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Implementation of ison iazid preventive therapy in southern Lima, Peru: an analysis of health center characteristics

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Infectious Diseases of Poverty 2021年第3期10卷 26-33页

作者： Roberto Zegarra-Chaponan Lily Victoria Bonadonna Courtney M.Yuen martha brigida martina-chavez Jhon Zeladita-Huaman Universidad Maria Auxiliadora LimaPeru Wayne State University School of Medicine DetroitMlUSA Harvard Medical School BostonMAUSA. Universidad Nacional Mayor de San Marcos LimaPeru.

Background:Tuberculosis(TB)prevention through the use of preventive treatment is a critical activity in the elimination *** multiple settings,limited staffing has been identified as a barrier to managing preventive treatment for TB *** study aims to determine how health center staffing,service type,and TB caseload affects implementation of isoniazid preventive therapy(IPT)forTB contacts in southern ***:We conducted an ecological study in 2019 in southern Lima,*** the review of medical records,we identified contacts ofTB patients who initiated IPT during 2016-2018,and who were 0-19 years old,the age group eligible for IPT according to Peruvian *** assessed bivariate associations between health center characteristics(numbers of physicians and nurses,types of services available,annual TB caseload)and IPT initiation and completion using binomial logistic ***:Among 977 contacts,69%took more than a week to start IPT and 41%did not complete *** those who successfully completed IPT,58%did not complete full medical *** was no significant difference in IPT completion or adherence based on whether health centers had more physicians and nurses,more comprehensive services,or higherTB *** contacts,female sex was associated with delay in initiating IPT(P=0.005),age 5-19 years old was associated with completion of IPT(P=0.025)and age<5 years old was associated with completion of clinical evaluations(P=0.041).Conclusions:There are significant gaps in IPT implementation in health centers of southern Lima,Peru,but insufficient staffing of health centers may not be *** research is needed to identify how IPT implementation can be improved,potentially through improving stafftraining or monitoring and supervision.

关键词： Contacts Chemotherapy Latent tuberculosis Children Adolescent

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