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A statistical model for the design of rotary HTS flux pumps based on deep-learning neuron network

Superconductivity 2022年第3期3卷 46-54页

作者： Zezhao Wen Hongye Zhang Mengyuan Tian Francesco Grilli markus mueller a School of Engineering University of EdinburghEdinburgh EH93JLUnited Kingdom School of Engineering University of ManchesterManchester M13BBUnited Kingdom Engineering Department University of CambridgeCambridge CB30FAUnited Kingdom Institute for Technical Physics Karlsruhe Institute of TechnologyKarlsruhe 76131Germany

Rotory high temperature superconducting(HTS)flux pumps can consistently generate a DC voltage by rotating magnets over superconducting tapes,and thus energize the circuit if a closed loop is *** voltage output is a crucial factor to reflect the performance of such an HTS flux pump,which is determined by a set of design specifications,and some of them have been investigated extensively in the current ***,no work has been done yet to study the HTS dynamo output voltage by efficiently integrating all the design parameters *** this paper,a well‐trained deep‐learning neuron network(DNN)with back‐propagation algorithms has been put forward and *** proposed DNN is capable of quantifying the output voltage of an HTS dynamo instantly with an overall accuracy of approximately 98%with respect to the simulated values with all design parameters explicitly *** model possesses a powerful ability to characterize the output behavior of HTS dynamos by considering multiple design parameters,e.g.,airgap,superconductor tape width,operating frequency,remanent flux density,rotor radius,and permanent magnet width,which have covered all the typical design *** output characteristics of an HTS dynamo against each of the design parameters have been successfully demonstrated using this *** to conventional time‐consuming finite element method(FEM)based numerical models,the proposed DNN model has the advantages of automatic learning,fast computation,as well as strong *** the DNN model can greatly facilitate the design and optimization process for HTS *** executable application has been developed accordingly based on the DNN model,which is believed to provide a useful tool for learners and designers of HTS dynamos.

关键词： HTS dynamo Flux pump Deep learning H‐A formulation Output characteristics

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An experimental study of rotational pressure loss in rotor-stator gap

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Propulsion and Power Research 2017年第2期6卷 147-156页

作者： Yew Chuan Chong Dave A.Staton markus A.mueller John Chick Motor Design Limited 4 Scotland Street.Ellesmere SY12 OEGUnited Kingdom Institute for Energy Systems School of Engineering.University of EdinburghThe King's BuildingsEdinburgh EH93DWUnited Kingdom

The annular gap between rotor and stator is an inevitable flow path of a throughflow ventilated electrical machine,but the flow entering the rotor-stator gap is subjected to the effects of *** pressure loss and volumetric flow rate across the rotor-stator gap were measured and compared between rotating and stationary *** experimental measurements found that the flow entering the rotor-stator gap is affected by an additional pressure *** the present study,the rotational pressure loss at the entrance of rotor-stator gap is *** upon dimensional analysis,the coefficient of entrance loss can be correlated with a dimensionless parameter,*** *** investigation leads to an original correlation for the entrance loss coefficient of rotor-stator gap arisen from the Coriolis and centrifugal effects in rotating reference frame.

关键词： Pressure drop Flow network analysis Rotating machinery Rotational pressure drop Rotor-stator gap Annular gap Electrical machines

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用二水硫酸钙促进半水熟石膏的凝结

用二水硫酸钙促进半水熟石膏的凝结

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2010中国建筑材料联合会石膏建材分会成立大会暨第五届全国石膏技术交流大会及展览会

作者： markus mueller Hans-Bertram Fisher Hans-Ulrich Humme Lathar Scheller 沈荣熹德国魏马建筑大学德国可耐福合资公司

在一项研究计划中对人们熟悉的用二水硫酸钙促进半水熟石膏的凝结进行了全面系统的分析,并对其某些方面提供了论据。这一发现可为生产一种工业用的高效促凝剂指明重要的技术途径,为增进此种促凝剂存储的稳定性提供专门的信息,并为改善...

在一项研究计划中对人们熟悉的用二水硫酸钙促进半水熟石膏的凝结进行了全面系统的分析,并对其某些方面提供了论据。这一发现可为生产一种工业用的高效促凝剂指明重要的技术途径,为增进此种促凝剂存储的稳定性提供专门的信息,并为改善其使用性能提出实际的建议

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奥德修纪——2016DMY柏林国际设计节

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流行色 2016年第7期 48-61页

作者：解冰 markus mueller Witte,DMY2016

DMY国际设计节自2003年举办以来,如今是第十四个年头了。DMY是Day、Month、Year（日、月、年）字母的缩写,举办之初,其创始人Joerg Suermann意在将人们每日每月每年的生活和工作中的创意展示出来,DMY因此而得名。今年,2016柏林DMY国际... 详细信息

DMY国际设计节自2003年举办以来,如今是第十四个年头了。DMY是Day、Month、Year（日、月、年）字母的缩写,举办之初,其创始人Joerg Suermann意在将人们每日每月每年的生活和工作中的创意展示出来,DMY因此而得名。今年,2016柏林DMY国际设计节将主题定为奥德修纪,来源于古希腊文学作品《荷马史诗》,为期四天的设计周于六月五日顺利结束。

关键词：奥德修纪 DMY 国际设计古希腊文学《荷马史诗》节将新锐设计设计过程展览场馆主场馆

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Salt Stress Triggers Phosphorylation of the Arabidopsis Vacuolar K＋ Channel TPK1 by Calcium-Dependent Protein Kinases （CDPKs）

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Molecular Plant 2013年第4期6卷 1274-1289页

作者： Andreas Latz Norbert Mehlmer Simone Zapf Thomas D. mueller Bernhard Wurzinger Barbara Pfister Edina Csaszar Rainer Hedrich markus Teige Dirk Becker Department of Molecular Plant Physiology and Biophysics Julius-von-Sachs-lnstitute University of Wurzburg Julius-von-Sachs-Platz 2 D-97082 Wurzburg Germany Department of Biochemistry and Cell Biology Max F. Perutz Laboratories University of Vienna Dr. Bohrgasse 9 A-1030 Vienna Austria Present address: Department of Biology I Botany Munich Center for Integrated Protein Science CiPSM Ludwig-Maximilians-Universitat Munchen D-82152 Planegg-Martinsried Germany College of Science King Saud University Riyadh 11451 Saudi Arabia

14-3-3 proteins play an important role in the regulation of many cellular processes. The Arabidopsis vacuolar two-pore K＋ channel 1 （TPK1） interacts with the 14-3-3 protein GRF6 （GF14-λ）. Upon phosphorylation of the putative binding motif in the N-terminus of TPK1, GRF6 binds to TPK1 and activates the potassium channel. In order to gain a deeper understanding of this 14-3-3-mediated signal transduction, we set out to identify the respective kinases, which regulate the phosphorylation status of the 14-3-3 binding motif in TPK1. Here, we report that the calcium-dependent protein kinases （CDPKs） can phosphorylate and thereby activate the 14-3-3 binding motif in TPK1. Focusing on the stress-activated kinase CPK3, we visualized direct and specific interaction of TPK1 with the kinase at the tonoplast in vivo. In line with its proposed role in K＋ homeostasis, TPK1 phosphorylation was found to be induced by salt stress in planta, and both cpk3 and tpkl mutants displayed salt-sensitive phenotypes. Molecular modeling of the TPK1-CPK3 interaction domain provided mechanistic insights into TPK1 stress-regulated phosphorylation responses and pinpointed two arginine residues in the N-terminal 14-3-3 binding motif in TPK1 critical for kinase interaction. Taken together, our studies provide evidence for an essential role of the vacuolar potassium channel TPK1 in salt-stress adaptation as a target of calcium-regulated stress signaling pathways involving Ca2＋, Ca2＋-dependent kinases, and 14-3-3 proteins.

关键词： potassium channel vacuole calcium calcium-dependent kinase 14-3-3 protein salt stress.

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Huge primitive neuroectodermal tumor of the pancreas:Report of a case and review of the literature

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World Journal of Gastroenterology 2006年第37期12卷 6070-6073页

作者： Thilo Welsch Gunhild Mechtersheimer Sebastian Aulmann Sascha A mueller markus W Buechler Jan Schmidt Peter Kienle Deptartment of Surgery University of Heidelberg INF 110 D-69120 Heidelberg Germany Deptartment of Pathology University of Heidelberg INF 220 D-69120 Heidel- berg Germany

Primitive neuroectodermal tumor (PNET) of the pancreas is an extremely rare tumor that usually occurs in children or young adults. We report a case of a 33-year-old male patient with an 18 cm × 18 cm × 16 cm mass arising from the pancreatic body and tail with a one- day history of abdominal pain. Initial CT scan showed no signs of metastatic tumor spread. The tumor caused intrabdominal bleeding and the patient underwent primary tumor resection including partial gastrectomy, left pancreatic resection and splenectomy. Diagnosis of PNET was confi rmed by histology, immunohistochemistry and FISH analysis. All neoplastic cells were stained positive for MIC2-protein (CD99). Approximately one month after surgery, several liver metastases were observed and the patient underwent chemotherapy according to the Euro- Ewing protocol. Subsequent relaparotomy excluded any residual hepatic or extrahepatic abdominal metastases. Although PNET in the pancreas is an extremely rare entity, it should be considered in the diffential diagnosis of pancreatic masses, especially in young patients. This alarming case particularly illustrates that PNET in the pancreas although in an advanced stage can present with only a short history of mild symptoms.

关键词：胰腺肿瘤腹部疾病肉瘤治疗

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VEGF-D expression correlates with colorectal cancer aggressiveness and is downregulated by cetuximab

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World Journal of Gastroenterology 2008年第26期14卷 4156-4167页

作者： markus Moehler Christian Frings Annett mueller Ines Gockel Carl C Schimanski Stefan Biesterfeld Institute of Pathology Johannes Gutenberg University Mainz 55101 Germany Peter R Galle Martin H Holtmann 1st Department of Medicine Johannes Gutenberg University Mainz 55101 Germany Department of General and Abdominal Surgery Johannes Gutenberg University Mainz 55101 Germany

AIM:To gain mechanistic insights into the role played by epidermal growth factor receptor (EGFR) in the regulation of vascular endothelial growth factors (VEGFs) in colorectal cancer (CRC). METHODS:The impact of high-level expression of the growth factor receptors EGFR and VEGF receptor (VEGFR)3 and the VEGFR3 ligands VEGF-C and VEGF-D on disease progression and prognosis in human CRC was investigated in 108 patients using immunohistochemistry. Furthermore, the expression of the lymphangiogenic factors in response to the modulation of EGFR signalling by the EGFR-targeted monoclonal antibody cetuximab was investigated at the mRNA and protein level in human SW480 and SW620 CRC cell lines and a mouse xenograft model. RESULTS: Human CRC specimens and cell lines displayed EGFR, VEGF-C and VEGF-D expression with varying intensities. VEGF-C expression was associated with histological grade. Strong expression of VEGF-D was significantly associated with lymph node metastases and linked to a trend for decreased survival in lymph node-positive patients. EGFR blockade with cetuximab resulted in a significant decrease of VEGF-D expression in vitro and in vivo. CONCLUSION:In conclusion, the expression of VEGF-D in colorectal tumours is significantly associated with lymphatic involvement in CRC patients and such expression might be blocked effectively by cetuximab.

关键词：结肠直肠癌淋巴管X射线血管内皮细胞生长因子 VEGF-D 基因表达

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