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第十八届国际反应堆结构力学大会

作者： martin brezina Ludovit Kupca Peter Beno VUJE Inc. TrnavaSlovak Republic VUJE Inc. TrnavaSlovak Republic VUJE Inc. TrnavaSlovak Republic

＜正＞ 1 INTRODUCTION Corrosion stability monitoring of safety related components is an important task for the safety operation and lifetime extension of NPPs. From the operational experience and from the demands of the national regulatory bodies follows requirements for corrosion behavior monitoring of main structural materials. As the respond to this requirement, several technical solutions have been prepared for the long-term monitoring of NPP materials. These monitoring systems are based on the principle of surveillance samples. All specimens made from original materials are placed into the original environment and loaded with

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Distinct gut microbiota profiles in patients with primary sclerosing cholangitis and ulcerative colitis

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World Journal of Gastroenterology 2017年第25期23卷 4548-4558页

作者： Lukas Bajer Miloslav Kverka martin Kostovcik Peter Macinga Jiri Dvorak Zuzana Stehlikova Jan brezina Pavel Wohl Julius Spicak Pavel Drastich Department of Gastroenterology and Hepatology Institute for Clinical and Experimental Medicine Institute of Microbiology the Czech Academy of Sciences Institute of Experimental Medicine the Czech Academy of Sciences Department of Genetics and Microbiology Faculty of ScienceCharles University BIOCEV Institute of Microbiologythe Czech Academy of Sciences

To characterize the gut bacterial microbiota of patients with primary sclerosing cholangitis (PSC) and ulcerative colitis (UC). METHODSStool samples were collected and relevant clinical data obtained from 106 study participants, 43 PSC patients with (n = 32) or without (n = 11) concomitant inflammatory bowel disease, 32 UC patients, and 31 healthy controls. The V3 and V4 regions of the 16S ribosomal RNA gene were sequenced on Illumina MiSeq platform to cover low taxonomic levels. Data were further processed in QIIME employing MaAsLin and LEfSe tools for analysis of the output data. RESULTSMicrobial profiles in both PSC and UC were characterized by low bacterial diversity and significant change in global microbial composition. Rothia, Enterococcus, Streptococcus, Veillonella, and three other genera were markedly overrepresented in PSC regardless of concomitant inflammatory bowel disease (IBD). Rothia, Veillonella and Streptococcus were tracked to the species level to identify Rothia mucilaginosa, Streptococcus infantus, S. alactolyticus, and S. equi along with Veillonella parvula and V. dispar. PSC was further characterized by decreased abundance of Adlercreutzia equolifaciens and Prevotella copri. Decrease in genus Phascolarctobacterium was linked to presence of colonic inflammation regardless of IBD phenotype. Akkermansia muciniphila, Butyricicoccus pullicaecorum and Clostridium colinum were decreased in UC along with genus Roseburia. Low levels of serum albumin were significantly correlated with enrichment of order Actinomycetales. CONCLUSIONPSC is associated with specific gut microbes independently of concomitant IBD and several bacterial taxa clearly distinguish IBD phenotypes (PSC-IBD and UC).

关键词： Dysbiosis Inflammatory bowel disease Ulcerative colitis Gut microbiota Primary sclerosing cholangitis

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