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Cellular & Molecular Immunology 2017年第12期14卷 976-985页

作者： Dejene Milkessa Tufa Fareed Ahmad Debanjana Chatterjee Gerrit Ahrenstorf Reinhold Ernst Schmidt Roland jacobs Department of Clinical Immunology and Rheumatology Hannover Medical School30625 HannoverGermany

To function optimally,human blood natural killer(NK)cells need to communicate with other immune ***,it has been shown that NK cells communicate with 6-sulfo LacNAc dendritic cells(slanDCs),which are able to stimulate NK cells in *** this study,we investigated how slanDCs regulate the level of NK cell *** secretion of interleukin(IL)-1βby slanDCs during coculture with NK cells increased as a result of signaling via intercellular adhesion molecule-1 on slanDCs following its interaction with lymphocyte functionassociated antigen-1 on NK ***-1βinduced the expression of Fas receptor(CD95)on NK *** binding of Fas ligand(CD178)to CD95 induced the apoptosis of activated NK ***,IL-1βalso induced increased cyclooxygenase-2 expression in slanDCs,which in turn enabled the cells to secrete prostaglandin(PG)-***,PGE2 acted as a suppressing agent,tuning down the activation level of NK *** summary,IL-1βlimits the level of NK cell activation by inducing apoptosis and suppression as a homeostatic regulatory function.

关键词： COX-2 Fas-induced apoptosis immunosuppression NK cells slanDCs

Comparison of dietary intakes of Canadian Armed Forces personnel consuming field rations in acute hot, cold, and temperate conditions with standardized infantry

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Military Medical Research 2020年第1期7卷 77-92页

作者： Mavra Ahmed Iva Mandic Wendy Lou Len Goodman Ira jacobs Mary R.L’Abbé Department of Nutritional Sciences Faculty of MedicineUniversity of TorontoMedical Science Building1 King's College CircleRoom 5368TorontoOntario M5S 1A8Canada Faculty of Kinesiology and Physical Education University of TorontoToronto M5S 2W6Canada Dalla Lana School of Public Health University of TorontoToronto M5T 3M2Canada Defence Research and Development Canada-Toronto Research Centre Toronto M3K 2C9Canada

Background:Dietary Reference Intakes are used to guide the energy intake of the Canadian Armed Forces(CAF)field rations provided to military personnel deployed for training or ***,the high energy expenditures likely to occur under harsh environmental/metabolically challenging deployment conditions may not be adequately *** study examined the Ad libitum energy and nutrient intakes of CAF personnel(n=18)consuming field rations in a resting thermoneutral environment and during a day of standardized strenuous infantry activities at varying environmental ***:Dietary intake was assessed using a measured food intake/food waste method during the experimental treatment and for 6 h after *** treatments were administered in a randomized counterbalanced design:exercise(as standardized infantry activities)in the heat(30℃),exercise in the cold(–10℃),exercise in temperate thermoneutral(21℃)air temperatures and a resting(sedentary)trial(21℃).Results:The average Ad libitum consumption of field rations was 70%of the provided total energy(2776±99 kcal/8 h)during all *** with an acute challenge of increased energy expenditure and temperature stress in the simulated field conditions,participants’energy intakes(1985±747 kcal/8 h)under hot,cold and temperate treatments did not differ from energy intake during the sedentary condition(1920±640 kcal/8 h).Participants’energy intakes(1009±527 kcal/6 h)did not increase during the 6 h posttreatment period when the stresses of the strenuous physical activities and the harsh environmental temperatures had ***:These results should be considered when planning the provision of field rations for CAF personnel expected to be engaged in strenuous physical activities with prolonged exposure to temperature extremes.

关键词： Dietary assessment Nutrient intakes Military personnel Physical activity Temperature extremes Field rations

A Relocation-based Initialization Scheme to Improve Track-forecasting of Tropical Cyclones

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Advances in Atmospheric Sciences 2014年第1期31卷 27-36页

作者： GAO Feng Peter P. CHILDS Xiang-Yu HUANG Neil A. jacobs Jinzhong MIN Nanjing University of Information Science & Technology National Center for Atmospheric Research Panasonic Avionics Corporation Morrisville Key Laboratory of Meteorological Disaster of the Ministry of Education

A relocation procedure to initialize tropical cyclones was developed to improve the representation of the initial conditions and the track forecast for Panasonic Weather Solutions Tropical Operational Forecasts. This scheme separates the vortex perturbation and environment field from the first guess, then relocates the initial vortex perturbations to Lhe observed position by merging them with the environment field. The relationships of wind vector components with stream function and velocity potential are used for separating the vortex disturbance from first guess. For the separation of scalars, a low-pass Barnes filter is employed. The irregular-shaped relocation area corresponding to the specific initial conditions is determined by mapping the edge of the vortex radius in 36 ***, the non-vortex perturbations in the relocation area are removed by a two-pass Barnes filter to retain the vortex perturbations, while the variable fields outside the perimeter of the modified vortex are kept *** to the original first guess. The potential impacts of this scheme on track forecasts were examined for three hurricane cases in the 2011-12 hurricane season. The experimental results demonstrate that the initialization scheme is able to effectively separate the vortex field from the environment field and maintain a relatively balanced and accurate relocated first guess. As the initial track error is reduced, the following track forecasts are considerably improved. The 72-h average track forecast error was redu,~ed by 32.6% for the cold-start cases, and by 38.4% when using the full-cycling data assimilation because of the accumulatedL improvements from the initialization scheme.

关键词： tropical cyclone vortex relocation data assimilation Barnes filtering

The measurement of proprioceptive accuracy:A systematic literature review

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Journal of Sport and Health Science 2023年第2期12卷 219-225页

作者： Àron Horváth Eszter Ferentzi Kristóf Schwartz Nina jacobs Pieter Meyns Ferenc Köteles Doctoral School of Psychology ELTE Eötvös Loránd UniversityKazinczy street 23-27Budapest 1075Hungary Institute of Health Promotion and Sport Sciences ELTE Eötvös Loránd UniversityPrielle Kornélia Street 47-49Budapest 1117Hungary Rehabilitation Research(REVAL) Faculty of Rehabilitation SciencesUniversity of HasseltMartelarenlaan 42Hasselt 3500Belgium

Background:Proprioceptive accuracy refers to the individual’s ability to perceive proprioceptive information,that is,the information referring to the actual state of the locomotor system,which originates from mechanoreceptors located in various parts of the locomotor system and from tactile receptors located in the *** accuracy appears to be an important aspect in the evaluation of sensorimotor functioning;however,no widely accepted standard assessment *** this systematic review,our goal was to identify and categorize different methods that are used to assess different aspects of proprioceptive ***:A literature search was conducted in 5 different databases(PubMed,SPORTDiscus,PsycINFO,ScienceDirect,and SpringerLink).Results:Overall,1139 scientific papers reporting 1346 methods were included in this *** methods assess 8 different aspects of proprioception:(a)the perception of joint position,(b)movement and movement extent,(c)trajectory,(d)velocity,and the sense of(e)force,(f)muscle tension,(g)weight,and(h)*** apply various paradigms of psychophysics(i.e.,the method of adjustment,constant stimuli,and limits).Conclusion:As the outcomes of different tasks with respect to various body parts show no associations(i.e.,proprioceptive accuracy is characterized by site-specificity and method-specificity),the appropriate measurement method for the task needs to be chosen based on theoretical considerations and/or ecological validity.

关键词： Assessment Kinesthesia Motor control Proprioception Proprioceptive accuracy

Platelet-rich plasma for regeneration of neural feedback pathways around dental implants: a concise review and outlook on future possibilities

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International Journal of Oral Science 2017年第1期9卷 1-9页

作者： Yan Huang Michael M Bornstein Ivo Lambrichts Hai-Yang Yu Constantinus Politis Reinhilde jacobs OMFS IMPATH Research Group Department of Imaging and PathologyFaculty of MedicineKU Leuven and Oral and Maxillofacial SurgeryUniversity Hospitals Leuven State Key Laboratory of Oral Diseases National Clinical Research Center for Oral DiseasesWest China Hospital of StomatologySichuan University Section of Dental Radiology and Stomatology Department of Oral Surgery and StomatologyUniversity of Bern Applied Oral Sciences Faculty of DentistryThe University of Hong KongPrince Philip Dental Hospital Group of Morphology Biomedical Research InstituteHasselt University

Along with the development of new materials, advanced medical imaging and surgical techniques, osseointegrated dental implants are considered a successful and constantly evolving treatment modality for the replacement of missing teeth in patients with complete or partial edentulism. The importance of restoring the peripheral neural feedback pathway and thus repairing the lack of periodontal rnechanoreceptors after tooth extraction has been highlighted in the literature. Nevertheless, regenerating the nerve fibers and reconstructing the neural feedback pathways around osseointegrated implants remain a challenge. Recent studies have provided evidence that platelet-rich plasma （PRP） therapy is a promising treatment for musculoskeletal injuries. Because of its high biological safety, convenience and usability, PRP therapy has gradually gained popularity in the clinical field Although much remains to be learned, the growth factors from PRP might play key roles in peripheral nerve repair mechanisms. This review presents known growth factors contributing to the biological efficacy of PRP and illustrates basic and （pre-）clinical evidence regarding the use of PRP and its relevant products in peripheral nerve regeneration. In addition, the potential of local application of PRP for structural and functional recovery of iniured peripheral nerves around dental implants is discussed.

关键词： neural regeneration osseoperception peripheral nerve degeneration peri-implant sensory feedback platelet-rich plasma

美国学前教育的现在与未来及其对高质量师资与研究的需求——全美幼儿教育协会主席Gera jacobs博士访谈录

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学前教育研究 2014年第7期 3-12页

作者： jacobs,Gera 夏竹筠宋占美张丹彤全美幼儿教育协会山东英才学院·学前教育研究院

全美幼儿教育协会（The National Association for the Education of Young Children，NAEYC）与Gera jacobs博士简介NAEYC是美国规模最大、最具影响力的非营利性民间幼儿教育组织，成立于1962年，目前已拥有会员近8万名，由幼儿教育领... 详细信息

全美幼儿教育协会（The National Association for the Education of Young Children，NAEYC）与Gera jacobs博士简介NAEYC是美国规模最大、最具影响力的非营利性民间幼儿教育组织，成立于1962年，目前已拥有会员近8万名，由幼儿教育领域的教师、研究者以及其他相关从业者构成。NAEYC的宗旨是满足儿童需要和权利，促进儿童健康发展，为儿童提供优质的教育和发展资源，其主要活动目标为：提高幼儿教育领域从业者的专业发展水平及工作条件；为幼儿教育项目提供支持，建设高质量幼儿教育系统；建立一个强大的、多元化的、包容性的组织，促进所有幼儿健康发展。

关键词：教育协会幼儿学前教育质量美国博士访谈录儿童健康

Small-Scale Mineralogical Heterogeneity from Variations in Phase Assemblages in the Transition Zone and D" Layer Predicted by Convection Modelling

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Journal of Earth Science 2011年第2期22卷 160-168页

作者： Arie P van den Berg David A Yuen Michael H G jacobs Maarten V de Hoop Earth Sciences Department Utrecht University Department of Geology and Geophysics and Minnesota Supercomputing Institute University of MinnesotaMinneapolisMN 55415USA Institut für Metallurgie TU ClausthalClausthal-ZellerfeldGermany Department of Mathematics and Center of Applied and Computational Mathematics Purdue UniversityWest LafayetteINUSA

Small-scale heterogeneity in the deep mantle is concentrated in the upper-mantle transition zone （TZ）, in the depth range 410-660 km and also at the bottom 250 km D＂ region. This encourages a more detailed investigation of the potential for seismic reflectivity imaging by modelling heterogeneous structures in mantle convection models including phase transitions of the TZ and D＂ regions. We applied finite elements with variable spacing near the boundary layers in 2-D cylindrical geometry that allow for sufficient spatial resolution. We investigated several models including an extended Boussinesq （EBA） model, focused on the D＂ region, and a compressible （ALA） model for the TZ region. The results for the D＂ region show typical lens-shaped structures of post-perovskite （PPV） embedded in the perovskite （PV） background mantle, where the thickness of the lenses, at 200-400 km, strongly depends on the Clapeyron slope of the PV-PPV transition. A second phase transition （double crossing） occurs in case the core temperature is higher than the intercept temperature Ti. Our phase-dependent rheology results in contrasting effective viscosity between PV and PPV. Our model results reveal a distinctly clear mechanical weakening of the PPV lenses with about an order of magnitude lower viscosity. The shear wave-speed distributions computed from our convection results are strongly correlated with the heterogeneous distribution of the mineral phase. Gradients in the seismic wave-speed that are the target of seismological reflectivity imaging are clearly revealed. The wave-speed results show a clear resolution of the top and bottom interfaces of the PPV lenses. Our ALA model for the TZ is based on a thermodynamical model for the magnesium end- member of an olivine-pyroxene mantle. The model predicts a much more complex distribution of mineral phases, compared to our D＂ results, in agreement with the greater number of mineral phases involved in the olivine-pyroxene phase diagram for the P

关键词： mantle convection phase transition post-perovskite mineralogical heterogeneity.

Pancreatic intraepithelial neoplasia arising from an ectopic pancreas in the small bowel

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Hepatobiliary & Pancreatic Diseases International 2014年第6期13卷 658-661页

作者： Francisco Igor Macedo Deepa Taggarshe Tafadzwa Makarawo Barry Herschman Michael J jacobs Department of General Surgery Providence Hospital and Medical Centers Southfield MI 48075 USA Department of General Surgery Providence Hospital and Medical Centers Southfield MI 48075 USA Department of Pathology Providence Hospital and Medical Centers Southfield MI 48075 USA

BACKGROUND： Ectopic pancreatic tissue is relatively uncommon, and is characterized as pancreatic tissue with no contact with the normal pancreas, and with its own ductal system and blood supply. It is usually asymptomatic, and can be incidentally diagnosed by conventional imaging studies. METHOD： A 69-year-old woman with a prior history of bilateral breast carcinoma presented with ectopic pancreatic intraepithelial neoplasia （PanIN） that was identified incidentally in the small bowel during an oncological resection of a synchronous primary pancreatic adenocarcinoma, and renal cell carcinoma. RESULTS： The patient underwent subtotal pancreatectomy with splenectomy, regional lymphadenectomy, radical left nephrectomy, and small bowel resection with primary anastomosis of ectopic PanlN-2. She had an uneventful hospitalization and was discharged home on postoperative day 7. CONCLUSIONS： The occurrence of ectopic PanIN is extremely unusual with only few cases previously reported in the literature. The need for negative margins after surgical resection of ectopic PanIN lesions remains controversial.

关键词： ectopic pancreas pancreatic intraepithelial neoplasia PanIN pancreatic adenocarcinoma

An alternative approach for sustainable sheep meat production:implications for food security

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Journal of Animal Science and Biotechnology 2021年第2期12卷 791-805页

作者： Eric N.Ponnampalam Matthew I.Knight Peter J.Moate Joe L.jacobs Animal Production Sciences Agriculture Victoria ResearchDepartment of JobsPrecincts and RegionsBundooraVIC 3083Australia Animal Production Sciences Agriculture Victoria ResearchDepartment of JobsPrecincts and RegionsHamiltonVIC 3300Australia Animal Production Sciences Agriculture Victoria ResearchDepartment of JobsPrecincts and RegionsEllinbankVictoria 3821Australia Centre for Agricultural Innovation School of Agriculture and FoodFaculty of Veterinary and Agricultural SciencesThe University of MelbourneMelbourneVictoria 3010Australia

Background:A pelleted diet containing camelina hay(CAMH)or camelina meal(CAMM)as a supplement along with a control pellet(CONT)diet formulated with commonly available feeds during summer was used to investigate an alternative pathway for sustainable meat *** meat production was based on a simple estimation of income from meat produced versus feed costs if animals were fed for an extended period over summer compared to early slaughter at the beginning of *** maternal composite wether lambs(Composite)based on Coopworth genetics and 80 pure Merino wether yearlings were divided into 10 groups within breed(n=8)using stratified randomisation based on *** 1 week of adaptation to experimental diets,animals were fed experimental diets for up to10 ***:Animals were slaughtered after either 8,9 or 10 weeks of full feeding when the average liveweight of diet/genetic combination reached a weight appropriate for either‘heavy lamb’or‘heavy hogget’production,which occurred between 8 and 10 weeks of full *** was no diet×breed interactions except for dressing percentage(DP),where Composite lambs fed the CAMH diet had the greatest DP(48.1±0.35)and the Merino yearlings fed the CAMM diet the lowest DP(45.8±0.33).Composite lambs gained 17.6–20.3 kg and Merino yearlings gained 10.7–12.9 kg *** on their DP,this resulted in the production of approximately 8.3–9.5 kg additional carcass weight in Composites and 4.9–5.7 kg in Merinos,which in turn produced greater profit per Composite lamb and a small profit per Merino ***:Composite lambs fed CAMM and CAMH had 5%greater carcass weights at slaughter compared to the CONT group,but dietary treatments did not change carcass weight of Merino yearlings at *** extended feeding approach offered the producer an estimated economic gain of AUD$20.00 to$25.00 when yearly average prices were used(Method 1)and AUD$40.00 to$47.70 when pre-and post-summer

关键词： Animal welfare Environmental sustainability Global demand Livestock Sheep meat Summer feeding

Assessing the Performance of a Three Dimensional Hybrid Central-WENO Finite Difference Scheme with Computation of a Sonic Injector in Supersonic Cross Flow

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Advances in Applied Mathematics and Mechanics 2012年第6期4卷 719-736页

作者： Wai-Sun Don Antonio de Gregorio Jean-Piero Suarez Gustaaf B.jacobs Department of Mathematics Hong Kong Baptist UniversityKowloon TongHong KongChina Department of Aerospace Engineering&Engineering Mechanics San Diego State University5500 Campanile Drive San DiegoCA 92182USA

A hybridization of a high order WENO-Z finite difference scheme and a high order central finite difference method for computation of the two-dimensional Euler equations first presented in[*** and ***,***.,204(2)(2007)]is extended to three-dimensions and for parallel *** Hybrid scheme switches dynamically from a WENO-Z scheme to a central scheme at any grid location and time instance if the flow is sufficiently smooth and vice versa if the flow is exhibiting sharp shock-type *** smoothness of the flow is determined by a high order multi-resolution *** method is tested on a benchmark sonic flow injection in supersonic cross *** of the order of the method reduces the numerical dissipation of the underlying schemes,which is shown to improve the resolution of small dynamic vortical *** are captured sharply in an essentially non-oscillatory manner via the high order shockcapturing WENO-Z *** of the injector flow with a WENO-Z scheme only and with the Hybrid scheme are in very close *** percent of grid points require a computationally expensive WENO-Z scheme for highresolution capturing of shocks,whereas the remainder of grid points may be solved with the computationally more affordable central *** computational cost of the Hybrid scheme can be up to a factor of one and a half lower as compared to computations with a WENO-Z scheme only for the sonic injector benchmark.

关键词： Weighted essentially non-oscillatory central difference multi-resolution hybrid shock injector