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Effects of silver adsorbed on fumed silica,silver phosphate glass,bentonite organomodified with silver and titanium dioxide in aquatic indicator organisms

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Journal of Environmental Sciences 2017年第6期29卷 230-239页

作者： Daiane Tomacheski Michele Pittol Douglas Naue Simoes Vanda Ferreira Ribeiro Ruth marlene Campomanes Santana Department of Materials Engineering Laboratory of Polymers-LAPOLUniversidade Federal do Rio Grande do SulPorto Alegre 91501-970Brazil Softer Brasil Cornpostos Termopldsticos Carnpo Born 93700-000Brazil

In order to reduce the level of transmission of diseases caused by bacteria and fungi, the development of antimicrobial additives for use in personal care, hygiene products, clothing and others has increased. Many of these additives are based on metals such as silver and titanium. The disposal of these products in the environment has raised concerns pertaining to their potential harmfulness for beneficial organisms. The objective of this study was to evaluate the influence of the shape, surface chemistry, size and carrier of three additives containing silver and one with titanium dioxide （TiQ） on microcmstacean survival. Daphnia ruagna was used as a bioindicator for acute exposure test in suspensions from 0.0001 to 10,000 ppm. Cefiodaphnia dubia was used for chronic test in Ti02 suspensions from 0.001 to 100 ppm, D. magna populations presented high susceptibihty to all silver based additives, with 100% mortahty after 24 hr of exposure. A different result was found in the acute experiments containing TiO2 suspensions, with mortality rates only after 48 hr of incubation. Even on acute and chronic tests, Ti02 did not reach a hnear concentration-response uersus mortality, with 1 ppm being more toxic than 10,000 ppm on acute test and 0.001 more toxic than 0.01 ppm on chronic assay. Silver based material toxicity was attributed to silver itself, and had no relation to either form （nano or ion） or carrier （silica, phosphate glass or bentonite）. Ti02 demonstrated to have a low acute toxicity against D. magna.

关键词： Daphnia magnaCeriodaphnia dubiaTitanium dioxideSilver ionNanosilver

STRENGTHENING REQUIREMENT SPECIFICATION IN SUSTAINABLE PROCUREMENT-AN INVESTIGATION OF CHALLENGES

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Journal of Green Building 2017年第1期12卷 107-122页

作者： marlene Hagen Eriksen Søren Peter Bjarløv Carsten Rode Technical University of Denmark Department of Civil EngineeringDenmark

To reap the benefits of sustainability in the construction sector,it is crucial that the stakeholders involved can implement it in *** have shown that choices made in the early phases of the building process are of very great importance for the outcome and the initiatives and decisions taken by the build-ing owner are *** paper presents research on Danish building practitioners’ability to make requirements for sustainability in *** the basis of an action research strategy,we asked practitioners to help identify the challenges involved in requiring sustainable solutions through *** included among others a lack of knowledge or experience in sustainable procurement and inter-disciplinary *** research showed that practitioners are able to for-mulate specific requirements for sustainability in *** the challenges found imply that a sustainable approach in procurement is not fully implemented in a Danish *** suggests that there is a need for guidance in the area,if the practitioners are to move from good intentions to making more specific requirements for sustainability in procurement.

关键词： sustainable procurement requirement specification procurement challenges Danish construction industry building life cycle

Role of ATG16L,NOD2 and IL23R in Crohn's disease pathogenesis

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World Journal of Gastroenterology 2012年第5期18卷 412-424页

作者： Saleh A Naser Melissa Arce Anam Khaja marlene Fernandez Najih Naser Sammer Elwasila Saisathya Thanigachalam Department of Molecular Biology and Microbiology Burnett School of Biomedical SciencesCollege of MedicineUniversity of Central FloridaOrlandoFL 32816United States Division of Research and Development BioSynseCaryNC 27513United States

Inflammatory bowel disease is a group of diseases that includes Crohn＇s disease （CD） and ulcerative colitis. CD is characterized as a chronic inflammatory disease of the gastrointestinal tract, ranging from the mouth to the anus. Although there are gross pathological and histological similarities between CD and Johne＇s dis- ease of cattle, the cause of CD remains controversial. It is vital to understand fully the cause of this disease because it affects approximately 500 000 people in North America and Europe. It ranges from 27 to 48 cases per 100 000 people. There are many theories on the cause of CD ranging from possible association with environmental factors including microorganisms to imbalance in the intestinal normal flora of the pa- tients. Regardless of the environmental trigger, there is strong evidence that a genetic disposition is a major key in acquiring CD. Many studies have proven the link between mutations in the ATG16L, NOD2/CARD15, IBDS, CTLA4, TNFSF15 and IL23R genes, and CD. The purpose of this review is to examine all genetic aspects and theories of CD, including up to date multiple popu- lation studies performed worldwide.

关键词： Crohn's disease ATG16L NOD2/CARD15 IBDS CTLA4 TNFSF15 IL23R

Running in the family:MALT lymphoma and autoimmune disease in mother and daughter

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World Journal of Gastrointestinal Oncology 2012年第2期4卷 26-29页

作者： Barbara Kiesewetter marlene Troch Leonhard Müllauer Markus Raderer De-partments of Internal Medicine I Division of Oncologyand the Comprehensive Cancer Center of the Medical University ViennaA-1090 ViennaAustria Departments of Internal Medicine I Divi-sion of Pathologyand the Comprehensive Cancer Center of the Medical University ViennaA-1090 ViennaAustria

Gastric B-cell lymphoma of the mucosa associated lym-phoid tissue(MALT) lymphoma is one of the most com-mon forms of extranodal *** addition to in-fection with Helicobacter pylori(***),the presence of an underlying autoimmune disease has also been associated with MALT lymphoma *** date,no familial predisposition for MALT lymphomas has been reported as opposed to other types of lymphoma.A 65-year-old woman was admitted at our institution in 1998 with a diagnosis of *** positive gastric MALT lymphoma and the presence of chronic autoim-mune thyroiditis was established on further *** eradication did not result in regression of the lymphoma and RT-PCR showed the presence of the t(11;18)(q21;q21) *** 1.5 years after *** eradication,chemotherapy with cladribine resulted in complete *** to lymphoma re-currence 13 mo later,radiotherapy to the stomach(46 Gy) resulted in minimal residual disease without further *** patient developed a second malig-nancy(Epstein-Bar virus-associated anaplastic large cell lymphoma in the mediastinum) in 2004 which initially responded to two courses of chemotherapy,but she re-fused further therapy and died of progressive lympho-ma in *** 2008,her 55 years old daughter with a long standing Sj gren's syndrome was diagnosed with MALT lymphoma of the right parotid,but no evidence of gastric involvement or *** infection was ***,she is alive without therapy and undergoing regular *** our knowledge,this is the first report of MALT lymphoma in a f irst-degree relative of a patient with gastric MALT lymphoma in the context of two autoimmune diseases without a clearly established familial background.

关键词： Mucosa associated lymphoid tissue lym-phoma Helicobacter pylori Autoimmunity Familial lym-phoma

Wound-Induced Shoot-to-Root Relocation of JA-Ile Precursors Coordinates Arabidopsis Growth

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Molecular Plant 2019年第10期12卷 1383-1394页

作者： Adina Schulze marlene Zimmer Stefan Mielke Hagen Stellmach Charles WMelnyk Bettina Hause Debora Gasperini Department of Molecular Signal Processing Leibniz Institute of Plant BiochemistryWeinberg 306120 Halle(Saale)Germany Department of Cell and Metabolic Biology Leibniz Institute of Plant Biochemistry06120 Halle(Saale)Germany Department of Plant Biology.Swedish University of Agricultural Sciences 75651 UppsalaSweden

Multicellular organisms rely on the movement of signaling molecules across cells,tissues,and organs to communicate among distal *** plants,localized leaf damage activates jasmonic acid(JA)-dependent transcriptional reprogramming in both harmed and unharmed *** it has been indicated that JA species can translocate from damaged into distal sites,the identity of the mobile compound(s),the tissues through which they translocate,and the effect of their relocation remain ***,we found that following shoot wounding,the relocation of endogenous jasmonates through the phloem is essential to initiate JA signaling and stunt growth in unharmed roots of Arabidopsis *** employing grafting experiments and hormone profiling,we uncovered that the hormone precursor cis-12-oxo-phytodienoic acid(OPDA)and its derivatives,but not the bioactive JA-Ile conjugate,translocate from wounded shoots into undamaged *** root relocation,the mobile precursors cooperatively regulated JA responses through their conversion into JA-Ile and JA signaling ***,our findings demonstrate the existence of long-distance translocation of endogenous OPDA and its derivatives,which serve as mobile molecules to coordinate shoot-to-root responses,and highlight the importance of a controlled redistribution of hormone precursors among organs during plant stress acclimation.

关键词： grafting jasmonate OPDA phloem phytohormone

Tritrichomonas foetus:New structures by high-resolution scanning helium ion microscopy

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BIOCELL 2021年第2期45卷 259-266页

作者： marlene BENCHIMOL ABIGAIL MIRANDA-MAGALHÃES ANTONIO PEREIRA-NEVES WANDERLEY DE SOUZA Universidade do Grande Rio Duque de Caxias25071-202Rio de Janeiro Departamento de Microbiologia Laboratório de Biologia Celular de PatógenosFiocruzInstituto Aggeu MagalhãesRecife52060-269Brazil Universidade Federal do Rio de Janeiro Instituto de Biofísica Carlos Chagas FilhoLaboratório de Ultraestrutura Celular Hertha Meyer Instituto Nacional de Ciência e Tecnologia(INBEB)and Centro Nacional de Biologia Estrutural e Bioimagens(CENABIO)Rio de Janeiro21941-902Brazil

Helium ion scanning microscopy(HIM)is a novel high-resolution scanning microscopy technique that uses helium ions instead of electrons to form images of the highest quality and resolution,providing a sub-nanometer resolution sputter uncoated biological ***,we took advantage of HIM to explore the cell surface of Tritrichomonas foetus,a protist parasite of cattle that provokes hard infection and abortion in *** describe thin protrusions,like nanotubes described in other cells,with different sizes(27 nm to 81 nm in thickness)and various lengths(from 73 nm to 2μm),as well bulbous structures either budding from the cell surface or present in the extremities of some *** flagella also presented these thin protrusions and different protein decoration,similar to those previously described using freeze-fracture *** between two cells were also seen,and their role in infection is *** cell surface was also examined and showed several pits indicative of endocytic activity and other types of arrays of *** observations were confirmed using Scanning Electron Microscopy(SEM),negative staining,and conventional thin sectioning for observation by transmission electron *** findings provide new and relevant information that may contribute to a better understanding of protozoan biology and its interaction with mammalian cells.

关键词： Nanotubes Microvesicles Surface specializations

Stricter regulation applies to antimicrobial substances when used as biocides compared to cosmetics under current EU legislation

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Emerging Contaminants 2022年第1期8卷 229-242页

作者： Diana Kaattstroom Anna Beronius Christina Ruden marleneÅgerstrand Department of Environmental Science Stockholm UniversityStockholmSweden Institute of Environmental Medicine Karolinska InstituteStockholmSweden

Antimicrobial substances are substances that have the ability to kill or slow down the growth of microorganisms such as bacteria,algae and *** of microorganisms to low concentrations of antimicrobial substances may lead to the development of antimicrobial *** protect human health and the environment and to limit resistance,the risks for the release of these substances into the environment should be minimized from all *** the current EU legal framework,some specific uses of antimicrobial substances are strictly regulated whereas others are *** antimicrobial substances are used as active substances in biocidal products,such as disinfectants,they are regulated by Biocidal Products *** the same substances are used as preservatives in cosmetic products they fall under Cosmetic Products *** this paper,we investigated how the regulation of antimicrobial substances differ when used in biocidal products compared to cosmetic *** was achieved by performing a systematic comparison using document analysis with focus on aims,scope,information requirements,and risk assessment procedures for biocidal active substances and cosmetic *** of the main differences identified is that no environmental data or environmental risk assessment are required for approval of cosmetic *** contrast,environmental data and risk assessment for both the active substances and one representative product would be required for the approval of the same substance if used as a biocidal active *** means first that a substance not approved for use in biocidal products due to its hazardous environmental properties can still be approved as a cosmetic *** second,the environmental release of antimicrobial substances from cosmetic products remains unassessed and uncontrolled,despite the obvious risks of cosmetic ingredients being emitted into the environment via *** this,we recommend that

关键词： Biocides Cosmetics Chemicals regulation Environmental risk assessment One substance one assessment Antimicrobial substances

Glycine-extended gastrin activates two independent tyrosine-kinases in upstream of p85/p110 phosphatidylinositol 3-kinase in human colonic tumour cells

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World Journal of Gastroenterology 2006年第12期12卷 1859-1864页

作者： Audrey Ferrand Aline Kowalski-Chauvel Claudine Bertrand Daniel Fourmy marlene Dufresne Catherine Seva Julie Pannequin INSERM U.531 Groupe de Recherche de Biologie et Pathologie DigestivesIFR31Institut Louis BugnardBP 8422531432 toulouse Cedex 4France University of Melbourne Department of Surgery Austin CampusARMCHeidelbergVictoria 3084Australia

AIM： To investigate whether Src, JAK2 and phosphatidylinositol 3-kinase （PI3K） pathways are involved in the proliferation of human colonic tumour cells induced by glycine-extended gastrin （G-gly）, the precursor of the mature amidated gastrin and to elucidate the molecular interaction between these three kinases in response to this peptide. METHODS： Using the human colonic tumour cell line HCT116 as a model, we first measured the activation of PI3K, p60-Src and JAK2 in response to G-gly by in vitro kinase assays. Then we investigated the involvement of these kinases in G-gly-induced cell proliferation by MTT test. RESULTS： G-gly stimulation induced p60-Src, JAK2 and PI3K activation in HCT116. The different pathways were involved in proliferation of human colon cancer cells induced by G-gly. Furthermore, we found that both Src and JAK2 were necessary to PI3K regulation by this peptide. However, we did not find any cross-talk between the two tyrosine kinases. CONCLUSION： Our results suggest that the p60-Src/ PI3K and JAK2/PI3K pathways act independently to mediate G-gly proliferative effect on human colonic tumour cells.

关键词： Colon cancer Src JAK2 Phosphatidylinositol 3-kinase Glycine-extended gastrin

Chances and risks of sodium-glucose cotransporter 2 inhibitors in solid organ transplantation:A review of literatures

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World Journal of Transplantation 2021年第7期11卷 254-262页

作者： marlene Schwarzenbach Flavia Elena Bernhard Cecilia Czerlau Daniel Sidler Department of Nephrology and Hypertension University Hospital Insel BernBern 3010Switzerland

Solid organ transplantation offers life-saving treatment for patients with endorgan *** survival and quality of life have improved over the past few decades as a result of pharmacological development,expansion of the donor pool,technological advances and standardization of practices related to ***,transplantation is associated with cardiovascular complications,of which post-transplant diabetes mellitus(PTDM)is one of the most *** increases mortality,which is best documented in patients who have received kidney and heart *** results from traditional risk factors seen in patients with type 2 diabetes mellitus,but also from specific posttransplant risk factors such as metabolic side effects of immunosuppressive drugs,post-transplant viral infections and *** hypoglycaemic agents are the first choice for the treatment of type 2 diabetes mellitus in non-transplanted ***,the evidence on the safety and efficacy of oral hypoglycaemic agents in transplant recipients is *** favourable risk/benefit ratio,which is suggested by large-scale and long-term studies on new glucoselowering drug classes such as glucagon-like peptide 1 receptor agonists and sodium-glucose cotransporter 2 inhibitors,makes studies warranted to assess the potential role of these agents in the management of PTDM.

关键词： Solid organ transplantation Post-transplant diabetes mellitus Antidiabetic treatment Sodium-glucose cotransporter 2 inhibitors Renoprotection