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Prospective Analysis of Patients Treated with Chemotherapy in Metastatic Adenocarcinoma of Lung—Single Centre Experience

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Journal of Cancer Therapy 2017年第9期8卷 838-844页

作者： B. J. Srinivasa L. P. Bhanu girish Badarke Mohammad Nasiruddin Sulav Sapkota D. Tousif Vishal Kulkarni P. K. Kiran Vinu Sarathy g. S. Deepika Amritanshu Ram Raghavendra Rao Shekar patil Radheshyam Naik Department of Medical Oncology HCG SC Bangalore India

Background: Lung cancer is the leading cause of cancer-related death worldwide with an estimated 1.6 million new cases diagnosed each year. According to standard guidelines in NSCLC, the effectiveness of combined chemotherapy regimen comprises of pemetrexed and platinum, and very few reports are available in Indian population. This study shows the experience with pemetrexed and platinum combination chemotherapy in metastatic NSCLC in first line setting. Methods: Total 61 patients with following inclusion criteria were recruited such as: 1) PS of 1 and 2;2) NSCLC of non-squamous histology;3) locally advanced or metastatic disease at diagnosis;4) should have received minimum 3 cycles of pemetrexed and platinum as first line treatment and or continued for 6 cycles;5) EgFR/ALK mutated or EgFR/ALK unknown patients but must have received upfront chemo. Primary endpoint of the present study is to assess Disease Control Rate (DCR) (CR + PR + SD). Progression Free Survival, OS and Toxicity assessment were secondary endpoints. Results: The mean number of average chemotherapy cycles was found to be 4.38. The range of chemotherapy was 2 - 6 cycles. Disease control rate, defined as (CR + PR + SD), was seen in 44 (72.1%) patients. (PR in 26 (42.62%), SD 18 (29.5%)), Progressive disease (PD) was observed in 17 (27.9%) patients. Overall study showed that patients had PFS of 9.414 months (95% CI 6.709 - 12.120) and OS of 13.437 months (95% CI 10.721 - 16.153). Conclusion: Pemetrexed and platinum combination is effective and well-tolerated chemotherapy regimen in patients with metastatic adenocarcinoma lung cancer patients. Pemetrexed and cisplatin may be more effective in particular. Early switch over to TKIs is preferred immediately after obtaining molecular subtype result.

关键词： Pemetrexed Carboplatin NSCLC Cisplatin EgFR

mTOR抑制剂抑制皮质发育不良小鼠癫痫发作

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癫痫杂志 2017年第1期3卷 70-79页

作者： Nguyen LH Brewster AL Clark ME Regnier-golanov A Sunnen CN patil VV D'Arcangelo g Anderson AE 迟潇洒慕洁

哺乳动物雷帕霉素靶蛋白(mammalian target of rapamycin,m TOR)在皮质发育不良(Cortical dysplasia,CD)及癫痫动物模型中超活化。在神经元特异性Pten基因敲除(Neuronsubsetspecific Pten knockout,NS-Pten KO)小鼠模型中,尽管在早期癫痫发生过程中抑制m TOR信号通路能够减少癫痫样活动,但m TOR抑制剂在癫痫建立后的作用尚不清楚。文章通过建立伴有严重慢性癫痫的NS-Pten KO成年小鼠模型,探究m TOR抑制剂对其癫痫样活动和其他神经病理的作用。NSPten KO小鼠癫痫样活动、m TOR信号通路的异常调节和相关神经病理随年龄增长的变化通过视频脑电(video-electroencephalography,VEEg),蛋白免疫印迹和免疫组化检测。NS-Pten KO小鼠出生后9周开始接受m TOR抑制剂雷帕霉素治疗(10 mg/kg i.p,5d/周)并采用VEEg监测癫痫样活动。通过蛋白免疫印迹和免疫组化检测雷帕霉素的作用。试验发现,随着年龄增长,NS-Pten KO小鼠的癫痫样活动恶化,同时伴有m TOR复合物1和2(m TOR complex 1 and 2,m TORC1 and m TORC2)调节异常和进展性的星形胶质细胞和小胶质细胞增生。雷帕霉素治疗抑制癫痫样活动,改善基线脑电活动并提高严重癫痫NS-Pten KO小鼠的预后。在分子水平,雷帕霉素治疗降低m TORC1和m TORC2水平并减少星形胶质细胞和小胶质细胞增生。研究表明在NS-Pten KO小鼠中,雷帕霉素成功治疗癫痫有较宽的时间窗。抑制m TOR可能是CD伴慢性癫痫及m TOR信号通路基因调节异常的潜在治疗手段。

关键词：皮质发育畸形癫痫雷帕霉素星形胶质细胞增生小胶质细胞增生

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提高拉幅机效率的参数优化

国际纺织导报 2021年第8期49卷 23-24页

作者： T.A.Shinde L.N.patil A.Zingabhoi 胡柳(译) SVKMS NMIMSMukesh Patel工学院(印度) 不详

研究了决纺织品染色工业中拉幅机效率损失的处理。拉幅机是化学加工的核心,它能决定染色工业的实际产量,并且可以控制织物的幅宽、面密度、扭曲、收缩率、固化率以及回潮率,所以拉幅机在染色环节中扮演着重要的角色。因此,有必要控制拉... 详细信息

研究了决纺织品染色工业中拉幅机效率损失的处理。拉幅机是化学加工的核心,它能决定染色工业的实际产量,并且可以控制织物的幅宽、面密度、扭曲、收缩率、固化率以及回潮率,所以拉幅机在染色环节中扮演着重要的角色。因此,有必要控制拉幅机的效率损失。染色工序中导致拉幅机产生效率损失的因素有很多,如程序切换、温度调整、维护、轧车清洗以及其他因素(如换挡、断电、故障)。对于纺织品领域的技术人员而言,急需采取一些措施去控制这些因素以提高拉幅机的效率。在考虑输送原料品质的前提下对如何提高拉幅机的生产率进行了详细研究。

关键词：拉幅机纺织品染色工业效率损失参数优化

Development and Validation of New RP-HPLC Method for the Estimation of Alfuzosin Hydrochloride in Bulk and Tablet Dosage Form

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American Journal of Analytical Chemistry 2013年第1期4卷 34-43页

作者： Vandana P. patil Subhash J. Devdhe Suwarna H. Kale Vijay J. Nagmoti Sadanand D. Kurhade Yuvraj R. girbane Mahesh T. gaikwad Yash Institute of Pharmacy Aurangabad India

A reverse phase high performance liquid chromatographic method (HPLC) has been developed for the estimation of Alfuzosin hydrochloride (ALH) in the pharmaceutical formulation using RP-C18 column. The mobile phase (Tetrahydrofuran, Acetonitrile and buffer (pH 3.50) was pumped at a flow rate of 1.5 ml/min in the ratio of 1:20:80 and the eluents were monitored at 254.0 nm. Linearity was obtained in the concentration range of 80 - 120 μg/mL for ALH. The method was statistically validated and RSD was found to be less than 2% indicating high degree of accuracy and precision of the proposed HPLC method. Due to its simplicity, rapidness, high precision and accuracy, the proposed HPLC method may be used for determination of Alfuzosin hydrochloride in bulk drugs and in pharmaceutical dosage form.

关键词： Alfuzosin HCl RP-HPLC Linearity Precision Accuracy Robustness Ruggedness

Anticancer activity of gloriosa superba Linn in EAC tumor-bearing Balb/c mice

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TMR Cancer 2021年第3期4卷 1-6页

作者： Priyanka patil Shalavadi Mallappa VM Chandrashekhar College of Pharmacy Karnataka IndiaBagalkot Department of Pharmacology and Toxicology HSK College of PharmacyKarnataka India

Cancer is a pathogenic condition due to abnormal growth of cells,which is one of the leading reasons for the death of majority of the population throughout the *** associated with the majority of the adverse effects such as cardiotoxicity,hepatotoxicity,nephrotoxicity that suggests identifying new drug which would be safer than well-established *** is a need to get a promising line for research over various diseases including *** superba Linn has a long history of use in folk medicine including wounds,hemorrhoids,kidney problems,and *** present study explores the ethanolic extract of gloriosa superba Linn as the anti-cancer agent using in vitro MTT assay and in vivo Ehrlich’s ascites carcinoma(EAC)bearing Balb/c mice ***,the study reports the IC50 value of the DPPH was 1.21μg/mL,and the IC50 of MTT assay against Hela and MCF7 was found to be 148.50μg/mL and 147.23μg/mL ***,in vivo study,animals were divided into five groups(n=6)experimented for 14 *** tumor was induced by intraperitoneal transplantation of Ehrlich’s ascites carcinoma cells in Balb/c *** normal and control group received normal *** 24 hours of Ehrlich’s Ascites Carcinoma transplantation,treatment was started by injecting Cyclophosphamide(50 mg/kg)intraperitoneal whereas gloriosa superba Linn extract(5 mg/kg&10 mg/kg)was administrated *** the 15th day,mice were sacrificed to estimate hematology,biochemical estimation,and *** extract showed a significant decrease(Pght in the treatment group compare to the control group further there was amelioration in hematology,biochemical estimation,and *** the result,it was concluded that the extract has a potent antitumor activity.

关键词： Anticancer Cytotoxicity Ehrlich ascites carcinoma gloriosa superba

水分胁迫情况下甘蔗叶片脯氨酸累积和活体内硝酸还原酶活性的遗传

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福建甘蔗 2004年第2期 42-44页

作者： R．M．Naik B．S．Kadam R．A．Pandhare S．M．Pawar R．C．patil P.g．Bhoi 陈玉水中央甘蔗研究站 Padegaon 不详

评价了以甘蔗品种Co740和Co671作为父本或母本杂交选育的几个甘蔗品系在水分胁迫下叶片渗透保护剂脯氨酸和叶片体内硝酸还原酶活性的遗传。结果表明，在水分胁迫下，抗旱耐盐甘蔗品种Co740的叶片脯氨酸含量比Co671高，叶片硝酸还原酶活... 详细信息

评价了以甘蔗品种Co740和Co671作为父本或母本杂交选育的几个甘蔗品系在水分胁迫下叶片渗透保护剂脯氨酸和叶片体内硝酸还原酶活性的遗传。结果表明，在水分胁迫下，抗旱耐盐甘蔗品种Co740的叶片脯氨酸含量比Co671高，叶片硝酸还原酶活性比Co671低，而且，以Co740作为母本的甘蔗杂种的叶片脯氨酸含量也比较高，叶片硝酸还原酶活性也比较低。从同样都以Co671作为父本的甘蔗杂种Co86032与Co94014之间抗旱性的不同或许可以认为所用母本的抗旱性具有天然遗传潜力。

关键词：水分胁迫甘蔗叶片脯氨酸硝酸还原酶遗传品系

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榕属植物提取物止泻作用的研究(英文)

中西医结合学报 2012年第3期10卷 347-352页

作者： Vikas V.patil Shandavi C.Bhangale Prashant J.Chaudhari Kundan P.Chaudhari Rajanikant T.Kakade Vinod M.Thakare Chandrakant g.Bonde Vijay R.patil Department of Pharmaceutical Chemistry Tapi Valley Education Society's Honorable Loksevak MadhukarraoChaudhari College of Pharmacy School of Pharmacy and Technology Management Narsee Monjee Institute of Management Studies University

目的:印度贾尔贡地区森林里的榕属植物多年来被当地人用来治疗腹泻。本研究根据当地人的用药传统选取3类榕属植物的特定部位来研究它们对不同大鼠腹泻模型的治疗及缓解作用。方法:不限性别地选取体质量在180~200 g的Wistar大鼠240只,在... 详细信息

目的:印度贾尔贡地区森林里的榕属植物多年来被当地人用来治疗腹泻。本研究根据当地人的用药传统选取3类榕属植物的特定部位来研究它们对不同大鼠腹泻模型的治疗及缓解作用。方法:不限性别地选取体质量在180~200 g的Wistar大鼠240只,在每个独立实验中,大鼠分别被分为8组,每组10只。通过蓖麻油诱导大鼠腹泻、大鼠胃肠蠕动测试及前列腺素E2诱导大鼠小肠淤积的3个独立实验来评估孟加拉榕树树皮、聚果榕树叶以及无花果叶的乙醇提取物治疗腹泻的作用。结果:孟加拉榕树树皮、聚果榕树叶和无花果叶的提取物具有显著抑制由蓖麻油诱发的大鼠腹泻及前列腺素诱导的大鼠小肠淤积的作用。当给予大鼠400、600 mg/kg的乙醇提取物时,腹泻显著减少。与标准对照药组对比,服用3种植物乙醇提取物的大鼠表现出显著的剂量依赖性腹泻缓解现象(P<0.01)。与蓖麻油诱导大鼠腹泻实验中的对照组相比,榕属植物的乙醇提取物被证实具有显著的降低粪便排泄量及排泄次数的作用(P<0.01)。所有的植物提取物具有显著减缓木炭餐在大鼠小肠内的推进速度并抑制由前列腺素E2引起的大鼠小肠淤积的作用。结论:印度贾尔贡地区的榕属植物具有止泻作用。这些植物的作用机制主要通过解痉和抗小肠淤积来缓解腹泻,这可能与榕属植物的乙醇提取物内含有鞣酸及类黄酮有关。

关键词：止泻药榕属植物皮植物叶植物提取物大鼠

Synthesis and characterization of strontium-doped barium titanate thin film by dip and dry technique

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Journal of Advanced Dielectrics 2021年第1期11卷 6-12页

作者： S.g.Chavan A.N.Tarale D.J.Salunkhe Nano-composite Laboratory Department of Physics Karmaveer Bhaurao Patil Mahavidyalaya PandharpurSolapurIndia Science College Pauni Dist.Bhandara-441910 India

Thin films of polycrystalline(Ba_(1−x)Sr_(x))TiO_(3)(x=0.2 and 0.3)with Perovskite structure were prepared by a dip and dry technique on a platinum-coated silicon *** good quality thin films with uniform microstructure and thickness were successfully produced by dip-coating techniques annealed at 730℃ for 1 *** resulting thin film shows a well-developed dense polycrystalline structure with more uniform grain size *** BST thin films were characterized for their structural,Raman spectroscopy,morphological properties,and complex impedance *** dielectric constant-frequency curve showed the good dielectric constant and loss dielectric loss with low-frequency *** BST 0.3 thin film reveals that the dielectric constant and dielectric loss at a frequency of 1 kHz were 578 and 0.02,*** obtained results on dielectric properties can be analyzed in terms of the Maxwell-Wagner model.

关键词： Ceramics sol-gel synthesis thin film dielectric properties

Rapid Process of Synthesizing Nanocrystalline NiFe2O4 Using Thermal Plasma Technique

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Rapid Process of Synthesizing Nanocrystalline NiFe2O4 Using ...