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Discoloration on Methylene Blue Solutions by Direct and Catalytic Ozonation

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Journal of Materials Science and Chemical Engineering 2013年第5期1卷 33-38页

作者： Antonio D. Rodriguez-Lopez Jose garcia-Garrido Cynthia perez-Ramiro Esperanza M. garcia-Castello Grupo de Tecnologías de Control de Aguas y Residuos (TECAR) Universitat Politècnica de València Camino de Vera Valencia Spain Grupo de Tecnologías de Control de Aguas y Residuos (TECAR) Universitat Politècnica de ValènciaCamino de Vera Valencia Spain Institute of Food Engineering for Development Universitat Politècnica de València Camino de Vera Valencia Spain

During textile manufacturing, huge amounts of wastewaters characterized by removed impurities and high concentrations of dye are produced. These wastewaters cause several problems when they are discharged to the environment. The use of ozone in wastewater treatment results of interest. In this work we propose to assess the discoloration rate of different synthetic wastewaters as a function of pH, dye concentration (methylene blue (MB)) and reaction time. A comparison of discoloration rate between conventional ozonation and catalytic ozonation salts of copper, zinc, silver and nickel was also performed. For the optimization of the ozonation process of colored solutions, it was used a central composite experimental design with five replicates of the center point resulting to evaluate the influence of the independent variables at different ranges of pH, [MB] and time. In the catalyst-assisted ozonation, [MB], pH and the reaction time were fixed to 100 mg/L, 5.5 and 15 min, respectively. The optimized experimental conditions to provide maximum discoloration were pH=3.3;[MB]=8.6 mg/L and time=74.3 min. Regarding the catalyst-assisted ozonation, it was found that CuSO4 catalyst gave better color reduction if compared with other catalysts assayed.

关键词： Textile Wastewater Methylene Blue Discoloration Ozonation Catalytic

High-resolution patterns of palaeoenvironmental changes during the Little Ice Age and the Medieval Climate Anomaly in the northwestern Iberian Peninsula

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Geoscience Frontiers 2020年第5期11卷 1461-1475页

作者： Daniel Castro Martin Souto Maria Isabel Fraga Eduardo garcia-Rodeja Sebastian perez-Diaz Jose Antonio Lopez Saez Xabier Pontevedra-Pombal Dpto.Botanica Fac.BioloxiaUniversidade de Santiago de CompostelaGaliciaSpain Dpto.Edafoloxia e Quimica Agricola Fac.BioloxiaUniversidade de Santiago de CompostelaGaliciaSpain Dpto.Geografia Urbanismo y Ordenacion Del TerritorioETS CaminosCanales y PuertosUniversidad de CantabriaSpain GI Arqueobiologia Instituto de HistoriaCCHS–CSICMadridSpain

to identify plant macrofossils,estimate peat humification and calculate hydroclimatic indices based on current bog species,with the overall aim of determining the climate conditions associated with evolution of the bog during the Medieval Climate Anomaly and the Little Ice *** proxies,together with historical and climate data,proved to be good indicators of the changes in bog surface ***:of the core led to identification of 9 different periods:two corresponding to the so-called Medieval Climate Anomaly(930 to 1345 AD,1075–665 calibrated years before present[*** BP]);four corresponding to the Little Ice Age(1345 to 1905 AD;665–105 cal yr BP);and three corresponding to the last century(1905 to 2000 AD).The findings revealed a generally dry climate that lasted until the 14th century,followed by a transition to a long period with a more humid,but characteristically very variable climate,which ended at the beginning of the 20th century and was followed by a rapid transition to more humid conditions and finally,a change to drier *** Medieval Climate Anomaly was indicated by the abundance of dry-adapted mosses(Leucobryum glaucum,Hypnum cupressiforme)and characterized by warm dry conditions and high levels of peat humification,with alternating wet *** LIA period was dated by a large abundance of Sphagnum species(an indicator of wetness)and a gradual increase in the humification ***,four different climate phases were differentiated in this ***-resolution reconstruction of the evolution of the CVM bog and the multiproxy approach have together enabled a more detailed identification of climatic variations in this area,which are generally consistent with the global models,as well as better definition of the elusive climatic oscillations in the last millennium and confirmation of the importance of local modulation of global *** study provides new information and a detailed chronology of climatic events that will hel

关键词： Last millennium Raised bog Plant macrofossil Humification analysis Southwest Europe Climate change

Alcoholic cardiomyopathy

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World Journal of Cardiology 2014年第8期6卷 771-781页

作者： Gonzalo Guzzo-Merello marta Cobo-Marcos Maria Gallego-Delgado Pablo garcia-Pavia Heart Failure and Inherited Cardiac Diseases Unit Department of CardiologyHospital Universitario Puerta de Hierro28222 MadridSpain

Alcohol is the most frequently consumed toxic substance in the world. Low to moderate daily intake of alcohol has been shown to have beneficial effects on the cardiovascular system. In contrast, exposure to high levels of alcohol for a long period could lead to progressive cardiac dysfunction and heart failure. Cardiac dysfunction associated with chronic and excessive alcohol intake is a specific cardiac disease known as alcoholic cardiomyopathy(ACM). In spite of its clinical importance, data on ACM and how alcohol damages the heart are limited. In this review, we evaluate available evidence linking excessive alcohol consumption with heart failure and dilated cardiomyopathy. Additionally, we discuss the clinical presentation, prognosis and treatment of ACM.

关键词： Alcohol Alcoholic cardiomyopathy Dilated cardiomyopathy Heart failure

Phase Ⅱ trial of CDK4/6 inhibitor palbociclib in advanced sarcoma based on mRNA expression of CDK4/CDKN2A

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Signal Transduction and Targeted Therapy 2023年第11期8卷 5518-5527页

作者： Javier Martin-Broto Jeronimo Martinez-garcia David SMoura Andres Redondo Antonio Gutierrez Antonio Lopez-Pousa Javier Martinez-Trufero Isabel Sevilla Roberto Diaz-Beveridge Maria Pilar Solis-Hernandez Amancio Carnero Marco perez David Marcilla Jesus garcia-Foncillas Pablo Romero Javier Fernandez-Jara Daniel Lopez-Lopez Ivan Arribas Nadia Hindi Health Research Institute-Fundación Jiménez Díaz University Hospital Universidad Autónoma de Madrid(IIS-FJDUAM)28040MadridSpain Medical Oncology Department Fundación Jimenez Diaz University Hospital28040MadridSpain General de Villalba University Hospital 28400MadridSpain Medical Oncology Department University Hospital Virgen de la Arrixaca30120MurciaSpain Department of Medical Oncology Hospital Universitario La Paz-IdiPAZP.Castellana26128046MadridSpain Hematology Department University Hospital Son Espases07120MallorcaSpain Medical Oncology Department Sant Pau Hospital08025BarcelonaSpain Medical Oncology Department University Hospital Miguel Servet50009ZaragozaSpain Investigación Clínica y Traslacional en Cáncer/Instituto de Investigaciones Biomédicas de Malaga(IBIMA)/Hospitales Universitarios Regional y Virgen de la Victoria de Malaga MalagaSpain Medical Oncology Department Hospital Universitari i Politècnic La Fe46026ValenciaSpain Medical Oncology Department Central University Hospital of Asturias33011OviedoSpain Instituto de Biomedicina de Sevilla(IBiS HUVRCSICUS)41013SevillaSpain Pathology Department Virgen del Rocio University Hospital41013SevillaSpain Radiology Department Fundación Jimenez Diaz University Hospital28040MadridSpain Computational Medicine Platform Fundación progreso y salud(FPS)Hospital Virgen del Rocío41013SevilleSpain Bioinformatics in Rare Diseases(BiER).Centro de Investigación Biomédica en Red de Enfermedades Raras(CIBERER) FPSHospital Virgen del RocioSevillaSpain Universitat de València-ERI-CES 46010ValenciaSpain

Cyclin-dependent kinases 4 and 6(CDK4/6)inhibitors demonstrated activity in terms of progression-free survival(PFS)in advanced dedifferentiated liposarcoma(DD-LPS),a sarcoma with CDK4 ***4 overexpression is by far more common than amplification in sarcomas and it might be a rational target for CDK *** investigators of this study found that CDK4 overexpression,while not of CDKN2A,was the most consistent predictive factor for palbociclib efficacy in *** adult-type soft-tissue sarcoma,excluding DD-LPS,or bone sarcoma patients,progressing after at least one systemic line,whose tumors overexpressed CDK4,but not CDKN2A at baseline biopsy,were accrued in this single-arm phase II trial(EudraCT number:2016-004039-19).With the main endpoint of a 6-month PFS rate,40%was considered promising in this *** was administered orally at 125 mg/day for 21 days in 28-day cycles.A total of 214 patients with 236 CDK4/CDKN2A determinations were assessed for prescreening,archival material(141),and screening,baseline biopsy(95).There were 28(29%)with favorable mRNA profiles from 95 screened patients at *** 23 enrolled patients,21 evaluable,the 6-month PFS rate was 29%(95%CI 9–48),and there were 6 patients out of 21 with a PFS longer than 6 *** median PFS and overall survival were 4.2(95%CI 3.6–4.8)and 12(95%CI 8.7–15.4)months,*** research showed a significant correlation between CDK4 mRNA and protein *** was active in a variety of sarcoma subtypes,selected by CDK4/CDKN2A,and deserves further investigation in the sarcoma context.

关键词： CDKN2A sarcoma CDK4

Cross-sectional evaluation of circulating hepatitis B virus RNA and DNA: Different quasispecies?

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World Journal of Gastroenterology 2021年第41期27卷 7144-7158页

作者： Selene garcia-garcia Maria Francesca Cortese David Tabernero Josep Gregori marta Vila Beatriz Pacín Josep Quer Rosario Casillas Laura Castillo-Ribelles Roser Ferrer-Costa Ariadna Rando-Segura Jesús Trejo-Zahínos Tomas Pumarola Ernesto Casis Rafael Esteban Mar Riveiro-Barciela Maria Buti Francisco Rodríguez-Frías Clinical Biochemistry Research Group Department of BiochemistryVall d'Hebron Institut Recerca-Hospital Universitari Vall d'HebronUniversitat Autònoma de BarcelonaBarcelona 08035Spain Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas Instituto de Salud Carlos IIIMadrid 28029Spain Liver Unit Liver Disease Laboratory-Viral HepatitisVall d'Hebron Institut Recerca-Hospital Universitari Vall d'HebronVall d’Hebron Barcelona Hospital CampusBarcelona 08035Spain Liver Pathology Unit Departments of Biochemistry and MicrobiologyHospital Universitari Vall d’HebronUniversitat Autònoma de BarcelonaBarcelona 08035Spain Department of Microbiology Hospital Universitari Vall d'HebronVall d'Hebron Barcelona Hospital CampusBarcelona 08035Spain Liver Unit Department of Internal MedicineHospital Universitari Vall d'HebronUniversitat Autónoma de BarcelonaBarcelona 08035Spain

BACKGROUND Different forms of pregenomic and other hepatitis B virus(HBV)RNA have been detected in patients’*** circulating HBV-RNAs may be useful for monitoring covalently closed circular DNA activity,and predicting hepatitis B eantigen seroconversion or viral rebound after nucleos(t)ide analog *** on serum HBV-RNA quasispecies,however,is *** is therefore important to develop methodologies to thoroughly analyze this quasispecies,ensuring the elimination of any residual *** circulating HBV-RNA quasispecies may facilitate achieving functional cure of HBV *** To establish a next-generation sequencing(NGS)methodology for analyzing serum HBV-RNA and comparing it with DNA *** Thirteen untreated chronic hepatitis B patients,showing different HBV-genotypes and degrees of severity of liver disease were enrolled in the study and a serum sample with HBV-DNA>5 Log10 IU/mL and HBV-RNA>4 Log10 copies/mL was taken from each ***-RNA was treated with DNAse I to remove any residual DNA,and the region between nucleotides(nt)1255-1611 was amplified using a 3-nested polymerase chain reaction protocol,and analyzed with ***/conservation and complexity was compared between HBV-DNA and RNA *** No HBV-DNA contamination was detected in cDNA samples from HBV-RNA *** quasispecies complexity showed heterogeneous behavior among *** Rare Haplotype Load at 1%was greater in DNA than in RNA quasispecies,with no statistically significant differences(P=0.1641).Regarding conservation,information content was equal in RNA and DNA quasispecies in most nt positions[218/357(61.06%)].In 102 of the remaining 139(73.38%),HBV-RNA showed slightly higher *** window analysis identified 4 hyper-conserved sequence fragments in each quasispecies,3 of them coincided between the 2 quasispecies:nts 1258-1286,1545-1573 and *** 2 hyper-variable sequence fragments also coincid

关键词： Hepatitis B virus RNA Hepatitis B X gene Quasispecies Next-generation sequencing Quasispecies conservation Quasispecies complexity

Role of nitric oxide in cerebral ischemia/reperfusion injury:A biomolecular overview

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World Journal of Clinical Cases 2025年第10期13卷 9-13页

作者： Roberto Anaya-Prado Abraham I Canseco-Villegas Roberto Anaya-Fernández Michelle Marie Anaya-Fernandez Miguel A Guerrero-Palomera Citlalli Guerrero-Palomera Ivan F garcia-Ramirez Daniel Gonzalez-Martinez Consuelo Cecilia Azcona-Ramírez Claudia garcia-perez Airim L Lizarraga-Valencia Aranza Hernandez-Zepeda Jacqueline F Palomares-Covarrubias Jorge HA Blackaller-Medina Jacqueline Soto-Hintze Mayra C Velarde-Castillo Dayri A Cruz-Melendrez Department of Research&Department of Surgery School of Medicine and Health SciencesTecnologico de MonterreyCorporate Hospitals Puerta de HierroZapopan 45116JaliscoMexico Direction of Research and Education Corporate Hospitals Puerta de HierroZapopan 45116JaliscoMexico Department of Research School of Medicine and Health SciencesTecnologico de MonterreyZapopan 45116JaliscoMexico Division of Research and Education Corporate Hospitals Puerta de HierroZapopan 45116JaliscoMexico Division of Research School of MedicineUniversity of GuadalajaraGuadalajara 44340JaliscoMexico Division of Research School of MedicineAutonomous University of GuadalajaraZapopan 45116JaliscoMexico Research&Education Corporate Hospitals Puerta de HierroZapopan 45116JaliscoMexico Division of Research Corporate Hospitals Puerta de HierroZapopan 45116JaliscoMexico Research School of MedicineUNIVA UniversityZapopan 45116JaliscoMexico

Nitric oxide(NO)is a gaseous molecule produced by 3 different NO synthase(NOS)isoforms:Neural/brain NOS(nNOS/bNOS,type 1),endothelial NOS(eNOS,type 3)and inducible NOS(type 2).Type 1 and 3 NOS are constitutively *** can serve different purposes:As a vasoactive molecule,as a neurotransmitter or as an *** plays a key role in cerebral ischemia/reperfusion injury(CIRI).Hypoxic episodes simulate the production of oxygen free radicals,leading to mitochondrial and phospholipid *** reperfusion,increased levels of oxygen trigger oxide synthases;whose products are associated with neuronal damage by promoting lipid peroxidation,nitrosylation and *** pathways in CIRI can be altered by *** effects are observed with eNOS *** nNOS interplay is prone to endothelial inflammation,oxidative stress and ***,nNOS appears to be *** interaction between NO and other free radicals develops peroxynitrite;which is a cytotoxic *** plays a main role in the likelihood of hemorrhagic events by tissue plasminogen activator(t-PA).Peroxynitrite scavengers are currently being studied as potential targets to prevent hemorrhagic transformation in CIRI.

关键词： Nitric oxide Cerebral ischemia/reperfusion injury Nitric oxide synthase Reactive nitrogen species Nitrosylation

Size Distribution of Particulate Matter of Metals in Urban Aerosols, Comarca Lagunera, Mexico

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Journal of Environmental Science and Engineering(A) 2012年第11期1卷 1260-1266页

作者： Roman perez Sylvia Miranda Alfredo Campos Jorge Carrillo Elias Ramirez Gonzalo garcia Herrera Renewable Energy and Environmental Protection Department Research Center on Advanced Materials C.S. (CIMAV)Chihuahua 31109 Mexico Faculty of Medicine Ju6rez University of Durango State Durango 35050 M~xico

This paper has demonstrated that there is great variation in the size range and chemical composition of metalliferous PM （particulate matter） present within Comarca Lagunera, M6xico due to the physiography of the terrain together the intense vehicular traffic, unpaved roads, cement and lime plants, marble quarries, brick plants, and the largest smelter of non-ferrous material in Latin America. Cascade impactor PM samples from six size ranges：〈 0.49 μm, 0.49-0.9 μm, 0.9-1.5μm, 1.5-3.0 p.m, 3.0-7.2 μm and 7.2-10 μm were collected from inside two stacks within G6mez Palacios and Torreon cities. ICP-AES （inductively coupled plasma-atomic emission spectrometry） analysis on collected Whatman fiberglass filters demonstrates that the PM are matrices mostly constituted of carbonates and silicates with abundant fine metalliferous particles. The metals with the most concentrations averaged over all size ranges were Cu, Fe, Mn, Ni, Pb and Ti. The size distributions of metals detected in this work have been plotted as normalized histogram concentration of each size fraction, the total concentration, and the aerodynamic particle diameter, which is a useful method for comparing the contributions of coarse and fine particles to pollutant concentrations.

关键词： Size distribution cascade impactor metals Comarca Lagunera Mexico ICP-AES.

Free-space local nonseparability dynamics of vector modes

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Photonics Research 2021年第4期9卷 439-445页

作者： Xiao-Bo Hu Benjamin perez-garcia Valeria Rodríguez-Fajardo Raul I.Hernandez-Aranda Andrew Forbes Carmelo Rosales-Guzmán Wang Da-Heng Collaborative Innovation Center Heilongjiang Provincial Key Laboratory of Quantum Manipulation and ControlHarbin University of Science and TechnologyHarbin 150080China Photonics and Mathematical Optics Group Tecnologico de MonterreyMonterrey 64849Mexico School of Physics University of the WitwatersrandJohannesburg 2050South Africa Centro de Investigaciones enÓptica A.C.Loma del Bosque 115Colonia Lomas del campestre37150 LeónGto.Mexico

One of the most prominent features of quantum entanglement is its invariability under local unitary transformations,which implies that the degree of entanglement or nonseparability remains constant during free-space propagation,true for both quantum and classically entangled *** we demonstrate an exception to this rule using a carefully engineered vectorial light field,and we study its nonseparability dynamics upon free-space *** show that the local nonseparability between the spatial and polarization degrees of freedom dramatically decays to zero while preserving the purity of the state and hence the global *** show this by numerical simulations and corroborate it *** results evince novel properties of classically entangled modes and point to the need for new measures of nonseparability for such vectorial fields,while paving the way for novel applications for customized structured light.

关键词： local dynamics quantum

Microstructure and Mechanical Properties of Alumina-Glass Composites Prepared by Melt Infiltration

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材料科学与工程（中英文版） 2010年第7期4卷 7-11页

作者： Claudia garcia Maria perez Maria Clsneros Hugo Lopez Eduardo Valdes Federico Zertuche Postgraduate Department Technological Institute of Saltillo Saltillo 2580 Mexico Materials Department University of Wisconsin Milwaukee WI53201 USA