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应用5F指引导管经桡动脉通路冠状动脉介入治疗(摘要)

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海南医学 2002年第11期13卷 75-76页

作者：田军赵全明 Gille Grollier martial hamon 河南省人民医院二内科郑州450003 法国冈城大学医疗中心心内科

目的 :评价应用 5F小腔径指引导管经桡动脉冠状动脉 (冠脉 )腔内成形术 (PTCA)和支架术的可行性、安全性 ,探讨其应用策略。方法 :①对象 :经冠脉造影证实冠脉病变需进行PTCA和支架置入的 12 0例患者 ,男 10 0例 ,女 2 0例 ,平均年龄 65... 详细信息

目的 :评价应用 5F小腔径指引导管经桡动脉冠状动脉 (冠脉 )腔内成形术 (PTCA)和支架术的可行性、安全性 ,探讨其应用策略。方法 :①对象 :经冠脉造影证实冠脉病变需进行PTCA和支架置入的 12 0例患者 ,男 10 0例 ,女 2 0例 ,平均年龄 65 (11岁 ;单支病变 86例 (71.6% ) ,双支病变 18例 (15 % ) ,三支病变 14例 (11.7% ) ,静脉旁路血管病变 2例 (1.7% )。②材料 :12 0例均应用MedtronicAVE 5FZ2指引导管。右冠病变 43例中有 2 9例 (67.4% )应用Judkins右冠导管 ,10例 (2 3 .3 % )应用Amplatz左冠导管 ,4例 (9.3 % )应用Amplatz右冠导管。 92例患者的 12 1处左冠病变 ,61例 (66.3 % )应用Judkins左冠导管 ,17例 (18.5 % )应用EBU导管 ,14例 (15 .2 % )应用Amplatz左冠导管。 2例静脉旁路血管病变均应用Judkins右冠导管。③手术通路 :96例 (80 % )经右侧挠动脉 ,2 4例 (2 0 % )经左侧挠动脉。结果 :对 12 0例患者的 166处病变 (左主干 3例 ,左前降支 77例 ,左回旋支 41例 ,右冠 43例 ,静脉旁路 2例 )进行了治疗 ,其中 119处 (71.7% )直接支架置入 ,42处 (2 5 .3 % )PTCA后支架置入 ,5处 (3 % )支架置入未成功 ,仅行PTCA ;置入支架 161枚 ,直径 2 .5 -4mm ,长度 8-3 3mm。治疗前后病变血管平均狭窄程度分别?

关键词：桡动脉通路介入治疗冠状动脉腔内血管成形术支架术 5F造影导管冠心病

The Deep Thioredoxome in Chlamydomonas reinhardtii： New Insights into Redox Regulation

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Molecular Plant 2017年第8期10卷 1107-1125页

作者： Maria Esther Perez-Perez Adeline Mauries Alexandre Maes Nicolas J. Tourasse Marion hamon Stephane D. Lemaire Christophe H. Marchand Institut de Biologie Physico-Chimique UMR8226 CNRS Sorbonne Universit6s UPMC Univ Paris 06 13 rue Pierre et Marie Curie 75005 Paris France Institut de Biologie Physico-Chimique Plateforme de Proteomique FRC550 CNRS 13 rue Pierre et Marie Curie 75005 Paris France Instituto de Bioquimica Vegetal y Fotosintesis Consejo Superior de Investigaciones Cientificas (CSIC)-Universidad de Sevilla Seville Spain ARNA Laboratory INSERM U1212 CNRS UMR5320 Universite Bordeaux 2 Bordeaux France

Thiol-based redox post-translational modifications have emerged as important mechanisms of signaling and regulation in all organisms, and thioredoxin plays a key role by controlling the thiol-disulfide status of target proteins. Recent redox proteomic studies revealed hundreds of proteins regulated by glutathio- nylation and nitrosylation in the unicellular green alga Chlamydomonas reinhardtii, while much less is known about the thioredoxin interactome in this organism. By combining qualitative and quantitative proteomic analyses, we have comprehensively investigated the Chlamydomonas thioredoxome and 1188 targets have been identified. They participate in a wide range of metabolic pathways and cellular pro- cesses. This study broadens not only the redox regulation to new enzymes involved in well-known thiore- doxin-regulated metabolic pathways but also sheds light on cellular processes for which data supporting redox regulation are scarce （aromatic amino acid biosynthesis, nuclear transport, etc）. Moreover, we char- acterized 1052 thioredoxin-dependent regulatory sites and showed that these data constitute a valuable resource for future functional studies in Chlamydomonas. By comparing this thioredoxome with proteomic data for glutathionylation and nitrosylation at the protein and cysteine levels, this work confirms the existence of a complex redox regulation network in Chlamydomonas and provides evidence of a tremendous selectivity of redox post-translational modifications for specific cysteine residues.

关键词： Chlamydomonas reinhardtii disulfide bond isotope-coded affinity tag redox proteomics redox regulation thioredoxin targets

Effect of the seeds provenance and treatment on the germination rate and plants growth of four forest trees species of Cote d’Ivoire

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Journal of Forestry Research 2021年第1期32卷 161-169页

作者： Sélastique Doff ou Akaff ou AiméKouassi Kouame Nestor Bi Boh Gore Georges Yao Abessika Henri Kouadio Kouassi Perla hamon Sylvie Sabatier Jerome Duminil Department for Seeds and Seedlings Production Jean Lorougnon GuédéUniversityBP 150DaloaCote d’Ivoire IRD UMR DIADEB.P.6450134394 Montpellier Cedex 5France CIRAD UMR AMAP34398 MontpellierFrance

The rapid rate of deforestation in Cote d’Ivoire has led to loss of plant species diversity and also threatens some commercial tree species with *** reforestation and aff orestation has been ***,for some species,the numbers of surviving transplants has ***,it is necessary to develop properly adapted and resilient genotypes that can eff ectively support the programs of forest *** this context we evaluated the eff ects of the provenances of seeds and of various treatments on the germination rates and on plant growth of four commercial trees species(Pycnanthus angolensis,Terminalia superba,Mansonia altissima and Pterygota macrocarpa).We analyzed these parameters for seeds of three provenances(Daloa,Akoupéand Daoukro)of four species and for thirty plants aged 6 months per *** to begin germination and time to reach maximum germination were similar among species,and were not infl uenced by either treatment or *** seeds and those soaked for 24 and 48 h in water at room temperature yielded the highest germination rates,irrespective of species or *** one exception was ***,for which no germination was *** species,some provenances produced higher germination percentages than did *** clear relationship was computed between the germination rate and the morphometric characteristics of the seeds which varied signifi cantly between *** growth and morphological variability also depended greatly on *** factors might be implicated,therefore provenance trials should be undertaken and ***,molecular analysis should be undertaken to confi rm the implications of genetic factors and allow for genetic selection.

关键词： Forest trees Seed germination Plant growth Provenance Cote d’Ivoire

Brown Bear-Human Conflict Management at Brooks River, Katmai National Park and Preserve

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Journal of Earth Science and Engineering 2013年第9期3卷 583-593页

作者： Cory Mosby Sherri Anderson John Campbell Troy hamon Resource Management Division Katmai National Park and Preserve King Salmon 99613 USA

From 1989-2009, 1,430 bear management report forms collected at Brooks Camp, KNP （Katmai National Park）, were placed in 1 of 9 categories representing bear-human interactions of concern. Using non-parametrical statistics the categories identified dominance interactions, fish-related dominance interactions, food obtained, food-related incidents, fish stolen, property damage, and use of deterrents either decreasing or exhibiting no significant trends over time. Aggressive behavior by bears towards park staff in bear management situations increased. An elevated walkway and platform at Brooks Falls and an electric fence at the campground marked significant decrease in bear-human interactions in these areas. Changes in fishing regulations in 1998 marked significant decreases in number of fish stolen. Changes in minimum distance regulations in 2003 marked no change in number of dominance interactions or bluff charges. Efforts to facilitate visitor traffic in areas around the floating bridge have marked significant increases in number of bear-human interactions. Management and policy efforts have been successful in minimizing bear-human interactions. Habituation of bears to human activity has likely contributed to both minimizing general interactions and increased aggressive bear behavior towards management staff. This study provides examples of successful adaptive management tactics for bears and humans in a visitor oriented setting.

关键词： Bear-human interaction brown bear Katmai National Park Ursus arctos

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沉积不整合中的高分辨率层序地层学

国外石油动态 2008年第2期 11-20页

作者： hamon Youri 刘春（译）

三十年来，层序地层学概念的发展和应用引起了把不整合面作为地层单元的边界面的浓厚兴趣。仅有很少的研究把焦点放在对成岩作用和沉积过程以及沉积不整合形成时间的理解上。然而，这些过程代表着不整合面形成期间仅有的环境变化沉积记... 详细信息

三十年来，层序地层学概念的发展和应用引起了把不整合面作为地层单元的边界面的浓厚兴趣。仅有很少的研究把焦点放在对成岩作用和沉积过程以及沉积不整合形成时间的理解上。然而，这些过程代表着不整合面形成期间仅有的环境变化沉积记录。本研究基于一种综合的研究方法（如油田数据、薄剖面、阴极发光、地球化学分析），其目的是根据沉积不整合介绍一个实际的地层层序记录的例子。在Lodève地区（法国东南盆地的西南边缘），上Hettangian阶到sinemurian阶为碳酸盐岩沉积序列，类似鲕粒灰岩的碳酸盐岩储层表明是复合不整合面。为了理解这些不整合的起源，其中一个不整合被详细地加以研究。地层的几个形成阶段已经被认可。首先是海侵侵蚀发生，接着是与铁矿物相关的石针迹和双杯迹的生物钻孔的发育，这可以显示是与后来最大海泛时期相对应的凝缩阶段。这些生物钻孔的晶体充填可以表征最大海泛时期之后的高水位时期。紧接着，在界面上和生物钻孔里面观察到的次生改造和侵蚀可能显示了一个与海退阶段和海退之后低位时期相关的时期的出现。最后，微泥堤（形成于瓣鳃和珊瑚吸收的细小石灰岩沉积物）可能表明了一个新的与海侵及其最大海泛时期相关的凝缩阶段。因此，这个不整合记录了一个半相对海平面变化旋回。储层的几何形状和岩石物性蕴含的含义是多方面的：1）这些独特的不整合可能在同一大陆背景下横向上与其它界面（古喀斯特）相关或与海相层序、变化的高分辨率层序相关。2）这些不整合面的侧向变化导致了成岩作用和岩石物性的非均质性（孔隙度、渗透率）。

关键词：高分辨率层序地层学沉积不整合碳酸盐岩储层相对海平面变化不整合面地球化学分析成岩作用岩石物性

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沉积不整合中的高分辨率层序地层学

海洋地质动态 2008年第4期24卷 38-42页

作者： hamon Youri 刘春高贵冬

30年来,层序地层学概念的发展和应用引起了把不整合面作为地层单元的边界面的浓厚兴趣.仅有很少的研究把焦点集中在对成岩作用和沉积过程以及对沉积不整合的形成时间的理解方面.然而,这些过程仅仅表现了在不整合面形成期间环境变化的沉... 详细信息

30年来,层序地层学概念的发展和应用引起了把不整合面作为地层单元的边界面的浓厚兴趣.仅有很少的研究把焦点集中在对成岩作用和沉积过程以及对沉积不整合的形成时间的理解方面.然而,这些过程仅仅表现了在不整合面形成期间环境变化的沉积记录.

关键词：高分辨率层序地层学沉积不整合不整合面地层单元形成时间沉积过程成岩作用沉积记录

Leveraging mathematical models of disease dynamics and machine learning to improve development of novel malaria interventions

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Infectious Diseases of Poverty 2022年第3期11卷 37-53页

作者： Monica Golumbeanu Guo-Jing Yang Flavia Camponovo Erin M.Stuckey Nicholas hamon Mathias Mondy Sarah Rees Nakul Chitnis Ewan Cameron Melissa A.Penny Swiss Tropical and Public Health Institute AllschwilSwitzerland Key Laboratory of Tropical Translational Medicine of Ministry of Education and School of Tropical Medicine and Laboratory Medicine The First and Second Affiliated Hospital of Hainan Medical UniversityHainan Medical UniversityHaikouHainanPeople’s Republic of China University of Basel BaselSwitzerland Center for Communicable Disease Dynamics Department of EpidemiologyHarvard T.H.Chan School of Public HealthBostonMA02115USA The Bill&Melinda Gates Foundation SeattleWAUSA Innovative Vector Control Consortium LiverpoolUK Malaria Atlas Project Big Data InstituteUniversity of OxfordOxfordUK Curtin University PerthAustralia Telethon Kids Institute Perth Children’s HospitalPerthAustralia

Background:Substantial research is underway to develop next-generation interventions that address current malaria control *** there is limited testing in their early development,it is difficult to predefine intervention properties such as efficacy that achieve target health goals,and therefore challenging to prioritize selection of novel candidate ***,we present a quantitative approach to guide intervention development using mathematical models of malaria dynamics coupled with machine *** analysis identifies requirements of efficacy,coverage,and duration of effect for five novel malaria interventions to achieve targeted reductions in malaria ***:A mathematical model of malaria transmission dynamics is used to simulate deployment and predict potential impact of new malaria interventions by considering operational,health-system,population,and disease *** method relies on consultation with product development stakeholders to define the putative space of novel intervention *** couple the disease model with machine learning to search this multi-dimensional space and efficiently identify optimal intervention properties that achieve specified health ***:We apply our approach to five malaria interventions under *** for malaria prevalence reduction,we identify and quantify key determinants of intervention impact along with their minimal properties required to achieve the desired health *** coverage is generally identified as the largest driver of impact,higher efficacy,longer protection duration or multiple deployments per year are needed to increase prevalence *** show that interventions on multiple parasite or vector targets,as well as combinations the new interventions with drug treatment,lead to significant burden reductions and lower efficacy or duration ***:Our approach uses disease dynamic models and machine learning to support

关键词： Infectious diseases Malaria Novel interventions Mathematical modelling Machine learning

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牛乳中的硫酸盐雌素酮及其与怀孕的关系

西南民族学院学报(畜牧兽医版) 1983年第1期 76-77页

作者： R·B·Heap M·hamon 邱忠权

从生物液体的取样检查来说,牛乳比血清提供更为实际的优越性,但是,在怀孕诊断上孕酮的测定可能引起在其它地地方讨论过的一些误差。对于怀孕检查,特别有价值的是孕体产

关键词：动情素雌素酮硫酸盐硫化合物孕体乳汁牛乳牛奶

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早期吸入一氧化氮能改善极早产儿的氧化平衡

世界核心医学期刊文摘（儿科学分册） 2005年第10期1卷 60-61页

作者： hamon I. Fresson J. Nicolas M.-B. 宁亮 Reanimation Neonatale Maternite Regionale Univ. de Nancy 10 rue du Dr Heydenreich 54 042 Nancy Ced ex France Dr.

Inhaled nitric oxide (iNO) improves oxygenation in premature infants, but conc ern has been raised about its potential oxidative toxicity. We designed this stu dy to assess the oxidative balance in premature infants who were exposed to low dose iNO and the relationship with their clinical outcome on day 28 of life. Ato tal of 274 infants who were < 32 wk gestation were randomized at birth to receiv e 5 ppm of iNO if they presented with hypoxemic respiratory failure. Nonhypoxemi c infants were studied as the reference group. Blood samples were withdrawn 24 h apart, within the first 4 d of life, to assess malondialdehyde (MDA)-concentra tion as oxidative stress marker and total plasmatic glutathione (GSH), intraeryt hrocyte GSH peroxidase, and GSH reductase activities as antioxidant defenses. Af ter 24 h, the rise in MDA was blunted in the iNO group compared with controls an d was close to the reference infants. Conversely, GSH was more stable in the iNO group, when there was no difference for the GSH peroxidase and GSH reductase ac tivities. On day 28, Oxygen dependence was linked with a higher increase in MDA as was the risk for death, whereas intraventricular hemorrhage was associated wi th a higher initial drop in GSH. Early low-dose iNO in hypoxemic preterm infant s improves oxidative balance and seems to be clinically beneficial up to day 28 of life.

关键词：氧化应激采集血样还原酶活性过氧化酶出生后低氧血症呼吸困难参照组谷胱甘肽