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Radioembolization for neuroendocrine liver metastases is safe and effective prior to major hepatic resection

Hepatobiliary Surgery and Nutrition 2020年第3期9卷 312-321页

作者： Florian Bosch Harun Ilhan Vanessa Pfahler Michael Thomas Thomas Knosel Valentin Eibl Sebastian Pratschke Peter Bartenstein Max Seidensticker Christoph J.Auernhammer Christine Spitzweg markus o.guba Jens Werner Martin K.Angele Department of General Visceraland Transplant SurgeryLudwig-Maximilians-University MunichMunichGermany Interdisciplinary Center of Neuroendocrine Tumors of the Gastro Entero Pancreatic System Ludwig-Maximilians-University MunichMunichGermany Department of Nuclear Medicine University HospitalLudwig-Maximilians-University MunichMunichGermany Department of Radiology Ludwig-Maximilians-University MunichMunichGermany Institute of Pathology Ludwig-Maximilians-University MunichMunichGermany Department of Internal Medicine 4 Ludwig-Maximilians-University MunichMunichGermany

Background:Radioembolization(RE)is well established in the treatment of neuroendocrine liver *** surgery is rarely performed after RE,although liver resection is the gold standard in the treatment of localized neuroendocrine liver ***,aim of the present study was to evaluate the safety and feasibility of liver resection after RE in a homogenous ***:From a prospective surgical(n=494)and nuclear medical(n=138)database patients with NELM who underwent liver resection and/or RE were *** September 2011 and December 2017 eight patients could be identified who underwent liver resection after RE(mean therapeutic activity of 1,746 Mbq).overall and progression free survival were evaluated as well as epidemiological and perioperative *** surgical specimens were analyzed for necrosis,fibrosis,inflammation,and ***:The mean hepatic tumor load of patients,who had liver surgery after RE,was 31.4%with a mean Ki-67 proliferation index of 5.9%.The majority of these patients(7/8)received whole liver RE prior to liver resection,which did not increase morbidity and mortality compared to a surgical *** for RE were oncological(6/8)or carcinoid syndrome associated reasons(2/8).Mean overall survival was 25.1 months after RE and subsequent *** necrosis in radioembolized lesions was 29.4%without evidence of fibrosis and inflammation in hepatic ***:This is the first study analyzing the multimodal therapeutic approach of liver resection following whole liver *** treatment algorithm is safe,does not lead to an increased morbidity and is associated with a favorable oncological ***,patient selection remains a key issue.

关键词： Radioembolization(RE) neuroendocrine tumor liver surgery

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Pancreatic panniculitis and elevated serum lipase in metastasized acinar cell carcinoma of the pancreas: A case report and review of literature

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World Journal of Clinical Cases 2020年第21期8卷 5304-5312页

作者： Rainer Christoph Miksch Tobias S Schiergens Maximilian Weniger Matthias Ilmer Philipp M Kazmierczak markus o.guba Martin K Angele Jens Werner Jan G D'Haese Department of General Visceraland Transplantation SurgeryLudwig-Maximilians-University MunichMunich 81377BavariaGermany Department of General Visceral Transplantat Vasc&Thorac Surg Campus GrosshadernUniversity of MunichMunich 81377Germany Department of General Ludwig Maximilians-University(LMU)Munich 81377Germany Department of Radiology Ludwig-Maximilians-University MunichMunich 81377Germany Department of Surgery University of MunichKlinikum GrosshadernMunich University HospitalMunich 81377Germany Department of General University of MunichKlinikum GrosshadernHospital of the University of MunichMunich 81377Germany Department of General Klinikum Univ MunchenKlin Allgemeine Viszeral Transplantat Gefass&ThStandort GrosshadernLudwig-Maximilians-University(LMU)Munich 81377Germany

BACKGRoUND Pancreatic panniculitis is an extremely rare condition associated with different underlying pancreatic disorders and characterized by subcutaneous fat necrosis induced by elevated serum lipase *** lesions usually affect the lower extremities and may precede abdominal symptoms of pancreatic *** cell carcinoma(ACC)of the pancreas is a rare pancreatic neoplasm,accounting for only 1%-2%of pancreatic tumors in *** present the case of a 72-year-old man with ACC of the pancreatic head and synchronous liver *** the primary tumor and liver metastases were *** lipase was elevated before surgery and decreased to normal *** serum lipase levels at follow-up led to the diagnosis of hepatic *** disease progression was then accompanied by pancreatic panniculitis,with subcutaneous fat necrosis and acute *** the best of our knowledge,only 4 cases have been reported in the literature and each showed a similar association of serum lipase levels with pancreatic panniculitis and progression of *** Clinical symptoms and progression of ACC may correlate with serum lipase levels,suggesting potential usefulness as a follow-up biomarker.

关键词： Pancreatic panniculitis Lipase Acinar cell carcinoma Pancreatic cancer Case report

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Evaluating grant proposals:lessons from using metrics as screening device

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数据与情报科学学报:英文版 2023年第2期8卷 66-92页

作者： Katerina guba Alexey Zheleznov Elena Chechik Center for Institutional Analysis of Science and Education European University at Saint PetersburgGagarinskaya 6/1A Saint Petersburg 191178Russian Federation

Purpose:This study examines the effects of using publication-based metrics for the initial screening in the application process for a project *** key questions are whether formal policy affects the allocation of funds to researchers with a better publication record and how the previous academic performance of principal investigators is related to future project ***/methodology/approach:We compared two competitions,before and after the policy raised the publication threshold for the principal *** analyzed 9,167 papers published by 332 winners in physics and the social sciences and humanities(SSH),and 11,253 publications resulting from each funded ***:We found that among physicists,even in the first period,grants tended to be allocated to prolific authors publishing in high-quality *** contrast,the SSH project grantees had been less prolific in publishing internationally in both periods;however,in the second period,the selection of grant recipients yielded better results regarding awarding grants to more productive authors in terms of the quantity and quality of *** was no evidence that this better selection of grant recipients resulted in better publication records during grant ***:This study contributes to the discussion of formal policies that rely on metrics for the evaluation of grant *** Russian case shows that such policy may have a profound effect on changing the supply side of applicants,especially in disciplines that are less suitable for metric-based *** spite of the criticism given to metrics,they might be a useful additional instrument in academic systems where professional expertise is corrupted and prevents allocation of funds to prolific researchers.

关键词： Grant funding Research evaluation Publication-based metrics Funding allocation

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High rate of complete histopathological response in hepatocellular carcinoma patients after combined transarterial chemoembolization and stereotactic body radiation therapy

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World Journal of Gastroenterology 2021年第24期27卷 3630-3642页

作者： Ulrike Bauer Sabine Gerum Falk Roeder Stefan Münch Stephanie E Combs Alexander B Philipp Enrico N De Toni Martha M Kirstein Arndt Vogel Carolin Mogler Bernhard Haller Jens Neumann Rickmer F Braren Marcus R Makowski Philipp Paprottka markus guba Fabian Geisler Roland M Schmid Andreas Umgelter Ursula Ehmer Internal Medicine Ⅱ Klinikum rechts der IsarTechnical University of MunichMunich 81675Germany Department of Radiotherapy and Radiation oncology University of SalzburgSalzburg 5020Austria Department of Radiation oncology University Hospital of MunichCampus GroßhadernLMU MunichMunich 81377Germany Department of Radiation oncology Klinikum rechts der IsarTechnical University of MunichMunich 81675Germany Department of Medicine II Liver CentreUniversity HospitalLMU MunichMunich 81377Germany Department of Gastroenterology Hepatology and EndocrinologyHannover Medical SchoolHannover 30625Germany Institute of Pathology Technical University of MunichMunich 81675Germany Institute of Medical Informatics Statistics and EpidemiologyKlinikum rechts der IsarTechnical University of MunichMunich 81675Germany Institute of Pathology Faculty of MedicineUniversity Hospital of MunichMunich 81377Germany Institute of Diagnostic and Interventional Radiology Klinikum rechts der IsarTechnical University of MunichMunich 81675Germany Institute of Diagnostic and Interventional Radiology Section for Interventional RadiologyKlinikum rechts der IsarTechnical University of MunichMunich 81675Germany Department of General- Visceral-Vascular-and Transplant-SurgeryUniversity hospital of MunichCampus GroßhadernLMU MunichMunich 81377Germany Emergency Department Vivantes hospital groupHumboldt hospitalBerlin 13509Germany

BACKGRoUND Liver transplantation(LT)presents a curative treatment option in patients with early stage hepatocellular carcinoma(HCC)who are not eligible for resection or ablation *** to a risk of up 30%for waitlist drop-out upon tumor progression,bridging therapies are used to halt tumor *** chemoembolization(TACE)and less commonly stereotactic body radiation therapy(SBRT)or a combination of TACE and SBRT,are used as bridging therapies in ***,it remains unclear if one of those treatment options is *** analysis of explant livers after transplantation provides the unique opportunity to investigate treatment response by *** To analyze histopathological response to a combination of TACE and SBRT in HCC in comparison to TACE or SBRT *** In this multicenter retrospective study,27 patients who received liver transplantation for HCC were *** received either TACE or SBRT alone,or a combination of TACE and SBRT as bridging therapy to liver *** explants of all patients who received at least one TACE and/or SBRT were analyzed for the presence of residual vital tumor tissue by histopathology to assess differences in treatment response to bridging *** analysis was performed using Fisher-Freeman-Halton exact test,Kruskal-Wallis and Mann-Whitney-U *** Fourteen patients received TACE only,four patients SBRT only,and nine patients a combination therapy of TACE and *** were no significant differences between groups regarding age,sex,etiology of underlying liver disease or number and size of tumor ***,analysis of liver explants revealed that almost all patients in the TACE and SBRT combination group(8/9,89%)showed no residual vital tumor tissue by histopathology,whereas TACE or SBRT alone resulted in significantly lower rates of complete histopathological response(0/14,0%and 1/4,25%,respectively,P valueoNCLUSIoN our data suggests th

关键词： Hepatocellular carcinoma Transarterial chemoembolization Stereotactic body radiation therapy Bridging therapy Liver transplantation

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Physical Limits of Computation

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Journal of Quantum Information Science 2017年第4期7卷 155-159页

作者： Tibor guba László Nánai Thomas F. George Department of optics and Quantum Electronics University of Szeged Szeged Hungary Department of Experimental Physics University of Szeged Szeged Hungary Department of Chemistry and Physics University of Missouri-St. Louis St. Louis MO USA

The paper deals with theoretical treatment of physical limits for computation. We are using some statements on base of min energy/bit, power delay product, Shannon entropy and Heisenberg uncertainty principle which re... 详细信息

关键词： Computation Power Product Entropy SNL Limit

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硅橡胶,三元乙丙烯橡胶复合绝缘子自然老化表面的湿润性研究

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电瓷避雷器译丛 1998年第45期 56-64页

作者： guba.,SM 马上

本文研究了硅橡胶、ＥＰＤＭ复合绝缘子护套自然老化后，整体和表面及硅橡胶涂层绝缘子老化后表面的湿润性问题。试样直接取于经电晕或盐污处理的绝缘子，结果表明：硅橡胶绝缘子表面的接触角大于室温硫化ＲＴＶ硅胶涂层和ＥＰＤＭ绝缘... 详细信息

本文研究了硅橡胶、ＥＰＤＭ复合绝缘子护套自然老化后，整体和表面及硅橡胶涂层绝缘子老化后表面的湿润性问题。试样直接取于经电晕或盐污处理的绝缘子，结果表明：硅橡胶绝缘子表面的接触角大于室温硫化ＲＴＶ硅胶涂层和ＥＰＤＭ绝缘子表面的接触角，试样老化后表现尤为显著。

关键词：复合绝缘子老化湿润性硅橡胶三元乙丙烯橡胶

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论自然界中化学元素的分布特征

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地球与环境 1988年第6期 59-60页

作者： J.gubaě 匡耀求湖南地质研究所

评价自然界中化学元素的分布,是地质工作者时常使用的一种研究矿化作用的方法。分析化学元素的分布可以反映出自然过程的形成条件。化学元素分布的物理解释最初是由戈尔德施密特于1937年作出的,他强调指出,自然界中的化学元素是受物理... 详细信息

评价自然界中化学元素的分布,是地质工作者时常使用的一种研究矿化作用的方法。分析化学元素的分布可以反映出自然过程的形成条件。化学元素分布的物理解释最初是由戈尔德施密特于1937年作出的,他强调指出,自然界中的化学元素是受物理状态控制的。鉴于戈尔德施密特在地球化学方面所作的贡献,离子半径、晶体的晶格间距(lattice distance)、电荷以

关键词：矿化作用表达式戈尔德施密特对数正态分布分布特征

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