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Frontiers of Environmental Science & Engineering 2024年第4期18卷 103-110页

作者： Mathias Fessler Qingxian Su marlene mark jensen Yifeng Zhang Department of Environmental and Resource Engineering Technical University of DenmarkCopenhagenDK-2800Denmark

Magnetotactic bacteria reside in sediments and stratified water *** are named after their ability to synthesize internal magnetic particles that allow them to align and swim along the Earth’s magnetic field ***,we show that two magnetotactic species,Magnetospirillum magneticum strain AMB-1 and Magnetospirillum gryphiswaldense strain MSR-1,are *** *** and *** were able to generate current in microbial fuel cells with maximum power densities of 27 and 11μW/m^(2),*** the presence of the electron shuttle resazurin both species were able to reduce the crystalline iron oxide hematite(Fe_(2)O_(3)).In addition,*** could reduce poorly crystalline iron oxide(FeOOH).Our study adds *** and *** to the growing list of known electroactive bacteria,and implies that electroactivity might be common for bacteria within the Magnetospirillum genus.

关键词： Magnetotactic bacteria Magnetospirillum magneticum Magnetospirillum gryphiswaldense Extracellular electron transfer Microbial fuel cells

marking RNA:m^6A writers,readers,and functions in Arabidopsis

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Journal of Molecular Cell Biology 2019年第10期11卷 899-910页

作者： marlene Reichel Tino Koster Dorothee Staiger RNA Biology and Molecular Physiology Faculty of BiologyBielefeld University33615 BielefeldGermany

N^6-methyladenosine(m^6A)emerges as an important modification in eukaryotic mRNAs.m^6A has first been reported in 1974,and its functional significance in mammalian gene regulation and importance for proper development have been well *** arsenal of writer,eraser,and reader proteins accomplish deposition,removal,and interpretation of the m^6A mark,resulting in dynamic *** led to the concept of an epitranscriptome,the compendium of RNA species with chemical modification ofthe nucleobases in the cell,in analogy to the *** m^6A has long been known to also exist in plant mRNAs,proteins involved in m^6A metabolism have only recently been detected by mutant analysis,homology search,and mRNA interactome capture in the reference plant Arabidopsis *** ofthe m^6A modification causes severe developmental abnormalities of leaves and roots and altered timing of reproductive ***,m^6A modification affects viral ***,we discuss recent progress in identifying m^6A sites transcriptome-wide,in identifying the molecular players involved in writing,removing,and reading the mark,and in assigning functions to this RNA modification in *** highlight similarities and differences to m^6A modification in mammals and provide an outlook on important questions that remain to be addressed.

关键词： Arabidopsis m^6A mRNA interactome posttranscriptional RNA-binding protein

Treatment of primary sclerosing cholangitis in children

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World Journal of Hepatology 2019年第1期11卷 19-35页

作者： Trevor J Laborda M Kyle jensen Marianne Kavan mark Deneau Department of Pediatrics University of Utah

Primary sclerosing cholangitis(PSC) is a rare disease of stricturing and destruction of the biliary tree with a complex genetic and environmental *** patients have co-occurring inflammatory bowel disease. Children generally present with uncomplicated disease, but undergo a variable progression to endstage liver disease. Within ten years of diagnosis, 50% of children will develop clinical complications including 30% requiring liver *** is a rare but serious complication affecting 1% of *** acid and oral vancomycin therapy used widely in children as medical therapy, and may be effective in a subset of patients. Gamma glutamyltransferase is a potential surrogate endpoint for disease activity, with improved survival in patients who achieve a normal value. Endoscopic retrograde cholangiopancreatography is a necessary adjunct to medical therapy to evaluate mass lesions or dominant strictures for malignancy, and also to relieve biliary obstruction. Liver transplantation remains the only option for patients who progress to end-stage liver disease. We review special considerations for patients before and after transplant, and in patients with inflammatory bowel disease. There is presently no published treatment algorithm or guideline for the management of children with PSC. We review the evidence for drug efficacy, dosing, duration of therapy, and treatment targets in PSC, and provide a framework for endoscopic and medical management of this complex problem.

关键词： Liver transplant Pediatric Ursodeoxycholic acid Oral vancomycin Oral vancomycin therapy Endoscopic retrograde cholangiopancreatography

Quantitation of Pesticide Residue in Water and Food in Louisiana, USA

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Journal of Water Resource and Protection 2016年第12期8卷 1145-1157页

作者： Olubode Adeniyi Amy Hernandez mark LeBlanc Joan King marlene Janes School of Nutrition and Food Science AgCenter Louisiana State University Baton Rouge USA Agricultural Chemistry Department AgCenter Louisiana State University Baton Rouge USA Agricultural Chemistry Division Louisiana State Department of Agriculture and Forestry Baton Rouge USA

Pesticides can remain in the environment for decades and contaminate surface water that is used for irrigation of produce. This study examined pesticide residues in some surface waters and foods in Louisiana. Samples of 8 foods (tomato, corn, rice, blueberry, cucumber, cabbage, wheat and melon) and 35 surface waters were studied using a QuEChERS extraction method for food samples and liquid-liquid extraction method for the water samples. Gas chromatography-mass spectrometry was used to analyze water and food samples. Nine pesticides were detected in the surface water samples and 5 in the food samples. Pesticides detected in foods were below FDA tolerance limit but 0.18 ppm cypermethrin found in tomato was within 90% of the FDA limit (0.2 ppm). Four water samples had atrazine levels that were above the FDA limit for potable water. This study suggests the need to intermittently monitor pesticide contamination in our food and water.

关键词： Gas Chromatography Mass Spectrometry QuEChERS Cypermethrin Atrazine Pesticide FDA

Alleviation of Pesticide Residue in Surface Water

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Journal of Water Resource and Protection 2017年第5期9卷 523-535页

作者： Olubode Adeniyi Amy Hernandez mark LeBlanc Joan M. King marlene Janes Agricultural Chemistry Department Ag Center Louisiana State University Baton Rouge Louisiana USA Pesticide Unit Louisiana State Department of Agriculture and Forestry Baton Rouge Louisiana USA School of Nutrition and Food Science Ag Center Louisiana State University Baton Rouge Louisiana USA

Reduction of environmental pollution incurred from pesticide use is very important. Zeolite is a natural mineral capable of removing certain chemical contaminants from water. This study was carried out to test the effect of zeolite treatment on pesticide residue alleviation in surface water. Ten surface water samples were treated with natural zeolite by filtering through. An EPA method was used to extract pesticide residue from the water samples and the surfactant used to modify the net charge on the zeolite was hexadecyltrimethylammonium chloride (HDTMA-Cl). Gas chromatography-mass spectrometry was used to analyze water samples. Alleviation was achieved in all the 10 water samples that were filtered through zeolite. The highest removal of pesticides from water with zeolite included 100% of bifenthrin in sample CLC, atrazine in BPH, CDG and LBT;metolachlor in CLC, LBT, BCH, TRH2 and BPI;acetolachlor in BBH and BCH;azoxystrobin in BBH;desethylatrazine in BCH and BPI;metribuzin in BCH, TRH2 and BPI;and both clomazone and bromacil in sample BDC. A minimum reduction of 10.9% was found for metolachlor in sample BRH. Further reduction of pesticide residues up to 50% was recorded in the SMZ treatment as the concentrations of 4 out of 8 pesticide residues were reduced. This study confirms the potential of both the natural zeolite-Clinoptilolite, and SMZ of alleviating pesticide residues in water.

关键词： EPA (United States Environmental Protection Agency) Gas Chromatography Mass Spectrometry Zeolite Hexadecyltrimethylammonium Chloride (HDTMA-Cl) Surface-Modified-Zeolite (SMZ) Bifenthrin Metolachlor Metribuzin Acetolachlor Azoxystrobin Desethylatrazine Clomazone Bromacil Atrazine Clinoptilolite Alleviation

Diagnostic procedures for submucosal tumors in the gastrointestinal tract

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World Journal of Gastroenterology 2007年第24期13卷 3301-3310页

作者： Laura Graves Ponsaing Katalin Kiss Annika Loft Lise Ingemann jensen mark Berner Hansen Department of Surgical Gastroenterology K Bispebjerg University Hospital of Copenhagen Denmark Department of Pathology Herlev University Hospital Gentofte Denmark Department of Nuclear Medicine CopenhagenUniversity Hospital Rigshospitalet Denmark Department of Radiology Bispebjerg University Hospital of Copenhagen Denmark

This review is part one of three, which will present an update on diagnostic procedures for gastrointestinal (GI) submucosal tumors (SMTs). Part two identifies the classification and part three the therapeutic methods regarding GI SMTs. Submucosal tumors are typically asymptomatic and therefore encountered incidentally. Advances in diagnostic tools for gastrointestinal submucosal tumors have emerged over the past decade. The aim of this paper is to provide the readers with guidelines for the use of diagnostic procedures, when a submucosal tumor is suspected. Literature searches were performed to find information on diagnostics for gastrointestinal submucosal tumors. Based on the searches, the optimal diagnostic procedures and specific features of the submucosal tumors could be outlined. Standard endoscppy, capsule endoscopy and push-and-pull enteroscopy (PPE) together with barium contrast X-ray do not alone provide sufficient information, when examining submucosal tumors. Endoscopic ultrasound (EUS), computed tomography (CT), magnetic resonance imaging (MRI) and fluorodeoxyglucose-labeled positron emission tomography (FDG-PET) are recommended as supplementary tools.

关键词： Submucosal tumor Diagnosis Endoscopy Endoscopic ultrasonography Computed tomography Magnetic resonance imaging Positron emission tomography Capsule endoscopy Push-and-pull enteroscopy Ponsaing LG, Kiss K, Loft A, jensen LI, Hansen MB.

A protein engineered to selectively bind uranyl with femtomolar affinity

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A protein engineered to selectively bind uranyl with femtomo...

Effects of water-aging for 6 months on the durability of a novel antimicrobial and protein-repellent dental bonding agent

第八届全国化学生物学学术会议

作者： Lu Zhou Mike Bosscher Changsheng Zhang Salih zubuku Liang Zhang Wen Zhang Charles J.Li Jianzhao Liu mark P.jensen Luhua Lai Chuan He Department of Chemistry and Institute for Biophysical Dynamics The University of Chicago BNLMS State Key Laboratory for Structural Chemistry of Unstable and Stable SpeciesCollege of Chemistry and Molecular Engineering and Center for Quantitative BiologyPeking University Center for Life Sciences Peking University Chemical Sciences and Engineering Division Argonne National Laboratory

Uranyl(UO),the predominant aerobic form of uranium,is present in the ocean at the concentration of～3.2 ppb(13.7 nM).This concentration equates to 4.5 billion tons of uranium in seawater,dwarfing traditional ***,competition among various metal ions and naturally occurring ligands has limited successful enrichment of uranyl fro in this vast resource in *** we report the engineering and rational development of a uranyl-binding protein with a K of 7.4 femtomolar(fM)

关键词： protein design uranium sequestration and remediation metalloprotein

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International Journal of Oral Science 2018年第3期10卷 160-167页

作者： Ning Zhang Ke Zhang Michael D.Weir David J.Xu mark A.Reynolds Yuxing Bai Hockin H.K.Xu Department of Orthodontics School of StomatologyCapital Medical UniversityBeijingChina Biomatexrials&Tissue Engineering Division Department of EndodonticsPeriodontics and ProsthodonticsUniversity of Maryland Dental SchoolBaltimoreMDUSA Center for Stem Cell Biology&Regenerative Medicine University of Maryland School of MedicineBaltimoreMDUSA marlene and Stewart Greenebaum Cancer Center University of Maryland School of MedicineBaltimoreMDUSA Department of Mechanical Engineering University of MarylandBaltimore CountyMDUSA

Biofilms at the tooth-restoration bonded interface can produce acids and cause recurrent caries. Recurrent caries is a primary reason for restoration failures. The objectives of this study were to synthesize a novel bioactive dental bonding agent containing dimethylaminohexadecyl methacrylate(DMAHDM) and 2-methacryloyloxyethyl phosphorylcholine(MPC) to inhibit biofilm formation at the tooth-restoration margin and to investigate the effects of water-aging for 6 months on the dentin bond strength and protein-repellent and antibacterial durability. A protein-repellent agent(MPC) and antibacterial agent(DMAHDM) were added to a Scotchbond multi-purpose(SBMP) primer and adhesive. Specimens were stored in water at 37 °C for 1, 30, 90, or 180 days(d).At the end of each time period, the dentin bond strength and protein-repellent and antibacterial properties were evaluated. Protein attachment onto resin specimens was measured by the micro-bicinchoninic acid approach. A dental plaque microcosm biofilm model was used to test the biofilm response. The SBMP + MPC + DMAHDM group showed no decline in dentin bond strength after water-aging for 6 months, which was significantly higher than that of the control(P 0.1). In conclusion, a bonding agent with MPC and DMAHDM achieved a durable dentin bond strength and long-term resistance to proteins and oral bacteria. The novel dental bonding agent is promising for applications in preventive and restorative dentistry to reduce biofilm formation at the tooth-restoration margin.

关键词： MPC Effects of water-aging for 6 months on the durability of a novel antimicrobial and protein-repellent dental bonding agent

奥利司他对肥胖青少年体重和机体组分的影响——随机对照试验

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美国医学会杂志（中文版） 2006年第1期25卷 34-43页

作者： Jean-Pierre Chanoine, MD, PhD Sarah Hampl, MD, FAAP Craig jensen, MD mark Boldrin, MS Jonathan Hauptman, MD 李呈亿（译） Endocrinology and Diabetes Unit British Columbia Children＇s Hospital Vancouver Children＇s Mercy Hospitals and Clinics Kansas City Mo Department of Medicine Baylor College of Medicine Houston rex Hoffmann-La Roche Inc NutJey NJ 不详

背景：儿童和青少年超重和肥胖正迅速增加。在该人群，单纯行为疗法减肥及维持体重下降的效果有限，但是对药物治疗尚未进行广泛的研究。目的：确定奥利州他（Orlistat）在青少年体重治疗方面的效果及其安个性。设计、地点和病例：于美... 详细信息

背景：儿童和青少年超重和肥胖正迅速增加。在该人群，单纯行为疗法减肥及维持体重下降的效果有限，但是对药物治疗尚未进行广泛的研究。目的：确定奥利州他（Orlistat）在青少年体重治疗方面的效果及其安个性。设计、地点和病例：于美国和加拿大32个中心、539例肥胖青少年（12—16岁；体重指数[body mass index，BMI]在第95百分化之上≥2单位）进行的多ln0、54剧（2000年8月至2002年10月）随机双盲研究。干预：给予奥利司他（n=357）或安慰剂（n=182）120mg，每口3次，持续1年；加适度低热卡饮食（脂肪占30％）、运动和行为治疗。主要观察指标：BMI变化；二级指标包括腰围和髋用、体重下降、脂质测量以及机体对口服葡萄糖的血糖和胰岛素反心。结果：至12周时，两组BMI均有下降；此后，奥利司他组体重维持稳定而安慰剂组则超过基线。研究结束时，奥利司他组BMI下降0．55。而安慰剂组则增加0．31（P=0．001）。与安慰剂组的15．7％相比，奥利司他组26．5％的病例BMI下降≥5％（P=0．005）；BMI下降≥10％者分别为4．5％和13．3％（P=0．002）。在研究结束时，奥利司他组体重增加0．53kg，安慰剂组增加3．14kg（P〈0．001）。双能X线吸收测量娃示，这种差异可用脂肪体再的变化解释。奥利司他组腰围下降，安慰剂组腰围上升（-1．33cm比＋0．12cm；P〈0．05）。奥利司他组发生轻至中度胃肠道不良事件者为9％-50％，安慰剂组为1％～13％。结论：与安慰剂比较，奥利司他与饮食、运动和行为改善联合可显著改善肥胖青少年体重的治疗。在这个青少年人群，连续使用奥利司他1年并无重要安全问题，尽管奥利司他组胃肠道不良事件较为常见。

关键词：青少年人群奥利司他体重下降随机对照试验肥胖机体低热卡饮食组分随机双盲研究双能X线吸收

Advanced smart biomaterials and constructs for hard tissue engineering and regeneration

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Bone Research 2018年第4期6卷 316-330页

作者： Ke Zhang Suping Wang Chenchen Zhou Lei Cheng Xianling Gao Xianju Xie Jirun Sun Haohao Wang Michael D.Weir mark A.Reynolds Ning Zhang Yuxing Bai Hockin H.K.Xu Department of Orthodontics School of Stomatology Capital Medical University Department of Advanced Oral Sciences and Therapeutics University of Maryland Dental School State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Deptartment of Cariology and Endodonics West China Hospital of Stomatology Sichuan University Department of Operative Dentistry and Endodontics Guanghua School of Stomatology Sun Yat-sen University Guangdong Provincial Key Laboratory of Stomatology Volpe Research Center American Dental Association Foundation National Institute of Standards and Technology Center for Stem Cell Biology & Regenerative Medicine University of Maryland School of Medicine marlene and Stewart Greenebaum Cancer Center University of Maryland School of Medicine

Hard tissue repair and regeneration cost hundreds of billions of dollars annually worldwide, and the need has substantially increased as the population has aged. Hard tissues include bone and tooth structures that contain calcium phosphate *** biomaterial-based tissue engineering and regenerative medicine methods have the exciting potential to meet this urgent need. Smart biomaterials and constructs refer to biomaterials and constructs that possess instructive/inductive or triggering/stimulating effects on cells and tissues by engineering the material’s responsiveness to internal or external stimuli or have intelligently tailored properties and functions that can promote tissue repair and regeneration. The smart material-based approaches include smart scaffolds and stem cell constructs for bone tissue engineering; smart drug delivery systems to enhance bone regeneration; smart dental resins that respond to pH to protect tooth structures; smart pH-sensitive dental materials to selectively inhibit acid-producing bacteria; smart polymers to modulate biofilm species away from a pathogenic composition and shift towards a healthy composition; and smart materials to suppress biofilms and avoid drug resistance. These smart biomaterials can not only deliver and guide stem cells to improve tissue regeneration and deliver drugs and bioactive agents with spatially and temporarily controlled releases but can also modulate/suppress biofilms and combat infections in wound sites. The new generation of smart biomaterials provides exciting potential and is a promising opportunity to substantially enhance hard tissue engineering and regenerative medicine efficacy.

关键词： regeneration engineering minerals