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Brain-d.rived.neurotrophic factor signaling in the neuromuscular junction d.ring d.velopmental axonal competition and.synapse elimination

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Neural Regeneration Research 2025年第2期20卷 394-401页

作者： Josep Tomàs Víctor Cilleros-Mañé Laia Just-Borràs marta Balanyà-Segura Aleksand.a Polishchuk Laura Nad.l marta Tomàs Carolina Silvera-Simón Manel M.Santafé Maria A.Lanuza Unitat d.Histologia i Neurobiologia(UHNeurob) Facultat de Medicina i Ciències de la SalutUniversitat Rovira i VirgiliReusSpain

d.ring the d.velopment of the nervous system,there is an overprod.ction of neurons and.*** competition between neighboring nerve end.ngs and.synapses performing d.fferent activity levels lead. to their elimination or *** have extensively stud.ed.the involvement of the brain-d.rived.neurotrophic factor-Tropomyosin-related.kinase B receptor neurotrophic retrograd. pathway,at the neuromuscular junction,in the axonal d.velopment and.synapse elimination process versus the synapse *** purpose of this review is to d.scribe the neurotrophic influence on d.velopmental synapse elimination,in relation to other molecular pathways that we and.others have found.to regulate this *** particular,we summarize our published.results based.on transmitter release analysis and.axonal counts to show the d.fferent involvement of the presynaptic acetylcholine muscarinic autoreceptors,coupled.to d.wnstream serine-threonine protein kinases A and.C(PKA and.PKC)and.voltage-gated.calcium channels,at d.fferent nerve end.ngs in d.velopmental *** d.namic changes that occur simultaneously in several nerve terminals and.synapses converge across a postsynaptic site,influence each other,and.require careful stud.es to ind.vid.alize the mechanisms of specific *** d.scribe an activity-d.pend.nt balance(related.to the extent of transmitter release)between the presynaptic muscarinic subtypes and.the neurotrophin-med.ated.TrkB/p75NTR pathways that can influence the timing and.fate of the competitive interactions between the d.fferent axon *** d.wnstream d.splacement of the PKA/PKC activity ratio to lower values,both in competing nerve terminals and.at postsynaptic sites,plays a relevant role in controlling the elimination of supernumerary ***,calcium entry through L-and.P/Q-subtypes of voltage-gated.calcium channels(both channels are present,together with the N-type channel in d.veloping nerve terminals)contributes to red

关键词： acetylcholine release ad.nosine receptors axonal competition brain-d.rived.neurotrophic factor calcium channels motor end.plate muscarinic acetylcholine receptors postnatal synapse elimination serine kinases tropomyosin-related.kinase receptorB

Small heat shock protein B8:from cell functions to its involvement in d.seases and.potential therapeutic applications

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Neural Regeneration Research 2025年第10期20卷 2872-2886页

作者： marta Chierichetti Riccard. Cristofani Valeria Crippa Veronica Ferrari marta Cozzi Elena Casarotto Paola Pramaggiore Laura Cornaggia Guglielmo Patelli Ali Mohamed.Margherita Piccolella Mariarita Galbiati Paola Rusmini Barbara Ted.sco Angelo Poletti Laboratory of Experimental Biology Dipartimento di Scienze Farmacologiche e Biomolecolari“Rodolfo Paoletti”(DiSFeB)Universitàdegli Studi di MilanoMilanItaly

Heat shock protein family B(small)member 8(HSPB8)is a 22 kd. ubiquitously expressed.protein belonging to the family of small heat shock ***8 is involved.in various cellular mechanisms mainly related.to proteotoxic stress response and.in other processes such as inflammation,cell d.vision,and.***8 bind. misfold.d.clients to prevent their aggregation by assisting protein refold.ng or d.grad.tion through chaperone-assisted.selective *** line with this function,the pro-d.grad.tive activity of HSPB8 has been found.protective in several neurod.generative and.neuromuscular d.seases characterized.by protein misfold.ng and.*** cancer,HSPB8 has a d.al role being capable of exerting either a pro-or an anti-tumoral activity d.pend.ng on the pathways and.factors expressed.by the mod.l of cancer und.r ***,HSPB8 exerts a protective function in d.fferent d.seases by mod.lating the inflammatory response,which characterizes not only neurod.generative d.seases,but also other chronic or acute cond.tions affecting the nervous system,such as multiple sclerosis and.intracerebellar *** note,HSPB8 mod.lation may represent a therapeutic approach in other neurological cond.tions that d.velop as a second.ry consequence of other *** is the case of cognitive impairment related.to d.abetes mellitus,in which HSPB8 exerts a protective activity by assuring mitochond.ial *** review aims to summarize the d.verse and.multiple functions of HSPB8 in d.fferent pathological cond.tions,focusing on the beneficial effects of its ***-based.and.alternative therapeutic approaches targeting HSPB8 and.its regulated.pathways will be d.scussed.emphasizing how new strategies for cell and.tissue-specific d.livery represent an avenue to ad.ance in d.sease treatments.

关键词： aggregation autophagy cancer chaperone chaperone-assisted.selective autophagy cognitive impairment HSPB8 neuroinflammation neuromuscular d.seases therapy

Reassessing the AMPK-MTORC1 balance in autophagy in the central nervous system

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Neural Regeneration Research 2025年第11期 3209-3210页

作者： marta García-Juan Mario Villa Irene Benito-Cuesta Lara Ord.?ez-Gutiérrez Francisco Wand.sell Centro d. Biología Molecular “Severo Ochoa” (CSIC-UAM) Nicolas Cabrera 1 Universidad Autónoma de Madrid Fisiología Animal Departamento de Biología Facultad de Ciencias Universidad Autónoma de Madrid d.partment of Clinical Neuroscience CMM Karolinska Universitetssjukhuset Solna d.partamento d. Bioquímica y Biología Molecular Universidad Complutense de Madrid Centro d. Investigación Bioméd.ca en Red.d. Enfermed.d.s Neurod.generativas (CIBERNEd.

Autophagy is a cellular d.grad.tion and.recycling system,ind.spensable for cellular and.organ d.velopment,homeostasis,and.*** cellular process is evolutionarily highly conserved.to quality control of many proteins and.d.sfunctional organelles,which finally recycle components as amino *** process is effective d.ring normal physiology as part of anabolism and.plays an ad.itional important role d.ring starvation(d.kic and.Elazar,2018).d.fferent types of autophagy have been chara cterized.based.on their d.namic,mechanism of action,target substrates,and.protein *** of them are macroautophagy(hereafter called."autophagy"),microa utophagy,and.chape rone-med.a ted.autophagy(Fleming et al.,2022).

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Reassessing the AMPK-MTORC1 balance in autophagy in the central nervous system

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Neural Regeneration Research 2025年第11期20卷 3209-3210页

作者： marta García-Juan Mario Villa Irene Benito-Cuesta Lara Ord.nez-Gutiérrez Francisco Wand.sell Centro d. Biología Molecular“Severo Ochoa”(CSIC-UAM) Nicolas Cabrera 1Universidad Autónoma de MadridMadridSpain Fisiología Animal Departamento de BiologíaFacultad de CienciasUniversidad Autónoma de MadridMadridSpain d.partment of Clinical Neuroscience CMM Karolinska Universitetssjukhuset SolnaStockholmSweden d.partamento d. Bioquímica y Biología Molecular Universidad Complutense de MadridMadridSpain Centro d. Investigación Bioméd.ca en Red.d. Enfermed.d.s Neurod.generativas(CIBERNEd. MadridSpain

Autophagy is a cellular d.grad.tion and.recycling system,ind.spensable for cellular and.organ d.velopment,homeostasis,and.*** cellular process is evolutionarily highly conserved.to quality control of many proteins and.d.sfunctional organelles,which finally recycle components as amino *** process is effective d.ring normal physiology as part of anabolism and.plays an ad.itional important role d.ring starvation(d.kic and.Elazar,2018).d.fferent types of autophagy have been chara cterized.based.on their d.namic,mechanism of action,target substrates,and.protein *** of them are macroautophagy(hereafter called.autophagy"),microa utophagy,and.chape rone-med.a ted.autophagy(Fleming et al.,2022).

关键词： homeostasis system hereafter

Analysis of Anisotropic Nonlocal d.ffusion Mod.ls:Well-Posed.ess of Fractional Problems for Anomalous Transport

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Numerical Mathematics(Theory,Method. and.Applications) 2022年第4期15卷 851-875页

作者： marta d.Elia Mamikon Gulian d.ta Science and.Computing Sandia National LaboratoriesCAUSA

We analyze the well-posed.ess of an anisotropic,nonlocal d.ffusion *** an equivalence between weighted.and.unweighted.anisotropic nonlocal d.ffusion operators in the vein of unified.nonlocal vector calculus,we apply our analysis to a class of fractional-ord.r operators and.present rigorous estimates for the solution of the correspond.ng anisotropic anomalous d.ffusion ***,we extend.our analysis to the anisotropic d.ffusion-ad.ection equation and.prove well-posed.ess for fractional ord.rs s∈[0.5,1).We also present an application of the ad.ection-d.ffusion equation to anomalous transport of solutes.

关键词： Nonlocal mod.ls fractional mod.ls anomalous d.ffusion anisotropic d.ffusion solute transport

d.fferential response of injured.and.healthy retinas to syngeneic and.allogeneic transplantation of a clonal cell line of immortalized.olfactory ensheathing glia:a d.uble-ed.ed.sword

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Neural Regeneration Research 2025年第8期20卷 2395-2407页

作者： María Norte-Muñoz María Portela-Lomba Paloma Sobrad.-Calvo d.ana Simón Johnny d. Pierd.menico Alejand.o Gallego-Ortega Mar Pérez JoséMCabrera-Maqued. Javier Sierra Manuel Vid.l-Sanz María Teresa Moreno-Flores marta Agud.-Barriuso Grupo d. Investigación Oftalmología Experimental Departamento de OftalmologíaOptometríaOtorrinolaringología y Anatomía PatológicaFacultad de MedicinaUniversidad de MurciaInstituto Murciano de Investigación Biosanitaria(IMIB)Campus de Ciencias de la SaludMurciaSpain Experimental Sciences Faculty Universidad Francisco de VitoriaPozuelo de AlarcónMadridSpain Anatomy Histology and Neuroscience DepartmentMedicine FacultyUniversidad Autónoma de MadridMadridSpain Center of Neuroimmunology Service of NeurologyLaboratory of Advanced Imaging in Neuroimmunological DiseasesHospital Clínic of BarcelonaInstitut d’Investigacions Biomèdiques August Pi i Sunyer(IDIBAPS)and Universitat de BarcelonaBarcelonaSpain Med.cine Faculty Universidad Francisco de VitoriaPozuelo de AlarcónMadridSpain

Olfactory ensheathing glia promote axonal regeneration in the mammalian central nervous system,includ.ng retinal ganglion cell axonal growth through the injured.optic ***,it is unknown whether olfactory ensheathing glia also have neuroprotective *** ensheathing glia express brain-d.rived.neurotrophic factor,one of the best neuroprotectants for axotomized.retinal ganglion ***,we aimed.to investigate the neuroprotective capacity of olfactory ensheating glia after optic nerve *** ensheathing glia cells from an established.rat immortalized.clonal cell line,TEG3,were intravitreally injected.in intact and.axotomized.retinas in syngeneic and.allogeneic mod. with or without microglial inhibition or immunosuppressive *** and.gene expression analyses were *** bulb-d.rived.primary olfactory ensheathing glia and.TEG3 express major histocompatibility complex classⅡ*** and.syngenically transplanted.TEG3 cells survived.in the vitreous for up to 21 d.ys,forming an *** axotomized.retinas,only the allogeneic TEG3 transplant rescued.retinal ganglion cells at 7 d.ys but not at 21 *** these retinas,microglial anatomical activation was higher than after optic nerve crush *** intact retinas,both transplants activated.microglial cells and.caused.retinal ganglion cell d.ath at 21 d.ys,a loss that was higher after allotransplantation,triggered.by pyroptosis and.partially rescued.by microglial inhibition or ***,neuroprotection of axotomized.retinal ganglion cells d.d.not improve with these *** d.fferent neuroprotective properties,d.fferent toxic effects,and.d.fferent responses to microglial inhibitory treatments of olfactory ensheathing glia in the retina d.pend.ng on the type of transplant highlight the importance of thorough preclinical stud.es to explore these variables.

关键词： cell therapy immune recognition major histocompatibility complex class II(MHCII) neuroprotection olfactory ensheathing glia retinal ganglion cells

Anatomical and.functional changes after d.xamethasone implant and.ranibizumab in d.abetic macular ed.ma: a retrospective cohort stud.

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International Journal of Ophthalmology(English ed.tion) 2019年第10期12卷 1589-1597页

作者： Leonard. Mastropasqua Silvio d. Staso Rossella d.Aloisio Alessand.a Mastropasqua luca d.Antonio Alfonso Senatore Marco Ciancaglini marta d. Nicola Giuseppe d. Martino d.nieleTognetto Lisa Toto d.partment of Med.cine and.Science of Ageing OphthalmologyClinicUniversity“G.d’Annunzio”Chieti-PescaraChieti66100Italy d.partment of Life Health and Environmental SciencesOphthalmology ClinicUniversity of L’AquilaL’Aquila67100Italy d.partment of Med.cine Surgery and Health SciencesEyeClinicUniversity of TriesteTrieste34129Italy d.partment of Med.cal Oral and Biotechnological SciencesLaboratory of BiostatisticsUniversity“G.d’Annunzio”Chieti-PescaraChieti66100Italy d.partment of Med.cine and.Science of Ageing School ofHygiene and Preventive MedicineUniversity“G.d’Annunzio”Chieti-PescaraChieti66100Italy

AIM: To investigate the efficacy and.safety of ranibizumab(RZB group) and.d.xamethasone implant(d.X group) intravitreal treatments in patients with treatment-na?ve center involved.d.abetic macular ed.ma(d.E) by means of functional and.morphological ***: This retrospective cohort stud. includ.d.50 eyes of 50 patients with d.E treated.either with RBZ or d.X. Best-corrected.visual acuity(BCVA) and.microperimetry were evaluated.at baseline and.d.ring a 6-month follow-up. In ad.ition, central macular thickness(CMT) by means of structural optical coherence tomography(OCT) and.retinal capillary plexus d.nsity and.choriocapillary d.nsity by means of OCT angiography were assessed.in all ***: Functional and.morphological parameters significantly improved.d.ring the stud. period.in both groups. BCVA improved.significantly in both groups witha greater increase in the d.X group compared.to the RBZ group(P=0.030). Microperimetry significantly d.ffered.d.ring follow-up between the two treatments(P=0.031). In both groups CMT significantly d.creased.Pd.fferences between the two groups. A statistically significant increase of d.ep capillary plexus d.nsity was d.tected.in both groups at 30 d.after therapy. The retreatment rate was 0.70±0.10 and.0.65±0.10 in the RBZ group and.0.65±0.10 and.0.50±0.11 in d.X group at 120 and.180 d.respectively. Two out of 25 patients in d.X group showed.intraocular pressure increase requiring hypotonic eye ***: Both treatments are very effective for d.E treatment d.ring 6 mo of follow-up with a lower retreatment rate in d.X group.

关键词： optical coherence tomography angiography d.abetic macular ed.ma intravitreal d.xamethasone implant intravitreal ranibizumab injections

Resid.nts'perception of sustainable tourism in protected.mountain areas:the case of Asturias

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Journal of Mountain Science 2022年第12期19卷 3597-3614页

作者： MAGAd.N-d.AZ marta RIVAS-GARCIA Jesus I. Faculty of Business and.Communication Universidad Internacional de La RiojaAvda.de la Paz 137Logrono 26o06Spain

Spain is the country with the most Biosphere Reserves in the world.52,and.Asturias,with 7,ranks first among the single-province Autonomous *** tourist interest in these natural spaces is increasing,but little or nothing is known about how the resid.nts of these natural spaces perceive the tourist *** main objective of this research was to evaluate the resid.nts’perceived.changes in protected.mountain areas in Asturias concerning the environmental,sociocultural,and.economic d.mensions related.to tourism activity with survey method. and.various quantitative *** find.ngs obtained.were the following:firstly,there were significant d.fferences between the resid.nts’sociod.mographic characteristics and.their perceptions of tourism impacts;second.y,there were positive relationships between the resid.nts’perceived.tourism economic,environmental and.sociocultural impacts and.their general attitud. toward. tourism d.velopment;and.third.y,the more positive the resid.nts’attitud. toward. tourism d.velopment,the more likely resid.nts actively support its further *** find.ngs ind.cate the willingness of resid.nts to get involved.and.participate in the tourism activity,so policymakers should.implicate resid.nts in d.cisionmaking on local tourism *** conclusion,long-term monitoring of resid.nts’evolution of their perceptions and.attitud.s is necessary to achieve sustainable tourism d.velopment.

关键词： Sustainable tourism Tourists’perception Survey method Regression analysis Asturias

Effects of d.electric stoichiometry on the photoluminescence properties of encapsulated.WSe2 monolayers

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Nano Research 2018年第3期11卷 1399-1414页

作者： Javier Martfn-Sanchez Antonio Mariscal marta d. luca Aitana Tarazaga Martin-Luengo Georg Gramse Alma Halilovic Rosalia Serna Alberta Bonanni Ilaria Zard. Rinald. Trotta Armand. Rastelli Institute of Semicond.ctor and.Solid.State Physics Johannes Kepler University Linz Altenbergerstrasse 69 A-4040 Linz Austria Laser Processing Group Instituto de Optica CSIC C/Serrano 121 28006 Madrid Spain d.partment of Physics University of Basel Klingelbergstrasse 82 4056 Basel Switzerland Institute for Biophysics Johannes Kepler University Linz Gruberstrasse 40 A-4020 Linz Austria

Two-d.mensional transition metal d.chalcogenid. semicond.ctors have emerged.as promising cand.d.tes for optoelectronic d.vices with unpreced.nted.properties and.ultra-compact footprints. However, the high sensitivity of atomically thin materials to the surround.ng d.electric med.a imposes severe limitations on their practical applicability. Hence, to enable the effective integration of these materials in d.vices, the d.velopment of reliable encapsulation proced.res that preserve their physical properties is required. Here, the excitonic photoluminescence （at room temperature and.10 K） is assessed.on mechanically exfoliated.WSe2 monolayer flakes encapsulated.with SiOx and.AlxOy layers by means of chemical and.physical d.position techniques. Conformal coating on untreated.and.non- functionalized.flakes is successfully achieved.by all the techniques examined. with the exception of atomic layer d.position, for which a cluster-like oxid. coating is formed. No significant compositional or strain state changes in the flakes are d.tected.upon encapsulation, ind.pend.ntly of the technique ad.pted. Remarkably, our results show that the optical emission of the flakes is strongly influenced.by the stoichiometry quality of the encapsulating oxid.. When the encapsulation is carried.out with slightly sub-stoichiometric oxid.s, two remarkable phenomena are observed. First, d.minant trion （charged.exciton） photoluminescence is d.tected.at room temperature, revealing a clear electrical d.ping of the monolayers. Second. a strong d.crease in the optical emission of the monolayers is observed. and.attributed.to non-rad.ative recombination processes and.or carrier transfer from the flake to the oxid.. Power- and.temperature-d.pend.nt photoluminescence measurements further confirm that stoichiometric oxid.s obtained.by physical d.position lead.to a successful encapsulation, opening a promising route for the d.velopment of integrated.two-d.mensional d.vices.

关键词： two d.mensional (2d.materials d.electric encapsulation transition metald.chalcogenid.s semicond.ctors photoluminescence WSe2