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Case Report: A Long Survivor Patient with Stage IV Gastric Adenocarcinoma

Journal of Cancer Therapy 2020年第6期11卷 357-364页

作者： marta pina Maria Leitão Manuela Machado Medical Oncology Department Portuguese Institute of Oncology of Porto Porto Portugal

Gastric cancer (GC) is the fifth most common malignancy of the world and third leading cause of cancer death. At diagnosis, 35% of GC patients have distant metastases and in these cases the survival rate is very poor with a median overall survival (OS) inferior to 1 year. We report a case of a 67-year-old woman with gastric carcinoma initially deemed limited stage on diagnosis (cT2N0M0), treated surgically with radical subtotal gastrectomy with Billroth II reconstruction. In the staging CT scan, the patient presented a liver image that was considered benign. Three months later, due to abdominal pain, the patient performed another CT scan and the diagnostic of a large single liver metastasis was made;retrospectively it was observed that the lesion was present at diagnosis and that it had increased. A biopsy was performed which confirmed the metastatic origin. In a multidisciplinary team, the lesion was considered unresectable. She was proposed for first line (1st L) palliative chemotherapy (ChT) with FOLFIRI, with partial response as best response. After 30 cycles of FOLFIRI, bone metastases were diagnosed. The patient was submitted to a cementoplasty of D11-12 and L1-2. Afterwards, she started 2nd L ChT with mFOLFOX6 and at the same time she started zoledronic acid every 28 days. The best response to mFOLFOX6 was stable disease. Since November 2018, the patient has been treated with zoledronic acid every 28 days alone and maintains stable disease without ChT.

关键词： Gastric Cancer Metastatic Gastric Cancer Palliative Surgery Palliative Chemotherapy Survival

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Characterization of the Ear Canal Bacterial Flora Present in Hearing Aids (HA) Wearing Subjects

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Advances in Microbiology 2019年第7期9卷 616-628页

作者： marta Aleandri Cecilia Ambrosi Maria Stefania Lepanto Antonietta Lucia Conte Massimiliano Marazzato Catia Longhi Mauro Nicoletti Carlo Zagaglia Paola Goldoni Francesco Bussu Roberta Anzivino Roberto Gallus Maria pina Battista Maria Pia Conte Anna Teresa Palamara Department of Public Health and Infectious Diseases “Sapienza” University of Rome Rome Italy Dani Di Giò Foundation-Onlus Rome Italy Department of Medical Oral and Biotechnological Sciences University “G. D’Annunzio” Chieti Italy Institute of Otolaryngology “Cattolica del Sacro Cuore” University Agostino Gemelli Polyclinic Rome Italy Otolaryngology Mater Olbia Hospital Olbia Italy Department of Public Health and Infectious Diseases “Sapienza” University of Rome Laboratory Affiliated to Institute Pasteur Italia Cenci-Bolognetti Foundation Rome Italy San Raffaele Pisana IRCCS Telematic University Rome Italy

The use of hearing aids (HA) is considered a predisposing factor for ear microbial infections. We undertook this study to compare the presence and nature of the microbial flora inhabiting of ears of HA and non-HA (nHA) users. Swab samples of the ears of HA and nHA users were collected from the Institute of Otolaryngology, “Cattolica del Sacro Cuore” University “Agostino Gemelli”, Rome, Italy. Swab samples were taken from the ear canal of 57 HA and 33 nHA users. The components of the microbial flora present on each swab sample were identified and characterized at the level of species. A total of 41 different bacterial species were identified. A statistically significant prevalence of polymicrobial communities was found in ears presenting signs of inflammation (2.5 ± 1.7 vs 2.1 ± 1.3;P = 0.02) and in HA users (2.3 ± 1.2 vs 1.7 ± 1.0;P = 0.002). Few putative pathogens were detected. Candida albicans spp. was not isolated in our study. A small number of swab samples presented no microbial growth. Bacterial species isolated from HA users with and without inflammation were assayed for the ability to form biofilm. Among gram-positive and gram-negative bacteria, S. aureus, CoNS, P. aeruginosa and K. pneumoniae were found to be strong biofilm producers. S. aureus and P. aeruginosa, isolated only from the ears of HA and nHA users presenting signs of inflammation, were further analyzed for their antibiotic-resistance profile and characterized by the Multilocus Sequence Typing (MLST) assay. The highest rates of antibacterial resistance were in S. aureus to penicillin (75.5%) and in P. aeruginosa, to amoxicillin-clavulanic acid, cefotaxime, ertapenem, tigecycline and trime-thoprim-sulfamethoxazole (100%). Moreover, three S. aureus strains (37.5%) were methicillin-resistant (MRSA). Of the eight S. aureus isolates, we identified six sequence types (ST) indicating that 75% are likely independent clones. For what it concerned P. aeruginosa, six different STs were assigned. Interesti

关键词： Ear Bacterial Flora Hearing Aids Acute Otitis Externa

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