检索结果-南通市图书馆

Autoantibodies against beta cells to predict early insulin requirements in pediatric patients with clinically diagnosed type 2 diabetes

引用

World Journal of diabetes 2024年第8期15卷 1717-1725页

作者： Jorge M Molina patricia G Medina Rita A Gomez Julia R Herrera nancy L martínez Brenda Hernández Yesenia García department of Endocrinology Children’s Hospital Federico GomezMexico 06720Mexico national Medical Center"Siglo XXI" UMAE Hosp EspecialidadesUnidad Invest Med Epidemiol ClinMexican Social Security InstituteMexico 06720Mexico Research division UMAE Hospital de EspecialidadesCentro Médico Nacional Siglo XXIMexican Institute of Social SecurityMexico 06720Mexico Epidemiology Research Unit in Endocrinology and nutrition Federico Gómez Children’s HospitalMexico 06720Mexico department of Endocrinology Comprehensive Health Unit for Trans PersonsMexico 11340Mexico

BACKGROUnd Autoimmunity has emerged as a probable disease modifier in patients with clinically diagnosed type 2 diabetes mellitus(T2dM),that is,patients who have insulin resistance,obesity,and other cardiovascular risk factors,suggesting that the presence of glutamic acid decarboxylase(anti-GAd65),islet antigen 2(anti-IA2),and zinc transporter 8(anti-Zn8T)antibodies could have deleterious effects on beta cell function,causing failure and earlier requirement for insulin *** To evaluate anti-GAd65,anti-IA2 and anti-Zn8T as predictors of early insulin requirement in adolescents with a clinical diagnosis of *** This was a case–control study in patients with clinically diagnosed with T2dM(68 cases and 64 controls with and without early insulin dependence respectively),male and female,aged 12–18 ***,blood pressure,glucose,insulin,C-peptide,glycated hemoglobin A1c,and lipid profiles were *** was used to measure anti-GAd65,anti-IA2,and anti-Zn8T *** statistics,pearson'sχ2 test,Student's t test,and logistic regression was performed.pnsidered statistically *** There were 132 patients(53.8%female),with a mean age was 15.9±1.3 years,and there was a disease evolution time of 4.49±0.88 *** presence of anti-GAd65,anti-IA2,and anti-Zn8T positivity was found in 29.5%,18.2%,and 15.9%,*** the groups by early or no insulin dependence showed that the group with insulin had a higher frequency of antibody positivity:anti-GAd65 odds ratio(OR):2.42(1.112–5.303,p=0.026);anti-IA2:OR:1.55(0.859–2.818,p=0.105);and anti-Zn8T:OR:7.32(2.039–26.279,p=0.002).COnCLUSIOn Anti-GAd65 positivity was high in our ***-GAd65 and anti-Zn8T positivity showed a significantly depleted beta cell reserve phenotype,leading to an increased risk of early insulin dependence.

关键词： diabetes Obesity Adolescents Autoimmunity Beta cell Insulin requirements

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

new Rotative Radiofrequency Technology: A Multicenter Retrospective Study on Efficacy and Safety

引用

Journal of Cosmetics, dermatological Sciences and Applications 2024年第1期14卷 69-83页

作者： José Antonio Ferrández martínez Gregorio Viera Mármol Fabrizio Vignoli Joanet perera Agustin Blanch Mara Suárez Alicia Robledo Jorge Reyna Vargas Lamas Sinclair Barcelona Spain Studio Vignoli Bologna Italy Clinica perla Medic Alicante Spain dr. Agustin Blanch Clinica Barcelona Spain Intek Medical Technology S.L.U. Barcelona Spain

Background: non-ablative radiofrequency (RF) technology is widely used for the treatment of signs of aging, skin laxity, localized fat and cellulite. However, many RF devices suffer from technical limitations that make the results highly dependent on the user’s experience or clinical limitations that compromise safety, efficacy and comfort. Objective: To evaluate the efficacy and safety of a novel semi-automatic non-ablative RF device for skin tightening, body shaping and cellulite reduction. Materials and methods: A retrospective multicenter study was performed using a novel rotative RF device with temperature and impedance control (Sculpt&Shapep>®p>, Sinclair, Spain). 58 subjects underwent a minimum of 4 treatments every 1-2 weeks. A total of 120 treatments (56.7% body and 43.3% facial) and 1034 sessions were performed. Efficacy was evaluated by 3 researchers using the Global Aesthetic Improvement Scale (GAIS) and anthropometric measurements were collected. Subject and practitioner satisfaction were recorded. Safety was evaluated by analyzing the perception of pain during the treatment and the side and adverse effects immediately after treatment and over the next 48 hours. Results: Between 25% and 50% improvement was achieved according to the GAIS. Statistically significant (p dominal fold reduction of 5.1 mm and circumference reduction of 32.0 mm, 16.4 mm and 13.9 mm were recorded for the abdomen, legs and arms, respectively. 77.5% of subjects and 94.9% of practitioners were either satisfied or very satisfied. Minor adverse effects were found in 0.97% of the sessions. Conclusion: This novel semi-automatic rotative RF device has been found to provide treatments that are effective, safe and comfortable for both practitioners and subjects. .

关键词： Rotative Radiofrequency RF Cellulite Skin Tightening Body Shaping

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

All-optical nonlinear chiral ultrafast magnetization dynamics driven by circularly polarized magnetic fields

引用

High power Laser Science and Engineering 2023年第6期11卷 154-161页

作者： Luis Sánchez-Tejerina Rodrigo martín-Hernández Rocío Yanes Luis plaja Luis López-díaz Carlos Hernández-García Grupo de Investigación en Aplicaciones del Láser y Fotónica Departamento de Física AplicadaUniversidad de SalamancaSalamancaSpain present address:departamento de Electricidad y Electrónica Universidad de ValladolidValladolidSpain departamento de Física Aplicada Universidad de SalamancaSalamancaSpain Unidad de Excelencia en Luz y Materia Estructuradas(LUMES) Universidad de SalamancaSalamancaSpain

Ultrafast laser pulses provide unique tools to manipulate magnetization dynamics at femtosecond timescales,where the interaction of the electric field usually dominates over the magnetic *** proposals using structured laser beams have demonstrated the possibility to produce regions where intense oscillating magnetic fields are isolated from the electric *** these conditions,we show that technologically feasible tesla-scale circularly polarized high-frequency magnetic fields induce purely precessional nonlinear magnetization *** fundamental result not only opens an avenue in the study of laser-induced ultrafast magnetization dynamics,but also sustains technological implications as a route to promote all-optical non-thermal magnetization dynamics both at shorter timescales-towards the subfemtosecond regime-and at THz frequencies.

关键词： chiral behavior nonlinear dynamics ultrafast dynamics

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Implication of 14-3-3ζ-BdnF pathway in long-lasting memory enhancement and the rescue from memory deficits

引用

neural Regeneration Research 2022年第12期17卷 2685-2686页

作者： Mariam Masmudi-martín Irene navarro-Lobato Zafar U.Khan Brain Metastasis Group National Cancer Research Centre(CNIO)MadridSpain donders Institute for Brain Cognition and Behaviour Radboud UniversityNijmegenThe Netherlands Laboratory of neurobiology CIMESUniversity of MalagaMalagaSpain department of Medicine Faculty of MedicineUniversity of MalagaMalagaSpain CIBERnEd Institute of Health Carlos ⅢMadridSpain

Intact memory function is critical for carrying out daily life activities,such as managing finances,remembering to take medications,driving in familiar environments,remembering a grandchild’s birthday,and learning to use a new ***,memory deficits not only accompany normal aging but are also comorbid with many psychiatric,neurological,and neurodegenerative *** disability,autism,attention deficit disorder,learning disability,schizophrenia,and depression all have memory deficit components,as do Alzheimer’s disease,parkinson’s disease,Huntington’s disease,and other neurodegenerative diseases(Khan et al.,2014).Therefore,a large proportion of the human population is affected by this brain disorder.

关键词： Huntington remember finance

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

nanomechanical hydrodynamic force sensing using suspended microfluidic channels

引用

微系统与纳米工程(英文) 2023年第3期9卷 95-102页

作者： Alberto martín-pérez daniel Ramos Optomechanics Lab Instituto de Ciencia de Materiales de Madrid(ICMMCSIC)3 Sor Juana Inés de la Cruz(Madrid)E-28049 MadridSpain

Microfluidics has demonstrated high versatility in the analysis of in-flow particles and can even achieve mechanical properties measurements of biological cells by applying hydrodynamic ***,there is currently no available technique that enables the direct measurement and tracking of these hydrodynamic forces acting on a flowing *** this work,we introduce a novel method for the direct measurement of the hydrodynamic force actuating on an in-flow particle based on the analysis of the induced resonance changes of suspended microchannel resonators(SMRs).This hydrodynamic force sensitivity depends on the device used;therefore,we considered the geometry and materials to advance this dependency on the SMR resonance frequency.

关键词： hydrodynamic applying flow

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hydrology and Estimation of Real Erosion in the patria nueva Micro-Basin for Five Return periods

引用

Journal of Water Resource and protection 2022年第12期14卷 783-789页

作者： martín Mundo-Molina José Luis pérez-díaz Investigation Centre Faculty of Engineer Autonomous University of Chiapas Chiapas Mexico

This paper will discuss the actual erosion estimation of the patria nueva micro basin in tons/ha/year (E), located in Tuxtla Gutiérrez Chiapas, Mexico. We used the universal soil loss equation (USLE), considered one of the best theoretical tools for planning and soil preservation in the USA and other countries. The actual erosion rates were estimated for 5, 20, 50, 100, and 500 years return periods (Rp), with elevated results due to high degrees of anthropogenic alteration of the micro-basin, especially in the last 50 years. High erosion rates generate the following problems: loss of soil, which is unfavorable for plant life, due to the soil being a non-renewable resource, the undermine can never renovate, the hydraulic area in the main channel reduces during the rainy season (when the river overflows). The sediment accumulates at the lower part of the micro-basin along with waste, garbage, and mud.

关键词： Erosion Return periods Basins USLE Sediment

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Supplementation of vitamin E or a botanical extract as antioxidants to improve growth performance and health of growing pigs housed under thermoneutral or heat-stressed conditions

引用

Journal of Animal Science and Biotechnology 2024年第3期15卷 1101-1118页

作者： Ysenia V.Silva‑Guillen Consuelo Arellano Jeffrey Wiegert R.dean Boyd Gabriela E.martinez Eric van Heugten department of Animal Science North Carolina State UniversityRaleighNC 27695USA department of Statistics North Carolina State UniversityRaleighNC 27695USA department of Animal Science Texas A&M UniversityCollege StationTX 77843USA Animal nutrition Research LLCAlvatonKY 42122USA.

Background Heat stress has severe negative consequences on performance and health of pigs,leading to significant economic *** objective of this study was to investigate the effects of supplemental vitamin E and a botanical extract in feed or drinking water on growth performance,intestinal health,and oxidative and immune status in grow-ing pigs housed under heat stress *** duplicate experiments were conducted,each using 64 crossbred pigs with an initial body weight of 50.7±3.8 and 43.9±3.6 kg and age of 13-week and 12-week,***(n=128)were housed individually and assigned within weight blocks and sex to a 2×4 factorial arrangement consisting of 2 environments(thermo-neutral(21.2℃)or heat-stressed(30.9℃))and 4 supplementation treatments(control diet;control+100 IU/L of d-α-tocopherol in water;control+200 IU/kg of dL-α-tocopheryl-acetate in feed;or control+400 mg/kg of a botanical extract in feed).Results Heat stress for 28 d reduced(p≤0.001)final body weight,average daily gain,and average daily feed intake(-7.4 kg,-26.7%,and-25.4%,respectively)but no effects of supplementation were detected(p>0.05).Serum vitamin E increased(pn E supplementation in water and in feed(1.64 vs.3.59 and 1.64 vs.3.24),but not for the botanical extract(1.64 vs.1.67 mg/kg)and was greater when supplemented in water ***(p=0.002).Liver vitamin E increased(pn E supplementations in water(3.9 vs.31.8)and feed(3.9 vs.18.0),but not with the botanical extract(3.9 vs.4.9 mg/kg).Serum malondialdehyde was reduced with heat stress on d 2,but increased on d 28(interaction,pnd was greater(pntioxidant supplementation compared to *** proliferation was reduced(p=0.037)in the jejunum under heat stress,but increased in the ileum when vitamin E was supplemented in feed and water under heat stress(interaction,p=0.04).Tumor necrosis factor-αin jejunum and ileum mucosa decreased by heat stress(pnd was re

关键词： Botanical extract Growing pigs Heat stress Immune status Oxidative status Tocopherol Water

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A clickable photoaffinity probe of betulinic acid identifies tropomyosin as a target

引用

Acta pharmaceutica Sinica B 2022年第5期12卷 2406-2416页

作者： pedro martín-Acosta Qianli Meng John Klimek Ashok p.Reddy Larry david Stefanie Kaech petrie Bingbing X.Li Xiangshu Xiao program in Chemical Biology Department of Chemical Physiology and BiochemistryOregon Health&Science UniversityPortlandOR 97239USA proteomics Shared Resource Oregon Health&Science UniversityPortlandOR 97239USA Knight Cancer Institute Oregon Health&Science UniversityPortlandOR 97239USA department of neurology Oregon Health&Science UniversityPortlandOR 97239USA

Target identification of bioactive compounds is important for understanding their mechanisms of action and provides critical insights into their therapeutic utility. While it remains a challenge,unbiased chemoproteomics strategy using clickable photoaffinity probes is a useful and validated approach for target identification. One major limitation of this approach is the efficient synthesis of appropriately substituted clickable photoaffinity probes. Herein, we describe an efficient and consistent method to prepare such probes. We further employed this method to prepare a highly stereo-congested probe based on naturally occurring triterpenoid betulinic acid. With this photoaffinity probe, we identified tropomyosin as a novel target for betulinic acid that can account for the unique biological phenotype on cellular cytoskeleton induced by betulinic acid.

关键词： Betulinic acid Cancer diazirine natural product photoaffinity probe Tropomyosin

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

patients with hepatocellular carcinoma that die during the first year of liver transplantation have high blood sFasL concentrations

引用

World Journal of Clinical Cases 2023年第8期11卷 1753-1760页

作者： Leonardo Lorente Sergio T Rodriguez pablo Sanz Agustín F González-Rivero Antonia pérez-Cejas Javier padilla dácil díaz Antonio González María M martín Alejandro Jiménez purificación Cerro Julián portero Manuel A Barrera Intensive Care Unit Hospital Universitario de CanariasLa Laguna 38320Spain Intensive Care Unit Hospital Universitario Nuestra Señora CandelariaSanta Cruz Tenerife 38010Spain department of Surgery Hospital Universitario Nuestra Señora de CandelariaSanta Cruz Tenerife 38010Spain department of Laboratory Hospital Universitario de CanariasLa Laguna 38320Spain department of digestive Hospital Universitario Nuestra Señora de CandelariaSanta Cruz Tenerife 38010Spain Research Unit Hospital Universitario de CanariasLa Laguna 38320Spain Transplant Unit Hospital Universitario Nuestra Señora CandelariaSanta Cruz Tenerife 38010Spain department of Radiology Hospital Universitario Nuestra Señora CandelariaSanta Cruz Tenerife 38010Spain

BACKGROUnd Fas ligand(FasL)is one ligand that activates extrinsic apoptosis *** expression in lymphocytes of FasL have been found in patients with acute rejection of liver transplantation(LT).no high blood concentrations of soluble FasL(sFasL)have been found in patients with acute LT rejection;however,the samples size of those studies was *** To determine whether patients with hepatocellular carcinoma(HCC)that dead during the first year of LT have higher blood sFasL concentrations previously to LT that those who that remain alive in a study of higher sample *** patients underwent LT due to HCC were included in this retrospective *** sFasL levels prior to LT were measured and one-year LT mortality was *** non-surviving patients(n=14)showed higher serum sFasL levels[477(269-496)vs 85(44-382)pg/mL;pn surviving patients(n=113).Serum sFasL levels(pg/mL)were associated with mortality(OR=1.006;95%CI=1.003-1.010;p=0.001)independently of age of LT donor in the logistic regression *** We report for the first time that HCC patients who die within the first year of HT have higher blood sFasL concentrations prior to HT than those who remain alive.

关键词： sFasL Hepatocellular carcinoma Liver transplantation Mortality Outcome

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Historical fluxes of metal and metalloids in an aquatic ecosystem affected by land-use change and mining activities in northwestern Mexico

引用

International Journal of Sediment Research 2023年第5期38卷 724-738页

作者： Ochoa-Contreras Roberto Jara-Marini martín Enrique Ruiz-Fernández Ana Carolina Sanchez-Cabeza Joan Albert Meza-Figueroa diana pérez-Bernal Libia Hascibe posgrado en Ciencias Centro de Investigación en Alimentación y Desarrollo Unidad Hermosillo 2. Centro de Investigación en Alimentación y Desarrollo Unidad Hermosillo Unidad Acad emica Mazatlán Instituto de Ciencias del Mar y Limnología Universidad Nacional Autónoma de M exico departamento de Geología División de Ciencias Exactas y Naturales Universidad de Sonora Rosales y Encinas

Freshwater reservoirs are essential owing because of their ecological, economic, and social *** are particularly vulnerable to contamination, as of metal and metalloids, derived from anthropogenic activities like mining. The temporal variations in trace element concentrations(arsenic(As),mercury(Hg), chromium(Cr), copper(Cu), nickel(ni), lead(pb), and zinc(Zn)), enrichment, fluxes, and possible sources were evaluated by studying two sediment cores from the La Angostura(AnG) Reservoir(northwest Mexico), using210pb geochronology. The enrichment factors showed from null to minor enrichment for most elements, but moderate to severe enrichment of mercury(Hg). Most trace element concentrations had a detrital origin, and notable Hg concentration increases since the past decade were associated with severe drought periods, likely resulting from wildfires. The observed sediment concentrations of As and Hg can cause adverse effects on biota in the ecosystem since they are above the probable effect level(pEL). development of strategies for metal attenuation in this reservoir is recommended and metals should be controlled until specific ecotoxicological studies are performed.

关键词： Aquatic ecosystems ~(210)pb geochronology Mining activities Metals Metalloids Enrichment factors

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：