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Open Journal of Animal Sciences 2013年第4期3卷 1-7页

作者： Emilio Pimentel Luz M. Vidal martha patricia cruces Mariusz Krzysztof Janczur Departamento de Biología Instituto Nacional de Investigaciones Nucleares (ININ) Ocoyoacac México Facultad de Ciencias Universidad Autónoma del Estado de México Toluca México

Protoporphyirin-IX (PP-IX) is a precursor of the biosynthesis of the hemo group, most of the cytochromes and the chlorophylls. The PP-IX is used for medical purposes, and recently a report indicated that it exhibits a dual action since it can decrease or increase the genetic damage caused by N-nitroso-N-ethylurea (ENU) in somatic cells of Drosophila. PP-IX is known to be able to act as an anti-or pro-oxidant agent. The aim of the present research was to study the role of PP-IX on the lifespan of Drosophila melanogaster, taking into account the fact that increasing levels of ROS can accelerate the aging process. The Canton-S strain (CS) was used as well as Sod and Cat which are deficient in the endogenous enzymes, superoxide dismutase and catalase, respectively. Groups of females and males were treated separately with 5 mg/ml of PP-IX solution. The comparison of survival curves indicates that this pigment extended the lifespan of CS. In contrast, Sod strain showed that the opposite effect and had no effect in Cat strain. The fact that PP-IX reduces the mean lifespan in Sod deficient strain might suggest a pro-oxidant action of PP-IX, and consequently the cumulating of ROS as a superoxide could have a mutagenic effect as was shown recently. The results presented evidence of the dual effect of PP-IX.

关键词： Protoporphyrin IX (PP-IX) Lifespan Sod Cat Reactive Oxygen Species Longevity Drosophila melanogaster

The Ways of Thinking in a Sample of the Student Community of the Subjects of Structured Programming and Numerical Methods in Engineering of the UAM-Azcapotzalco within the Emerging Remote Teaching Project (PEER)

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International Journal of Intelligence Science 2022年第3期12卷 39-56页

作者： Lourdes Sánchez-Guerrero Ana Lilia Laureano-cruces martha Mora-Torres Javier Ramírez-Rodríguez Departamento de Sistemas Universidad Autónoma Metropolitana-Azcapotzalco Mexico City Mexico Posgrado en Diseñ o y Visualización de la Información Universidad Autónoma Metropolitana-Azcapotzalco Mexico City Mexico

Due to the pandemic that is currently being experienced worldwide, educational institutions (HEIs) have had to reinvent and innovate the mode of teaching, in order to continue the process of training students at all educational levels. Higher education has not been immune to this situation, the institutions of this educational level face various challenges in remote teaching: one of them, perhaps the most important, was to answer the question: How to get the student to continue their undergraduate studies remotely? In this sense, it was necessary, on the part of the students and the teachers, a preparation to go from the face-to-face to the virtual mode. This paper addresses the specific case of the analysis of the teaching-learning process of the Teaching-Learning Unit (UEA for its acronym in Spanish) of Structured Programming and Numerical Methods for Engineering at the undergraduate level, at the Universidad Autónoma Metropolitana, Unidad Azcapotzalco (UAM-A) and its relation to the student’s way of thinking. Likewise, the analysis will be carried out if the way of thinking of the students of the sample influences their academic performance when studying the subject of Structured Programming and Numerical Methods for Engineering.

关键词： Intelligent Teaching Systems Emerging Remote Teaching Project (PEER) Way of Thinking Cognition Motivation and the Locus of Control

An Affective-Motivational Interface for a Pedagogical Agent

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International Journal of Intelligence Science 2014年第1期4卷 17-23页

作者： martha Mora-Torres Ana Lilia Laureano-cruces Fernando Gamboa-Rodríguez Javier Ramírez-Rodríguez Lourdes Sánchez-Guerrero CCADET Universidad Nacional Autónoma de México México City México Departamento de Sistemas Universidad Autónoma Metropolitana-Azcapotzalco México City México Laboratoire Informatique d’Avignon Université d’Avignon et des Pays de Vaucluse Avignon France Posgrado en Ciencia e Ingeniería de la Computación Universidad Nacional Autónoma de México México City México

This research is framed within the affective computing, which explains the importance of emotions in human cognition (decision making, perception, interaction and human intelligence). Applying this approach to a pedagogical agent is an essential part to enhance the effectiveness of the teaching-learning process of an intelligent learning system. This work focuses on the design of the inference engine that will give life to the interface, where the latter is represented by a pedagogical agent. The inference engine is based on an affective-motivational model. This model is implemented by using artificial intelligence technique called fuzzy cognitive maps.

关键词： Affective-Motivational Model Intelligent Learning System Pedagogical Agent Affective Computing Simulation of Emotions

Relevance of Family in Academic Success on Children

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Health 2017年第2期9卷 279-288页

作者： patricia Martínez Lanz Ana Cristina Losada Fernández Fabiola Pecchioni Fernández martha patricia Hernández Valdez Universidad Aná huac Mé xico M&eacute xico City M&eacute xico

The purpose of this study was to analyze the relationship between academic success and functional and dysfunctional families. A non-experimental, cross-sectional, descriptive correlational design was used. A convenience sample of 200 children between 6 and 13 years old, primary and junior high school students was conducted (32.3% were female and 67.7% were male). To assess the relationship, a study case of 21 reagents was designed to empty the obtained information from medical review records from a psychopedagogic clinic. Academic success was measured as from the revision of informal tests and standardized tests. Results showed that the population levels of academic success were average. However, a significant relationship between the age of the parents and the level of academic success was found, indicating that these variables are associated with this problem. Besides that, it was found that there is a tendency in children with cognitive, emotional and sensory problems reflected in low academic success. The findings provide information that could be considered for the development of programs of psychopedagogic intervention to treat children with learning disabilities and low academic success.

关键词： Academic Success Low Academic Success Functional Family Dysfunctional Family Children

A Novel Method to Improve Quality of Drinking Water, Based on the Eye’s Biology

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Journal of Water Resource and Protection 2022年第4期14卷 318-333页

作者： Arturo Solís Herrera María del Carmen Arias Esparza martha patricia Solís Arias Human Photosynthesis^TM Research Centre Aguascalientes México

Water represents a critical nutrient, the absence of which will be lethal within days. Water’s importance for the prevention of nutrition-related noncommunicable diseases has received more attention recently. There are major gaps in knowledge related to the measurement of total fluid intake and hydration status at the population level. It is poorly understood the effects of chronic mild dehydration and fluid consumption on specific health outcomes including obesity. Urolithiasis is the only disorder that has been consistently associated with chronic low daily water intake. Water is an essential nutrient required for life, but until now, it was considered mainly as a universal solvent, which served to prepare the broth of life inside the cells, but the function of water now takes unusual importance with our discovery of the unsuspected ability of the human body to transform the power of light into chemical energy by dissociating the molecule from water, as it happens in plants. The process that we replicated in the laboratory for the first time in 2007, represents a light at the end of the tunnel, in the growing and serious problem of contamination of the mysterious and vital liquid that we call water.

关键词： Drinking Water Hydrogen Oxygen Dissolved Oxygen Pollution Human Eye

Dynamic Interaction through a Reactive Interface in Patients with Dementia, by Means of Cognitive Stimulation

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E-Health Telecommunication Systems and Networks 2015年第4期4卷 57-67页

作者： Ana Lilia Laureano-cruces martha Mora-Torres Lourdes Sánchez-Guerrero Javier Ramírez-Rodríguez Itzel Iraís Montiel-Bernal Eric Benjamín Allier-Pavia Departamento de Sistemas Universidad Autónoma Metropolitana-Azcapotzalco México City México Posgrado en Ciencia e Ingeniería de la Computación Universidad Nacional Autónoma de México México City México Escuela Superior de Cómputo-Instituto Politécnico Nacional México City México Posgrado en Diseno Línea: Visualización de la Información Universidad Autónoma Metropolitana-Azcapotzalco México City México

Dementia is a syndrome of chronic and progressive nature, characterized by the deterioration of cognitive functions and behavior, which causes a disability and dependence on others. Alzheimer’s Disease is a type of dementia that affects cognitive functioning, behavior, and overall functionality of those who suffer from the irremediably progressive form, as it is a neurodegenerative disease. For this reason, development of a reactive interface is proposed to be inserted in a cognitive stimulation program. This program offers a series of exercises of mental functions, in order to delay or slow down the progress of this illness. The reactive interface allows access to these exercises and incorporates a user profile that predicts the possible emotions that may be experienced during the work sessions. In order to accomplish this, a cognitive structure of emotions is developed to be included in the reactive profile. This will allow enhancement of the interaction between the system and the patient. The user’s emotional state may interfere, considering within the design stage the phenomenon of altered consciousness during this degenerative process. The consciousness represents the interface of human beings with our environment. This proposal allows us to obtain information related to the user’s emotional state during the performance of specific cognitive tasks, permitting us to optimize the proposed stimulation activities.

关键词： Dementia Alzheimer Cognitive Stimulation Artificial Consciousness Cognitive Structure of the Emotions

Non-Painful Peripheral Inflammation Blocks Conditioned Place-Preference to Morphine and Nicotine through an Ibuprofen-Sensitive and an Ibuprofen Insensitive Pathway

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Journal of Behavioral and Brain Science 2018年第2期8卷 57-76页

作者： Marco Antonio Sotomayor-Sobrino Abraham Ochoa-Aguilar Eda patricia Tenorio martha León-Olea Roberto Velasco-González Israel Luna-Mendoza Claudia Gómez-Acevedo Departmento de Farmacología Facultad de Medicina Universidad Nacional Autónoma de México Ciudad de México México Departmento de Bioquímica Facultad de Medicina Universidad Nacional Autónoma de México Ciudad de México México Instituto Nacional de Psiquiatría “Ramón de la Fuente Muñ iz” Ciudad de México México

The field of neuroimmunology has expanded in recent years providing new insights and therapies into pathologies like stroke, autism, and depression. However, few works explore the relationship between inflammatory stimuli and motivation. Thus, the aim of this study was to determine how non-painful inflammatory stimuli affect reward. To test reward-response, we used the morphine and the nicotine induced conditioned place-preference and place-aversion model in rats with non-painful inflammation. The following inflammatory models were used: non-painful infectious inflammation: 24 hrs prior to conditioning sessions, an injection with Calmette-Guerin bacillus (CGB) 1 × 107 cfu, ip, was administered. Non-painful non-infectious inflammation: 24 hrs prior to conditioning sessions, rats’ sciatic nerve was blocked and cut, followed by the injection of carrageenan (750 μl) in the paw. We then measured the cytokine concentration to determine the inflammatory profile of each of our models. Finally, we administered ibuprofen to determine if it could prevent the effect of inflammation over conditioned place-preference. We show that carrageenan significantly reduced the morphine-induced reward. Non-painful inflammatory stimulus, CGB and denervation + carrageenan, inhibit the conditioned place-preference to morphine and nicotine, CGB also block conditioned place-aversion to nicotine;carrageenan has no effect on CPA. The administration of ibuprofen reinstates conditioned place-preference to morphine and nicotine in the carrageenan model, but has no effect in the CGB model;finally ibuprofen has no effect on CPA. Our data suggest that non-painful-inflammatory stimuli inhibit the reward system, independent of cytokine concentration. Furthermore, the administration of a PGE 2 inhibitor can importantly modulate this phenomenon.

关键词： Reward Addiction Pain Inflammation Prostaglandins Interferon

The Unexpected Capability of Melanin to Split the Water Molecule and the Alzheimer’s Disease

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Neuroscience & Medicine 2011年第3期2卷 217-221页

作者： Maria del Carmen Arias-Esparza Ruth Isabel Solís Arias Paola Eugenia Solís Arias martha patricia Solís Arias A. Solís-Herrera 不详

We began a study about the three main causes of blindness in 1990, because their incidence and prevalence have not changed in the last forty years. Twelve years later we concluded that the main source of energy for the human retina is water, not ATP. And this is also true for the entire human body. Water is the main source of energy. The amazing capability of eukaryotic cells to break or dissociate the water molecule was unsuspected to us because it takes 2000℃ degrees to dissociate water in a laboratory environment, and until today, it was believed that only plants were capable of accomplishing this. Photosynthesis occurs in humans as it does in plants. The water that we drink every day is not just to wash away detritus and toxins;it is not just a cleaner, nor a simple solvent. When our body dissociates the water molecule, cells are able to get their energy from Hydrogen (Hydrogen is the energy carrier that Nature uses the most). Water is our main source of energy. If our body couldn’t acquire energy from water, we would need to eat between 50 - 170 kg (110 - 374 lbs) daily. In any system, when a generalized failure occurs, we must suspect energy first. Parkinson and Alzheimer’s Disease are examples of a generalized failure. That explains why it is not uncommon that patients improve dramatically with pharmacological stimulation of the human photosynthesis process. Recall that the brain needs energy not only to grow or to perform its functions, but also to preserve its form and shape. The best energy for human cells is Hydrogen.

关键词： Melanin Water Dissociation Energy Glucose Alzheimer Biomass

Biosorption of Trivalent Chromium from Aqueous Solution by Red Seaweed Polysiphonia nigrescens

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Journal of Water Resource and Protection 2011年第11期3卷 832-843页

作者： patricia Blanes Cong Cong Adriana Cortadi María Frascaroli martha Gattuso Silvia García Juan González Masafumi Harada Cristina Matulewicz Yasuhiro Niwa Héctor Prado Luis Sala 不详

This paper presents the biosorption of chromium onto red seaweed (Polysiphonia nigrescens). Batch mode experiments were performed to determine experimental parameters affecting sorption process such as pH, contact time, initial metal ion concentration and biomass dosage. The Cr(III) sorption was dependent on pH and adsorbent dosage. The adsorption kinetic data could be fitted with a pseudo-second-order model and the equilibrium data with a Langmuir model. The maximum sorption capacity was of 16.11 mg/g at pH 4 and 10 g/L of biomass dosage. 0.1 M H2SO4 showed good desorption efficiency (>80%). Spectroscopy analysis showed that Cr(III) sorption on seaweed was mainly through the ion-exchange mechanism. This report indicates that P. nigrescens is an effective and economical sorbent for removal of Cr(III) from wastewaters.

关键词： Seaweed Polysiphonia nigrescens Biosorption Chromium Isotherms Kinetics Parameters

CIMAvax^(█)EGF vaccine therapy for non-small cell lung cancer:A weighted log-rank tests-based evaluation

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Modern Chemotherapy 2013年第3期2卷 51-56页

作者： Carmen Viada Gonzalez Jean-Francois Dupuy martha Fors López patricia Lorenzo Luaces Gisela González Marinello Elia Neninger Vinagera Beatriz García Verdecia Tania Crombet-Ramos Clinical Trials Department Center of Molecular ImmunologyHavanaCuba National Institute of Applied Sciences of Rennes RennesFrance National Coordinator Center of Clinical Trial HavanaCuba Hermanos Ameijeiras Hospital HavanaCuba

Time-to-event has become one of the primary endpoints of many clinical trials. Comparing treatments and therapies using time-to-event (or “survival”) data requires some care, since survival differences may occur either early or late in the follow-up period, depending on various factors such as the initial potency or the duration of efficacy of the drugs. In this work, we investigate the effect of the CIMAvax?EGF vaccine therapy on the survival of patients with non-small cell lung cancer, using stratified and unstratified weighted log-rank tests. Weighted log-rank tests are designed to identify early and late survival differences between treatments. Using these tests, we conclude that the vaccine is more efficient than the standard therapy among patients less than 60 years of age.

关键词： Log-Rank Test Fleming-Harrington Test Stratified Tests