检索结果-南通市图书馆

Hypertriglyceridemia-induced pancreatitis: A case-based review

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2006年第44期12卷 7197-7202页

作者： S Ian Gan Alun L edwards Christopher J Symonds paul L Beck Division of Gastroenterology and Endocrinology Foothills Hospital University of Calgary Calgary Alberta Canada

Hypertriglyceridemia is an established cause of pancreatitis. In a case-based approach, we present a review of hypertriglyceridemJa and how it can cause pancreatitis. We outline how to investigate and manage such patients. A 35 year old man presented to the emergency department with abdominal pain and biochemical evidence of acute pancreatitis. There was no history of alcohol consumption and biliary imaging was normal. The only relevant past medical history was that of mild hyperlipidemia, treated with diet alone. Physical exam revealed epigastric tenderness, right lateral rectus palsy, lipemia retinalis, bitemporal hemianopsia and a delay in the relaxation phase of his ankle reflexes. Subsequent laboratory investigation revealed marked hypertriglyceridemia and panhypopituarism. An enhanced CT scan of the head revealed a large suprasellar mass impinging on the optic chiasm and hypothalamus. The patient was treated supportively; thyroid replacement and lipid lowering agents were started. He underwent a successful resection of a craniopharyngioma. Postoperatively, the patient did well on hormone replacement therapy. He has had no further attacks of pancreatitis. This case highlights many of the factors involved in the regulation of triglyceride metabolism. We review the common causes of hypertriglyceridemia and the proposed mechanisms resulting in pancreatitis. The incidence and management of hypertriglyceridemiainduced pancreatitis are also discussed.

关键词： Hypertriglyceridemia Pancreatitis Hyperlipidemia

Longitudinal monitoring for the emergence of epidermal growth factor C797S resistance mutations in non-small cell lung cancer using blood-based droplet digital PCR

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cancer Drug Resistance 2019年第3期2卷 912-916页

作者： Mark Bowling Hyder Arastu Victoria edwards Leisa Jackson Scott Thurston Jordan Reese Hestia Mellert Gary Pestano paul Walker East Carolina University Mail Stop 628Internal Medicine-Hematology/OncologyGreenvilleNC 27834USA Biodesix Inc.2970 Wilderness PlaceBoulderCO 80301USA.

Validation of assays for the C797S mutation as a biomarker for osimertinib resistance is promising in guiding treatment decision-making for multidrug resistant non-small cell lung cancer. A newly developed droplet digital PCR (ddPCR) assay was used to retrospectively evaluate the emergence of the C797S mutation in six remnant plasma samples in this case report. It was found that the detected emergence of C797S clearly correlated with clinical signs of treatment resistance. Had these data been available to aid treatment selection in real time, there would have been hope for recaptured disease response and control instead of treatment cessation. The results of this study show that highly sensitive ddPCR methods can be used for the monitoring of emergent epidermal growth factor somatic variant mutations in circulation.

关键词： Epidermal growth factor non-small cell lung cancer C797S drug resistance

Human epidermal growth factor receptor-2 in oesophageal cancers:An observational study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2012年第44期18卷 6447-6451页

作者： Hazem Al-Momani Rachel Barnes Ahmed El-Hadi Rachit Shah Wyn G Lewis paul edwards Department of Surgery Nevill Hall HospitalAbergavenny NP7 7EGWalesUnited Kingdom Department of Surgery University Hospital of WalesCardiff CF14 4XWUnited Kingdom

AIM:To determine the incidence of human epidermal growth factor receptor 2(HER2) over expression in oesophageal ***:A retrospective study,of one hundred consecutive cases of endoscopic histological samples of oesophageal cancers from a single British cancer network were *** cases were diagnosed between April 2007 and June ***2 over expression was assessed using immunohistochemistry,those that scored "0" and "+1" were considered "negative" for HER2;those that scored "+3" were considered "Positive".Cases that were scored "+2" on immunohistochemistry further went on to have HER2 gene analysis using the Ventana HER brightfield dual-colourin situ hybridisations(HER B DISH) assay and either came back to be positive or negative for HER2 over *** survival was measured from date of histological diagnosis until date of death.93% of the cases were followed up till five years or death,and all were followed up till two *** of gastro-oesophageal junctional tumours were ***:The median age of our sample was 66 years(range:38-91 years).Eighty one were male and 19 ***-one of the cases were adenocarcinoma of the oesophagus and the rest were cases of squamous cell *** anatomical distribution of the tumours was;upper oesophagus 2,middle oesophagus 11,and 87 were in the lower *** resection was completed in 15 cases;seven cases had attempted surgical resections,i.e.,open and close,33 patients received definitive chemo-radiation and 52 had palliative ***-five of the cancers showed evidence of HER2 over expression,all were *** the 25 cases that showed evidence of HER2 over expression,21(84%) were located in the lower third of the *** staging,24 out of the 25 HER2 positive cases were at stage 3 or more(13 at stage 3 and 11 at stage 4),For HER2 negative cases 37 were at stage 3 and 32 were staged as stage *** out of twenty five cases(68%) with HER

关键词： Oesophageal adenocarcinoma, Human epi-dermal growth factor receptor 2, Immunohistochemis-try Dual-colour in situ hybridisations Trastuzumab

A Case Report of a Peripheral Giant Cell Granuloma in a Patient on Forteo

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Stomatology 2015年第6期5卷 147-151页

作者： Flavia Pirih Ana Dilza Barroso Nikolaos Tatarakis Kitrina Cordell Laurie McCauley paul edwards Section of Periodontics University of California Los Angeles Los Angeles CA USA Unit of Periodontology Eastman Dental Institute University College of London London UK Division of Oral and Maxillofacial Pathology Department of Comprehensive Dentistry Louisiana State University School of Dentistry New Orleans LA USA University of Michigan School of Dentistry Ann Arbor MI USA Department of Oral Pathology Oral Medicine and Radiology Indiana University School of Dentistry Indianapolis IN USA

Peripheral giant cell granuloma (PGCG) is a common reactive gingival lesion that histologically resembles the central giant cell granuloma, and is a central lesion of the jaws. Occasionally, central giant cell granuloma-like lesions may be seen in association with hyperparathyroidism. Rarely, PGCG-like lesions have been described in a background of hyperparathyroidism. We describe the case of a 91-year-old woman taking teriparatide for the treatment of osteoporosis and presented with a peripheral giant cell granuloma of the mandibular posterior area.

关键词： Peripheral Giant Cell Granuloma Central giant Cell Granuloma Hyperparathyroidism Teriparatide Parathyroid Hormone

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

初识XQuery

程序员 2008年第1期 96-98页

作者： Sam edwards paul Tremblett 丁力

上期程序员做了数据库专题，主要揭示了数据库技术结合xml的一些发展，本文可看作这一专题的继续，有兴趣的读者在这里可看到一个更为详尽的描述。

关键词： XQuery 数据库技术程序员 xml 专题

Pushing the boundaries of diode-pumped solid-state lasers for high-energy applications

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

High Power Laser Science and Engineering 2020年第2期8卷 77-79页

作者： Saumyabrata Banerjee paul Mason Jonathan Phillips Jodie Smith Thomas Butcher Jacob Spear Mariastefania De Vido Gary Quinn Danielle Clarke Klaus Ertel Cristina Hernez-Gomez Chris edwards John Collier Central Laser Facility STFC Rutherford Appleton LaboratoryDidcot OX110QXUK Heriot-Watt University School of Engineering and Physical SciencesEH144ASUK

We report on the successful demonstration of a 150 J nanosecond pulsed cryogenic gas cooled,diode-pumped multi-slab Yb:YAG laser operating at 1 *** the best of our knowledge,this is the highest energy ever recorded fo... 详细信息

关键词： cryogenic gas cooling diode-pumped solid-state laser multi-slab amplifier Yb:YAG

Protection against oxidized low density lipoprotein induced pathological responses in human retinal pigment epithelial cells by Inhibition of APE1/Ref-1 Redox Activity

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Protection against oxidized low density lipoprotein induced ...

APE1/Ref-1 Redox Inhibition by APX3330 Attenuates Angiogenesis of Retinal and Choroidal Vascular Endothelial Cells

第十四届西北五省眼科学术大会

作者： Yue Li Xiuli Liu Tongrong Zhou Mark R.Kelley Xiaoxi Qiao paul edwards Hua Gao Department of Ophthalmology Xijing HospitalFourth Military medical University Department of Ophthalmology Henry Ford Health System Herman B Wells Center for Pediatric Research Indiana University School of Medicine

＜正＞Purpose:Oxidative and inflammatory stress induced senescence and dysfunction of retina pigment epithelial（RPE） cells are essential factors implicated in the pathogenesis of age related macular degeneration（AMD）.The current study was conducted to test the hypothesis that specifically inhibition of the APE1/Ref-1 redox activity with a novel small molecule inhibitor,APX3330,may

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

APE1/Ref-1 Redox Inhibition by APX3330 Attenuates Angiogenes...

对医生的投诉早发现并纠正不佳沟通技巧可减少投诉

第十四届西北五省眼科学术大会

作者： Yue Li Ju Sheng Tongrong Zhou Mark R.Kelley Xiaoxi Qiao paul edwards Hua Gao Department of Ophthalmology Xijing HospitalFourth Military medical University Department of Ophthalmology Henry Ford Health System Herman B Wells Center for Pediatric Research Indiana University School of Medicine

＜正＞Background ＆ Objectives:It has been reported that the reduction-oxidation（redox） activity of APE/Ref-1 regulates angiogenesis in vivo and in *** have previously demonstrated

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

英国医学杂志中文版 2008年第4期11卷 200-201页

作者： paul Kinnersley Adrian edwards 付晓霞(译) Department of Primary Care and Public Health Cardiff University Cardiff CF14 4XN 不详

临床沟通技巧是医疗工作的中心，沟通技巧欠佳是造成医疗投诉甚至诉讼的重要原因。加拿大一项最近的研究显示，在职业生涯早期就可以判断出那些日后工作表现不佳的医生，并有可能给予他们有针对性的帮助和更多适当的培训。

关键词：医疗投诉医生临床沟通技巧医疗工作工作表现职业生涯