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A Hybrid Statistical-Dynamical Downscaling of Air Temperature over Scandinavia Using the WRF Model

Advances in Atmospheric Sciences 2020年第1期37卷 57-74页

作者： Jianfeng WAnG Ricardo M.FOnSECA Kendall RUTLEDGE Javier martÍn-TORRES Jun YU Department of Mathematics and Mathematical Statistics UmeåUniversitySE 90187UmeåSweden Group of Atmospheric Science Division of Space TechnologyDepartment of Computer ScienceElectrical and Space EngineeringLuleåUniversity of TechnologySE 97187 LuleåSweden novia University of Applied Sciences PO BOX 6FI-65201 VaasaFinland Instituto Andaluz de Ciencias de la Tierra 18100 GranadaSpain The Pheasant Memorial Laboratory for Geochemistry and Cosmochemistry Institute for Planetary MaterialsOkayama University at MisasaTottori 682-0193Japan

An accurate simulation of air temperature at local scales is crucial for the vast majority of weather and climate *** this work,a hybrid statistical–dynamical downscaling method and a high-resolution dynamical-only downscaling method are applied to daily mean,minimum and maximum air temperatures to investigate the quality of localscale estimates produced by *** two downscaling approaches are evaluated using station observation data obtained from the Finnish Meteorological Institute over a near-coastal region of western *** dynamical downscaling is performed with the Weather Research and Forecasting(WRF)model,and the statistical downscaling method implemented is the Cumulative Distribution Function-transform(CDF-t).The CDF-t is trained using 20 years of WRF-downscaled Climate Forecast System Reanalysis data over the region at a 3-km spatial resolution for the central month of each *** performance of the two methods is assessed qualitatively,by inspection of quantile-quantile plots,and quantitatively,through the Cramer-von Mises,mean absolute error,and root-mean-square error *** hybrid approach is found to provide significantly more skillful forecasts of the observed daily mean and maximum air temperatures than those of the dynamical-only downscaling(for all seasons).The hybrid method proves to be less computationally expensive,and also to give more skillful temperature forecasts(at least for the Finnish near-coastal region).

关键词： WRF air temperature Cumulative Distribution Function-transform hybrid statistical–dynamical downscaling,model evaluation Scandinavian Peninsula

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Cholangiocarcinoma:early detection and screening in high-risk population

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Hepatoma Research 2022年第1期8卷 352-362页

作者： Sergio Muñoz-martínez Jordi Rimola María Carlota Londoño Andrés Cárdenas alejandro Forner Barcelona Clinic Liver Cancer(BCLC)group Liver UnitICMDMHospital Clinic BarcelonaIDIBAPSUniversity of BarcelonaBarcelona 08036Spain Barcelona Clinic Liver Cancer(BCLC)group Radiology DepartmentHospital Clinic BarcelonaIDIBAPSBarcelona 08036Spain Liver Unit ICMDMHospital Clinic BarcelonaIDIBAPS.University of BarcelonaBarcelona 08036Spain GI/Liver Transplant Unit ICMDMHospital Clinic BarcelonaIDIBAPSUniversity of BarcelonaBarcelona 08036Spain Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas(CIBERehd) MadridSpain

Cholangiocarcinoma(CCA)is a highly lethal malignancy that comprises approximately 15%of all the primary liver tumors and 3% of gastrointestinal *** is often done when the disease is already at advanced stages,resulting in poor *** of risk factors and early diagnosis are the cornerstones for improving *** diagnosis is feasible in the setting of surveillance programs in patients at high risk of CCA such as patients with primary sclerosing ***,surveillance of CCA in this population is hampered by the low diagnostic accuracy of current tumor markers at earlier stages,the difficulties of imaging techniques for the differential diagnosis between benign and malignant biliary strictures,and the need for invasive procedures for diagnostic *** this review we discuss the rationale for surveillance of CCA in high-risk populations,particularly patients with primary sclerosing cholangitis,the recommended tools for surveillance and diagnostic work-up,and future perspectives.

关键词： Surveillance cholangiocarcinoma primary sclerosing cholangitis magnetic resonance tumor biomarker

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Output feedback adaptive super twisting sliding mode control for quadrotor UAVs

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Control Theory and Technology 2024年第1期22卷 92-105页

作者： Oscar Salas-Peña Jesus DeLeón-Morales Susana V.Gutiérrez-martínez École Centrale de nantes-LS2n UMR 6004 CNRS44300NantesFrance Facultad de Ingeniería Mecánica y Eléctrica Universidad Autónoma de Nuevo León66451San Nicolás de Los GarzaMexico

In this paper, a sliding mode control with adaptive gain combined with a high-order sliding mode observer to solve the tracking problem for a quadrotor UAV is addressed, in presence of bounded external disturbances and parametric uncertainties. The high order sliding mode observer is designed for estimating the linear and angular speed in order to implement the proposed scheme. Furthermore, a Lyapunov function is introduced to design the controller with the adaptation law, whereas an analysis of finite time convergence towards to zero is provided, where sufficient conditions are obtained. Regarding previous works from literature, one important advantage of proposed strategy is that the gains of control are parameterized in terms of only one adaptive parameter, which reduces the control effort by avoiding gain overestimation. numerical simulations for tracking control of the quadrotor are given to show the performance of proposed adaptive control–observer scheme.

关键词： Adaptive super twisting controller High-order sliding modes observer UAV

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Animal models used to study direct peripheral nerve repair: a systematic review

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neural Regeneration Research 2020年第3期15卷 491-502页

作者： Francisco Javier Vela Guadalupe martínez-Chacón Alberto Ballestín JoséLuis Campos Francisco Miguel Sánchez-Margallo Elena Abellán Department of Microsurgery Jesús Usón Minimally Invasive Surgery CentreCáceresSpain Scientific Director Jesús Usón Minimally Invasive Surgery CentreCáceresSpain

Objective:Peripheral nerve repair is required after traumatic *** common condition represents a major public health problem *** after nerve repair depends on several factors,including the severity of the injury,the nerve involved,and the surgeon’s technical *** the precise microsurgical repair of nerve lesions,adequate functional recovery is not always achieved and,therefore,the regeneration process and surgical techniques are still being ***-clinical animal models are essential for this research and,for this reason,the focus of the present systematic review(according to the PRISMA statement)was to analyze the different animal models used in pre-clinical peripheral nerve repair *** sources:Original articles,published in English from 2000 to 2018,were collected using the Web of Science,Scopus,and PubMed *** selection:Only preclinical trials on direct nerve repair were included in this *** articles were evaluated by the first two authors,in accordance with predefined data *** measures:The primary outcomes included functional motor abilities,daily activity and regeneration *** outcomes included coaptation technique and animal ***:This review yielded 267 articles,of which,after completion of the screening,49 studies were *** were 1425 animals in those 49 studies,being rats,mice,guinea pigs,rabbits,cats and dogs the different pre-clinical *** nerves used were classified into three groups:head and neck(11),forelimb(8)and hindlimb(30).The techniques used to perform the coaptation were:microsuture(46),glue(12),laser(8)and mechanical(2).The follow-up examinations were histology(43),electrophysiological analysis(24)and behavioral observation(22).Conclusion:The most widely used animal model in the study of peripheral nerve repair is the *** animal models are also used but the cost-benefit of the rat model provides several strengths over the ***

关键词： nerve microsurgery peripheral nerve regeneration repair reconstruction direct nerve repair animal model coaptation PRISMA systematic review

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Real-time fluorescence image-guided gastrointestinal oncologic surgery:Towards a new era

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World Journal of Gastrointestinal Oncology 2021年第9期13卷 1029-1042页

作者： Elías martínez-López Aleix martínez-Pérez Sergio navarro-martínez Juan Carlos Sebastián-Tomás nicola de'Angelis Eduardo García-Granero Department of Surgery University of ValenciaValencia 46010Spain Department of General and Digestive Surgery Hospital Universitario Doctor PesetValencia 46017Spain Faculty of Health Sciences Valencian International UniversityValencia 46002Spain Minimally Invasive and Robotic Digestive Surgery Unit Miulli HospitalAcquaviva delle Fonti 70021Italy Department of General and Digestive Surgery Hospital Universitario y Politécnico La FeValencia 46026Spain

Technological improvements are crucial in the evolution of ***-time fluorescence-guided surgery(FGS)has spread worldwide,mainly because of its usefulness during the intraoperative decision-making *** success of any gastrointestinal oncologic resection is based on the anatomical identification of the primary tumor and its regional lymph *** allows also to evaluate the blood perfusion at the gastrointestinal stumps after colorectal or esophageal ***,a reduction on the anastomotic leak rates has been postulated as one of the foreseeable benefits provided by the use of FGS in these *** the use of fluorescence in lymph node detection was initially described in breast cancer surgery,the technique is currently applied in gastric or splenic flexure cancers,as they both present complex and variable lymphatic *** allows also to perform intraoperative lymphograms or sentinel lymph node *** applications of FGS are being developed to assist in the detection of peritoneal metastases or in the evaluation of the tumor resection *** present review aims to provide a general overview of the current status of real-time FGS in gastrointestinal oncologic *** put a special focus on the different applications of FGS,discussing the main findings and limitations found in the contemporary literature and also the promising near future applications.

关键词： Surgery Colorectal cancer Esophageal cancer Fluorescence Image-guided surgery Anastomotic leak Lymph node

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Applications of Microalgae in Five Areas of Biotechnology

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Phyton-International Journal of Experimental Botany 2023年第10期92卷 2737-2759页

作者： Héctor alejandro Reza-Solis Ofelia Adriana Hernández-Rodríguez Andrés Francisco martínez-Rosales Dámaris Leopoldina Ojeda-Barrios Facultad de Ciencias Agrotecnológicas Universidad Autónoma de ChihuahuaChihuahua31000Mexico Facultad de Zootecnia y Ecología Universidad Autónoma de ChihuahuaChihuahua33820Mexico

Microalgae are mostly photoautotrophic microscopic *** to their cellular structure,they are classified into two types,eukaryotes,and prokaryotes,and they are distributed in all types of ecosystems,presenting unique qualities due to the fact that they synthesize high value-added molecules used in various productive and environmental activities,and because their biomass is used as raw material to obtain various ***,the objective of this review was to collect,organize,and collate current information on the use of microalgae in the development of biotechnology involving the areas of agriculture,health,food,bioremediation,and *** results show that the microalga Chlorella stands out for its multiple uses in the five areas considered in this *** search for healthier and more environmentally friendly technologies has contributed to the development of new biotechnological applications that require the study and incorporation of specialized microorganisms to replace and/or improve existing applications.

关键词： Agriculture health food bioremediation biofuels

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Wood anatomical acclimation in the endemic genus Polylepis in Peruvian Andean forests

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Journal of Mountain Science 2024年第9期21卷 2986-3000页

作者： Anthony GUERRA Fressia n.AMES-martÍnEZ Ernesto C.RODRÍGUEZ-RAMÍREZ Postgraduate Programme in Agronomy/Plant Physiology Department of Biology-Institute of natural Sciences Federal University of LavrasLavras 37203-202Minas Gerais 30000-31999Brazil Laboratory of Biotechnology and Molecular Biology Continental UniversitySan Antonio UrbanizationHuancayo 12000Peru Ecology and Biodiversity Research Programme ANDINUS AssociationMiguel Grau Street 370Huancayo 12000Peru Dendrochronology Laboratory Continental UniversitySan Carlos Avenue 1980Huancayo 12000Peru

Polylepis(Queñua)is a dominant woody plant genus in Andean Puna forests that occurs in a wide range of montane habitats and is ecologically diverse in endemism,which may be particularly threatened by climate *** anatomical traits are essential for understanding how plants adjust their ecophysiological requirements and maximize their resilience,resistance,and recovery to extreme *** the effects of extreme climatic conditions in high altitude ecosystems have been studied extensively,our knowledge is relatively limited to quantitative differences in the main xylem *** address this gap,we assessed the acclimation of wood anatomical traits in six Peruvian Andean Polylepis species with different water availability(semi-dry with high moisture and semiarid with dry winters).We selected hydraulic diameter,vessel density,vessel grouping index,solitary vessel index,vulnerability index,mesomorphy index,vessel element length,fiber length,fiber wall thickness,fiber lumen diameter,and total fiber diameter that can provide relevant eco-wood anatomical acclimation to hydric *** performed multivariate analysis to determine the leading dimensions of covariation among Polylepis species and climatic *** wood anatomical traits(vessel grouping index,vulnerability index,and fiber wall thickness)were dissimilar between xeric-and mesic-Polyelpis *** study demonstrates that wood anatomical traits in Peruvian Andean Polylepis species provides high-resolution and long-term eco-wood anatomical signals on how climate oscillations drive the acclimation processes of fiber and vessel *** findings underscore the significance of xylem hydraulic adjustment to various hydrological environments in Andean puna *** evaluating the effects of drought on wood anatomical characteristics and ecological function,we demonstrate the capacity of tree species to adapt and endure climate-related changes,thereby emphasizing their resilience and ada

关键词： Carlquist indices Climatic resilience Vessel traits Fiber Functional trait Hydric stress

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Use of recycled concrete aggregates in asphalt mixtures for pavements:A review

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Journal of Traffic and Transportation Engineering(English Edition) 2022年第5期9卷 725-741页

作者： Juan Gabriel Bastidas-martínez Fredy Alberto Reyes-Lizcano Hugo Alexander Rondón-Quintana Faculty of Engineering Universidad Piloto de ColombiaBogotáDC 110231Colombia Faculty of Engineering Pontificia Universidad JaverianaBogotáDC 110131Colombia Facultad del Medio Ambiente y Recursos naturales Universidad Distrital Francisco Joséde CaldasBogotáDC 110131Colombia

Large quantities of natural aggregates(nA)are required in the manufacturing of asphalt mixtures for *** extraction of nA generates high environmental impacts that negatively affect environmental preservation and *** alternative materials obtained in construction and demolition processes in civil construction worked have been studies as possible replacements for nA,with the purpose of reducing these environmental *** foregoing study presents a state of knowledge review referring to the use of recycled concrete aggregates(RCA)when these are used in the manufacturing of asphalt mixtures(mainly hot-mix asphalt HMA type).Environmental aspects are presented,as well as possible benefits and limitations of using RCA as replacements for nA in asphalt ***,it is not possible to establish a behavior pattern,since the characteristics of the RCA are very heterogeneous and vary from the original source of the *** is highlighted from the literature that RCA has a wide potential for use in the manufacture of asphalt mixtures,since in most studies,the mixtures with these materials comply the quality requirements contemplated by the construction specifications,mainly in low-volume ***,based on the literature review,some recommendations and suggestions are presented for future research.

关键词： Recycled concrete aggregates Asphalt mixtures Mechanical properties Volumetric composition

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Patients with hepatocellular carcinoma that die during the first year of liver transplantation have high blood sFasL concentrations

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World Journal of Clinical Cases 2023年第8期11卷 1753-1760页

作者： Leonardo Lorente Sergio T Rodriguez Pablo Sanz Agustín F González-Rivero Antonia Pérez-Cejas Javier Padilla Dácil Díaz Antonio González María M martín alejandro Jiménez Purificación Cerro Julián Portero Manuel A Barrera Intensive Care Unit Hospital Universitario de CanariasLa Laguna 38320Spain Intensive Care Unit Hospital Universitario Nuestra Señora CandelariaSanta Cruz Tenerife 38010Spain Department of Surgery Hospital Universitario Nuestra Señora de CandelariaSanta Cruz Tenerife 38010Spain Department of Laboratory Hospital Universitario de CanariasLa Laguna 38320Spain Department of Digestive Hospital Universitario Nuestra Señora de CandelariaSanta Cruz Tenerife 38010Spain Research Unit Hospital Universitario de CanariasLa Laguna 38320Spain Transplant Unit Hospital Universitario Nuestra Señora CandelariaSanta Cruz Tenerife 38010Spain Department of Radiology Hospital Universitario Nuestra Señora CandelariaSanta Cruz Tenerife 38010Spain

BACKGROUnD Fas ligand(FasL)is one ligand that activates extrinsic apoptosis *** expression in lymphocytes of FasL have been found in patients with acute rejection of liver transplantation(LT).no high blood concentrations of soluble FasL(sFasL)have been found in patients with acute LT rejection;however,the samples size of those studies was *** To determine whether patients with hepatocellular carcinoma(HCC)that dead during the first year of LT have higher blood sFasL concentrations previously to LT that those who that remain alive in a study of higher sample *** Patients underwent LT due to HCC were included in this retrospective *** sFasL levels prior to LT were measured and one-year LT mortality was *** non-surviving patients(n=14)showed higher serum sFasL levels[477(269-496)vs 85(44-382)pg/mL;Pn surviving patients(n=113).Serum sFasL levels(pg/mL)were associated with mortality(OR=1.006;95%CI=1.003-1.010;P=0.001)independently of age of LT donor in the logistic regression *** We report for the first time that HCC patients who die within the first year of HT have higher blood sFasL concentrations prior to HT than those who remain alive.

关键词： sFasL Hepatocellular carcinoma Liver transplantation Mortality Outcome

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A systematic review of real-time detection and classification of power quality disturbances

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Protection and Control of Modern Power Systems 2023年第1期8卷 30-66页

作者： Joaquín E.Caicedo Daniel Agudelo-martínez Edwin Rivas-Trujillo Jan Meyer Faculty of Engineering Universidad Distrital Francisco Joséde CaldasBogotáColombia Institute of Electrical Power Systems and High Voltage Engineering Technische Universität DresdenDresdenGermany Bogotá Colombia

This paper offers a systematic literature review of real-time detection and classification of Power Quality Disturbances(PQDs).A particular focus is given to voltage sags and notches,as voltage sags cause huge economic losses while research on voltage notches is still very incipient.A systematic method based on scientometrics,text similarity and the analytic hierarchy process is proposed to structure the review and select the most relevant literature.A biblio-metric analysis is then performed on the bibliographic data of the literature to identify relevant statistics such as the evolution of publications over time,top publishing countries,and the distribution by relevant topics.A set of articles is subsequently selected to be critically *** critical review is structured in steps for real-time detection and classification of PQDs,namely,input data preparation,preprocessing,transformation,feature extraction,feature selec-tion,detection,classification,and *** associated with the type of disturbance(s)addressed in the literature are also explored throughout the review,including the perspectives of those studies aimed at multiple PQDs,or specifically focused on voltage sags or voltage *** real-time performance of the reviewed tools is also ***,unsolved issues are discussed,and prospects are highlighted.

关键词： Bibliometric analysis Classification Detection Power quality(PQ) Real-time Systematic review Voltage sag Voltage notch

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