检索结果-南通市图书馆

Revealing the kinetics of Leishmania chagasi infection in the male genital system of hamsters

Infectious Diseases of Poverty 2016年第1期5卷 261-265页

作者： Amanda P.N.Quintal Bruna C.Borges Paula C.Brígido Rebecca T.Silva Ana F.Notário marlus a.santos Maria A.de Souza Fernanda G.O.Nascimento Antônio V.Mundim Guilherme M.J.Costa André B.Vasconcelos Claudio V.da Silva Instituto de Ciências Biomédicas Universidade Federal de UberlândiaUberlândiaMinas GeraisBrasil Hospital Veterinário Universidade Federal de UberlândiaUberlândiaMinas GeraisBrasil Departamento de Ciências Biomédicas Universidade Federal de Minas GeraisBelo HorizonteBrasil Universidade de Uberaba UberabaMinas GeraisBrasil Departamento de Imunologia–Instituto de Ciências Biomédicas Universidade Federal de UberlândiaCampus UmuaramaUberlândiaMGBrasil

Background:Leishmaniasis causes alterations and lesions in the genital system,which leads to azoospermia and testicular atrophy in animals during the chronic phase of the *** aim of this study was to reveal the kinetics of Leishmania chagasi infection in the genital system of male golden hamsters(Mesocricetus auratus).Methods:Animals were intraperitoneally inoculated with amastigotes from *** different time points animals were euthanized and genital organs processed for histo-pathological,qPCR,cytokines and testosterone detection ***:Our results showed a high parasite load in testis,followed by an increase of pro-inflammatory cytokines IL1-β,TNF-αand IFN-γ,and ***,IL-4 expression was upregulated and basal parasite persistence in testis was observed using the experimental ***:Extracellular amastigotes migrated to the epididymis posing as a potential major factor of parasite persistence and venereal transmission of *** infection in hamsters.

关键词： Leishmania chagasi Extracellular amastigotes Testis Epididymis Immune response Testosterone

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Breaking barriers:The potential of nanosystems in antituberculosis therapy

引用

Bioactive Materials 2024年第9期39卷 106-134页

作者： Christian S.Carnero Canales Jessica Ingrid Marquez Cazorla Renzo Marianito Marquez Cazorla Cesar Augusto Roque-Borda Giulia Polin′ario Rufo A.Figueroa Banda Rafael Miguel S′abio marlus Chorilli H′elder a.santos Fernando Rog′erio Pavan School of Pharmacy Biochemistry and BiotechnologySanta Maria Catholic UniversityArequip104013Peru Tuberculosis Research Laboratory School of Pharmaceutical ScienceSao Paulo State University(UNESP)Araraquar114800-903Brazil School of Medicine Santa Maria Catholic UniversityArequip104013Peru School of Pharmaceutical Science Sao Paulo State University(UNESP)Araraquar114800-903Brazil Department of Biomaterials and Biomedical Technology University Medical Center Groningen(UMCG)University of GroningenGroningen9713 AVthe Netherlands Drug Research Program Division of Pharmaceutical Chemistry and TechnologyFaculty of PharmacyUniversity of HelsinkiHelsinkiFI-00014Finland

Tuberculosis(TB),caused by Mycobacterium tuberculosis,continues to pose a significant threat to global *** resilience of TB is amplified by a myriad of physical,biological,and biopharmaceutical barriers that challenge conventional therapeutic *** review navigates the intricate landscape of TB treatment,from the stealth of latent infections and the strength of granuloma formations to the daunting specters of drug resistance and altered gene *** these challenges,traditional therapies often fail,contending with inconsistent bioavailability,prolonged treatment regimens,and socioeconomic *** Drug Delivery Systems(NDDSs)emerge as a promising beacon,ready to overcome these barriers,offering better drug targeting and improved patient *** a critical approach,we evaluate a spectrum of nanosystems and their efficacy against MTB both in vitro and in *** review advocates for the intensification of research in NDDSs,heralding their potential to reshape the contours of global TB treatment strategies.

关键词： Tuberculosis Mycobacterium tuberculosis Nanoscale drug delivery systems Barriers Drug resistance

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Validation of a HPLC Method for Determination of Glutamine in Food Additives Using Post-Column Derivatization

引用

American Journal of Analytical Chemistry 2012年第2期3卷 113-117页

作者： marlus Chorilli Herida Regina Nunes Salgado Fabiana De Santana.santos Lucelia Magalhaes Da Silva Departamento de Farmacos e Medicamentos Faculdade de Ciencias Farmaceuticas de AraraquaraUniversidade Estadual Paulista(UNESP)AraraquaraBrazil Faculdade de Americana AmericanaBrazil Programa de Pos-Graduacao em Ciencias Farmaceuticas Faculdade de Ciencias Farmaceuticas de AraraquaraUniversidade Estadual Paulista(UNESP)AraraquaraBrazil

An ion-exchange chromatography (IEC) followed by post-column derivatization method was validated for the determination of glutamine in food additive products. The chromatographic method was carried out on a sodium cation-exchange column and using detection at 570 nm. The mobile phase consisted of sodium eluant, pH 3.15, with 5% sulfolane, sodium eluant, pH 7.40 and sodium column regenerant. The method was linear in the range of 4 - 50 μg/mL (r2 = 0.9999). The accuracy was 99.78%. Moreover, method validation demonstrated acceptable results for precision and robustness. The method was found to be able to use for routine analysis of the glutamine.

关键词： Glutamine Food Additive Product Liquid Chromatography

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：