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Fine mapping of genomic regions associated with female fertility in Nellore beef cattle based on sequence variants from segregating sires

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Journal of Animal Science and Biotechnology 2020年第2期11卷 303-315页

作者： Gerson A.Oliveira Júnior Daniel J.A.Santos Aline S.M.Cesar Solomon A.Boison Ricardo V.Ventura Bruno C.perez JoséF.garcia JoséBento S.Ferraz Dorian J.Garrick Department of Veterinary Medicine University of São Paulo(USP)Faculty of Animal Science and Food EngineerPirassunungaSPBrazil Department of Animal Bioscience Center for Genetic Improvement of LivestockUniversity of GuelphGuelphONCanada Department of Animal and Avian Sciences University of MarylandCollege ParkMarylandUSA Department of Animal Science University of São Paulo(USP)PiracicabaSPBrazil Department of Sustainable Agricultural Systems University of Natural Resources and Life SciencesViennaAustria Department of Animal Nutrition and Production School of Veterinary Medicine and Animal ScienceUniversity of São Paulo(USP)PirassunungaBrazil Department of Support Production and Animal HealthSchool of Veterinary MedicineSão Paulo State University(Unesp)AraçatubaSPBrazil School of Agriculture Massey UniversityRuakura Ag CentreHamiltonNew Zealand

Background:Impaired fertility in cattle limits the efficiency of livestock production *** the genetic architecture of fertility traits would facilitate their improvement by *** this study,we characterized SNP chip haplotypes at QTL blocks then used whole-genome sequencing to fine map genomic regions associated with reproduction in a population of Nellore(Bos indicus)***:The dataset comprised of 1337 heifers genotyped using a GeneSeek®Genomic Profiler panel(74677 SNPs),representing the daughters from 78 *** performing marker quality control,64800 SNPs were *** carried by each sire at six previously identified QTL on BTAs 5,14 and 18 for heifer pregnancy and BTAs 8,11 and 22 for antral follicle count were constructed using findhap *** significance of the contrasts between the effects of every two paternally-inherited haplotype alleles were used to identify sires that were heterozygous at each ***-genome sequencing data localized to the haplotypes from six sires and 20 other ancestors were used to identify sequence variants that were concordant with the haplotype *** analyses were applied to these variants using KEGG and MeSH ***:A total of six(BTA 5),six(BTA 14)and five(BTA 18)sires were heterozygous for heifer pregnancy QTL whereas six(BTA 8),fourteen(BTA 11),and five(BTA 22)sires were heterozygous for number of antral follicles’*** to inadequate representation of many haplotype alleles in the sequenced animals,fine mapping analysis could only be reliably performed for the QTL on BTA 5 and 14,which had 641 and 3733 concordant candidate sequence variants,*** KEGG“Circadian rhythm”and“Neurotrophin signaling pathway”were significantly associated with the genes in the QTL on BTA 5 whereas 32 MeSH terms were associated with the QTL on BTA *** the concordant sequence variants,0.2%and 0.3%were classified as missense variants for BTAs 5 and 14,respe

关键词： Antral follicles Causal variants Haplotype Heifer pregnancy WGS

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Model construction and clinical therapeutic potential of engineered cardiac organoids for cardiovascular diseases

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Biomaterials Translational 2024年第4期5卷 337-354页

作者： Yongtao Wang Yan Hou Tian Hao marta garcia-Contreras Guoping Li Dragos Cretoiu Junjie Xiao Cardiac Regeneration and Ageing Lab School of MedicineShanghai UniversityShanghaiChina Institute of Cardiovascular Sciences Shanghai Engineering Research Center of Organ RepairJoint International Research Laboratory of Biomaterials and Biotechnology in Organ Repair(Ministry of Education)School of Life ScienceShanghai UniversityShanghaiChina Cardiovascular Division of the Massachusetts General Hospital and Harvard Medical School BostonMAUSA Department of Medical Genetics Carol Davila University of Medicine and PharmacyBucharestRomania Materno-Fetal Assistance Excellence Unit Alessandrescu-Rusescu National Institute for Mother and Child HealthBucharestRomania

Cardiovascular diseases cause significant morbidity and mortality *** cardiac organoids are being developed and used to replicate cardiac tissues supporting cardiac morphogenesis and *** organoids have applications in drug screening,cardiac disease models and regenerative ***,a thorough understanding of cardiac organoids and a comprehensive overview of their development are essential for cardiac tissue *** review summarises different types of cardiac organoids used to explore cardiac function,including those based on co-culture,aggregation,scaffolds,and *** self-assembly of monolayers,multilayers and aggravated cardiomyocytes forms biofunctional cell aggregates in cardiac organoids,elucidating the formation mechanism of scaffold-free cardiac *** contrast,scaffolds such as decellularised extracellular matrices,three-dimensional hydrogels and bioprinting techniques provide a supportive framework for cardiac organoids,playing a crucial role in cardiac *** geometries are engineered to create cardiac organoids,facilitating the investigation of intrinsic communication between cardiac organoids and biomechanical ***,this review emphasises the relationship between cardiac organoids and the cardiac system,and evaluates their clinical *** review aims to provide valuable insights into the study of three-dimensional cardiac organoids and their clinical potential.

关键词： cardiac organoids cardiovascular diseases clinical applications scaffolds self-assembly

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Correlative spatter and vapour depression dynamics during laser powder bed fusion of an Al-Fe-Zr alloy

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International Journal of Extreme Manufacturing 2024年第5期6卷 298-310页

作者： Da Guo Rubén Lambert-garcia Samy Hocine Xianqiang Fan Henry Greenhalgh Ravi Shahani marta Majkut Alexander Rack Peter D Lee Chu Lun Alex Leung UCL Mechanical Engineering University College LondonLondon WC1E 7JEUnited Kingdom Research Complex at Harwell Harwell CampusDidcot OX110FAUnited Kingdom HiETA Technologies Bristol BS167FRUnited Kingdom Constellium Technology Centre 38341 VoreppeFrance ESRF—The European Synchrotron 38000 GrenobleFrance

Spatter during laser powder bed fusion(LPBF)can induce surface defects,impacting the fatigue performance of the fabricated ***,we reveal and explain the links between vapour depression shape and spatter dynamics during LPBF of an Al-Fe-Zr aluminium alloy using high-speed synchrotron x-ray *** quantify the number,trajectory angle,velocity,and kinetic energy of the spatter as a function of vapour depression zone/keyhole morphology under industry-relevant processing *** depression zone/keyhole morphology was found to influence the spatter ejection angle in keyhole versus conduction melting modes:(i)the vapour-pressure driven plume in conduction mode with a quasi-semi-circular depression zone leads to backward spatter whereas;and(ii)the keyhole rear wall redirects the gas/vapour flow to cause vertical spatter ejection and rear rim droplet *** the opening of the keyhole or vapour depression zone can reduce entrainment of solid *** discover a spatter-induced cavity mechanism in which small spatter particles are accelerated towards the powder bed after laser-spatter interaction,inducing powder denudation and cavities on the printed *** quantifying these laser-spatter interactions,we suggest a printing strategy for minimising defects and improving the surface quality of LPBF parts.

关键词： spatter vapour depression x-ray imaging defects surface quality

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Food groups, diet quality and colorectal cancer risk in the Basque Country

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World Journal of Gastroenterology 2020年第28期26卷 4108-4125页

作者： Iker Alegria-Lertxundi Carmelo Aguirre Luis Bujanda Francisco J Fernandez Francisco Polo JoseMªOrdovas MªCarmen Etxezarraga Inaki Zabalza Mikel Larzabal Isabel Portillo Marian M de Pancorbo Koldo garcia-Etxebarria Ana MªRocandio marta Arroyo-Izaga Department of Pharmacy and Food Sciences Faculty of PharmacyUniversity of the Basque Country UPV/EHUVitoria-Gasteiz 01006Spain Pharmacovig ilance Unit Galdakao-Usansolo University HospitalOsakidetzaGaldakao 48960Spain Department of Gastroenterology Donostia University Hospital/BiodonostiaUniversity of the Basque Country UPV/EHUCentro de Investigación Biomédica en Red de Enfermedades Hepaticas y Digestivas(CIBERehd)San Sebastian 20014Spain Department of Gastroenterology Galdakao-Usansolo University HospitalOsakidetzaGaldakao 48960Spain Department of Gastroenterology Basurto University HospitalOsakidetzaBilbao 48013Spain Nutrition and Genomics Laboratory Jean Mayer Human Nutrition Research Center on AgingTufts UniversityBostonMassachusetts 02111United States of AmericaIMDEA FoodMadrid 28049Spain Department of Pathology Basurto University HospitalOsakidetzaBilbao 48013Spain Department of Physician and Surgeon Specialities University of the Basque Country UPV/EHULeioa 48940Spain Department of Pathology Galdakao-Usansolo University HospitalOsakidetzaGaldakao 48960Spain Department of Pathology Donostia Hospital/BiodonostiaCentro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas(CIBERehd)San Sebastian 20014Spain Colorectal cancer screening programme OsakidetzaBilbao 48011Spain BIOMICs Research Group University of the Basque Country UPV/EHUVitoria-Gasteiz 01006Spain Biodonostia Gastrointestinal genetics groupCentro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas(CIBERehd)San Sebastian 20014Spain

BACKGROUND The results obtained to date concerning food groups,diet quality and colorectal cancer(CRC)risk vary according to criteria used and the study *** To study the relationships between food groups,diet quality and CRC risk,in an adult population of the Basque Country(North of Spain).METHODS This observational study included 308 patients diagnosed with CRC and 308 ageand sex-matched subjects as *** recruitment,dietary,anthropometric,lifestyle,socioeconomic,demographic and health status information was *** to the dietary recommendations was evaluated utilizing the Healthy Eating Index for the Spanish Diet and the *** logistic regressions were used to evaluate the associations of food group intakes,diet quality scores,categorized in tertiles,with CRC *** The adjusted models for potential confounding factors showed a direct association between milk and dairy products consumption,in particular high-fat cheeses[odds ratio(OR)third tertile vs first tertile=1.87,95%confidence intervals(CI):1.11-3.16],and CRC *** the consumption of fiber-containing foods,especially whole grains(OR third tertile vs first tertile=0.62,95%CI:0.39-0.98),and fatty fish(OR third tertile vs first tertile=0.53,95%CI:0.27-0.99)was associated with a lower risk for ***,higher MD adherence was associated with a reduced CRC risk in adjusted models(OR third tertile vs first tertile=0.40,95%CI:0.20-0.80).CONCLUSION Direct associations were found for high-fat cheese,whereas an inverse relation was reported for fiber-containing foods and fatty fish,as well as adherence to a Mediterranean dietary pattern.

关键词： Colorectal cancer Food group Dietary quality Mediterranean diet Riskfactors Case-control study

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Increased Susceptibility to Pneumococcal Disease in Sjogren Syndrome Patients

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World Journal of Vaccines 2014年第2期4卷 45-49页

作者： Maria Ercibengoa marta Alonso Jose M.Marimon Jose Ramon Saenz-Domínguez Emilio perez-Trallero Biomedical Research Centre Network for Respiratory Diseases(CIBERES) San SebastianSpain Servicio de Microbiología-Instituto Biodonostia Hospital Universitario DonostiaSan SebastiánSpain Department of Preventive Medicine and Public Health Faculty of MedicineBasque Country UniversityUPV/EHUSan SebastiánSpain

Susceptibility to pneumococcal infections in Sj?gren syndrome (SS)―an autoimmune inflammatory disease―patients is not well known, although these patients frequently develop respiratory diseases. The relative risk of developing pneumococcal disease in SS patients versus diabetes mellitus type 2 (DM-2) patients, matched by age, gender, and length of enrolment was studied. From January 1998 to September 2013 the records of Donostia University Hospital were analyzed, which among other patient’s data includes: number and type of hospital admissions and number and type of laboratory determinations. Streptococcus pneumoniae isolates of the same serotype causing recurrent infections were characterized by PFGE. The study comprised 127 patients in the SS group (69 primary and 58 secondary) and 127 in the DM-2 group as control. In 12 SS patients, (9.4%) 22 pneumococcal disease episodes were detected. Two patients (1.6%) with a single episode each one were observed among DM-2 patients, p = 0.01, RR for SS patients 6 (95% CI 1.4 to 26.3). No differences could be demonstrated between the two groups of patients in infections caused by Staphylococcus aureus or Streptococcus agalactiae. Most pneumococcal serotypes in SS patients belonged to the 13-valent (50%) and 23-valent (75%) anti-pneumococcal vaccine. SS patients are associated with and increased risk of suffering from pneumococcal disease. Vaccination should be considered in this group of patients.

关键词： Sjogren Syndrome Diabetes Mellitus Type 2 Pneumococcal Vaccine Streptococcus pneumoniae

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Skeletal muscle myogenesis is regulated by G protein-coupled receptor kinase 2

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Journal of Molecular Cell Biology 2014年第4期8卷 299-311页

作者： Lucia garcia-Guerra Rocio Vila-Bedmar marta Carrasco-Rando marta Cruces-Sande Mercedes Martin Ana Ruiz-Gomez Mar Ruiz-Gomez Margarita Lorenzo Sonia Fernandez-Veledo Federico Mayor Jr. Cristina Murga Iria Nieto-Vazquez Department of Biochemistry and Molecular Biology II School of Pharmacy Complutense University 28040 Madrid Spain CIBER de Diabetes y Enfermedades Metab61icas Asociadas (CIBERDEM) 08017 Barcelona Spain Instituto de Investigaciones Biomedicas Alberto Sols (CSIC-UAM) 28029 Madrid Spain CIBER de enfermedades neurodegenerativas (CIBERNED) 28049 Madrid Spain Departament of Molecular Biology and Centro de Biologia Molecular Severo Ochoa (CSIC-UAM) 28049 Madrid Spain Instituto de Investigacion Sanitaria la Princesa 28006 Madrid Spain Centro de Biologia Molecular Severo Ochoa (UAM-CSIC) 28049 Madrid Spain Hospital Universitari de Tarragona Joan XXIII. IISPV. Universitat Rovira i Virgili 43007 Tarragona Spain

G protein-coupled receptor kinase 2 （GRK2） is an important serine/threonine-kinase regulating different membrane receptors and intraceUular proteins. Attenuation of Drosophila Gprk2 in embryos or adult flies induced a defective differentiation of somatic muscles, loss of fibers, and a flightless phenotype. In vertebrates, GRK2 hemizygous mice contained less but more hypertrophied skeletal muscle fibers than wild-type littermates. In C2C12 myoblasts, overexpression of a GRK2 kinase-deficient mutant （K220R） caused precocious differentiation of ceUs into immature myotubes, which were wider in size and contained more fused nuclei, while GRK2 overexpression blunted differentiation. Moreover, p38MAPK and Akt pathways were activated at an earlier stage and to a greater extent in K220R-expressing cells or upon kinase downregulation, while the activation of both kinases was impaired in GRK2-overexpressing cells. The impaired differentiation and fewer fusion events promoted by enhanced GRK2 levels were recapitulated by a p38MAPK mutant, which was able to mimic the inhibitory phosphorylation of p38MAPK by GRK2, whereas the blunted differentiation observed in GRK2-expressing clones was rescued in the presence of a constitutively active upstream stimulator of the p38MAPK pathway. These results suggest that balanced GRK2 function is necessary for a timely and complete myogenic process.

关键词： GRK2 p38MAPK Akt skeletal muscle myogenesis

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Distribution and Relation of Primes with Tesla Numbers 3, 6, and 9

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Journal of Applied Mathematics and Physics 2024年第4期12卷 1021-1027页

作者： Javier Mendoza-Navarrete Huetzin perez Ismael Ojeda Victor Verdugo Gabriel Luna Sandoval Ricardo Jimenez garcia Jaime Alvarez Departametno de Matemá ticas CBTis 256 DGETI Cabo San Lucas M&#233xico DCI Departamento de Fisica Mé dica Universidad de Guanajuato Leon M&#233xico Divisió n de Ingenieria en Sistemas Computacionales Tecnol&#243gico Nacional de M&#233xico ITES Los Cabos Cabo San Lucas M&#233xico Departamento de Ingenieria Industrial en Manufactura Universidad Estatal de Sonora Navojoa M&#233xico Departamento de Elé ctrica-Electr&#243nica Tecnol&#243gico Nacional de M&#233xico Campus Mexicali Mexicali M&#233xico Guanajuato M&#233xico

This work presents a different approach to twin primes, an approach from the perspective of the Tesla numbers and gives a refresh and new observation of twin primes that could lead us to an answer to the Twin Prime Conjecture problem. We expose a peculiar relation between twin primes and the generation of prime numbers with Tesla numbers. Tesla numbers seem to be present in so many domains like time, vibration and frequency [1], and the space between twin primes is not the exception. Let us say that twin primes are more than just prime numbers plus 2 or minus 2, and Tesla numbers are more involved with twin primes than we think, and hopefully, this approach give us a better understanding of the distribution of the twin pairs.

关键词： Tesla Numbers Prime Number Twin Prime Numbers Twin Pair

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Dielectric and Mechanical Nonlinear Behavior of Mn Doped PMN-35PT Ceramics

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Journal of Modern Physics 2010年第4期1卷 211-216页

作者： Diouma Kobor Abdelowahed Hajjaji Jose E. garcia Rafel perez Alfons Albareda Laurent Lebrun Daniel Guyomar 不详

This paper presents an investigation on dielectric and mechanical nonlinear properties in Mn-doped PMN-35PT ceramics. The structural study of the ceramics verifies that the 1% mol Mn doped PMN-35PT is a pure perovskite phase with a tetragonal symmetry. SEM micrograph shows the same microstructural mor- phology of an undoped ceramic. From the EPR spectra, it has been concluded that the major part of Mn is present in Mn2+ rather than in Mn4+ form. The addition of Mn2+ ions acts on the dielectric, piezoelectric and mechanical properties by decreasing the relative dielectric permittivity (3800 to 2074), the dielectric losses (0.60 to 0.53), the piezoelectric coefficient d33 (650 to 403 pC/N), and increasing the mechanical quality fac- tor Qm (78 to 317). It was found that in Mn2+ doped ceramics the dielectric response can not be described by Rayleigh law. This result can be understood taking into account that reversible motion of the domain wall is a relevant contribution to response of this material.

关键词： Piezoelectrics Ceramics Nonlinearity Dielectric properties Mechanical Properties PMN-PT

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Metabolic dysregulation in term infants from SARS-CoV-2-infected mothers

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World Journal of Pediatrics 2023年第9期19卷 912-917页

作者： Mari Merce Cascant-Vilaplana Inmaculada Lara-Cantón Victoria Ramos-garcia Alejandro Pinilla-González Álvaro Solaz-García Guillermo Quintás Purificación Marín-Reina marta Aguar Laura Torrejón-Rodríguez Máximo Vento Julia Kuligowski María Cernada Neonatal Research Unit Health Research Institute Hospital La FeUniversity Polytechnic Hospital La FeAvda.Fernando Abril Martorell 10646026ValenciaSpain Leitat Technological Center ValenciaSpain Analytical Unit Health Research Institute La FeValenciaSpain Division of Neonatology University and Polytechnic Hospital La FeValenciaSpain

Severe acute respiratory syndrome coronavirus 2(SARSCoV-2)is a novel beta coronavirus that causes coronavirus disease 2019(COVID-19),a severe infectious respiratory *** January 2020,the World Health Organization(WHO)d... 详细信息

关键词： mother respiratory acute

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Antimicrobial potential of aqueous coffee extracts against pathogens and Lactobacillus species:A food matrix application

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Food Bioscience 2022年第3期47卷 1142-1149页

作者： Luiza Andrea Canci marta de Toledo Benassi Cristiane Canan Daneysa Lahis Kalschne Eliane Colla Departamento de Alimentos Universidade Tecnológica Federal do ParanáAvenida Brasil4232Bairro Independência85884-000MedianeiraPRBrazil Centro de Ciências Agrárias Universidade Estadual de LondrinaRodovia Celso Garcia Cid PR 445 Km 38086057-970LondrinaParanáBrazil

Coffee is recognized by its bioactive potential,mainly antioxidant and antimicrobial *** aim of this study was to evaluate the antimicrobioal potential of aqueous extracts of Coffea arabica(AR)(roasted)and Coffea canephora[roasted(CR)and green(CG)]against patogens Salmonella Typhimurium and Escherichia coli,and probiotics Lactobacillus plantarum and Lactobacillus ***,the strain's sensitivity were tested by disk diffusion method,followed by the evaluation of growth kinetics(lag phase duration,maximum specific growth rate and logarithmic increase in the population)in culture media and in a food matrix(milk)by the adjustment of Gompertz predictive *** the step of strain sensivity tests,*** and *** were sensitive against all coffee extracts from 0.5%to 5.0%,while the Lactobacilli growth were not *** the growth kinetic tests in culture media,roasted coffees extracts reduced logarithmic increase in the population and maximum specific growth rate and improved lag phase for ***;for *** the growth was completely inhibited with 2.5%CR and 5.0%*** correlations between growth parameters with coffee bioactive contents suggested that melanoidins had the main antimicrobial *** the step of food matrix application(growth kinetics in milk),the addition of 5.0%CR reduced *** and *** multiplication,while the probiotics *** and *** where not inhibetd,suggesting a selective effect of coffee extracts as an antimicrobial agent,which may be of great interest for the food industry,especially for probiotic foods application.

关键词： Coffea arabica Coffea canephora Escherichia coli Green coffee Roasted coffee Salmonella Typhimurium

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