检索结果-南通市图书馆

抗PD-1免疫疗法与雄激素剥夺疗法联合可显著增强诱导转移性去势敏感前列腺癌的免疫浸润

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中国临床药理学杂志 2024年第1期40卷 51-51页

作者： hawley J E OBRADOVIC A Z DALLOS M C 孟海峰

引自:hawley J E,OBRADOVIC A Z,DALLOS M C,et ***-PD-1 immunotherapy with androgen depriva⁃tion therapy induces robust immune infiltration in metastatic castration-sensitive prostate cancer[J].Cancer Cell,2023,41(11):1972-1988.研究表明,与其他恶性肿瘤比较,原发性和去势抗性前列腺癌症(CRPC)的肿瘤微环境(TME)缺乏免疫浸润。尽管雄激素剥夺疗法(ADT)可以在局部性前列腺癌中诱导复杂的免疫浸润,但在转移性去势敏感性前列腺癌(mCSPC)中TME的组成、ADT或其它治疗方法在这方面的作用尚不明确。研究者对参与Ⅱ期临床试验(NCT03951831)患者的转移灶进行了全面的单细胞RNA测序(scRNA-seq)分析,该试验评估了标准化疗激素疗法联合抗PD-1免疫疗法的疗效。研究者基于蛋白质活性对TME亚群进行了纵向分析,揭示了在多个转移灶中的免疫亚群。研究者还观察到这些免疫亚群对治疗反应的动态变化以及与临床结果具有相关性。本研究揭示了一种具有治疗耐药性、转录不同的肿瘤亚群,该亚群在治疗难治性患者中细胞数量增加。

关键词： Ⅱ期临床试验肿瘤微环境免疫疗法标准化疗前列腺癌临床结果激素疗法去势

Frequency dependent polarization analysis of ambient seismic noise recorded at a broadband seismometer in the central United States

在线全文

学校读者我要写书评

暂无评论

Earthquake Science 2010年第5期23卷 439-447页

作者： Keith D. Koper Veronica L. hawley Department of Geology and Geophysics University of Utah Department of Earth and Atmospheric Sciences Saint Louis University

We present a new approach to polarization analysis of seismic noise recorded by three-component seismometers. It is based on statistical analysis of frequency-dependent particle motion properties determined from a large number of time windows via eigenanalysis of the 3-by-3, Hermitian, spectral covariance matrix. We applied the algorithm to continuous data recorded in 2009 by the seismic station SLM, located in central North America. A rich variety of noise sources was observed. At low frequencies （〈0.05 Hz） we observed a tilt-related signal that showed some elliptical motion in the horizontal plane. In the microseism band of 0.05-0.25 Hz, we observed Rayleigh energy arriving from the northeast, but with three distinct peaks instead of the classic single and double frequency peaks. At intermediate frequencies of 0.5-2.0 Hz, the noise was dominated by non-fundamental-mode Rayleigh energy, most likely P and Lg waves. At the highest frequencies （〉3 Hz）, Rayleigh-type energy was again dominant in the form of Rg waves created by nearby cultural activities. Analysis of the time dependence of noise power shows that a frequency range of at least 0.02-1.0 Hz （much larger than the microseism band） is sensitive to annual, meteorologically induced sources of noise.

关键词： seismic noise polarization analysis central North America

Energy System Selection for Small Underwater Vehicles

在线全文

学校读者我要写书评

暂无评论

Journal of Thermal Science 1994年第1期3卷 7-14页

作者： G.T.Reader J.G.hawley 等 DepartmentofMechanicalEngineering UniversityofCalgaryCalgaryAlbertaCanada RoyalNavalEngineeringCol

The oceans cover almost three-quarters of the earth's surface and provide a highway for commerceor conquest and constitute a rich source of nutrients, materials and energy. The exploration and exploitation of oceanic resources accelerated in the 1970s because of the emerging offshore oil and gasindustry. The extraction and national protection of these and other resources will increase rapidlyin the next century and in support of these activities one of the most useful tools will be the smallunderwater vehicle. However, if these vehicles are to carry out the envisaged tasks in a cost--effectiveand mission-effective manner they will require high performance energy systems. A number of suchsystems are being developed and the problem arises as which one to select for a particular task. In thispaper the development of software based techniques for the selection of energy systems is described.

关键词： energy system selection small underwater vehicles

Growth trends and environmental drivers of major tree species of the northern hardwood forest of eastern North America

在线全文

学校读者我要写书评

暂无评论

Journal of Forestry Research 2023年第1期34卷 37-50页

作者： Rebecca L.Stern Paul G.Schaberg Shelly A.Rayback Christopher F.Hansen Paula F.Murakami Gary J.hawley Rubenstein School of Environment and Natural Resources The University of VermontBurlingtonVT 05405USA ERM MalvernPA 19355USA Forest Service United States Department of AgricultureNorthern Research StationBurlingtonVT 05405USA Department of Geography The University of VermontBurlingtonVT 05405USA

The future health and productivity of tree species in the northern hardwood forest of eastern North America are uncertain considering changes in climate and pollution loading *** better understand the trajectory of the northern hardwood forest,we studied the growth of three tree species emblematic of it:sugar maple(Acer saccharum Marsh),American beech(Fagus grandifolia Ehrh.),and yellow birch(Betula alleghaniensis Britton),plus a fourth species,red maple(Acer rubrum L.),whose abundance has increased in the *** also analyzed the link between growth and several factors for690 trees in 45 plots throughout Vermont,USA:tree age and size,site elevation,and climate and acid deposition *** their chronologies(1945-2014),all four species exhibited increasing growth followed by plateaued growth indicative of a maturing *** all species,summer moisture was positively correlated with growth,summer temperature was negatively associated with growth,and winter moisture or snow were positively correlated with *** last association was expected for sugar ***,our data suggest that winter snowpack may be more broadly relevant in sustaining tree growth in a region where snow has historically insulated the soil from freezing that can damage roots and lead to reduced aboveground *** of pollution deposition were also correlated with growth for all species except American beech—a species with documented tolerance to pollutant *** the four species studied,red maple had the fewest associations with environmental variables,which suggests that it may be less susceptible to growth reductions as the climate changes.

关键词： Climate change Sugar maple Yellow birch American beech Red maple

Fashion brands and sustainable practices:Differences between American and Chinese consumers

在线全文

学校读者我要写书评

暂无评论

China Textile 2016年第5期 42-48页

作者： Youfang Chen Jana M.hawley School of Business Beijing Institute of Fashion Technology Family and Consumer Sciences University of Arizona

By use of the research method of Personal Mind Mapping(PMM),this research investigates the differences between American and Chinese evaluations of fast fashion regarding sustainable *** research results show there exist distinct *** opinions of American consumers are widely divergent but only confine to American and European *** the other hand,the opinions of Chinese consumers are more consistent and involve Asian brands as well.

关键词：消费者可持续发展美国中国品牌时尚 PMM

在线全文

学校读者我要写书评

暂无评论

苯基功能化介孔二氧化硅薄膜

稀有金属材料与工程 2008年第A2期37卷 1-7页

作者： Benjamin M.D.O'Driscoll Adrian M. hawley Stephen J. Roser Karen J. Edler 巴斯大学化学系

采用共凝法制备了自发形成的苯基功能化的介孔二氧化硅薄膜。利用中子反射技术及布儒斯特角显微镜(Brewster Angle Microscopy)检测所得薄膜,并利用中子小角散射技术检测溶液中的胶束。结果表明:随着苯基功能化先驱体含量的增多,薄膜发... 详细信息

采用共凝法制备了自发形成的苯基功能化的介孔二氧化硅薄膜。利用中子反射技术及布儒斯特角显微镜(Brewster Angle Microscopy)检测所得薄膜,并利用中子小角散射技术检测溶液中的胶束。结果表明:随着苯基功能化先驱体含量的增多,薄膜发生结构损失,这种变化会附有非团聚双层结构的形成。当苯基含量较高时,该双层结构随表面活性剂烷基链的倾斜而稳定。上述结果均同制备含筒状胶束薄膜的无烷基系统形成进行了对比。

关键词：薄膜二氧化硅共凝法

在线全文

学校读者我要写书评

暂无评论

可用单节电池供电的高效率串接LED背光

世界电子元器件 2008年第4期 26-28页

作者： Steve hawley 研诺公司

传统做法中，系统设计师多采用CCFL为手机、便携式多媒体播放机、笔记本电脑等便携式消费电子产品的大尺寸LCD显示屏提供背光。新的高亮度LED的出现使得系统设计师能够考虑用LED为大尺寸LCD显示屏提供背光。与CCFL相比，LED背光可使用... 详细信息

传统做法中，系统设计师多采用CCFL为手机、便携式多媒体播放机、笔记本电脑等便携式消费电子产品的大尺寸LCD显示屏提供背光。新的高亮度LED的出现使得系统设计师能够考虑用LED为大尺寸LCD显示屏提供背光。与CCFL相比，LED背光可使用较少的元件数量，却能提供更高的工作效率、更长的使用寿命、更好的调光能力和更深的颜色深度。

关键词： LED背光电池供电便携式消费电子产品 LCD显示屏串接多媒体播放机高亮度LED CCFL

在线全文

学校读者我要写书评

暂无评论

电荷泵最大化便携产品电源效率

电子测试（新电子） 2006年第11期 29-32页

作者： Steve hawley AnalogicTech

当前的便携式设备具有各种各样的功能,这使得电源管理设计过程大大地复杂化。设计师增加每个新的功能,系统总电源需求也随之增加。然而,用户却越来越多地将便携式产品的质量与电池寿命挂钩。很明显,当前大多数便携式产品要取得市场成功... 详细信息

当前的便携式设备具有各种各样的功能,这使得电源管理设计过程大大地复杂化。设计师增加每个新的功能,系统总电源需求也随之增加。然而,用户却越来越多地将便携式产品的质量与电池寿命挂钩。很明显,当前大多数便携式产品要取得市场成功,很大程度上依赖于设计师是否能在增加功能的同时保持最大的功率效率,以此延长电池的寿命。

关键词：电源效率便携产品最大化电荷泵便携式产品电池寿命便携式设备设计过程

在线全文

学校读者我要写书评

暂无评论

OLED的电源管理

今日电子 2006年第8期 32-33页

作者： Steve hawley Advanced

为OLED选择电源管理IC是一个严峻的挑战在今后的几年内,有机发光二极管(OLED)无疑将突破手机副屏这一目前的主要应用领域.韩国市场调研公司DisplayBank的研究表明,由于更多的数码相机、MP3播放器和掌上游戏机等便携产品的生产商开始采用... 详细信息

为OLED选择电源管理IC是一个严峻的挑战在今后的几年内,有机发光二极管(OLED)无疑将突破手机副屏这一目前的主要应用领域.韩国市场调研公司DisplayBank的研究表明,由于更多的数码相机、MP3播放器和掌上游戏机等便携产品的生产商开始采用OLED,其全球销售量今年将增长64%(从2005年的6100万件到2006年的约1亿件).

关键词： OLED 电源管理有机发光二极管 Display MP3播放器掌上游戏机市场调研 Bank 数码相机便携产品