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Development and assessment of a cutaneous tissue stretch device as a novel scar therapy

Plastic and Aesthetic Research 2016年第1期3卷 351-358页

作者： Jonathan Kanevsky Joshua Vorstenbosch Julian Diaz-Abele Tyler Safran markus prinz Youssef Tahiri Mirko Gilardino Satya Prakash Division of Plastic and Reconstructive Surgery McGill University Health CentreMontrealQC H3G 1B3Canada Section of Plastic and Reconstructive Surgery University of ManitobaWinnipegMB R3T 2N2Canada McGill Medical School McGill UniversityMontrealQC H3G 2M1Canada Division of General Surgery University of SherbrookeSherbrookeQC J1K 2R1Canada Division of Plastic and Reconstructive Surgery Indiana UniversityIndianapolisIN 46202USA Biomedical Engineering Department Artificial Cells and Organs Research CentreMontrealQC H3A 2B4Canada

Aim:Scar prevention and reduction is an area of therapeutic opportunity and unmet medical *** no current effective scar therapy,patients are often disappointed in their appearance post surgery and re-present to surgeons,only to be turned *** purpose of this study was to develop and test a device that produces intermittent parallel stretch on new scars and to analyze its potential to reduce ***:Mice were randomized into 5 scar stretch treatment groups:1 control,1 sham,and 3 stretch models(0.5×,1×,or 2×device strength)and treated for 10 *** were scored using the Vancouver Scar *** tissue samples were compared by histology and transforming growth factor beta 1(TGF-β1)expression between control and treatment ***:Scar scores of 0.5×and 1×groups were significantly lower than the control group(P<0.05).Scar scores from the 1×treatment group were also significantly lower than the 0.5×group(P<0.05).Sham,control scar and 2×groups showed more collagen deposition and a thicker dermal scar than the 0.5×and 1×*** scars had fewer fibroblasts with more collagen deposition than the 0.5×and 2×***-β1 levels were significantly lower in the 0.5×(342.1±9.2)and 1×(254.1±3.1)groups than in the control group(P<0.05).TGF-β1 levels in the 1×treatment group were also significantly lower than the 0.5×treatment group(P<0.05).Conclusion:Intermittent cutaneous tissue stretch parallel to scars during the proliferative phase of wound healing decreases fibrosis on a macroscopic,microscopic and biochemical level.

关键词： Mechanotransduction scar therapy hypertrophic scar skin stretch

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