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A case of methicillin-resistant Staphylococcus aureus infection following bile duct stenting

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World Journal of Gastroenterology 2005年第9期11卷 1396-1398页

作者： markus K Diener Alexis Ulrich Theresia Weber Moritz N Wente markus W büchler Helmut Friess Department of General Surgery

AIM: To present a case of methicillin-resistant Staphylococcus aureus (MRSA) infection following bile duct stenting in a patient with malignant biliary ***: A 78-year-old male patient was admitted to a community hospital with progredient painless jaundice lasting over two weeks, weight loss and sweating at *** a stent should be implanted pre-operatively in jaundiced patients or whether these patients should directly undergo surgical resection, was ***: ERC and a biopsy from the papilla of Vater revealed an adenocarcinoma. In addition, a 7-Ch plastic stent was placed into the common bile duct. Persistent abdominal pain, increasing jaundice, weakness and indigestion led to the transfer of the patient to our hospital.A pylorus-preserving pancreatoduodenectomy wasperformed. Intraoperatively, bile leaked out of the transected choledochus andthe stent was found to be dislocated in the duodenum. A smear of the bile revealed an infection with MRSA, leading to post-operative isolation of the ***:As biliary stents can cause severe infection of the bile, the need for pre-operative placement of biliary stents should be carefully evaluated in each individual case.

关键词： Methicillin-resistant Staphylococcus aureus bile Infection Stent biliary obstruction Malignancy Surgery

Autoimmune pancreatitis associated with a large pancreatic pseudocyst

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World Journal of Gastroenterology 2006年第36期12卷 5904-5906页

作者： Thilo Welsch Jrg Kleeff Irene Esposito markus W büchler Helmut Friess Department of Surgery University of Heidelberg Heidelberg Germany Department of Pathology University of Heidel-berg Heidelberg Germany

Pancreatic cystic lesions comprise various entities with different histopathological characteristics and their dif-ferential diagnosis is often a challenge for clinicians. Autoimmune pancreatitis (AIP) is usually not considered in the differential diagnosis of cystic lesions, but often mimics the morphological aspects of pancreatic neo-plasm. We report the case of a 64-year-old male patient with a cystic pancreatic head lesion (diameter 5 cm) and stenosis of the distal bile duct requiring repeated stent-ing. because of the clinical presentation together with moderate elevation of serum CA19-9 and massive eleva-tion of cyst fluid CA19-9 (122.695 U/L; normal range: be considered in the differential diagnosis of cys-tic pancreatic lesions. Early examination of serum IgG, IgG4 and auto-antibodies might save these patients from unnecessary endoscopical and surgical procedures.

关键词： Pseudocyst Autoimmune pancreatitis Pancreatic cancer Tumor marker CEA CA19-9

TbSSvis:Visual analytics for Temporal blind Source Separation

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Visual Informatics 2022年第4期6卷 51-66页

作者： Nikolaus Piccolotto markus bögl Theresia Gschwandtner Christoph Muehlmann Klaus Nordhausen Peter Filzmoser Silvia Miksch TU Wien Institute of Visual Computing&Human-Centered TechnologyFavoritenstrasse 9–11A-1040 ViennaAustria Erste Group bank AG Am Belvedere 1A-1100 ViennaAustria TU Wien Institute of Statistics and Mathematical Methods in EconomicsWiedner Hauptstrasse 8–10A-1040 ViennaAustria University of Jyväskylä Department of Mathematics and StatisticsFI40014 JyväskyläFinland

Temporal blind Source Separation(TbSS)is used to obtain the true underlying processes from noisy temporal multivariate data,such as *** has similarities to Principal Component Analysis(PCA)as it separates the input data into univariate components and is applicable to suitable datasets from various domains,such as medicine,finance,or civil *** TbSS’s broad applicability,the involved tasks are not well supported in current tools,which offer only text-based interactions and single static *** are limited in analyzing and comparing obtained results,which consist of diverse data such as matrices and sets of time ***,parameter settings have a big impact on separation performance,but as a consequence of improper tooling,analysts currently do not consider the whole parameter *** propose to solve these problems by applying visual analytics(VA)*** primary contribution is a design study for TbSS,which so far has not been explored by the visualization *** developed a task abstraction and visualization design in a user-centered design ***-specific assembling of well-established visualization techniques and algorithms to gain insights in the TbSS processes is our secondary *** present TbSSvis,an interactive web-based VA prototype,which we evaluated extensively in two interviews with five TbSS *** and observations from these interviews show that TbSSvis supports the actual workflow and combination of interactive visualizations that facilitate the tasks involved in analyzing TbSS results.

关键词： blind source separation Ensemble visualization Visual analytics Parameter space exploration

Quality of life after curative liver resection: A single center analysis

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World Journal of Gastroenterology 2010年第19期16卷 2388-2395页

作者： Helge bruns Kirsten Krtschmer Ulf Hinz Anette brechtel Monika Keller markus W büchler Peter Schemmer Department of General Surgery Ruprecht-Karls-University 69120 Heidelberg Germany Psychosomatic Medicine Section Psychooncology Ruprecht-Karls-University 69120 Heidelberg Germany

AIM: To evaluate quality of life (QoL) after curative liver resection and identify variables associated with decreased QoL. METHODS: From October 2001 to July 2004, 323 patients underwent liver resection. At 3-36 mo after discharge, 188 patients were disease free. QoL was assessed using the Short Form (SF)-12 Health Survey with mental and physical component scales (SF-12 MCS and PCS), supplemented with generic questions concerning pain and liver-specific items. RESULTS: Sixty-eight percent (128/188) returned the questionnaire, which was completed in 75% (96/128) of cases. Median SF-12 PCS and MCS were 46.7 (inter- quartile range: 34.2-53.9) and 54.1 (42.8-58.2). Fifty percent were pain free with a median symptom score of 1.75 (1.38-2.13). PCS was higher after major hepatec-tomy [57% (55/96)] compared to minor resection (P = 0.0049), which represented an improved QoL. QoL was not affected by sex but by age compared to the general German population. MCS was higher after liver surgery for metastatic disease [55.9 (47.5-58.8)] compared to primary carcinoma [49.6 (36.5-55.1)] and benign disease [49.2 (37.7-56.3)] (P = 0.0317). There was no correlation between length of postoperative period and QoL. Pain, def iciencies in everyday life and a high symptom score significantly decreased MCS and PCS. CONCLUSION: Most patients were only marginally affected even after major liver resection; however, minor complications were associated with decreased SF-12 MCS and PCS and need careful attention.

关键词： Quality of life Liver resection

Synergistic effects of interferon-alpha in combination with chemoradiation on human pancreatic adenocarcinoma

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World Journal of Gastroenterology 2005年第10期11卷 1521-1528页

作者： Jian-Hua Ma Emilia Patrut Jan Schmidt Hanns-Peter Knaebel markus W. büchler Angela M(a|¨)rten Department of Surgery

AIM: To determine whether IFN-α is the agent that turns a slightly effective treatment (radiochemotherapy) into a potent therapy, we tested IFN-α for its synergistic ***: Eight pancreatic carcinoma cell lines were treated with the single agents and combinations of *** role of IFN-α regarding a) direct inhibitory effects; b)radio and chemosensitizing effects; c) anti-angiogenic properties and d) enhancement of immunogenicity was ***: Our results show that IFN-α has direct inhibitory properties and some synergistic influence as determined by AnnexinV/PI stain and cell count. IFN-α is also able to prevent the increase in proliferation rate and VEGF secretion of CDDP resistant cells. Having taken the results from immunogenicity experiments together, we found cells that can be influenced by IFN-α but were less susceptible against T cells. Furthermore, high expression of MHC molecules, CD118, EGF-R and Fas was predictive for a good ***: In conclusion, IFN-α has direct cytotoxic effects, acts as a radiosensitizer and circumvents tumor cell-regrowth after CDDP treatment. These mechanisms may be responsible for the good clinical outcome of CapRI.

关键词： Interferon-alpha Pancreatic adenocarcinoma Synergistic effects Combination therapy

Extrapulmonary sarcoidosis of liver and pancreas: A case report and review of literature

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World Journal of Gastroenterology 2007年第17期13卷 2504-2509页

作者： Hermann Harder markus W büchler boris Frhlich Philipp Strbel Frank bergmann Wolfgang Neff Manfred V Singer Department of Medicine Ⅱ (Gastroenterology Hepatology and Infectious Diseases) University Hospital of Heidelberg at Mannheim Germany Department of Surgery University of Heidelberg GermanyFrank Bergmann Institute of Pathology University of Heidelberg Germany Institute of Pathology University Hospital of Heidelberg at Mannheim Germany Institute of Pathology University of HeidelbergGermany Institute of Radiology University Hospital of Heidelberg at Mannheim Germany

Sarcoidosis is a chronic multisystemic granulomatous disease of unknown origin, which can involve nearly all organs. In the case of an infrequent gastrointestinal tract involvement in systemic sarcoidosis, granulomas of the liver are most commonly described while isolated pancreatic sarcoid lesions are rarely seen. We report a case of systemic sarcoidosis with exclusive extrapulmonal involvement of the liver and the pancreas in a 71-year- old white man. The diagnosis of liver involvement was confirmed by biopsy. Pancreatic surgery was needed because preoperative evaluation could not exclude pancreatic cancer and for biliary decompression. An extensive literature review of systemic sarcoidosis, focusing on reported cases with unusual presentation of sarcoidosis in the liver and the pancreas, its diagnosis, treatment, and prognosis was made.

关键词： Systemic Sarcoidosis Extrapulmonary Liver Pancreas

TIPSS for variceal hemorrhage after living related liver transplantation:A dangerous indication

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World Journal of Gastroenterology 2006年第3期12卷 493-495页

作者： Peter Schemmer boris Radeleff Christa Flechtenmacher Arianeb Mehrabi Gtz M Richter markus W büchler Jan Schmidt Department of General Surgery Ruprecht-KarlsUniversity69120 HeidelbergGermany Department of RadiologyRuprecht-Karls-University69120 HeidelbergGermany Department of PathologyRuprechtKarls-University69120 HeidelbergGermany

The introduction of transjugular intrahepatic portalsystemic stent-shunt （TIPSS） has been a major breakthrough in the treatment of portal hypertension, which has evolved to a large extent, into a routine procedure. A 21-year-old male patient with progressive graft fibrosis/cirrhosis requiring TIPSS for variceal hemorrhage in the esophagus due to portal hypertension was unresponsive to conventional measures two years after living related liver transplantation （LDLT）. Subsequently, variceal hemorrhage was controlled, however, liver function decreased dramatically with consecutive multi organ failure. CT scan revealed substantial necrosis in the liver. The patient underwent successful ＂high urgent＂ cadaveric liver transplantation and was discharged on postoperative d 20 in a stable condition.

关键词： Portal hypertension Liver necrosis Fibrosis Cirrhosis

Generation of polarized particle beams at relativistic laser intensities

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High Power Laser Science and Engineering 2020年第4期8卷 44-58页

作者： markus büscher Anna Hiitzen Liangliang Ji Andreas Lehrach Peter Griinberg Institut(PGI-6) Forschungszentrum JiilichJiilichGermany Institut fur Laser-und Plasmaphysik Heinrich-Heine-Universitat DiisseldorfDUsseldorfGermany State Key Laboratory of High Field Laser Physics Shanghai Institute of Optics and Fine MechanicsChinese Academy of SciencesShanghai 201800China CAS Center for Excellence in Ultra-intense Laser Science Shanghai 201800China JARA-FAME(Forces and Matter Experiments) Forschungszentrum Jiilich and RWTH Aachen UniversityAachenGermany Institut fur Kemphysik(IKP-4) Forschungszentrum JiilichJiilichGermany

The acceleration of polarized electrons,positrons,protons and ions in strong laser and plasma fields is a very attractive option for obtaining polarized beams in the multi-mega-electron volt ***,there has been substantial progress in the understanding of the dominant mechanisms leading to high degrees of polarization,in the numerical modeling of these processes and in their experimental *** review paper presents an overview on the current state of the field,and on the concepts of polarized laser–plasma accelerators and of beam polarimetry.

关键词： high power laser laser-driven plasma accelerator laser-plasma interactions PIC simulations polarized particle beams

Prospective study to evaluate the prognostic value of different nutritional assessment scores in liver surgery: NURIMAS Liver (DRKS00006340)

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Hepatobiliary Surgery and Nutrition 2020年第4期9卷 400-413页

作者： Pascal Probst Juri Fuchs Michael R.Schön Georgios Polychronidis Christos Stravodimos Arianeb Mehrabi markus K.Diener Philipp Knebel markus W.büchler Katrin Hoffmann Department of General Visceral and Transplantation SurgeryUniversity of HeidelbergIm Neuenheimer Feld 11069120 HeidelbergGermany Department of General and Visceral Surgery Städtisches Klinikum KarlsruheMoltkestraße 9076133 KarlsruheGermany

background:Malnutrition is recognised as a preoperative risk factor for patients undergoing hepatic *** is important to identify malnourished patients and take preventive therapeutic action before ***,there is no evidence regarding which existing nutritional assessment score(NAS)is best suited to predict outcomes of liver ***:All patients scheduled for elective liver resection at the surgical department of the University Hospital of Heidelberg and the Municipal Hospital of Karlsruhe were screened for *** NASs were calculated before operation,and patients were categorised according to each score as being either at risk or not at risk for *** association of malnutrition according to each score and occurrence of at least one major complication was the primary endpoint,which was achieved using a multivariate logistic regression analysis including established risk factors in liver surgery as ***:The population consisted of 182 *** percentage of patients deemed malnourished by the NAS varied among the different scores,with the lowest being 2.20%(Mini Nutritional Assessment)and the highest 52.20%(Nutritional Risk Classification).Forty patients(22.0%)had a major *** of the scores were significantly associated with major ***:None of the twelve investigated NAS defined a state of malnutrition that was independently associated with postoperative *** means of measuring malnutrition in liver surgery should be investigated prospectively.

关键词： Malnutrition liver surgery hepatic resection nutritional assessment