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Griseofulvin enantiomers and bromine-containing griseofulvin derivatives with antifungal activity produced by the mangrove endophytic fungus Nigrospora ***1

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Marine Life science & Technology 2024年第1期6卷 102-114页

作者： ge Zou Wencong Yang Tao Chen Zhaoming Liu Yan Chen Taobo Li Gulab said Bing sun Bo Wang Zhigang she school of Chemistry Sun Yat-sen UniversityGuangzhou 510275China state Key Laboratory of Applied Microbiology southern China Guangdong Provincial Key Laboratory of Microbial Culture Collection and ApplicationInstitute of MicrobiologyGuangdong Academy of SciencesGuangzhou 510070China school of Pharmacy Anhui Medical UniversityHefei 230032China Department of Chemistry Women University SwabiSwabi 23430Pakistan

Marine microorganisms have long been recognized as potential sources for drug *** was one of the first antifungal natural products and has been used as an antifungal agent for *** this study,12 new griseofulvin derivatives[(±)-1-2,(+)-3,(±)-4,10-12,and 14-15]and two new griseofulvin natural products(9 and 16)together with six known analogues[(-)-3,5-8,and 13]were isolated from the mangrove-derived fungus Nigrospora ***1 treated with 0.3%NaCl or 2%NaBr in rice solid *** 2D structures and absolute configurations were established by extensive spectroscopic analysis(1D and 2D NMR,HResIMs),eCD spectra,computational calculation,DP4+analysis,and X-ray single-crystal *** 1-4 represent the first griseofulvin enantiomers with four absolute configurations(2s,6's;2R,6'R;2s,6'R;2R,6's),and compounds 9-12 represent the first successful production of brominated griseofulvin derivatives from fungi via the addition of NaBr to the culture *** the antifungal assays,compounds 6 and 9 demonstrated significant inhibitory activities against the fungi Colletotrichum truncatum,Microsporum gypseum,and Trichophyton mentagrophyte with inhibition zones varying between 28 and 41 mm(10μg/disc).The structure-activity relationship(sAR)was analyzed,which showed that substituents at C-6,C-7,C-6'and the positions of the carbonyl and double bond of griseofulvin derivatives significantly affected the antifungal activity.

关键词： Mangrove endophytic fungus Nigrospora sp. Griseofulvin Antifungal activity

engineering of self-supported electrocatalysts on a Three-Dimensional Nickel Foam Platform for efficient Water electrolysis

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Transactions of Tianjin University 2024年第2期30卷 103-116页

作者： Ceneng Chen Xian Wang Zijun Huang jiahui Mo Xiaoyan Zhang Chao Peng Mohamed Khairy junjie ge Zhi Long Multiscale Crystal Materials Research Center Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China school of Chemistry and Materials science University of Science and Technology of ChinaHefei 230026China Chemistry Department Faculty of ScienceSohag UniversitySohâg 82524Egypt Dalian National Laboratory for Clean energy Dalian 116023China

economical water electrolysis requires highly active non-noble electrocatalysts to overcome the sluggish kinetics of the two half-cell reactions,oxygen evolution reaction,and hydrogen evolution *** intensive efforts have been committed to achieve a hydrogen economy,the expensive noble metal-based catalysts remain under ***,the engineering of self-supported electrocatalysts prepared using a direct growth strategy on three-dimensional(3D)nickel foam(NF)as a conductive substrate has garnered significant *** is due to the large active surface area and 3D porous network offered by these electrocatalysts,which can enhance the synergistic eff ect between the catalyst and the substrate,as well as improve electrocatalytic ***-assisted growth,microwave heating,electrodeposition,and other physical methods(i.e.,chemical vapor deposition and plasma treatment)have been applied to NF to fabricate competitive electrocatalysts with low overpotential and high *** this review,recent advancements in the development of self-supported electrocatalysts on 3D NF are ***,we provide future perspectives of self-supported electrode platforms in electrochemical water splitting.

关键词： Nickel foam Water splitting surface modification Hydrothermal method Microwave-assisted method electrodeposition Chemical vapor deposition Plasma treatment

Tumor microenvironment-responsive arsenic-loaded layered double hydroxides film with synergistic anticancer and bactericidal activity

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Rare Metals 2024年第3期43卷 1207-1221页

作者： shun Xing Dong-Hui Wang Hai-Feng Zhang Li-Dan Liu Cheng-Ce Li Chao Wei jun-Yu Liu Nai-jian ge Xuan-Yong Liu state Key Laboratory of High Performance Ceramics and superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai200050China Center of Materials science and Optoelectronics engineering University of Chinese Academy of SciencesBeijing100049China Intervention Center Eastern Hepatobiliary Surgery HospitalThe Third Affiliated Hospital of Naval Medical UniversityShanghai200438China school of Health sciences and Biomedical engineering Hebei University of TechnologyTianjin300130China

Malignant obstruction makes gallbladder cancer have a high mortality ***-titanium alloy(nitinol)stents are commonly used as a local intervention to maximize patient survival time,but the stents lack antitumor and antibacterial capacity and are vulnerable to secondary ***-based drugs show good therapeutic promise against gallbladder *** meet clinical *** layered double hydroxides(LDHs)film is constructed on the nitinol,whose arsenite loading amounts rose by 60%after simple heat treatment compared with the conventional anion-exchange *** addition,calcination promotes the dissolution of nickel ions from the LDHs lattice,resulting in a powerful synergistic killing effect on tumor cells together with the released *** importantly,the calcined arsenic-loaded LDHs are sensitive to the acidic microenvironment of tumor tissues,which presents a much lower arsenic and nickel release amount in the normal tissues,guaranteeing its ***,the vertically sharp LDHs nanosheets can synergize with arsenic to achieve effective physical cleavage and chemical killing of adherent and planktonic *** short,we attempt to use arsenic drugs for local interventions and reasonably avoid their toxic side effects,which provides a new design idea for nitinol stents applied in the treatment of gallbladder cancer.

关键词： Nitinol Layered double hydroxides Arsenic Gallbladder cancer

Fibroblast growth factor 21 inhibits ferroptosis following spinal cord injury by regulating heme oxygenase-1

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Neural Regeneration Research 2024年第7期19卷 1568-1574页

作者： Qi Gu Weiping sha Qun Huang jin Wang Yi Zhu Tianli Xu Zhenhua Xu Qiancheng Zhu jianfei ge shoujin Tian Xiaolong Lin Department of Orthopaedic surgery Zhangjiagang Hospital Affiliated to Soochow UniversitySuzhouJiangsu ProvinceChina Orthopedics Laboratory The First People’s Hospital of Zhangjiagang CitySuzhouJiangsu ProvinceChina Department of Anesthesiology Zhangjiagang Hospital Affiliated to Soochow UniversitySuzhouJiangsu ProvinceChina

Interfering with the ferroptosis pathway is a new strategy for the treatment of spinal cord *** growth factor 21 can inhibit ferro ptosis and promote neurofunctional recovery,while heme oxygenase-1 is a regulator of iron and reactive oxygen species *** relationship between heme oxygenase-1and ferroptosis remains controve *** this study,we used a spinal co rd injury rat model to show that the levels of fibroblast growth factor 21 in spinal co rd tissue decreased after spinal cord *** addition,there was a significant aggravation of ferroptosis and a rapid increase in heme oxygenase-1 expression after spinal cord *** r,heme oxygenase-1 aggravated fe rroptosis after spinal cord injury,while fibroblast growth factor 21 inhibited fe rroptosis by downregulating heme ***,the activation of fibroblast growth factor 21 may provide a potential treatment for spinal co rd *** findings could provide a new potential mechanistic explanation for fibroblast growth factor 21 in the treatment of spinal cord injury.

关键词： ferroptosis fibroblast growth factor 21 functional recovery heme oxygenase-1 lipid peroxidation neuron reactive oxygen species spinal cord injury

Ultra-high spatio-temporal resolution imaging with parallel acquisition-readout structured illumination microscopy(PAR-sIM)

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Light(science & Applications) 2024年第6期13卷 1140-1158页

作者： Xinzhu Xu Wenyi Wang Liang Qiao Yunzhe Fu Xichuan ge Kun Zhao Karl Zhanghao Meiling Guan Xin Chen Meiqi Li Dayong jin Peng Xi Department of Biomedical engineering College of Future TechnologyPeking UniversityBeijing100871China Wallace H.Coulter Dept.of Biomedical engineering Georgia Institute of Technology and Emory UniversityAtlanta30332GAUSA National Biomedical Imaging Center Peking UniversityBeijing100871China Department of Biomedical engineering College of EngineeringSouthern University of Science and TechnologyShenzhen518055GuangdongChina Airy Technologies Co. Ltd.Beijing100086China eastern Institute for Advanced study Eastern Institute of TechnologyNingboZhejiang315200China school of Life science Peking UniversityBeijing100871China Institute for Biomedical Materials and Devices(IBMD) Faculty of ScienceUniversity of Technology SydneySydneyNSW2007Australia

structured illumination microscopy(sIM)has emerged as a promising super-resolution fluorescence imaging technique,offering diverse configurations and computational strategies to mitigate phototoxicity during real-time imaging of biological *** efforts to enhance system frame rates have concentrated on processing algorithms,like rolling reconstruction or reduced frame reconstruction,or on investments in costly sCMOs cameras with accelerated row readout *** this article,we introduce an approach to elevate sIM frame rates and region of interest(ROI)coverage at the hardware level,without necessitating an upsurge in camera expenses or intricate ***,parallel acquisition-readout sIM(PAR-sIM)achieves the highest imaging speed for fluorescence imaging at currently available detector *** using the full frame-width of the detector through synchronizing the pattern generation and image exposure-readout process,we have achieved a fundamentally stupendous information spatial-temporal flux of 132.9 MPixels·s^(−1),9.6-fold that of the latest techniques,with the lowest sNR of−2.11 dB and 100 nm ***-sIM demonstrates its proficiency in successfully reconstructing diverse cellular organelles in dual excitations,even under conditions of low signal due to ultra-short exposure ***,mitochondrial dynamic tubulation and ongoing membrane fusion processes have been captured in live COs-7 cell,recorded with PAR-sIM at an impressive 408 *** posit that this novel parallel exposure-readout mode not only augments sIM pattern modulation for superior frame rates but also holds the potential to benefit other complex imaging systems with a strategic controlling approach.

关键词： hardware illumination resolution

Model dependent analysis of D^(+)_(s)→η^(′)l+v_(l) decays in beyond standard model

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Chinese Physics C 2024年第9期48卷 82-95页

作者： s.Mahata M.Mandal H.Mahapatra s.Biswas s.sahoo Department of Physics National Institute of Technology Durgapur Durgapur 713209West BengalIndia

Motivated by the recent experimental results of branching fractions for D^(+)_(s)→η^(′)l+v_(l) decays,which deviate from their sM predictions,we hve investigated these decays in W' model and scalar leptoquark model to determine potential signatures of new physics(NP) in semileptonic charm decays induced by c→(s,d)l+v_(l) *** recent experimental results of branching fractions for semileptonic D meson decays,new coupling parameters are predicted for the aforementioned NP *** fraction,forward-backward asymmetry,and lepton polarization asymmetry are examined by considering the predicted NP coupling *** results of branching fractions in scalar leptoquark model are found very close to the experimental results and exist around the range of 1σ *** presented a comparative study of the NP models to check their sensitivity on these *** anticipate that further research on these decays will significantly support our findings.

关键词： charm decay new physics W′boson scalar leptoquark flavour changing charged current

saturation estimation with Complex electrical Conductivity for Hydrate-Bearing Clayey sediments:An experimental study

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journal of Ocean University of China 2024年第1期23卷 173-189页

作者： XING Lanchang ZHANG shuli ZHANG Huanhuan WU Chenyutong WANG Bin LAO Liyun WeI Wei HAN Weifeng WeI Zhoutuo ge Xinmin DeNG shaogui College of Control science and engineering China University of Petroleum(East China)Qingdao 266580China school of Water Energy and EnvironmentCranfield UniversityCranfield MK430ALUnited Kingdom Department of Alternative energy PetroChina Research Institute of Petroleum Exploration&DevelopmentLangfang 065007China school of geosciences China University of Petroleum(East China)Qingdao 266580China Laboratory for Marine Mineral Resources Qingdao National Laboratory for Marine Science and TechnologyQingdao 266071China

Clays have considerable influence on the electrical properties of hydrate-bearing *** is desirable to understand the electrical properties of hydrate-bearing clayey sediments and to build hydrate saturation(s_(h))models for reservoir evaluation and *** electrical properties of tetrahydrofuran-hydrate-bearing sediments with montmorillonite are characterized by complex conductivity at frequencies from 0.01 Hz to 1 *** effects of clay and sh on the complex conductivity were analyzed.A decrease and increase in electrical conductance result from the clay-swelling-induced blockage and ion migration in the electrical double layer(eDL),*** quadrature conductivity increases with the clay content up to 10%because of the increased surface site density of counterions in *** the in-phase conductivity and quadrature conductivity decrease consistently with increasing sh from 0.50 to *** sets of models for sh evaluation were *** model based on the simandoux equation outperforms Archie’s formula,with a root-mean-square error(e_(RMs))of 1.8%and 3.9%,respectively,highlighting the clay effects on the in-phase *** fre-quency effect correlations based on in-phase and quadrature conductivities exhibit inferior performance(e_(RMs)=11.6%and 13.2%,re-spectively)due to the challenge of choosing an appropriate pair of frequencies and intrinsic uncertainties from two *** second-order Cole-Cole formula can be used to fit the complex-conductivity *** pair of inverted Cole-Cole parameters,i.e.,characteristic time and chargeability,is employed to predict s_(h) with an e_(RMs) of 5.05%and 9.05%,respectively.

关键词： gas hydrate complex electrical conductivity hydrate-bearing clayey sediment hydrate saturation simandoux equation frequency dispersion Cole-Cole formula

Targeting AsIC1a Promotes Neural Progenitor Cell Migration and Neurogenesis in Ischemic stroke

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Research 2024年第1期2023卷 369-387页

作者： Hongfei ge Tengyuan Zhou Chao Zhang Yupeng Cun Weixiang Chen Yang Yang Qian Zhang Huanhuan Li jun Zhong Xuyang Zhang Hua Feng Rong Hu Department of Neurosurgery and Key Laboratory of Neurotrauma Southwest HospitalThird Military Medical University(Army Medical University)400038 ChongqingChina Medical Research Center Southwest HospitalThird Military Medical University(Army Medical University)400038 ChongqingChina Pediatric Research Institute Ministry of Education Key Laboratory of Child Development and DisordersNational Clinical Research Center for Child Health and DisordersChildren’s Hospital of Chongqing Medical University400014 ChongqingChina

Cell replacement therapy using neural progenitor cells(NPCs)has been shown to be an effective treatment for ischemic ***,the therapeutic effect is unsatisfactory due to the imbalanced homeostasis of the local microenvironment after *** acidosis is a common imbalanced homeostasis in the penumbra and could activate acid-sensing ion channels 1a(AsIC1a),a subunit of proton-gated cation channels following ischemic ***,the role of AsIC1a in NPCs post-ischemia remains ***,our results indicated that AsIC1a was expressed in NPCs with channel functionality,which could be activated by extracellular *** evidence revealed that AsIC1a activation inhibited NPC migration and neurogenesis through RhoA signaling-mediated reorganization of filopodia formation,which could be primarily reversed by pharmacological or genetic disruption of *** vivo data showed that the knockout of the AsIC1a gene facilitated NPC migration and neurogenesis in the penumbra to improve behavioral recovery after stroke.

关键词： AsIC1a homeostasis inhibited

Hierarchical self-assembly of Atomically Precise Au Nanoclusters with Molecular Rotor-based Ligands

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Chemical Research in Chinese Universities 2024年第4期40卷 670-674页

作者： WANG Guanzhong LU Hui LI jiang WANG Lihua ZHU Ying sONG shiping ge Zhilei LI Qian CHeN jing FAN Chunhai Division of Physical Biology Shanghai Institute of Applied PhysicsChinese Academy of SciencesShanghai201800P.R.China University of Chinese Academy of sciences Beijing100049P.R.China Zhangjiang Laboratory Shanghai201210P.R.China Institute of Materiobiology Department of ChemistryCollege of SciencesShanghai UniversityShanghai200444P.R.China school of Chemistry and Chemical engineering New Cornerstone Science LaboratoryFrontiers Science Center for Transformative MoleculesZhangjiang Institute for Advanced Study and National Center for Translational MedicineShanghai Jiao Tong UniversityShanghai200240P.R.China

The hierarchical assemblies of precise nanoparticles(NPs)have created materials with emergent properties and ***,the complex assemblies remain unclear at a precise ***,we show the hierarchical self-assembly of atomically precise gold nanoclusters(Au NCs)with molecular rotor-based ligands(MRL),featuring a double-layer *** to two other types of monolayer-protected(MLP)Au NCs,the significantly reduced surface density for MRL Au NCs profoundly influences their assembly behavior within the ***,the long length of rotor-based ligands and the rotational freedom of the phenyl-rings of rotor-based ligands also facilitate the assembly of *** works elucidate the hierarchical assembly on a precise scale,suggesting that the rotor-based ligand’s strategy offers promising potential for designing well-defined and more complex structures in supercrystals.

关键词： Gold nanocluster Molecular rotor Hierarchical assembly Double-layer surface