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Post-transplant biliary complications using liver grafts from deceased donors older than 70 years:Retrospective case-control study

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World Journal of Gastrointestinal Surgery 2023年第8期15卷 1615-1628页

作者： Carlos Jimenez-Romero Iago Justo-Alonso Pilar del Pozo-Elso Alberto Marcacuzco-Quinto Cristina martín-Arriscado-Arroba alejandro Manrique-Municio Jorge Calvo-Pulido Alvaro García-Sesma Ricardo San Román Oscar Caso-Maestro Unit of HPB Surgery and Abdominal Organs Transplantation `12 de Octubre´University HospitalMadrid 28041Spain Clinical Research Unit(I+12) `12 de Octubre´University HospitalMadrid 28041Spain Department of Radiology `12 de Octubre´University HospitalMadrid 28041Spain

BACKGROUnD The shortage of liver grafts and subsequent waitlist mortality led us to expand the donor pool using liver grafts from older *** To determine the incidence,outcomes,and risk factors for biliary complications(BC)in liver transplantation(LT)using liver grafts from donors aged>70 *** Between January 1994 and December 31,2019,297 LTs were performed using donors older than 70 *** excluding 47 LT for several reasons,we divided 250 LTs into two groups,namely post-LT BC(n=21)and without BC(n=229).This retrospective case-control study compared both *** Choledocho-choledochostomy without T-tube was the most frequent technique(76.2%in the BC group vs 92.6%in the non-BC group).Twenty-one patients(8.4%)developed BC(13 anastomotic strictures,7 biliary leakages,and 1 nonanastomotic biliary stricture).nine patients underwent percutaneous balloon dilation and nine required a Rouxen-Y hepaticojejunostomy because of dilation *** incidence of post-LT complications(graft dysfunction,rejection,renal failure,and non-BC reoperations)was similar in both *** were no significant differences in the patient and graft survival between the ***,only three deaths were attributed to *** female donors were protective factors for BC,donor cardiac arrest was a risk *** The incidence of BC was relatively low on using liver grafts>70 *** could be managed in most cases by percutaneous dilation or Roux-en-Y hepaticojejunostomy,without significant differences in the patient or graft survival between the groups.

关键词： Older liver Liver transplant Biliary complications Biliary strictures Septuagenarian donors Octogenarian donors

树轮记录的自公元1200年以来强火山喷发事件与高亚洲南部河流源区气候水文变化的关联

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第四纪研究 2021年第2期41卷 323-333页

作者：陈友平陈峰张合理胡茂王世杰 Hadad martín ARIEL Roig Junent Fidel alejandro 云南大学国际河流与生态安全研究院国际河流与跨境生态安全重点实验室云南昆明650504 中国气象局乌鲁木齐沙漠气象研究所树木年轮理化研究重点开放实验室/新疆树木年轮生态实验室新疆乌鲁木齐830002 Laboratorio de Dendrocronología e Historia Ambiental IANIGLACCT CONICETMendozaP.O.Box330MendozaArgentina

强火山喷发作为气候变化重要的外强迫因素,其所造成的气候环境效应一直是气候变化研究热点,而其对于流域水循环影响较少受关注。本文利用采自高亚洲南部河流源区麦吊云杉(Picea brachytyla)树轮样本,研制出一个长达885 a的树木年轮标准... 详细信息

强火山喷发作为气候变化重要的外强迫因素,其所造成的气候环境效应一直是气候变化研究热点,而其对于流域水循环影响较少受关注。本文利用采自高亚洲南部河流源区麦吊云杉(Picea brachytyla)树轮样本,研制出一个长达885 a的树木年轮标准宽度年表。基于树轮气候响应分析结果,利用线性回归模型重建研究区自公元1200年上年11月至当年2月平均最低气温变化,重建方程方差解释量47.1%。该气温重建序列显示,研究区自公元1200年经历了8个冷期和9个暖期,包含有10个极冷年和23个极暖年。同时,该气温重建序列验证了自公元1200年来27次强火山喷发(VEI≥5)对于青藏高原东南部河流源区气候的影响,包括1257年Samalas和1815年Tambora等强火山喷发事件。该气温重建序列与相关河流径流数据对比结果表明强火山喷发在引起高亚洲南部河流源区气温出现明显下降的同时,也可能会进一步导致水循环减缓,使得高亚洲南部河流径流量出现减少。

关键词：树木年轮气温重建火山喷发水文效应青藏高原

Behavioral parameters of six populations of/Wecavs phyllosomus longipennis(Heteroptera:Reduviidae)from areas with high and low prevalences of Trypanosoma cruzi human infection

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Insect Science 2021年第3期28卷 850-860页

作者： Jose alejandro martinez-lbarra Benjamin nogueda-Torres Oziel Dante Montanez-Valdez J.Guadalupe Michel-Parra Miguel Angel Ambriz-Santos Laboratories de Entomologia Medica Centro Universitario del SurUniversidad de GuadalajaraCiudad GuzmanJaliscoMexico Cuerpo Academico de Cuencas Humedales y SustentabilidadDepartamento de Ciencias de la NaturalezaCentro Universitario del SurUniversidad de GuadalajaraCiudad GuzmanJaliscoMexico Becario de COFAA Escuela Nacional de Ciencias BioldgicasInstituto Politecnico NacionalCiudad de MexicoMexico

Three behaviors of epidemiological importance,namely feeding latency,feeding duration and defecation latency,for six populations of Meccus phyllosomus longipennis(Usinger)from areas of central,western and north-central Mexico with high(HP)and low(LP)prevalence of Trypanosoma cruzi(Chagas)human infection were evaluated in this *** median feeding latency(the time taken to begin feeding)was highly variable between ***-instar comparisons showed that at least 65%of the LP populations(n3 to adult)started to feed significantly(Pn the HP population,with n1 showing no difference,and n2 from LP populations feeding sooner than those from HP *** six populations had similar median feeding durations within instars.A higher(Pntage of the instars from HP populations defecated faster than the respective instars from the three LP *** 25%of the young nymphs(n1 to n3)and females in the HP populations defecatedn postfeeding,compared with 4%-6%of the young nymphs and 1.3%-3%of females in the LP ***,17.7%-38.8%of the older nymphs(n4 to n5)in the HP populations and 6.8%-13.4%in the LP populations defecated during or immediately after *** results indicate that the HP populations have a greater potential than the LP populations to transmit *** infections,which may underlie the differences in the prevalence of *** infection in some areas where M *** is currently distributed.

关键词： Chagas disease Meccus phyllosomus longipennis populations Mexico Tri-atominae Trypanosoma cruzi vectorial capacity

Improving the radiological diagnosis of hepatic artery thrombosis after liver transplantation: Current approaches and future challenges

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World Journal of Transplantation 2024年第1期14卷 1-8页

作者： Cristian Lindner Raúl Riquelme Rodrigo San martín Frank Quezada Jorge Valenzuela Juan P Maureira martín Einersen Department of Radiology Faculty of MedicineUniversity of ConcepciónConcepción 4030000Chile Department of Radiology Hospital Clínico Regional Guillermo Grant BenaventeConcepción 4030000Chile Department of Statistics Catholic University of MauleTalca 3460000Chile neurovascular Unit Department of RadiologyHospital Clínico Regional Guillermo Grant BenaventeConcepción 4030000Chile

Hepatic artery thrombosis(HAT)is a devastating vascular complication following liver transplantation,requiring prompt diagnosis and rapid revascularization treatment to prevent graft *** present,imaging modalities such as ultrasound,computed tomography,and magnetic resonance play crucial roles in diagnosing *** imaging techniques have improved sensitivity and specificity for HAT diagnosis,they have limitations that hinder the timely diagnosis of this *** this sense,the emergence of artificial intelligence(AI)presents a transformative opportunity to address these diagnostic *** development of machine learning algorithms and deep neural networks has demonstrated the potential to enhance the precision diagnosis of liver transplant complications,enabling quicker and more accurate detection of *** article examines the current landscape of imaging diagnostic techniques for HAT and explores the emerging role of AI in addressing future challenges in the diagnosis of HAT after liver transplant.

关键词： Liver transplantation Postoperative complications Hepatic artery Thrombosis Radiology Artificial intelligence

How does anodization time affect morphological and photocatalytic properties of iron oxide nanostructures?

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Journal of Materials Science & Technology 2020年第3期38卷 159-169页

作者： Bianca Lucas-Granados Rita Sánchez-Tovar Ramón MFernández-Domene JoséMaría Estívalis-martínez JoséGarcía-Antón Ingeniería Electroquímica y Corrosión(IEC).Instituto Universitario de Seguridad Industrial Radiofísica y Medioambiental(ISIRYM)Universitat Politècnica de ValènciaCamino de Vera s/n46022ValenciaSpain Departmento de Ingeniería Química Universitat de ValènciaAv de les Universitatss/n46100 BurjassotSpain

Iron oxide nanostructures are promising materials to be used as photocatalysts in different photoelectrochemical applications. There are different techniques in order to synthesize these nanostructures, but one of the most inexpensive and simple method is electrochemical anodization. This method can lead to different nanostructures by controlling its parameters. Anodization time is one of the most critical parameters since it considerably affects the properties of the obtained nanostructures. In this work, different anodization times(5, 10, 15, 30 and 60 min) were studied. The resulting nanotubes were characterized by field emission scanning electron microscopy, Raman laser confocal microscopy, water splitting measurements, Mott-Schottky analysis and electrochemical impedance spectroscopy, in order to test their viability for being used as photocatalysts in photoelectrochemical applications. Results showed that the best photocurrent density values in water splitting tests(0.263 m A m-2) were achieved for the sample anodized for 10 min under hydrodynamic conditions.

关键词： Iron oxide Metallic nanostructures Photoelectrochemistry Anodization Time

Carbon nanodots:a new precursor to achieve reactive nanoporous HOPG surfaces

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nano Research 2020年第12期13卷 3425-3432页

作者： Cristina Gutiérrez-Sánchez Emiliano martínez-Periñán Carlos Busó-Rogero Mónica Revenga-Parra Félix Pariente Encarnación Lorenzo Departamento de Química Analítica y Análisis Instrumental Universidad Autónoma de MadridCampus de CantoblancoMadrid28049Spain Institute for Advanced Research in Chemical Sciences(IAdChem) Universidad Autónoma de MadridCampus de CantoblancoMadrid28049Spain IMDEA-nanoscience.Faraday 9 Campus Cantoblanco-UAMMadrid28049Spain

In the present work we develop an electrochemical assisted method to form nanopores on the surface of highly oriented pyrolytic graphite(HOPG),which was accomplished by a simple electrochemical route and a scalable nanomaterial,carbon nanodots,without applying high voltages,high temperatures or toxic *** electrodes are in a solution of n-enrich carbon nanodots in acidic media and the potential scans applied on HOPG lead to the formation of a spatially inhomogeneous porous *** diameter of the resulting nanopores can be tuned by controlling the number of electrochemical reduction *** resulting nanoporous surfaces are characterized by atomic force microscopy,Raman spectroscopy,scanning electrochemical microscopy,electrochemical impedance spectroscopy and *** nanoporous HOPG showed high *** the potential of these surfaces to the development of energy storage devices is demonstrated.

关键词： nanoporous highly oriented pyrolytic graphite(HOPG) carbon nanodots supercapacitor

Hadronic spectra from deformed AdS backgrounds

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Chinese Physics C 2020年第6期44卷 109-122页

作者： Eduardo Folco Capossoli Miguel Angel martín Contreras Danning Li Alfredo Vega Henrique Boschi-Filho Instituto de Física Universidade Federal do Rio de Janeiro21.941-972-Rio de Janeiro-RJ-Brazil Departamento de Física/Mestrado Profissional em Práticas da Educação Básica(MPPEB) Colégio Pedro II20.921-903-Rio de Janeiro-RJ-Brazil Instituto de Física y Astronomía Universidad de ValparaísoA.Gran Bretaña 1111ValparaísoChile Department of Physics and Siyuan Laboratory Jinan UniversityGuangzhou 510632China

Because of the presence of modified warp factors in metric tensors,we use deformed AdS5 spaces to apply the AdS/CFT correspondence to calculate the spectra for even and odd glueballs,scalar and vector mesons,and baryons with different *** the glueball cases,we derive their Regge trajectories and compare them with those related to the pomeron and the *** the scalar and vector mesons,as well as baryons,the determined masses are compatible with the *** particular,for these hadrons we found Regge trajectories compatible with another holographic approach as well as with the hadronic spectroscopy,which present an universal Regge slope of approximately 1.1 GeV^2.

关键词： hadronic spectra AdS/QCD model Regge trajectories

Yearly variation in the structure and diversity of a non-breeding passerine bird community in a Mediterranean wetland

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Avian Research 2020年第3期11卷 238-245页

作者： Juan Arizaga Daniel Alonso ArinCrespo Xabier Esparza Efrén Fernández Iógo López David martín Antonio Vilches Department of Ornithology Aranzadi Sciences Society S. Sebastián Spain

Background:The dynamics and structure of many bird communities are changing due to the global warming and changes in the land use and *** Ebro Valley constitutes one of the chief wintering areas for several passerine species in Iberia,and the reed beds spread across this Valley concentrate huge numbers of birds that use them to roost,while the surrounding agricultural areas serve as main foraging *** aims of this work are(1)to quantify how variable a non-breeding passerine bird community associated to a reed bed area in the Ebro Valley is,and,(2)to test for the effect of weather on possible annual fluctuations in species’proportions at a regional/local ***:We used for that ringing data collected at Badina de Escudera lagoon(navarra)over a 12-year ***:Though,overall,the assemblage did not vary strongly among years(most similarity values were>0.8),we still found a significant linear effect of year on the proportion of captures of Reed Buntings(Emberiza schoeniclus),i.e.,the dominant species detected in our passerine *** increasing loss of weight of Reed Buntings in the community was due to a progressive decrease in its ***:The structure and diversity of passerine community in Badina Escudera was not influenced by meteorological conditions at a local scale,suggesting that local weather would not have an impact on numbers of Reed Buntings in winter.

关键词： navarra Emberiza schoeniclus Ringing Long-term monitoring

Sarcoma stratification by combined pH2AX and MAP17(PDZK1IP1)levels for a better outcome on doxorubicin plus olaparib treatment

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Signal Transduction and Targeted Therapy 2020年第1期5卷 697-709页

作者： Marco Perez JoséManuel García-Heredia Blanca Felipe-Abrio Sandra Muñoz-Galván Javier martín-Broto Amancio Carnero Instituto de Biomedicina de Sevilla(IBIS) Hospital Universitario Virgen del RocíoUniversidad de SevillaConsejo Superior de Investigaciones CientíficasSevillaSpain Ciber de Cancer IS Carlos IIIMadridSpain Departamento de Bioquímica Vegetal y Biología Molecular Universidad de SevillaSevillaSpain Departamento de Anatomía Patológica Hospital Universitario Virgen del RocíoSevillaSpain

Sarcomas constitute a rare heterogeneous group of tumors,including a wide variety of histological *** advances in our understanding of the pathophysiology of the disease,first-line sarcoma treatment options are still limited and new treatment approaches are *** H2AX phosphorylation is a sensitive marker for double strand breaks and has recently emerged as biomarker of DnA damage for new drug *** this study,we explored the role of H2AX phosphorylation at Ser139 alone or in combination with MAP17 protein,an inducer of DnA damage through ROS increase,as prognostic biomarkers in sarcoma ***,we proposed doxorubicin and olaparib combination as potential therapeutic strategies against sarcomas displaying high level of both *** evaluate retrospectively the levels of pH2AX(Ser139)and MAP17 in a cohort of 69 patients with different sarcoma types and its relationship with clinical and pathological *** found that the levels of pH2AX and MAP17 were related to clinical features and poor ***,we pursued PARP1 inhibition with olaparib to potentiate the antitumor effect of DnA damaging effect of the DnA damaging agent doxorubicin to achieve an optimal synergy in *** demonstrated that the combination of olaparib and doxorubicin was synergistic in vitro,inhibiting cell proliferation and enhancing pH2AX intranuclear accumulation,as a result of DnA *** synergism was corroborated in patient-derived xenografts(PDX)where the combination was effective in tumors with high levels of pH2AX and MAP17,suggesting that both biomarkers might potentially identify patients who better benefit from this combined therapy.

关键词： H2AX doxorubicin treatment