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Ne.roinflammation and oxidative.stre.s act in conce.t to promote.ne.rode.e.e.ation in the.diabe.ic re.ina and optic ne.ve.gale.tin-3 participation

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Ne.ral Re.e.e.ation Re.e.rch 2020年第4期15卷 625-635页

作者： He.rique.Rocha Me.donca Raul Carpi-santos Karin da Costa Calaza Ana Maria Blanco Martine. Laboratorio de.Ne.rode.e.e.acao e.Re.aro Departamento de PatologiaPrograma de Pos-graduacao em Anatomia PatologicaFaculdade de MedicinaHospital Universitrio Clementino Fraga FilhoFederal University of Rio de JaneiroRio de JaneiroBrazil Polo Unive.sitario Macae Unidade Integrada de Pesquisa em Produtos Bioativos e BiocienciasFederal University of Rio de JaneiroMacaeBrazil Laboratorio Inte.rado de.Morfologia Instituto de Biodiversidade e SustentabilidadeNucleo de Pesquisas Ecologicas de MacaeFederal University of Rio de JaneiroMacaeBrazil Laboratorio de.Ne.robiologia Ce.ular Instituto de Ciencias BiomedicasCentro de Ciencias da SaudeFederal University of Rio de JaneiroRio de JaneiroBrazil Laboratorio de.Ne.robiologia da Re.ina Departamento de NeurobiologiaPrograma de Pos-Graduacao em NeurocienciasFluminense Federal UniversityNiteroiBrazil

Diabe.e. is a life.ong dise.se.characte.ize. by glucose.me.abolic imbalance.in which low insulin le.e.s or impaire. insulin signaling le.d to hype.glyce.ic *** 20 ye.rs of diabe.e. progre.sion,95%of patie.ts will have.diabe.ic re.inopathy,the.le.ding cause.of visual de.e.ts in working-age.pe.ple.*** diabe.e. is conside.e. a microvascular dise.se.re.e.t studie. have.shown that ne.rode.e.e.ation pre.e.e. vascular change. within the.diabe.ic visual syste.,albe.t its me.hanisms are.still unde. *** and oxidative.stre.s are.intrinsically re.ate. phe.ome.a,since.macrophage.microglia and astrocyte. are.the.main source. of re.ctive.oxyge. spe.ie. during ce.tral ne.vous syste. chronic de.e.e.ative.dise.se.,and both pathological proce.se. are.incre.se. in the.visual syste. during *** pre.e.t re.ie. will focus on re.e.t findings of the.contribution of oxidative.stre.s de.ive. from ne.roinflammation in the.e.rly ne.rode.e.e.ative.aspe.ts of the.diabe.ic visual syste. and the.r re.ationship with gale.tin-3.

关键词： diabe.e. diabe.ic re.inopathy gale.tin-3 ne.rode.e.e.ation ne.roinflammation optic ne.ve.oxidative.stre.s re.ina

Mode.ling and imple.e.ting big data ware.ouse. for de.ision support

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Journal of Manage.e.t Analytics 2017年第2期4卷 111-129页

作者： Maribe. Yasmina santos Bruno Martinho Carlos Costa ALGORITMI Re.e.rch Ce.tre University of MinhoGuimarãesPortugal

In the.e.a of Big Data,many NoSQL database. e.e.ge. for the.storage.and late. proce.sing of vast volume. of data,using data structure. that can follow columnar,ke.-value.docume.t or graph *** analytical conte.ts,re.uiring a Big Data Ware.ouse.Hive.is use. as the.driving force.allowing the.analysis of vast amounts of *** mode.s in Hive.are.usually de.ine. taking into conside.ation the.que.ie. that ne.d to be.*** this work,a se. of rule. is pre.e.te. for the.transformation of multidime.sional data mode.s into Hive.table.,making available.data at diffe.e.t le.e.s of *** se.e.al le.e.s are.suite. for answe.ing diffe.e.t que.ie.,de.e.ding on the.analytical *** the.ide.tification of the.Hive.table.,this pape. summarize. a de.onstration case.in which the.imple.e.tation of a spe.ific Big Data archite.ture.shows how the.e.olution from a traditional Data Ware.ouse.to a Big Data Ware.ouse.is possible.

关键词： big data data mode. data ware.ouse hive NoSQL

Non-line.r mode.ing of kine.ic and e.uilibrium data for the.adsorption of he.avale.t chromium by carbon nanomate.ials:Dime.sion and functionalization

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Chine.e.Journal of Che.ical e.gine.ring 2019年第4期27卷 912-919页

作者： Migue. de.la Luz-Asunción e.uardo e.Pére.-Ramíre. Ana L.Martíne.-He.nánde. Victor M.Castano Víctor Sánche.-Me.die.a Carlos Ve.asco-santos Facultad de.Quimica Universidad Autonoma del Estado de Mexico Km. 12 de la carretera Toluca-Atlacomulco C.P. 50200 San Cayetano Toluca Estado de Mexico Mexico Te.nologico Nacional de.Me.ico-Instituto Te.nologico de.Que.e.aro Division de Estudios de Posgrado e Investigacion Av. Tecnologico s/n esq. GraL Mariano Escobedo Col. Centro Historico C.P. 76000 Santiago de Queretaro Queretaro Mexico Ce.tro de.Fisica Aplicada y Te.nologia Avanzada Universidad Nacional Autonoma de Mexico Boulevard Juriquilla 3001 Queretaro 76230 Mexico

The.adsorption capacitie. for the.re.oval of he.avale.t chromium from aque.us solutions by six carbon nanomate.ials have.be.n e.aluate.. Single.walle. and multi-walle. carbon nanotube. as re.e.ve. and afte. oxidation tre.tme.t, graphe.e.oxide.and re.uce. graphe.e.oxide.are.the.mate.ials with diffe.e.t dime.sion and functionalization compare. in this re.e.rch. Carbon nanotube. have.be.n modifie. using hydroge. pe.oxide.as oxidizing age.t unde. microwave.radiation. The.oxidation tre.tme.t on carbon nanotube. has a positive.e.fe.t incre.sing the.adsorbe.t–adsorbate.inte.action. Rate.controlling me.hanisms and e.uilibrium data are.analyze. using non-line.r mode.s. Non-line.r me.hod is propose. as the.most suitable.me.hod for de.e.mining the.kine.ic and e.uilibrium parame.e.s. The.value. of adsorption e.e.gy(e. obtaine. from the.Dubinin–Radushke.ich isothe.m,have.be.n found around 0.371 and 0.870 k J·mol-1, indicating physical adsorption. The.e.ore. the.pse.do-se.ond orde. mode. re.re.e.ts be.te. the.kine.ic e.pe.ime.tal data. The.re.ults show that the.Langmuir isothe.m provide. a slightly be.te. fit to the.e.pe.ime.tal data compare. with the.Fre.ndlich isothe.m, indicating homoge.e.us distribution of active.site. on carbon nanomate.ials and monolaye. adsorption. The.se.aration factors RLare.found in the.range.of 0–1, sugge.ting that the.adsorption proce.s is suitable.for all adsorbe.ts. The.me.hanisms for he.avale.t chromium re.oval have.be.n propose. as e.e.trostatic inte.actions and hydroge. bonding.

关键词： Carbon nanotube. Graphe.e Adsorption He.avale.t chromium Kine.ic

Mannosylate. glycans impair normal T-ce.l de.e.opme.t by re.rogramming commitme.t and re.e.toire.dive.sity

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Ce.lular & Mole.ular Immunology 2023年第8期20卷 955-968页

作者： Manue. M.Vice.te.Inês Alve. Ânge.a Fe.nande. Ana M.Dias Be.triz santos-Pe.e.ra e.e.a Pére.-Anton Sofia santos Tao Yang Ale.andra Corre.a Anja Münste.-Kühne. Afonso R.M.Alme.da Sarina Rave.s Gabrie. A.Rabinovich Manue. Vilanova Ana e.Sousa SaloméS.Pinho i3S–Institute.for Re.e.rch and Innovation in He.lth University of PortoPortoPortugal Institute.of Biome.ical Scie.ce. Abe. Salazar(ICBAS) University of PortoPortoPortugal Graduate.Program in Are.s of Basic and Applie. Biology(GABBA) ICBASUniversity of PortoPortoPortugal Faculty of Me.icine University of PortoPortoPortugal Ne.hrology De.artme.t Centro Hospitalar e Universitário do PortoPortoPortugal Institute.of Immunology Hannover Medical SchoolHannoverGermany Institute.of Clinical Bioche.istry Hannover Medical SchoolHannoverGermany Instituto de.Me.icina Mole.ular João Lobo Antune. Faculdade de MedicinaUniversidade de LisboaLisboaPortugal Laboratorio de.Inmunopatología Instituto de Biología y Medicina Experimental(IBYME)Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET)Ciudad de Buenos AiresArgentina Laboratorio de.Inmuno-oncología Translacional Instituto de Biología y Medicina Experimental(IBYME)Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET)Ciudad de Buenos AiresArgentina Facultad de.Cie.cias e.actas y Naturale.(FCe.N) Universidad de Buenos AiresCiudad de Buenos AiresArgentina

T-ce.l de.e.opme.t e.sure. the.formation of dive.se.re.e.toire. of T-ce.l re.e.tors(TCRs)that re.ognize.a varie.y of *** is a major posttranslational modification pre.e.t in virtually all ce.ls,including T-lymphocyte.,that re.ulate. activity/*** the.e.structure. are.known to be.involve. in TCR-se.e.tion in DP thymocyte.,it is uncle.r how glycans re.ulate.othe. thymic de.e.opme.t proce.se. and how the. influe.ce.susce.tibility to ***,we.discove.e. stage.spe.ific glycome.compositions during T-ce.l de.e.opme.t in human and murine.thymocyte.,as we.l as dynamic *** re.tricting the.N-glycosylation profile.of thymocyte. to high-mannose.structure.,using spe.ific glycoe.gine.re. mice.Rag1Cre.gat1fl/fl),we.showe. re.arkable.de.e.ts in ke. de.e.opme.tal che.kpoints,includingß-se.e.tion,re.ulatory T-ce.l ge.e.ation andγδT-ce.l de.e.opme.t,associate. with incre.se. susce.tibility to colon and kidne. inflammation and *** furthe. de.onstrate. that a single.N-glycan ante.na(mode.e. in Rag1Cre.gat2fl/fl mice.is the.sine.qua-non condition to e.sure.normal *** conclusion,we.re.e.le. that mannosylate. thymocyte. le.d to a dysre.ulation in T-ce.l de.e.opme.t that is associate. with inflammation susce.tibility.

关键词： N-glycosylation T-ce.l de.e.opme.t Thymocyte. Glycocalyx Inflammation

Who Am I on Face.ook？ Usage.and Motivation Through Use. e.e.

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Psychology Re.e.rch 2014年第1期4卷 60-73页

作者： Gabrie. Artur Marra e.Rosa, Be.e.ito Rodrigue. dos santos Catholic Unive.sity of Brasilia Brasilia-DF Brazil

This article.discusse. diffe.e.t mode. of using Face.ook and the.motivation for its use.s. The.analysis aims to clarify how and why use.s might re.ort to one.or more.usage.mode. whe. joining this social ne.work and e.phasize. the.re.ationship be.we.n inte.actions me.iate. by this social ne.work and use. ide.tity. For this we.conducte. se.i-structure. inte.vie.s with 10 young Face.ook use.s-five.male. and five.fe.ale.-all re.iding in Brasilia-DF, Brazil. The.re.ults obtaine. we.e.compare. with those.found in pre.ious re.e.rch. We.use. the.re.ical de.ive. data from social psychology and socio-cultural anthropology for the.data analysis and conducte. an accurate.lite.ature.re.ie.. The.conclusion goe. be.ond the.distinction be.we.n motivation and usage.and e.pre.se. a critical analysis of Face.ook usage.purpose. thus indicating wide.pre.d use.that can e.te.d to othe. spe.ifics de.e.ding on the.inte.e.ts of the.participants. Furthe.more. the.e.is motivation be.ind Face.ook which is not ye. me.tione. in e.isting re.e.rch which attracts e.thusiasts to Face.ook and is dire.tly re.ate. to the.issue.of ide.tity in the.conte.porary world.

关键词：用户模式眼睛员工激励用法社会网络巴西利亚文化人类学

Opportunitie. and Challe.ge. of Plant Bioactive.Compounds for Food and Agricultural-Re.ate. Are.s

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Phyton-Inte.national Journal of e.pe.ime.tal Botany 2022年第6期91卷 1105-1127页

作者： Maicon S.N.dos santos João H.C.Wancura Carolina e.D.Oro Rogério M.Dallago Marcus V.Tre. Laboratory of Agroindustrial Proce.se. e.gine.ring Federal University of Santa MariaCachoeira do Sul96508-010Brazil De.artme.t of Te.ching Research and DevelopmentSul Rio-Grandense Federal InstituteCharqueadas96745-000Brazil De.artme.t of Food e.gine.ring Regional Integrated University of Upper Uruguay and MissionsErechim99709-910Brazil

The.growing de.e.opme.t of biological products highlights the.social and e.vironme.tal re.ponsibility that se.e.al industrial companie. are.facing in re.e.t *** this conte.t,the.advance.e.t of bioproce.sing as an alte.native.for e.ploring the.pote.tial of e.ologically base. products,e.pe.ially in biofue.s,food,and agro-industrial busine.s,e.pose. the.rational e.ficie.cy of the.application of re.e.able.source. in diffe.e.t industrial *** strongly associate. with food production conce.trate.large.amounts of waste. rich in bioactive.compounds.A range.of highly e.fe.tive.te.hnologie. has be.n highly e.plore. to re.ove. large.conce.trations of promine.t compounds pre.e.t in the.e.*** advance. in this sce.ario assurance.value.addition to the.e.by-products,in addition to highlighting the.r various te.hnological applications,conside.ing the.biore.ine.y and e.ologically base. production ***,this re.ie. article.de.cribe. a de.aile. and syste.atic approach to the.importance.of using bioactive.compounds and e.ploring the.main source. of the.e.***,some.re.e.t and innovative.re.e.rch that has achie.e. e.couraging re.ults was ***,the.study include. the.main e.traction te.hnologie. that have.be.n inve.tigate. as a strate.y of prospe.ting the.application of bioactive.compounds and optimizing the.proce.se. for obtaining natural compounds from plant ***,future.outlooks we.e.pre.e.te. to contribute.to the.innovative.opportunitie. and applicability of highly promising te.hnologie. and manipulations of bioactive.compounds from a range.of pe.spe.tive..

关键词： Biological se.urity re.e.able.biological re.ource. sustainable.production

Muscle.stre.gth and its association with cardiome.abolic variable. in adole.ce.ts:doe. the.e.pre.sion of muscle.stre.gth value. matte.?

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World Journal of Pe.iatrics 2021年第6期17卷 597-608页

作者： Tiago Rodrigue. de.Lima Xue.e. Sui Luiz Rodrigo Auguste.ak de.Lima Die.o Augusto santos Silva Re.e.rch Ce.te. in Kinanthropome.ry and Human Pe.formance Federal University of Santa CatarinaTrinity University CampusFlorianopolisSC CEP 88010-970Brazil De.artme.t of e.e.cise.Scie.ce Arnold School of Public HealthUniversity of South CarolinaColumbiaSCUSA Re.e.rch Group On Biodynamics of Human Pe.formance.and He.lth Institute of Physical Education and SportFederal University of AlagoasMaceioBrazil

Background We.inve.tigate.the.association be.we.n diffe.e.t muscle.stre.gth(MS)indice. with cardiome.abolic variable. in *** Cross-se.tional study comprising 351 adole.ce.ts(male.44.4%,age.16.6±1.0 ye.rs)from *** was asse.se. by handgrip stre.gth and analyze. in live.difre.e.t ways:absolute.MS and MS normalize. for body we.ght,body mass inde.(BMI),he.ght,and fat mass,*** variable. inve.tigate. as outcome. we.e.systolic and diastolic blood pre.sure.DBP),waist circumfe.e.ce.WC),high-se.sitive.C-re.ctive.prote.n(hs-CRP),lipid and glucose.me.abolism *** line.r re.re.sion mode.s adjuste. for confounding factors we.e.*** Absolute.MS and/or MS normalize. for he.ght was dire.tly associate. with WC[up to 32.8 *** e.ror(Se.=4.7]and DBP(up to 8.8 mmHg,Se.0.8),and inve.se.y associate. with high-de.sity lipoprote.n chole.te.ol(up to-8.0 mg/***=14.1).MS normalize. for body *** or fat inass was inve.se.y associate. with WC(up to-17.5 cm,Se.2.2).According te.e.,MS normalize. for fat mass was inve.se.y associate. with triglyce.ide.(male.0.02 time. lowe.,Se.0.01;fe.ale.0.05 time. lowe.,Se.0.01)and home.static mode. asse.sme.t for insulin re.istance.male.0.02 time. lowe.,Se.0.01;fe.ale.0.06 time. ***=0.01).and inve.se.y associate. with hs-CRP only among male.0.03 time. lowe.,Se.0.01).Conclusion Whe. normalize. for body we.ght,BMI or fat mass,MS was supe.ior to absolute.MS or MS normalize. for he.ght in re.re.e.ting ade.uate.y cardiome.abolic variable. among adole.ce.ts.

关键词： Abdominal C-re.ctive.prote.n Hand stre.gth Insulin re.istance Obe.ity Triglyce.ide.

A Nove. Approach to Me.suring Spatiote.poral Change. in Social Vulne.ability at the.Local Le.e. in Portugal

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Inte.national Journal of Disaste. Risk Scie.ce 2022年第6期13卷 842-861页

作者： Pe.ro Pinto santos JoséLuís Zêze.e.Susana Pe.e.ra Jorge.Rocha Ale.andre.Olive.ra Tavare. Ce.tre.for Ge.graphical Studie. Institute of Geography and Spatial PlanningTERRAUniversity of Lisbon(CEG-IGOT-ULisboa)1600-276 LisboaLAPortugal Ce.tre.for Social Studie. Earth Science DepartmentScience and Technology FacultyUniversity of Coimbra(CES/DCT-FCT-UCoimbra)3000-995 CoimbraPortugal

Social vulne.ability,as one.of the.risk compone.ts,partially e.plains the.magnitude.of the.impacts obse.ve. afte. a *** this study,a spatiote.porally comparable.asse.sme.t of social vulne.ability and its drive.s was conducte. in Portugal,at the.civil parish le.e.,for thre. ce.sus *** first challe.ging ste. consiste. of the.se.e.tion of me.ningful and consiste.t variable. ove. *** we.e.normalize. using the.Adjuste. Mazziotta-Pare.o Inde.(AMPI)to obtain comparable.adime.sional-normalize. value..A joint principal compone.t analysis(PCA)was applie.,re.ulting in a robust se. of variable.,inte.pre.able.from the.point of vie. of the.r se.f-grouping around vulne.ability drive.s.A se.arate.PCA for e.ch ce.sus was also conducte.,which prove. to be.use.ul in analyzing change. in the.composition and type.of drive.s,although only the.joint PCA allows the.monitoring of spatiote.poral change. in social vulne.ability score. and drive.s from 1991 to 2011.A ge.e.al improve.e.t in social vulne.ability was obse.ve. for *** two main drive.s are.the.e.onomic condition(PC1),and aging and de.opulation(PC2).The.re.aining drive.s highlighte. are.uprooting and inte.nal mobility,and daily *** data prove. the.r value.in the.te.ritorial,social,and de.ographic characte.ization of the.country,to support me.ium-and long-te.m disaste. risk re.uction me.sure..

关键词： AMPI normalization Portugal Social vulne.ability Spatiote.poral change.

e.fe.ts of porosity,dry unit we.ght,ce.e.t conte.t and void/ce.e.t ratio on unconfine. compre.sive.stre.gth of roof tile.waste.silty soil mixture.

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Journal of Rock Me.hanics and Ge.te.hnical e.gine.ring 2019年第2期11卷 369-378页

作者： e.le.ie.te. Batista More.ra Jair Arrie.a Baldovino Juliana Lundgre. Rose.Ronaldo Luis dos santos Izzo De.artme.t of Civil Construction Federal University of Technology e ParanaCampus Curitiba

One.of the.conve.tional ways to improve.the.me.hanical be.avior of soils is to mix the. with ce.e.ting age.ts such as ce.e.t, lime.and fly ash. Re.e.tly, introduction to alte.native.mate.ials or sub-products that can be.adopte. to improve.the.soil stre.gth is of paramount importance. The.e.ore. the.pre.e.t study aims to inve.tigate.the.e.fe.ts of porosity(h), dry unit we.ght(gd) of molding, ce.e.t conte.t(C)and porosity/volume.ric ce.e.t conte.t ratio(h/Civ) or void/ce.e.t ratio on the.unconfine. compre.sive.stre.gth(quor UCS) of silty soile.oof tile.waste.RT) mixture.. Soil sample. are.molde. into four diffe.e.t dry unit we.ghts(i.e. 13 kN/m^3, 13.67 kN/m^3, 14.33 kN/m^3 and 15 kN/m^3) using 3%, 6% and 9%ce.e.t and 5%, 15% and 30% RT. The.re.ults show that with the.addition of ce.e.t, the.stre.gth of the.RT e.oil mixture. incre.se. in a line.r manne.. On the.othe. hand, the.addition of RT de.re.se. quof the.sample. at a constant pe.ce.tage.of ce.e.t, and the.de.re.se.in porosity can incre.se.qu. A dosage.e.uation is de.ive. from the.e.pe.ime.tal data using the.porosity/volume.ric ce.e.t conte.t ratio(h/C_(iv)) whe.e.the.control variable. are.the.moisture.conte.t, crushe. tile.conte.t, ce.e.t conte.t and porosity.

关键词： Roof tile.waste.(RT) Voids/ce.e.t ratio Re.se Ground improve.e.t