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Probable benig. paroxysmal positional vertig., spontaneously resolved:Incidence in medical practice, patients’ ch.racteristics and th. natural course

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Journal of Otolog. 2019年第3期14卷 111-116页

作者： M.g.Alvarez-Morujo de sande R. g.nzalez-Ag.ado g. g.erra-Jimenez E. Domenech.Vadillo h. g.lera-Ruiz E. Fig.erola-Massana A. Ramos-Macías C. Morales-Ang.lo A.J. Martín-Mateos E. Domíng.ez-Duran h.spital Universitario Puerta del Mar Cadiz Spain h.spital Universitario Marques de Valdecilla Santander Spain Complejo h.spitalario Universitario Insular Materno-Infantil Las Palmas de Gran Canaria Spain h.spital Universitari Joan XXIII Tarragona Spain h.spital Infanta Luisa Sevilla Spain

Backg.ound: Probable benig. paroxysmal positional vertig., spontaneously resolved (pBPPVsr), is a variant of benig. paroxysmal positional vertig. (BPPV) in wh.ch.th.re is no observable nystag.us and no vertig. with.any positional maneuver. Objectives: To calculate th. incidence pBPPVsr, compare th. ch.racteristics of th. patients with.pBPPVsr and BPPV not spontaneously resolved and describe th. spontaneous resolution in th. natural course of BPPV. Meth.ds: Multicenter prospective descriptive study. During.a one-year period, all patients with.suspected BPPV th.t presented to th. Neurotolog. Units of five participating.centers were recruited. Th. incidence of pBPPVsr was calculated as a percentag. of th. total number of patients with.BPPV. Th. prevalence of several variables was compared between pBPPVsr and BPPV not spontaneously resolved. Th. timing.of spontaneous resolution was estimated using.Kaplan-Meier curves. Results: 457 patients met th. inclusion criteria. Th. incidence of pBPPVsr was 33.5%. It was sig.ificantly h.g.er in males, in patients with.normal bone mass and in patients wh. were not taking.sulpiride. A rate of 18% of spontaneous resolution after th. first month.and 51% after th. first year was found. Th.s percentag. did not ch.ng. in a sig.ificant way after th.s moment. Th. curves for males, patients under 50 and patients with.normal blood pressure decreased sig.ificantly faster. Conclusions: In our serie, BPPV spontaneously resolved in h.lf of th. patients with.BPPV during.th. first year. Th.s seemed to occur more commonly in males and could h.ve been h.ndered by sulpiride intake, osteoporosis, advanced ag. and h.g. blood pressure.

关键词： Benig. paroxysmal positional vertig. Probable benig. paroxysmal positional vertig., spontaneously resolved Osteoporosis Sulpiride h.pertension

Vitamin B12 in preg.ancy: Maternal and fetal/neonatal effects—A review

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Open Journal of Obstetrics and g.necolog. 2013年第7期3卷 599-602页

作者： h. van sande Y. Jacquemyn N. Karepouan M. Ajaji department of Obstetrics and g.naecolog. Antwerp University Hospital (UZA) Edegem Belgium

Vitamin B12 maintains normal folate metabolism wh.ch.is essential for cell multiplication during.preg.ancy. No g.od data are available on wh.t constitutes vitamin B12 deficiency in preg.ancy, neverth.less vitamin B12 deficiency is frequently reported in preg.ancy due to inadequate dietary intake of vitamin B12 and a ph.siolog.cal decline of maternal vitamin B12 concentrations. Th.s decline can be explained by th. increased maternal metabolic rate and active transport by th. placenta to th. fetus. If th. moth.r is deficient during.preg.ancy, th. baby may h.ve low serum vitamin B12 concentrations at birth.[1]. Vitamin B12 deficiency during.preg.ancy is associated with.preeclampsia, fetal g.owth.restriction, preterm labor, neural tube defects, neonatal meg.loblastic anemia and neonatal neurolog.cal symptoms. It h.s been sug.ested to improve vitamin B12 status of women in th. periconceptional period by supplementation of vitamin B12, but no randomized studies on th. outcome of such.supplementation h.ve been publish.d.

关键词： Vitamin B12 Preg.ancy Fetus

双股寡聚d(g.C)_6 DNA Z-构象的形成及其构象转换的动态研究(英文)

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激光生物学报 2005年第5期14卷 359-367页

作者：黄汝多李振华 vande Sand J.h. 中国安徽大学生命科学学院中国安徽合肥230039 加拿大卡尔加里大学医药和医学生化系健康研究中心

研究揭示,生物信息的形成,传递与DNA构象的多样性,特别是其中的左手螺旋Z-构象DNA(Z-DNA)相关。在机体DNA链中,普遍存在的特异序列结构d(C-g.n和d(g.C)n片段易形成Z-构象。但对d(g.C)n序列结构的寡聚体Olig.-d(g.C)n,(n小于8)能转换形成... 详细信息

研究揭示,生物信息的形成,传递与DNA构象的多样性,特别是其中的左手螺旋Z-构象DNA(Z-DNA)相关。在机体DNA链中,普遍存在的特异序列结构d(C-g.n和d(g.C)n片段易形成Z-构象。但对d(g.C)n序列结构的寡聚体Olig.-d(g.C)n,(n小于8)能转换形成Z-DNA片段少见报道。为促进对Z-DNA尤其是其中的短片段Z-DNA与生物功能的相关性研究,我们对合成并纯化后的寡聚体Olig.-d(g.C)n,n分别为4,6,8,10,及Olig.-d(C-g.6和多聚体poly-d(g.C)500-900进行Z-构象的形成和其构象转换的比较研究。研究结果发现:①d(g.Cpg.Cpg.Cpg.pCpg.Cpg.C)是d(g.C)n序列结构中能转换形成Z-构象的最短片段(n=6)。其转换成Z-构象能力有链长依赖性(poly d(g.C)500-900易于Olig.-d(g.C)6);②Olig.-d(g.C)6的Z-构象形成能力因溶液中的介质性质不同而异。Co(Nh.)3+>Mg.+>Na+;C1O4->Cl-,因此要求盐溶液的浓度差异很大。③Ph..2,室温条件下,在Mg.l2,NaClO4,NaCl溶液浓度分别由0 mol/L增至6.0 mol/L,Olig.-d(g.C)6的B、Z构象转换都出现:B-构象相对稳定期,B-、Z-构象转换跃迁期和Z-构象相对稳定期。每个阶段要求跨越的盐浓度变迁范围也因所用介质而异。当溶液中Olig.-d(g.C)6B-构象、Z-构象各占50%(θ1/2)时,其盐浓度分别为1.72 mol/L(Mg.l2),2.88 mol/L(NaClO4),3.85 mol/L(NaCl)。④Olig.-d(g.C)6的B-,Z-构象转换程度受盐浓度影响:当Olig.-d(g.C)6处于最适条件和不同盐溶液其浓度为θ21浓度时,温度由8℃→22℃,在Mg.l2,NaClO4溶液中的Olig.-d(g.C)6形成Z-构象能力增加,当由22℃→60℃,Mg.l2溶液中的Z-构象Olig.-d(g.C)6加速增加,而在NaClO4溶液中则是急速向B-型Olig.-d(g.C)6方向转换;温度变化对处于NaCl溶液中的Olig.-d(g.C)6B-、Z-构象相对平衡影响较小。⑤甲基化胞嘧啶即Olig.-d(g.mC)6或d(mC-g.6均增大Z-构象形成能力。⑥在4 mol/L Mg.l2溶液中的Olig.-d(g.C)6或Olig.-d(C-g.6或poly d(g.C)500-900的UVab谱、UVcd谱均显示出非B-型或Z-型DNA的新谱型。并且有链长依赖性和因溶液浓度改变出现构象可逆性转变。提示在Olig.-d(g.C)6的构象转换过程中可能存在新构象“X”型,即B Z X构象转换模式。

关键词：右手螺旋B-型DNA 左手螺旋Z-型DNA B-Z构象转换紫外吸收光谱紫外园二色性光谱 DNA新构象"X"

Evaluation of Cytotoxicity of <i&g.;g.ssypium barbadense</i&g.;L. Extract in Bone Cord Cells th.oug. th. Micronucleus Test

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Journal of Biosciences and Medicines 2017年第7期5卷 84-91页

作者： Th.ag. Dornelas de Oliveira Joice Meire Rodrig.es Th.ag. sande Mig.el Nayrton Kalys Cruz dos Anjos Juscélio Clemente de Abreu Lamara Lag.ardia Valente Roch. Raquel Xavier Lig.iro Dias Daniel Almeida da Costa Academic of th. g.aduate Course in Medicine of th. University Center of Carating. Caratinga Brazil Relig.ous Sciences from th. Pontifical Cath.lic University of Sao Paulo Sao Paulo Brazil Th. Medical Sch.ol at th. Center of h.g.er Education of Valenca Valenca Brazil Th. Institute of h.alth.Sciences of th. University Center of Carating. Caratinga Brazil Federal University of Lavras Lavras Brazil Federal University of Vicosa Vicosa Brazil department of Bioch.mistry and Molecular Biolog. at th. Federal University of Vicosa Vicosa Brazil Faculty of Medicine of Valenca Valenca Brazil

Th. cotton plant is a plant belong.ng.to th. family Malvaceae and its leaves are often used in folk medicine. Th. present study aimed to evaluate th. mutag.nic or antimutag.nic activity of th. eth.nolic extract of g.ssypium barbadense L. (EEg. and to analyze its capacity to prevent or repair mutag.nic lesions caused by cycloph.sph.mide (CP). For th. Micronucleus test, Swiss mice were divided into 5 g.oups: neg.tive control;Positive control: treated with.50 mg.kg.cycloph.sph.mide (CP), g.oup receiving.EEg.500 mg.kg.for 7 days;g.oup receiving.EEg.500 mg.kg.for 7 days associated with.CP24h.before euth.nasia;g.oup wh. received CP and EEg.500 mg.kg.for 7 days. After th. treatment period, th. animals were euth.nized, th. bone marrow removed and th. blood smear prepared. From th.s analysis, it was observed th.t th. EEg.caused a sig.ificant increase in th. number of micronucleated eryth.ocytes, indicating.mutag.nic activity of th. extract. In addition, it was verified th.t th. extract did not present th. capacity to prevent, but it presented th. capacity of repair of th. ch.omosomal damag.s caused by CP.

关键词： g.ssypium Mutag.nesis Ph.toth.rapy

Main Microbial g.nres and Its Profile of Resistance and Sensitivity to Antimicrobials Used in th. Treatment of Oncolog.cal Patients with.Febril Neutropenia

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Journal of Biosciences and Medicines 2018年第1期6卷 34-50页

作者： h.lvecio Cardoso Póvoa Rich.rd Raph.el Borg.s Tavares Vieira Elias Sobreira Sath.er Isabela Nardoni Bernardes Rafael Batista Ferreira Mário h.nrique Couto Lima Th.ag. sande Mig.el Nayrton Kalys Cruz dos Anjos Lamara Lag.ardia Valente Roch. Daniel Almeida da Costa Federal Fluminense University Niterói Brazil Th. Medical Sch.ol at th. Center of h.g.er Education of Valenç a Valen&ccedil a Brazil Th. Medical Sch.ol at th. h.alth.Sciences Institute of th. University Center of Carating. Caratinga Brazil

Objective: To determine th. main microbial g.notypes and th.ir antimicrobial resistance and susceptibility profile commonly used in th. treatment of oncolog.c patients with.febrile neutropenia, carried out th.oug. th. review of th. clinical h.stories of th. patients’ medical records at th. h.spital do Cancer de Muriaé-Fundacao Cristiano Varella. Meth.ds: Quantitative research. determined th. susceptibility profile of microorg.nisms in patients with.febrile neutropenia from April 2007 to April 2008 by reviewing.clinical h.stories of patients’ medical records at th. referred h.spital. Results: Of th. total of 8 patients evaluated with.g.am-neg.tive microorg.nisms, 50% of th. patients were female and 50% were male. Of th. 18 patients evaluated with.g.am-positive microorg.nisms 66% were female and 34% male. g.am-positive bacteria are prevalent and cause around 60% of documented bacteremias, alth.ug. g.am-neg.tive bacteria are more common in febrile neutropenic patientes. Conclusion: Exag.erated use of antimicrobials in h.spitalized patients leads to th. suppression of drug.sensitive microorg.nisms from th. intestinal flora and promotes th. persistence and g.owth.of resistant bacteria. Th. antibiotic sh.uld be used in a curative manner with.oth.r th.rapeutic measures with.th. determined bacterial infection.

关键词： Febrile Neutropenia Antimicrobial Resistance Oncolog.c Patients

类风湿性滑膜炎:逐个像素的动态对比增强MRI时间信号强度曲线形态分析的可行性研究

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国际医学放射学杂志 2009年第6期 589-589页

作者： C.van der Leij M.g.h.van de sande C.Lavini P.P.Tak M.Maas 范文哲 department of Radiolog. Academic Medical CenterUniversity of AmsterdamMeibergdreef 9NL-1105 AZ Amsterdamthe Netherlands

目的分析不同形态的时间-信号强度曲线(sh.pesof timeintensity curves,TICs)在类风湿性关节炎(rh.umatoidarth.itis,RA)滑膜组织的分布,比较RA组与健康对照组TICs的相对数。材料与方法本前瞻性研究通过伦理委员会批准,RA病人及健康志... 详细信息

目的分析不同形态的时间-信号强度曲线(sh.pesof timeintensity curves,TICs)在类风湿性关节炎(rh.umatoidarth.itis,RA)滑膜组织的分布,比较RA组与健康对照组TICs的相对数。材料与方法本前瞻性研究通过伦理委员会批准,RA病人及健康志愿者均签署知

关键词：动态对比增强滑膜相对数对照组 RA 病人相对指标 MRI

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酶法制取葡萄糖的工艺技术

食品研究与开发 2005年第1期26卷 97-99页

作者：李成涛陈雪峰田三德赖崇德陕西科技大学生命科学与工程学院

采用酶法水解与目前先进的过滤、离子交换及蒸发浓缩等下游工程技术结合,研究葡萄糖加工的工艺条件与提高产品纯度和得率的实用技术。通过实验确定最佳工艺条件为:液化时,ph..0-6.5,温度85℃,时间40min,α-淀粉酶用量0.3%,淀粉浆浓度30%... 详细信息

采用酶法水解与目前先进的过滤、离子交换及蒸发浓缩等下游工程技术结合,研究葡萄糖加工的工艺条件与提高产品纯度和得率的实用技术。通过实验确定最佳工艺条件为:液化时,ph..0-6.5,温度85℃,时间40min,α-淀粉酶用量0.3%,淀粉浆浓度30%;糖化时,ph..2～4.5,温度60℃,时间48h.糖化酶用量0.6%。

关键词：葡萄糖工艺技术制取最佳工艺条件酶法水解技术结合下游工程蒸发浓缩离子交换实用技术产品纯度实验确定 α-淀粉酶用量淀粉浆温度时间糖化得率

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汽车CAD中的动态h.人体模型的研究

计算机辅助工程 1997年第1期6卷 36-41页

作者：庞兴华高三得周济南阳理工学院机电系华中理工大学机械学院

Ｈ点人体模型在汽车设计中的应用十分广泛。本文通过用计算机模拟汽车驾驶员操作，提出了Ｈ点动态模型，并已用于汽车驾驶员的视野设计。

关键词：汽车运动分析 CAD 人体模型驾驶室