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Cyclooxygenase 2 in liver dysfunction and carcinogenesis: Facts and perspectives

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World Journal of Gastroenterology 2017年第20期23卷 3572-3580页

作者： Paloma martín-Sanz marta Casado Lisardo Boscá Department of Metabolism and Cell Signaling Institute of Biomedical Research Alberto Sols Biomedical network Center for the Study of Hepatic and Digestive Disease and Cardiovascular Diseases Metabolic Experimental Pathology Unit Biomedical Institute of ValenciaJaume Roig 11

The biosynthesis of prostaglandins and thromboxanes has been a focus of interest in the management of many liver *** are the enzymes involved in the first step of the biosynthesis of these lipid mediators and selective inhibitors for these isoenzymes as well as pharmacological analogues of prostaglandins have been developed and are currently applied *** we discuss the implications of these enzymes in the onset of metabolic and lipid disorders in the liver and their potential role in the progression of the diseases towards fibrosis and hepatocellular carcinogenesis.

关键词： Cyclooxygenase-2 nAS Prostaglandin non-alcoholic steatohepatitis Hepatocellular carcinoma

Intestinal bile acid physiology and pathophysiology

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World Journal of Gastroenterology 2008年第37期14卷 5630-5640页

作者： Olga martínez-Augustin Fermín Sánchez de Medina Department of Biochemistry and Molecular Biology II School of Pharmacy University of Granada Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y DigestivasGranada 18071 Spain Department of Pharmacology School of Pharmacy University of Granada Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y DigestivasGranada 18071 Spain

Bile acids (BAs) have a long established role in fat digestion in the intestine by acting as tensioactives, due to their amphipatic characteristics. BAs are reabsorbed very efficiently by the intestinal epithelium and recycled back to the liver via transport mechanisms that have been largely elucidated. The transport and synthesis of BAs are tightly regulated in part by specific plasma membrane receptors and nuclear receptors. In addition to their primary effect, BAs have been claimed to play a role in gastrointestinal cancer, intestinal inflammation and intestinal ionic transport. BAs are not equivalent in any of these biological activities, and structural requirements have been generally identified. In particular, some BAs may be useful for cancer chemoprevention and perhaps in inflammatory bowel disease, although further research is necessary in this field. This review covers the most recent developments in these aspects of BA intestinal biology.

关键词： Colitis Bile acid absorption Colon cancer

Interpolation of Ideal Measures by Abstract K and J Spaces

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Acta Mathematica Sinica,English Series 2007年第8期23卷 1357-1374页

作者： Luz M.FERnnDEZ-CABRERA Antón martínEZ Sección Departamental de Matemática Aplicada Escuela de EstadísticaUniversidad Complutense de Madrid28040 MadridSpain Departamento de Matemática Aplicada I E.T.S.Ingenieros IndustrialesUniversidad de Vigo36200

We work with the abstract K and J interpolation method generated by a sequence lattice Г. We investigate the deviation of an interpolated operator from a given operator ideal by establishing formulae for the ideal measure of the interpolated operator in terms of the ideal measures of restrictions of the operator. Formulae are given in terms of the norms of the shift operators on Г.

关键词： real interpolation ideal measures operator ideals shift operators

Influence of Coke and Graphite on the Decomposition and Melting Behavior of a Mold Flux

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材料科学与工程（中英文B版） 2018年第1期8卷 1-7页

作者： Edgardo Benavidez Leandro Santini alejandro martín Elena Brandaleze Facultad Regional San nicolás Universidad Tecnológica Nacional San Nicolás 2900 Argentina

COX-2 in liver,from regeneration to hepatocarcinogenesis:What we have learned from animal models?

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World Journal of Gastroenterology 2010年第12期16卷 1430-1435页

作者： Paloma martín-Sanz Rafael Mayoral marta Casado Lisardo Boscá Biomedical network Center for the Study of Hepatic and Digestive Diseases(CIBERehd) Department of Metabolism and Cell Signaling Institute of Biomedical Research "Alberto Sols"(CSIC-UAM) Department of Pathology and Molecular and Cellular Therapy Institute of Biomedicine of Valencia(IBV-CSIC)

The use of animals lacking genes or expressing genes under the control of cell-specific promoters has signifi cantly increased our knowledge of the genetic and molecular basis of physiopathology,allowing testing of functional hypotheses and validation of biochemical and pharmacologic approaches in order to understand cell ***,with unexpected frequency,gene knockout animals and,more commonly,animal models of transgenesis give experimental support to even opposite conclusions on gene *** we summarize what we learned on the role of cyclooxygenase 2(COX-2) in liver and revise the results obtained in 3 independent models of mice expressing a COX-2 transgene specifi cally in the *** challenge with pro-inflammatory stimuli,the animals behave very differently,some transgenic models having a protective effect but others enhancing the *** addition,one transgene exerts differential effects on normal liver physiology depending on the transgenic animal model used.

关键词： Cyclooxygenase 2 Prostaglandins Liver diseases Apoptosis Inflammation Animal models

Distribution of Malpighia mexicana in Mexico and its implications for Barranca del Río Santiago

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Journal of Forestry Research 2021年第3期32卷 1095-1103页

作者： martín Tena Meza Rafael Manavarro-Cerrillo Diego Brizuela Torres Instituto de Botánica Centro Universitario de Ciencias Biológicas y AgropecuariasUniversidad de GuadalajaraMéxicoCamino Ramón Padilla Sánchez No.2100.Nextipac45200 ZapopanJaliscoMexico Depto.Ingeniería Forestal Laboratorio de SelviculturaDendrocronología y Cambio ClimáticoDendrodatLab-ERSAFUniversidad de CórdobaCampus de RabanalesCtra.N-IVkm.39614071 CórdobaSpain Departamento de Producción Forestal Centro Universitario de CienciasBiológicas y AgropecuariasUniversidad de GuadalajaraMéxicoCamino Ramón Padilla Sánchez No.2100 Nextipac45200 ZapopanJaliscoMexico

Wild plants represent relatively unexplored resource of high economic potential,especially as an alternative to developing new crops and,even more relevant,for improving existing crops and contributing to nutrition and *** wild species M alpighia mexicana(manzanita)has a wide tradition of food,medicinal and ornamental use in *** is part of the American-origin group of tropical shrubs that produce edible red fruits,such as A cerola,which is considered the most important natural source of vitamin C in the *** the role played by *** in Mexico,and particularly in Barranca del Río Santiago(Santiago River Canyon),we modelled its potential distribution in both geographical *** used species'records from databases,local herbaria and records collected by the authors as well as climatic variables representing long term average,variability and extreme conditions of temperature and *** fit the models we used the modelling algorithm Maxent and selected an adequate configuration by testing a range of model complexity *** results indicate a clear species preference for warm-dry tropical forest,most extensively in the Balsas river depression and the central valleys of *** probability of the species presence in the western region was also high,although the probability was also high for smaller surface areas,such as the region of Santiago river canyons,which are covered by warm-dry tropical forests.

关键词： Malpighia mexicana Maxent Warmdry tropical forest Río Santiago Genetic resources Ecological niche model Manzanita

CO_2 adsorption using TiO_2 composite polymeric membranes:A kinetic study

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Journal of Environmental Sciences 2015年第9期27卷 163-171页

作者： Sarah Hafeez X.Fan Arshad Hussain C.F.martín School of Chemical and Materials Engineering (SCME) National University of Sciences & Technology Institute for Materials and Processes School of Engineering University of Edinburgh University of Aberdeen School of Engineering Fraser Noble Building King's College

CO2is the main greenhouse gas which causes global climatic changes on larger scale. Many techniques have been utilised to capture CO2. Membrane gas separation is a fast growing CO2 capture technique, particularly gas separation by composite membranes. The separation of CO2 by a membrane is not just a process to physically sieve out of CO2 through the controlled membrane pore size. It mainly depends upon diffusion and solubility of gases, particularly for composite dense membranes. The blended components in composite membranes have a high capability to adsorb CO2. The adsorption kinetics of the gases may directly affect diffusion and solubility. In this study, we have investigated the adsorption behaviour of CO2 in pure and composite membranes to explore the complete understanding of diffusion and solubility of CO2 through membranes. Pure cellulose acetate（CA） and cellulose acetatetitania nanoparticle（CA-TiO2） composite membranes were fabricated and characterised using SEM and FTIR analysis. The results indicated that the blended CA-TiO2 membrane adsorbed more quantity of CO2 gas as compared to pure CA membrane. The high CO2 adsorption capacity may enhance the diffusion and solubility of CO2 in the CA-TiO2 composite membrane, which results in a better CO2 separation. The experimental data was modelled by Pseudo first-order, pseudo second order and intra particle diffusion *** to correlation factor R2, the Pseudo second order model was fitted well with experimental data. The intra particle diffusion model revealed that adsorption in dense membranes was not solely consisting of intra particle diffusion.

关键词： Global warming Cellulose acetate Gas adsorption Pseudo order models CO2 Ti O2

On the non-evolution of the dependence of black hole masses on bolometric luminosities for QSOs

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Research in Astronomy and Astrophysics 2012年第3期12卷 249-259页

作者： martín López-Corredoira Carlos M. Gutirrez Instituto de Astrofísica de Canarias Departamento de Astrofísica Universidad de La Laguna

There are extremely luminous quasi stellar objects （QSOs） at high redshift which are absent at low redshift. The lower luminosities at low redshifts can be understood as the external manifestation of either a lower Eddington ratio or a lower mass. To distinguish between both effects, we determine the possible dependence of masses and Eddington ratios of QSOs with a fixed luminosity as a function of redshifts; this avoids the Malmquist bias or any other selection effect. For the masses and Eddington ratios derived for a sample of QSOs in the Sloan Digital Sky Survey, we model their evolution by a double linear fit separating the dependence on redshifts and luminosities. The validity of the fits and possible systematic effects were tested by the use of different estimators of masses or bolometric luminosities, and possible intergalactic extinction effects. The results do not show any significant evolution of black hole masses or Eddington ratios for equal luminosity QSOs. The black hole mass only depends on the bolometric luminosity without significant dependence on the redshift as （M BH/10 9 M ）≈ 3.4 （L bol/10 47 erg s-1）0.65 on average for z ≤ 5. This must not be confused with the possible evolution in the formation of black holes in QSOs. The variations of the environment might influence the formation of the black holes but not their subsequent accretion. It also leaves a question to be solved： Why are there not QSOs with very high mass at low redshift？ A brief discussion of the possible reasons for this is tentatively pointed out.

关键词： accretion—methods: statistical—quasars: general

MCRO-PUF:A novel Modified Crossover RO-PUF with an Ultra-Expanded CRP Space

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Computers, Materials & Continua 2023年第3期74卷 4831-4845页

作者： Hassan Rabiei Masoud Kaveh Mohammad Reza Mosavi Diego martín Department of Electrical Engineering Iran University of Science and TechnologyTehran13114-16846Iran Department of Communication and networking Aalto UniversityEspoo00076Finland ETSI de Telecomunicación Universidad Politécnica de MadridAv.Complutense 30Madrid28040Spain

With the expanding use of the Internet of Things(IoT)devices and the connection of humans and devices to the Internet,the need to provide security in this field is constantly *** conventional cryptographic solutions need the IoT device to store secret keys in its non-volatile memory(nVM)leading the system to be vulnerable to physical *** addition,they are not appropriate for IoT applications due to their complex ***,physically unclonable functions(PUFs)have been introduced to simultaneously address these *** are lightweight and easy-toaccess hardware security primitives which employ the unique characteristics of integrated circuits(ICs)to generate secret *** all proposed PUFs,ring oscillator PUF(RO-PUF)has had amore suitable structure for hardware implementation because of its high reliability and easier providing of circuital ***,RO-PUF has not been so attractive for authentication purposes due to its limited supported challenge-response pairs(CRPs).A few efforts have been made in recent years that could successfully improve the RO-PUF CRP space,such as configurable RO-PUF(CRO-PUF).In this paper,by considerably improving the CRO-PUF structure and adding spare paths,we propose a novel strong RO-PUF structure that exponentially grows the CRP space and dramatically reduces the hardware *** implement our design on a simple and low-cost FPGA chip named XC6SLX9-2tqg144,stating that the proposed design can be used in IoT *** addition,to improve the CRP space,our design creates a suitable improvement in different security/performance terms of the generated responses,and dramatically outperforms the *** average reliability,uniqueness,and uniformity of the responses generated are 99.55%,48.49%,and 50.99%,respectively.

关键词： RO-PUF CRP space configurable design