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Mole.ular approache. for spinal cord injury tre.tme.t

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Ne.ral Re.e.e.ation Re.e.rch 2023年第1期18卷 23-30页

作者： Fe.nanda Martins de.Alme.da Sue.e. Adriani Marque. Anne.Caroline.Rodrigue. dos santos Caio Andrade.Prins Fe.lipe.Soare. dos santos Cardoso Luiza dos santos He.inge. He.rique.Rocha Me.donça Ana Maria Blanco Martine. Laboratório de.Ne.rode.e.e.ação e.Re.aro Programa de Pós-Graduação em Medicina:Anatomia PatológicaDepartamento de PatologiaFaculdade de MedicinaHospital Universitário Clementino Fraga FilhoCentro de Ciências da SaúdeUniversidade Federal do Rio de JaneiroRio de JaneiroBrazil Instituto de.Ciências Biomédicas Centro de Ciências da SaúdeUniversidade Federal do Rio de JaneiroRio de JaneiroBrazil Instituto de.Biologia Departamento de NeurobiologiaLaboratório de Regeneração Neural e FunçãoUFFRio de JaneiroBrazil Laboratório Inte.rado de.Morfologia Instituto de Biodiversidade e Sustentabilidade NUPEMPrograma de Pós-graduação Multicêntrico em Ciências Fisiológicas-SBFisCentro Multidisciplinar UFRJ-MacaéUniversidade Federal do Rio de JaneiroMacaéBrazil

Injurie. to the.spinal cord re.ult in pe.mane.t disabilitie. that limit daily life.*** main re.sons for the.e.poor outcome. are.the.limite. re.e.e.ative.capacity of ce.tral ne.rons and the.inhibitory milie. that is e.tablishe. upon traumatic *** de.ade. of re.e.rch,the.e.is still no e.ficie.t tre.tme.t for spinal cord *** strate.ie. are.te.te. in pre.linical studie. that focus on ame.iorating the.functional outcome. afte. spinal cord *** the.e.mole.ular compounds are.curre.tly be.ng use. for ne.rological re.ove.y,with promising *** mole.ule. targe. the.axon collapse. growth cone.the.inhibitory microe.vironme.t,the.survival of ne.rons and glial ce.ls,and the.re.e.tablishme.t of lost *** this re.ie. we.focuse. on mole.ule. that are.be.ng use.,e.the. in pre.linical or clinical studie.,to tre.t spinal cord injurie.,such as drugs,growth and ne.rotrophic factors,e.zyme.,and *** me.hanisms of action of the.e.mole.ule. are.discusse.,conside.ing traumatic spinal cord injury in rode.ts and humans.

关键词： axonal re.e.e.ation drugs e.zyme. growth factors mole.ular the.apy ne.rotrophic factors purine. spinal cord injury

Re.in-angiote.sin syste. in the.pathoge.e.is of live. fibrosis

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World Journal of Gastroe.te.ology 2009年第21期15卷 2579-2586页

作者： Re.ina Maria Pe.e.ra Robson Augusto Souza dos santos Filipi Le.e. da Costa Dias Mauro Martins Te.xe.ra Ana Cristina Simoe. e.Silva De.artme.t of Pe.iatrics Faculty of MedicineFederal University of Minas Gerais Laboratory of Hype.te.sion Department of Physiology and BiophysicsInstitute of Biological SciencesFederal University of Minas Gerais Laboratory of Immunopharmacology Department of Biochemistry and ImmunologyInstitute of Biological SciencesFederal University of Minas Gerais

He.atic fibrosis is conside.e. a common re.ponse.to many chronic he.atic injurie.. It is a multifunctional proce.s that involve. se.e.al ce.l type., cytokine., che.okine. and growth factors le.ding to a disruption of home.static me.hanisms that maintain the.live. e.osyste.. In spite.of many studie. re.arding the.de.e.opme.t of fibrosis, the.unde.standing of the.pathoge.e.is re.ains obscure. The.he.atic tissue.re.ode.ing proce.s is highly comple., re.ulting from the.balance.be.we.n collage. de.radation and synthe.is. Among the.many me.iators that take.part in this proce.s, the.compone.ts of the.Re.in angiote.sin syste. （RAS） have.progre.sive.y assume. an important role. Angiote.sin （Ang） II acts as a profibrotic me.iator and Ang-（1-7）, the.ne.ly re.ognize. RAS compone.t, appe.rs to e.e.t a counte.-re.ulatory role.in live. tissue. We.brie.ly re.ie. the.live. fibrosis proce.s and curre.t aspe.ts of the.RAS. This re.ie. also aims to discuss some.e.pe.ime.tal e.ide.ce.re.arding the.participation of RAS me.iators in the.pathoge.e.is of live. fibrosis, focusing on the.putative.role.of the.ACe.-Ang-（1-7）- Mas re.e.tor axis.

关键词： He.atic fibrosis Re.in angiote.sin syste. Angiote.sin II Angiote.sin-(1-7) Re.e.tor Mas Angiote.sin conve.ting e.zyme.2

Microstructural characte.ization and me.hanical be.avior analysis of 7075-T6 aluminum subje.te. to simulate. lightning strike.

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Chine.e.Journal of Ae.onautics 2021年第12期34卷 39-50页

作者： Luis He.rique.santos We.le. Patrick Te.dosio SOUSA Sara Silva Fe.re.ra De.DAFe.Pe.ro Ame.ico Magalhae. JUNIOR De.artme.t of Me.hanical e.gine.ring Pontificia Universidade Catolica de Minas GeraisBelo Horizonte 30535-901Brazil

Aircrafts damage. cause. by lightning strike. have.be.n known since.the.e.rly days of ***,the.physical e.fe.ts on the.aircraft structure.are.still be.ng *** work se.ks to e.aluate.the.lightning strike.e.fe.ts in the.aluminum alloy *** we.e.submitte. to lightning strike.simulation in laboratory and the.damage. e.aluate. through characte.ization *** and profilome.ry te.ts have.shown mate.ial loss to 0.272 mm de.th in the.damage. *** addition,it was de.e.te. the.mate.ial accumulation occurre.ce.in the.damage.vicinity of the.*** the.damage.it was found a re.ion whe.e.me.allurgical change. we.e.*** te.sile.and microhardne.s te.ts re.ults have.shown re.uction in the.pe.ce.tage.e.ongation and hardne.s incre.sing in the.mate.ial affe.te. by *** re.ults are.corroborate. by the.X-Ray Diffraction(XRD)and Rie.ve.d Me.hod(re. line.that indicate. an incre.sing in dislocation de.sity and micro-de.ormation in the.mate.ial *** microscopy re.ults have.shown the.pre.e.ce.of microcracks on the.normal and cross-se.tion surface.of the.sample. *** e.e.gy Dispe.sive.X-Ray Spe.troscopy(e.XS)and e.e.tron Backscatte.e. Diffraction Te.t(e.SD)found coarse.inte.me.allic phase. and pre.ipitate. compounds with dime.sions gre.te. than 1 lm in *** we.e.re.ponsible.for nucle.tion of the.microcracks that propagate.along the.mate.ial grain boundarie..

关键词： Aircraft structure Characte.ization te.hnique. Lightning strike. Pre.ipitate. Microcracks

De.e.mination of the.physical and inte.action prope.tie. of sorghum grains:Application to computational fluid dynamics-discre.e.e.e.e.t me.hod simulations of the.fluid dynamics of a conical spoute. be.

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Particuology 2021年第1期19卷 91-101页

作者： J.N.M.Batista D.A.santos R.Be.te.a Fe.e.al Unive.sity of São Carlos Department of Chemical EngineeringSPBrazil Institute.of Che.istry Federal University of GoiásGOBrazil

Computational simulation is an important tool for de.ign and improve.e.t of industrial *** fluid dynamics(CFD)couple. with the.discre.e.e.e.e.t me.hod(De.)has be.n applie. to simulate.drying e.uipme.t that usually involve. gas-solid *** re.iable.re.ults of CFD-De. simulations,the.prope.tie. re.ate. to the.inte.actions of the.mate.ial within the.industrial e.uipme.t,such as the.re.titution or friction coe.ficie.ts,must be.*** this study,CFD-De. was applie. to simulate.the.fluid dynamics inside.a conical spoute. be. ope.ating with sorghum *** physical prope.tie. of the.particulate.phase.and the.particle.particle.and particle.wall inte.action parame.e.s we.e.de.e.mine. by the.dire.t me.sure.e.t approach and applie. to *** inte.action parame.e.s we.e.e.pe.ime.tally de.e.mine.,including the.particle.particle.inte.action parame.e.s ofη=0.46,μ^(S)=0.79,andμ_(R)=0.70,and the.particle.wall inte.action parame.e.s ofη=0.56,μ_(S)=0.75,andμ_(R)=*** simulate. minimum spouting ve.ocity and characte.istic curve. we.e.compare. with the.e.pe.ime.tal *** was good agre.me.t be.we.n the.simulate. and e.pe.ime.tal re.ults.

关键词： Re.titution coe.ficie.t Static friction coe.ficie.t Rolling friction coe.ficie.t CFD De.

He.icobacte. pylori infe.tion: Be.ond gastric manife.tations

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World Journal of Gastroe.te.ology 2020年第28期26卷 4076-4093页

作者： Maria Luisa Corde.ro santos Bre.o Bitte.court de.Brito Filipe.Antonio França da Silva Mariana Miranda Sampaio Hanna santos Marque. Natalia Olive.ra e.Silva Dulcie.e.Maria de.Magalhae. Que.roz Fabricio Fre.re.de.Me.o Instituto Multidisciplinar e. Saude Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil Unive.sidade.e.tadual da Bahia Vitória da Conquista 45083-900BahiaBrazil Laboratory of Re.e.rch in Bacte.iology Faculdade de MedicinaUniversidade Federal de Minas GeraisBelo Horizonte 30130-100Minas GeraisBrazil

He.icobacte. pylori(***)is a bacte.ium that infe.ts more.than a half of world’s *** it is mainly re.ate. to the.de.e.opme.t of gastroduode.al dise.se.,se.e.al studie. have.shown that such infe.tion may also influe.ce.the.de.e.opme.t and se.e.ity of various e.tragastric *** to the.curre.t e.ide.ce.whe.e.s this bacte.ium is a risk factor for some.of the.e.manife.tations,it might play a prote.tive.role.in othe. pathological *** that conte.t,whe. conside.e. the.gastrointe.tinal tract,*** positivity have.be.n re.ate. to Inflammatory Bowe. Dise.se.Gastroe.ophage.l Re.lux Dise.se.Non-Alcoholic Fatty Live. Dise.se.He.atic Carcinoma,Chole.ithiasis,and ***,lowe. se.um le.e.s of iron and vitamin B12 have.be.n found in patie.ts with *** infe.tion,le.ding to the.e.e.ge.ce.of ane.ias in a portion of *** re.ards to ne.rological manife.tations,a growing numbe. of studie. have.associate. that bacte.ium with multiple.scle.osis,Alzhe.me.’s dise.se.Parkinson’s dise.se.and Guillain-Barré***,the.risk of de.e.oping cardiovascular disorde.s,such as athe.oscle.osis,is also influe.ce. by the.*** that,the.***-associate. inflammation may also le.d to incre.se. insulin re.istance.le.ding to a highe. risk of diabe.e. me.litus among infe.te. ***,the.occurre.ce.of de.matological and ophthalmic disorde.s have.also be.n re.ate. to that *** this se.se.this minire.ie. aims to gathe. the.main studie. associating *** infe.tion with e.tragastric conditions,and also to e.plore.the.main me.hanisms that may e.plain the.role.of *** in those.dise.se..

关键词： He.icobacte. pylori e.tragastric Ne.rological Cardiovascular Autoimmune Ophthalmic Diabe.e. Time.ine Tre.tme.t

Comme.t on “Constraining the.smoothne.s parame.e. and dark e.e.gy using obse.vational H(z) data”

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Re.e.rch in Astronomy and Astrophysics 2011年第6期11卷 637-640页

作者： V.C.Busti R.C.santos Instituto de.Astronomia Geofísica e Ciências AtmosféricasUniversidade de So PauloSo Paulo05508-090 SPBrazil De.artame.to de.Ciê ncias e.atas e.da Te.ra Universidade Federal de So Paulo(UNIFESP)Diadema09972-270 SPBrazil

We.discuss a re.e.t analysis by Yu e. al.[RAA 11,125（2011）] about constraints on the.smoothne.s parame.e. α and dark e.e.gy mode.s using obse.vational H（z） *** is argue. he.e.that the.r proce.ure.is conce.tually inconsiste.t with the.basic assumptions unde.lying the.adopte. Dye.-Roe.e. *** orde. to prope.ly quantify the.influe.ce.of the.H（z） data on the.smoothne.s parame.e. α,a χ2-te.t involving a sample.of type.Ia supe.novae.and H（z） data in the.conte.t of a flat ΛCDM mode. is *** re.ult is confronte. with an e.rlie. approach discusse. by santos e. al.（2008） without H（z） *** the.Ωm,α） plane.it is found that such parame.e.s are.now re.tricte. to be.in the.inte.vals 0.66 ≤ α ≤ 1.0 and 0.27 ≤ Ωm ≤ 0.37 within the.95.4 confide.ce.le.e.（2σ）,and,the.e.ore.are.fully compatible.with the.homoge.e.us *** basic conclusion is that a joint analysis involving H（z） data can indire.tly improve.our knowle.ge.about the.influe.ce.of the.***,this happe.s only be.ause.the.H（z） data provide.tighte. constraints on the.matte. de.sity parame.e. Ωm.

关键词： cosmology — dark e.e.gy — cosmological parame.e.s

Global multiplicity of solutions to a de.ocusing quasiline.r Schrodinge. e.uation with the.singular te.m

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Scie.ce.China Mathe.atics 2023年第8期66卷 1789-1812页

作者： Siyu Che. Carlos Albe.to santos Minbo Yang Jiazhe.g Zhou De.artme.t of Mathe.atics Zhejiang Normal UniversityJinhua 321004China De.artame.to de.Mate.atica Universidade de BrasiliaBraslia 70910-900Brazil

We.conside. a class of modifie. quasiline.r Schrodinge. e.uations-△u+k/2u△u^(2)=λα(x)u^(-α)+b(x)u^(β) in Ω with u(x)=0 on■Ω,whe.e.Ω■R^(N)is a bounde. domain with a re.ular boundary,N≥3,a and b are.bounde. me.surable.functions,0e.two *** e.tablish the.global e.iste.ce.and multiplicity re.ults of positive.solutions in H^(1)_(0)(Ω)∩L^(∞)(Ω)for appropriate.classe. of parame.e.s k andλand coe.ficie.ts a(x)and b(x).

关键词： quasiline.r Schrodinge. e.uation singular te.m square.diffusion te.m

Analysis of 12 variants in the.de.e.opme.t of gastric and colore.tal cance.s

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World Journal of Gastroe.te.ology 2017年第48期23卷 8533-8543页

作者： Giovanna C Cavalcante.Marcos AT Amador Andre.M Ribe.ro dos santos Darle. C Carvalho Robe.ta B Andrade.e.dras e. Pe.e.ra Marianne.R Fe.nande. Danie.le.F Costa Ne. PC santos Paulo P Assumpcao Andre. Ribe.ro dos santos Sidne. santos Laboratório de.Ge.ética Humana e.Médica Universidade Federal do Pará Núcle. de.Pe.quisas e. Oncologia Universidade Federal do Pará

AIM To e.aluate.the.re.ation be.we.n 12 polymorphisms and the.de.e.opme.t of gastric cance.(GC) and colore.tal cance.(CRC).Me.HODS In this study,we.include. 125 individuals with GC diagnosis,66 individuals with CRC diagnosis and 475 cance.-fre. individuals. All participants re.ide. in the.North re.ion of Brazil and authorize. the.use.of the.r sample.. The.12 polymorphisms(in CASP8,CYP2 e.,CYP19 A1,IL1 A,IL4,MDM2,NFKB1,PAR1,TP53,TYMS,UGT1 A1 and XRCC1 ge.e.) we.e.ge.otype. in a single.PCR for e.ch individual,followe. by fragme.t analysis. To avoid misinte.pre.ation due.to population substructure.we.applie. a pre.iously de.e.ope. se. of 61 ance.tryinformative.marke.s that can also be.ge.otype. by multiple. PCR. The.statistical analyse. we.e.pe.forme. in Structure.v.2.3.4,R e.vironme.t and SPSS *** Afte. statistical analyse. with the.control of confounding factors,such as ge.e.ic ance.try,thre. marke.s(rs79071878 in IL4,rs3730485 in MDM2 and rs28362491 in NFKB1) we.e.positive.y associate. with the.de.e.opme.t of GC. One.of the.e.marke.s(rs28362491) and the.marke. in the.UGT1 A1 ge.e.rs8175347) we.e.positive.y associate. with the.de.e.opme.t of CRC. The.e.ore.we.inve.tigate. whe.he. the.joint pre.e.ce.of the.de.e.e.ious alle.e. of e.ch marke. could affe.t the.de.e.opme.t of cance. and we.obtaine. positive.re.ults in all analyse.. Carrie.s of the.combination of alle.e. RP1 + De.(rs79071878 and rs28361491,re.pe.tive.y) are.at 10-time. gre.te. risk of de.e.oping GC than carrie.s of othe. combinations. Similarly,carrie.s of the.combination of De. + RARe.rs283628 and rs8175347) are.at about 12-time. gre.te. risk of de.e.oping CRC than carrie.s of othe. *** The.e.findings are.important for the.compre.e.sion of gastric and CRC de.e.opme.t,particularly in highly admixe. populations,such as the.Brazilian population.

关键词： Inflammatory proce.se. Immune.re.ponse Ge.omic and ce.lular stability Gastric cance. Colore.tal cance. Amazon

Ske. Pairs of Ide.pote.ts in Transformation Se.igroups

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Acta Mathe.atica Sinica,e.glish Se.ie. 2006年第6期22卷 1705-1714页

作者： T.S.BLYTH M.H.ALMe.DA santos Mathe.atical Institute University of St Andrews De.artame.tode.Mate.ática F.C.T.Universidade Nova de Lisboa

An orde.e. pair （e. f） of ide.pote.ts of a re.ular se.igroup is calle. a ske. pair if e. is not ide.pote.t whe.e.s fe.is ide.pote.t. We.have.shown pre.iously that the.e.are.four distinct type. of ske. pairs of ide.p... 详细信息

关键词： full transformation se.igroups ide.pote.ts ske. pairs