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Prospective study to evaluate the prognostic value of different nutritional assessment scores in liver surgery: NURIMAS Liver (DRKS00006340)

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Hepatobiliary Surgery and Nutrition 2020年第4期9卷 400-413页

作者： Pascal Probst Juri Fuchs Michael R.Schön Georgios Polychronidis Christos Stravodimos Arianeb Mehrabi markus K.Diener Philipp Knebel markus w.büchler Katrin Hoffmann Department of General Visceral and Transplantation SurgeryUniversity of HeidelbergIm Neuenheimer Feld 11069120 HeidelbergGermany Department of General and Visceral Surgery Städtisches Klinikum KarlsruheMoltkestraße 9076133 KarlsruheGermany

background:Malnutrition is recognised as a preoperative risk factor for patients undergoing hepatic *** is important to identify malnourished patients and take preventive therapeutic action before ***,there is no evidence regarding which existing nutritional assessment score(NAS)is best suited to predict outcomes of liver ***:All patients scheduled for elective liver resection at the surgical department of the University Hospital of Heidelberg and the Municipal Hospital of Karlsruhe were screened for *** NASs were calculated before operation,and patients were categorised according to each score as being either at risk or not at risk for *** association of malnutrition according to each score and occurrence of at least one major complication was the primary endpoint,which was achieved using a multivariate logistic regression analysis including established risk factors in liver surgery as ***:The population consisted of 182 *** percentage of patients deemed malnourished by the NAS varied among the different scores,with the lowest being 2.20%(Mini Nutritional Assessment)and the highest 52.20%(Nutritional Risk Classification).Forty patients(22.0%)had a major *** of the scores were significantly associated with major ***:None of the twelve investigated NAS defined a state of malnutrition that was independently associated with postoperative *** means of measuring malnutrition in liver surgery should be investigated prospectively.

关键词： Malnutrition liver surgery hepatic resection nutritional assessment

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胰腺癌外科

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临床外科杂志 2010年第9期18卷 577-581页

作者： Thilo Hackert 王剑明 markus w. btichler Jens werner 德国海德堡大学附属医院欧洲肝胆胰外科中心华中科技大学同济医学院附属同济医院胆胰外科及腔镜外科中心

胰腺癌是人类最有侵犯性的实体肿瘤之一,其治疗仍然面临挑战,切除术是唯一的潜在性治愈方法 ,切除后的5年生存率大约为25%.在过去的数十年,由于手术技术和围手术期管理的发展,胰腺外科已经有了翻天覆地的变化.经典的whipple术式于上世... 详细信息

胰腺癌是人类最有侵犯性的实体肿瘤之一,其治疗仍然面临挑战,切除术是唯一的潜在性治愈方法 ,切除后的5年生存率大约为25%.在过去的数十年,由于手术技术和围手术期管理的发展,胰腺外科已经有了翻天覆地的变化.经典的whipple术式于上世纪70年代被修改,提出保留幽门,这种改良被广泛接受.除外胰头和十二指肠切除,应提出一个标准化的淋巴结清扫术,这包括切除肝十二指肠韧带,清扫沿肝总动脉,门静脉,肠系膜上静脉头盖部分,腹腔干右侧,沿肠系膜上动脉右侧淋巴结.更大范围的淋巴结清扫术没有意义.切除一旦完成,术中冰冻切片送检,以确保剩余胰腺和胆管切缘无瘤组织.胰十二指肠切除术后重建中至关重要的一步是胰肠吻合术,我们开展了一种端侧双层胰管空肠缝合技术,使胰瘘率低于3.5%.胆管重建也应标准化.长期生存率表明门静脉或肠系膜上静脉切除具有潜在治愈性.辅助治疗可以提高生存期.作为对比,肿瘤浸润肠系膜上动脉,腹腔干或肝动脉是胰腺癌不能切除的标准,这一观念已被接受.但是,动脉肿瘤粘附并不意味着已经浸润,因动脉壁较静脉壁更有保护性.最近的一份回顾分析报道,在联合门静脉或肠系膜上静脉切除的胰腺手术中,15%同步实施动脉切除,尽管他们的肿瘤学价值有待商榷.远端胰腺切除后胰瘘仍然是我们所要面临的问题,我们自2009年2月,开展了一项由21个欧洲机构参与,360例患者组成的多中心随机对照研究,以比较锐性切除后残端缝合封闭与订书机式切除.在良性胰腺疾病或IPMN中,若脾脏血管未被累及,可实施脾脏保留的远端胰腺切除术.有不断积累的证据表明腔镜下行远端胰腺切除有良好的效果.根据肿瘤学观点,广泛的主胰管IPMN,有癌变进展的IPMN,常见的或多病灶的胰腺癌,胰腺有多发转移是全胰腺切除的指征.大约35%的胰腺癌侵及邻近器官.我们的结论是,胰腺癌患者实施多脏器联合切除术的长期生存率与标准切除术相似.扩大切除包括结肠系膜,结肠,肾上腺,肝脏,胃.因此,为获得治愈性切除,对波及邻近器官的肿瘤实施扩大切除术是正确的.对胰腺癌局部复发的病患,最近的研究支持＂只要有可能,即实施外科探查和切除＂的概念.这种方法可与术中放疗联合进行.为得到最佳结局,多学科的序贯治疗非常有必要.

关键词：胰腺癌标准外科程序长期生存

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Small and simple:next-generation miniaturized diffraction-based spectrometer with computational reconstruction algorithms

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Light(Science & Applications) 2024年第6期13卷 1008-1011页

作者： markus Suta Inorganic Photoactive Materials Faculty of Mathematics and Natural SciencesHeinrich Heine University DusseldorfDusseldorfGermany

An ultra-simple and miniaturized spectrometer using an arbitrarily shaped pinhole as diffraction element reconstructs a broadband spectrum from the information of diffraction of monochromatic radiation by clever computational reconstruction *** circumvents complex calibration procedures and paves the way to cost-effective on-chip spectrometers combining fast acquisition without significant loss in spectral resolution.

关键词： arbitrarily shaped element

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Embracing substrate multispecificity in plant AbC transporters

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Molecular Plant 2024年第7期17卷 990-992页

作者： markus M.Geisler Department of biology University of Fribourg1700 FribourgSwitzerland

by analogy,the first plant ATP-binding cassette(AbC)transporters were identified as vacuolar detoxifiers transporting glutathione conjugates into the vacuole(Martinoia et al.,1993).This somewhat negative image as"unspecific detoxifiers"still clings to plant AbC transporters today,although they have since been described to be involved in completely different programs,including development and defense(Park et al.,2017).In this context,some key plant AbC transporters have been shown to own exceptionally high substrate *** example,the transporter of the native auxin indole-3-acetic acid(IAA),Arabidopsis AbCb1,has been shown to also export the synthetic auxin 1-naphtaleneacetic acid but is even able to distinguish this substrate from its structural isomer,2-naphtaleneacetic acid(Geisler et al.,2005).Likewise,AbCG36 and AbCG37,which are known to have a broader substrate portfolio(Park et al.,2017;Aryal et al.,2023),export IbA but do not touch IAA(Aryal et al.,2023).Recently,several reports have challenged our current view on the reported high substrate specificity of plant AbCs,which requires clarification.

关键词： specificity analogy exceptional

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Two hits are better than one:rational dual strategy efficiently fights neuroblastoma

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Signal Transduction and Targeted Therapy 2024年第5期9卷 1802-1804页

作者： Jacques Zimmer Camille Rolin markus Ollert Department of Infection and Immunity Luxembourg Institute of HealthEsch-sur-AlzetteLuxembourg University of Luxembourg Esch-sur-AlzetteLuxembourg Department of Dermatology and Allergy Center Odense Research Center for Anaphylaxis(ORCA)University of Southern DenmarkOdenseDenmark

The recently published landmark paper by bergaggio et *** Roberto Chiarle’s group in Cancer Cell1 investigates an elegant double-hit strategy to improve anti-cancer *** important approach demonstrates in a preclinical model that chimeric antigen receptor(CAR)-T cell treatment can be rendered more efficient by increasing the cell surface expression of the CAR target structure via a small molecule.

关键词： neuroblastoma Cancer

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Linking IL-10 signaling with lipid metabolic programs in macrophages:dysregulated ceramide homeostasis drives colitis

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Signal Transduction and Targeted Therapy 2024年第7期9卷 2835-2836页

作者： Imke Atreya markus F.Neurath Department of Medicine 1 University Hospital of ErlangenFriedrich-Alexander University Erlangen-NürnbergErlangenGermany Deutsches Zentrum Immuntherapie(DZI) ErlangenGermany

In a recent study published in Nature,York and coworkers identified the immunometabolic regulation of mono-unsaturated fatty acid(MUFA)pools and the subsequent increase in sphingolipid biosynthesis in TLR2-activated macrophages as an important link between impaired IL-10 signaling and the development of intestinal inflammation.1 Thus,targeted interference with the newly identified IL-10/MUFA/sphingolipid axis appears as a promising strategy to restore immunometabolic homeostasis in the intestine of patients with inflammatory bowel diseases(IbD).

关键词： homeostasis impaired intestine

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Compressive property and energy absorption characteristic of interconnected porous Mg-Zn-Y alloys with adjusting Y addition

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Journal of Magnesium and Alloys 2024年第1期12卷 171-185页

作者： J.A.Liu S.J.Liu b.wang w.b.Sun X.J.Liu Z.w.Han College of Materials Science and Engineering Key Laboratory of Automobile Materials(Ministry of Education)Jilin UniversityChangchun 130022PR China Key Laboratory of bionic Engineering(Ministry of Education) College of Biological and Agricultural EngineeringJilin UniversityChangchun130022PR China weihai Institute for bionics-Jilin University Weihai 264205PR China

In this study,interconnected porous Mg-2Zn-xY alloys with different phase compositions were prepared by various Y additions(x=0.4,3,and 6 wt.%)to adjust the compressive properties and energy absorption *** characterization methods were then applied to identify the microstructure of the porous Mg-Zn-Y and describe the details of the second *** tests were performed at room temperature(RT),200℃,and 300℃to study the impact of the Y addition and testing temperature on the compressive properties of the porous *** experimental results showed that a high Y content promotes a microstructure refinement and increases the volume fraction of the second *** the Y content increases,different Mg-Zn-Y ternary phases appear:I-phase(Mg_(3)Zn_(6)Y),w-phase(Mg_(3)Zn_(3)Y_(2)),and LPSO phase(Mg_(12)ZnY).when the Y content ranges between 0.4%and 6%,the compressive strength increases from 6.30MPa to 9.23 MPa,and the energy absorption capacity increases from 7.33 MJ/m^(3)to 10.97 MJ/m^(3)at RT,which is mainly attributed to the phase composition and volume fraction of the second ***,the average energy absorption efficiency is independent of the Y *** addition,the compressive deformation behaviors of the porous Mg-Zn-Y are altered by the testing *** compressive strength and energy absorption capacity of the porous Mg-Zn-Y decrease due to the softening effect of the high temperature on the *** deformation behaviors at different temperatures are finally observed to reflect the failure mechanisms of the struts.

关键词： Porous magnesium Rare earth elements Microstructure Compressive behavior Energy absorption characteristic

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Probing the bardeen-Kiselev black hole with the cosmological constant caused by Einstein equations coupled with nonlinear electrodynamics using quasinormal modes and greybody bounds

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Communications in Theoretical Physics 2024年第6期76卷 102-119页

作者： S R wu b Q wang Z w Long College of Physics Guizhou UniversityGuiyang 550025China College Pharmacy Guizhou University of Traditional Chinese MedicineGuiyang 550025China

In this work,we investigate a static and spherically symmetric bardeen-Kiselev black hole(bH)with the cosmological constant,which is a solution of the Einstein-non-linear Maxwell field *** compute the quasinormal frequencies for the bardeen-Kiselev bH with the cosmological constant due to electromagnetic and gravitational *** varying the bH parameters,we discuss the behavior of both real and imaginary parts of the bH quasinormal frequencies and compare these frequencies with the Reissner-Nordström-de Sitter bH surrounded by quintessence(RN-dSQ).Interestingly,it is shown that the responses of the bardeen-Kiselev bH with the cosmological constant and the RN-dSQ under electromagnetic perturbations are different when the charge parameter q,the state parameter w and the normalization factor c are varied;however,for the gravitational perturbations,the responses of the bardeen-Kiselev bH with the cosmological constant and the RN-dSQ are different only when the charge parameter q is ***,compared with the gravitational perturbations,the electromagnetic perturbations can be used to understand nonlinear and linear electromagnetic fields in curved spacetime *** interesting observation is that,due to the presence of Kiselev quintessence,the electromagnetic perturbations around the bardeen-Kiselev bH with the cosmological constant damps faster and oscillates slowly;for the gravitational perturbations,the quasinormal mode decays slowly and oscillates *** also study the reflection and transmission coefficients along with the absorption cross section in the bardeen-Kiselev bH with the cosmological constant;it is shown that the transmission coefficients will increase due to the presence of Kiselev quintessence.

关键词： quasinormal modes greybody factors bardeen-Kiselev black hole with cosmological constant

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Controlling the reaction network of Ni/silica derived conversion of bio-oil surrogate guaiacol

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Carbon Resources Conversion 2024年第1期7卷 39-60页

作者： Nils Kretzschmar Oliver busse markus Seifert Technische Universität Dresden Faculty of Chemistry and Food Chemistry01062 DresdenGermany

Replacing fossil carbon sources with green bio-oils is a promising route to switch to a sustainable chemical industry,although their high oxygen contents are *** hydrodeoxygenation is a favored route to upgrade bio-oils to renew.ble fuels and basic *** this work,we investigated Ni/SiO2 catalysts with differing metal dispersity in continuous mode conversion of guaiacol with a statistical experimental design for 250℃to 400℃,2 h up to 5 h time on stream(ToS)and subsequently different residence time besides other *** low temperature(250℃)promotes cyclohexanol formation from guaiacol,high temperature(400℃)inhibits hydrogenation,leading to phenol and *** medium temperature(340℃),the selectivity for cyclohexanone *** and cyclohexanone(KA-oil)are the industrial basis for polyamide ***,we clarified the role of 2-methoxycyclohexanol(2MC)in the reaction network towards KA-oil for continuous-mode *** analysis was used to predict and optimize product selectivity and yield,leading to the best yield of cyclohexanone/-ol at 327.5℃,low ToS,medium residence time,high particle dispersity,and medium hydrogen pressure(15 bar(g)).

关键词： Hydrodeoxygenation Design of experiments bio-oil Nickel silica catalyst Continuous mode flow reactor KA-oil Cyclohexanol Cyclohexanone

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Semi-analytical calculation model for friction of polymers on the example of POM|PE-UHMw and steel|PE-UHMw

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Friction 2024年第10期12卷 2355-2369页

作者： André bERGMANN Jens SUMPF Niels DALLINGER Martin MONEKE markus GOLDER Professorship of Conveying Engineering and Materials Handling Chemnitz University of TechnologySachsen 09126Germany Institute of Plastics Engineering Darmstadt University of Applied SciencesDarmstadt 64295Germany

In this paper,a semi-analytical calculation model for the coefficient of friction(COF)of single spherical protrusions is *** allows the prediction of the deformative friction part(μ_(def))and adhesive friction part(μ_(def))of the friction pairings steel|polyethylene with ultra-high molecular weight(PE-UHMw)and polyoxymethylene(POM)|*** experimental studies included unlubricated friction tests,which served to determine the total COF(μ_(def)),as well as tests being lubricated with silicone oil,from whichμ_(def)is *** on the verification tests,it could be shown that both states of lubrication result in the same deformation and that the relationship between the rear angle(w)andμ_(def)postulated in the calculation model is ***,friction tests with segmented spheres were carried out,which allow a specific variation of *** can be concluded that for both pairings theμ_(def)is generally of minor significance(approx.1/3μ_(tot))and the influence of theμ_(adh)predominates(approx.2/3μ_(tot))the friction *** themtot decreases with increasing contact pressure especially in the low pressure range and depends on the form of motion(continuous and discontinuous).

关键词： tribology friction polymers model contact polyoxymethylene(POM) polyethylene with ultra-high molecular weight(PE-UHMw)

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