as all populations were maintained under identical conditions （similar densities, standard diet and exposed to identical temperature, relative humidity and photoperiod）. We measured thirty beetles of each sex for all populations, and found body size variation across populations, and （as expected） female-biased SSD in all populations. We test whether Rensch＇s rule holds for our populations, but find isometry, i.e. no allometry for SSD. Our results thus show that Rensch＇s rule does not hold across populations within this species. Our intraspecific test matches previous interspecific studies showing that Rensch＇s rule fails in species with female-biased SSD.

关键词： allometry body size Coleoptera sexual selection sexual size dimorphism Tenebrionidae