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Communications in Computational Physics 2012年第5期11卷 1591-1617页

作者： marta m.betcke Heinrich Voss Department of Computer Science University College LondonGower StreetLondon WC1E 6BTUK Institute of Numerical Simulation Hamburg University of TechnologyD-21071 HamburgGermany

In this work the one-band effective Hamiltonian governing the electronic states of a quantum dot/ring in a homogenous magnetic field is used to derive a pair/quadruple of nonlinear eigenvalue problems corresponding to different spin orientations and in case of rotational symmetry additionally to quantum number±ℓ.We show,that each of those pair/quadruple of nonlinear problems allows for the minmax characterization of its eigenvalues under certain conditions,which are satisfied for our examples and the common InAs/GaAs *** the minmax property we devise efficient iterative projection methods simultaneously handling the pair/quadruple of nonlinear problems and thereby saving up to 40%of the computational time as compared to the nonlinear Arnoldi method applied to each of the problems separately.

关键词： Quantum dot quantum ring nonlinear eigenvalue problem minmax characterization iterative projection method electronic state spin orbit interaction magnetic field

Brain-derived neurotrophic factor signaling in the neuromuscular junction during developmental axonal competition and synapse elimination

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Neural Regeneration Research 2025年第2期20卷 394-401页

作者： Josep Tomàs Víctor Cilleros-mañé Laia Just-Borràs marta Balanyà-Segura Aleksandra Polishchuk Laura Nadal marta Tomàs Carolina Silvera-Simón manel m.Santafé maria A.Lanuza Unitat d’Histologia i Neurobiologia(UHNeurob) Facultat de Medicina i Ciències de la SalutUniversitat Rovira i VirgiliReusSpain

During the development of the nervous system,there is an overproduction of neurons and *** competition between neighboring nerve endings and synapses performing different activity levels leads to their elimination or *** have extensively studied the involvement of the brain-derived neurotrophic factor-Tropomyosin-related kinase B receptor neurotrophic retrograde pathway,at the neuromuscular junction,in the axonal development and synapse elimination process versus the synapse *** purpose of this review is to describe the neurotrophic influence on developmental synapse elimination,in relation to other molecular pathways that we and others have found to regulate this *** particular,we summarize our published results based on transmitter release analysis and axonal counts to show the different involvement of the presynaptic acetylcholine muscarinic autoreceptors,coupled to downstream serine-threonine protein kinases A and C(PKA and PKC)and voltage-gated calcium channels,at different nerve endings in developmental *** dynamic changes that occur simultaneously in several nerve terminals and synapses converge across a postsynaptic site,influence each other,and require careful studies to individualize the mechanisms of specific *** describe an activity-dependent balance(related to the extent of transmitter release)between the presynaptic muscarinic subtypes and the neurotrophin-mediated TrkB/p75NTR pathways that can influence the timing and fate of the competitive interactions between the different axon *** downstream displacement of the PKA/PKC activity ratio to lower values,both in competing nerve terminals and at postsynaptic sites,plays a relevant role in controlling the elimination of supernumerary ***,calcium entry through L-and P/Q-subtypes of voltage-gated calcium channels(both channels are present,together with the N-type channel in developing nerve terminals)contributes to red

关键词： acetylcholine release adenosine receptors axonal competition brain-derived neurotrophic factor calcium channels motor end-plate muscarinic acetylcholine receptors postnatal synapse elimination serine kinases tropomyosin-related kinase receptorB

Small heat shock protein B8:from cell functions to its involvement in diseases and potential therapeutic applications

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Neural Regeneration Research 2025年第10期20卷 2872-2886页

作者： marta Chierichetti Riccardo Cristofani Valeria Crippa Veronica Ferrari marta Cozzi Elena Casarotto Paola Pramaggiore Laura Cornaggia Guglielmo Patelli Ali mohamed margherita Piccolella mariarita Galbiati Paola Rusmini Barbara Tedesco Angelo Poletti Laboratory of Experimental Biology Dipartimento di Scienze Farmacologiche e Biomolecolari“Rodolfo Paoletti”(DiSFeB)Universitàdegli Studi di MilanoMilanItaly

Heat shock protein family B(small)member 8(HSPB8)is a 22 kDa ubiquitously expressed protein belonging to the family of small heat shock ***8 is involved in various cellular mechanisms mainly related to proteotoxic stress response and in other processes such as inflammation,cell division,and ***8 binds misfolded clients to prevent their aggregation by assisting protein refolding or degradation through chaperone-assisted selective *** line with this function,the pro-degradative activity of HSPB8 has been found protective in several neurodegenerative and neuromuscular diseases characterized by protein misfolding and *** cancer,HSPB8 has a dual role being capable of exerting either a pro-or an anti-tumoral activity depending on the pathways and factors expressed by the model of cancer under ***,HSPB8 exerts a protective function in different diseases by modulating the inflammatory response,which characterizes not only neurodegenerative diseases,but also other chronic or acute conditions affecting the nervous system,such as multiple sclerosis and intracerebellar *** note,HSPB8 modulation may represent a therapeutic approach in other neurological conditions that develop as a secondary consequence of other *** is the case of cognitive impairment related to diabetes mellitus,in which HSPB8 exerts a protective activity by assuring mitochondrial *** review aims to summarize the diverse and multiple functions of HSPB8 in different pathological conditions,focusing on the beneficial effects of its ***-based and alternative therapeutic approaches targeting HSPB8 and its regulated pathways will be discussed,emphasizing how new strategies for cell and tissue-specific delivery represent an avenue to advance in disease treatments.

关键词： aggregation autophagy cancer chaperone chaperone-assisted selective autophagy cognitive impairment HSPB8 neuroinflammation neuromuscular diseases therapy

Differential response of injured and healthy retinas to syngeneic and allogeneic transplantation of a clonal cell line of immortalized olfactory ensheathing glia:a double-edged sword

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Neural Regeneration Research 2025年第8期20卷 2395-2407页

作者： maría Norte-muñoz maría Portela-Lomba Paloma Sobrado-Calvo Diana Simón Johnny Di Pierdomenico Alejandro Gallego-Ortega mar Pérez JosémCabrera-maqueda Javier Sierra manuel Vidal-Sanz maría Teresa moreno-Flores marta Agudo-Barriuso Grupo de Investigación Oftalmología Experimental Departamento de OftalmologíaOptometríaOtorrinolaringología y Anatomía PatológicaFacultad de MedicinaUniversidad de MurciaInstituto Murciano de Investigación Biosanitaria(IMIB)Campus de Ciencias de la SaludMurciaSpain Experimental Sciences Faculty Universidad Francisco de VitoriaPozuelo de AlarcónMadridSpain Anatomy Histology and Neuroscience DepartmentMedicine FacultyUniversidad Autónoma de MadridMadridSpain Center of Neuroimmunology Service of NeurologyLaboratory of Advanced Imaging in Neuroimmunological DiseasesHospital Clínic of BarcelonaInstitut d’Investigacions Biomèdiques August Pi i Sunyer(IDIBAPS)and Universitat de BarcelonaBarcelonaSpain medicine Faculty Universidad Francisco de VitoriaPozuelo de AlarcónMadridSpain

Olfactory ensheathing glia promote axonal regeneration in the mammalian central nervous system,including retinal ganglion cell axonal growth through the injured optic ***,it is unknown whether olfactory ensheathing glia also have neuroprotective *** ensheathing glia express brain-derived neurotrophic factor,one of the best neuroprotectants for axotomized retinal ganglion ***,we aimed to investigate the neuroprotective capacity of olfactory ensheating glia after optic nerve *** ensheathing glia cells from an established rat immortalized clonal cell line,TEG3,were intravitreally injected in intact and axotomized retinas in syngeneic and allogeneic mode with or without microglial inhibition or immunosuppressive *** and gene expression analyses were *** bulb-derived primary olfactory ensheathing glia and TEG3 express major histocompatibility complex classⅡ*** and syngenically transplanted TEG3 cells survived in the vitreous for up to 21 days,forming an *** axotomized retinas,only the allogeneic TEG3 transplant rescued retinal ganglion cells at 7 days but not at 21 *** these retinas,microglial anatomical activation was higher than after optic nerve crush *** intact retinas,both transplants activated microglial cells and caused retinal ganglion cell death at 21 days,a loss that was higher after allotransplantation,triggered by pyroptosis and partially rescued by microglial inhibition or ***,neuroprotection of axotomized retinal ganglion cells did not improve with these *** different neuroprotective properties,different toxic effects,and different responses to microglial inhibitory treatments of olfactory ensheathing glia in the retina depending on the type of transplant highlight the importance of thorough preclinical studies to explore these variables.

关键词： cell therapy immune recognition major histocompatibility complex class II(mHCII) neuroprotection olfactory ensheathing glia retinal ganglion cells

N-acetyl-L-leucine: a promising treatment option for traumatic brain injury

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Neural Regeneration Research 2022年第9期17卷 1957-1958页

作者： Chinmoy Sarkar marta m.Lipinski Shock Trauma and Anesthesiology Research(STAR)CenterDepartment of AnesthesiologyUniversity of Maryland School of MedicineBaltimoreMDUSA Department of Anatomy and Neurobiology University of Maryland School of MedicineBaltimoreMDUSA

Traumatic brain injury(TBI)is a mechanical injury to the brain,which can be sustained due to falls,accidents,contact sports or in combat *** is a serious health problem-affecting people of all ages *** per the recent epidemiological study,more than 55 million people suffer from TBI annually(GBD 2016 Traumatic Brain Injury and Spinal Cord Injury Collaborators,2019),and its prevalence has increased by almost 8.4%between 1990 and 2016(GBD 2016 Traumatic Brain Injury and Spinal Cord Injury Collaborators,2019).Depending on severity,TBI can lead to premature death and disability.

关键词： sustained Traumatic injury

Autophagy in neuroinflammation after traumatic brain injury

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Neural Regeneration Research 2024年第5期19卷 951-952页

Traumatic brain injury(TBI)is an acquired injury of the brain caused by the impact of external forces on the brain(maas et al.,2008).It is a major cause of death and disability among people of all ages(maas et al.,2008).The primary mechanical injury to the brain initiates a cascade of secondary biochemical events that lead to acute and chronic neurodegeneration and activation of inflammatory pathways(maas et al.,2008).Both brain-resident microglia and blood-derived myeloid cells-macrophages and monocytes that infiltrate the brain due to injury-induced blood-brain barrier damage,contribute to the inflammatory responses after TBI(morganti et al.,2015).

关键词： damage death after

modification of autophagy-lysosomal pathway as a neuroprotective treatment for spinal cord injury

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Neural Regeneration Research 2015年第6期10卷 892-893页

作者： marta m.Lipinski Junfang Wu University of maryland School of medicine Department of Anesthesiology & ShockTrauma and Anesthesiology Research (STAR)Center

Spinal cord injury （SCI） is one of the most common causes of long-term disability among young adults world-wide. In the United States, 12,000-20,000 new cases are reported annually and approximately half a million people currently live with SCI. Unfortunately, beyond surgery for immobilization of the spine and prolonged rehabilitation there are no effective treatments to improve functional outcomes after SCI. This is at least in part due to the complex and heterogeneous nature of injury after spinal cord trauma. The physical impact during SCI results in direct mechanical damage to some cells and tissues （primary injury）. Primary injury also sets off a cascade of widespread, progressive biochemical changes leading to further neuronal and glial cell death, neuroinflammation and glial scar formation （secondary injury）（Beattie et al., 2002）.

关键词： SCI modification of autophagy-lysosomal pathway as a neuroprotective treatment for spinal cord injury

Leaves of Field-Grown mastic Trees Suffer Oxidative Stress at the Two Extremes of their Lifespan

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Journal of Integrative Plant Biology 2012年第8期54卷 584-594页

作者： marta Juvany maren müller Sergi munn-Bosch Departament de Biologia Vegetal Facultat de BiologiaUniversitat de BarcelonaAvinguda Diagonal643E-08028 BarcelonaSpain

Leaf senescence is a complex phenomenon occurring in all plant species, but it is still poorly understood in plants grown in mediterranean field conditions and well-adapted to harsh climatic conditions. To better understand the physiological processes underlying leaf senescence in mastic trees （Pistacia lentiscus L.）, we evaluated leaf growth, water and N content, photosystem II （PSII） photochemistry, lipid peroxidation and levels of photosynthetic pigments, antioxidants, abscisic acid, and salicylic acid and jasmonic acid during the complete leaf lifespan, from early expansion to late senescence in relation to natural climatic conditions in the field. While mature leaves suffered from water and N deficit during late spring and summer, both young （emerging） and old （senescing） leaves were most sensitive to photo- oxidative stress, as indicated by reductions in the Fv/Fm ratio and enhanced lipid peroxidation during late autumn and winter. Reductions in the FvlFm ratio were associated with low ^-tocopherol （vitamin E） levels, while very old, senescing leaves additionally showed severe anthocyanin losses. We have concluded that both young （emerging） and old （senescing） leaves suffer oxidative stress in mastic trees, which may be linked in part to suboptimal temperatures during late autumn and winter as well as to low vitamin E levels.

关键词： Leaf senescence lentisc (Pistacea lentiscus L.) oxidative stress phytohormones seasonal effects.

Non-destructive corrosion study on a magnesium alloy with mechanical properties tailored for biodegradable cardiovascular stent applications

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Journal of materials Science & Technology 2021年第7期66卷 128-138页

作者： Changhong Cai marta m.Alves Renbo Song Yongjin Wang Jingyuan Li School of materials Science and Engineering University of Science and Technology BeijingBeijing100083China Centro de Qufmica Estrutural Instituto Superior TecnicoUniversidade de LisboaAv.Rovisco Pais1049-001LisboaPortugal

Anmg-2Zn-0.6Zr-0.6Nd alloy for biodegradable cardiovascular stent applications was prepared through indirect extrusion. The alloy exhibited a superior combination of tensile yield strength(TYS), ultimate tensile strength(UTS) and elongation(EL) of about 269 mPa, 298 mPa and 25.6 %, respectively. In addition,the non-destructive electrochemical frequency modulation(EFm) technique was used for the first time to investigate the corrosion behavior of mg alloys combined with electrochemical impedance spectroscopy(EIS) in Dulbecco’s modified Eagle’s medium(DmEm) and in Hank’s solution. Compared with the corrosion rate of 0.07 mm/year in Hank’s solution, lower corrosion rate of 0.03 mm/year was achieved in DmEm. The significant differences between the corrosion rate trends were discussed and related with the composition of the corrosion layer formed. Depending on the biomimetic fluids tested, different corrosion products were precipitated on the alloy’s surface: a compact and homogeneous layer of mg_(x)Ca_(y)(PO_(4))_(z) and Zn(OH)_(2) and organic compounds was formed in DmEm, whereas a partial coverage of mg_(x)Ca_(y)(PO_(4))_(z) and Zn(OH)_(2) was formed in Hank’s solution.

关键词： mg-Zn-Zr-Nd alloy mechanical property Corrosion EIS EFm

Evolution of temperature indices in the periglacial environment of the European Alps in the period 1990-2019

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Journal of mountain Science 2021年第11期18卷 2842-2853页

作者： NIGRELLI Guido CHIARLE marta National Research Council Research Institute for Geo-hydrological ProtectionStrada delle Cacce73–TorinoItaly

Air temperature in the European Alps shows warming over recent decades at an average rate of 0.3℃/10 years,therebyoutpacing the global warming rate of 0.2℃/10 *** periglacial environment of the Alps is particularly important for several aspects(*** production,tourism,natural hazards,indicator of global warming).However,there is a lack of specific and updated studies relating to temperature change in this *** order to fill this gap,the recent temperature trends in the periglacial environment of the Alps were ***/maximum/minimum daily air temperatures recorded by 14 land-based meteorological stations were used,and the temperature indices for the period 1990-2019 were *** periglacial environment of the Alps showed a warming rate of 0.4℃/10 years,0.6℃/10 years and 0.8℃/10 years for the mean/maximum/minimum temperatures,*** warming rates are higher than that observed for the entire Alpine *** 2050 many glaciers of the Alps below 3000 m altitude are expected to be extinct,and all the areas previously occupied by glaciers will become *** order to manage and adapt to these changes,more in-depth climate analyses are *** is necessary for all the mountainous areas of the world,which are undergoing similar changes.

关键词： mountain climate Cryosphere Climate change Extreme temperature Air temperature trend