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Hemopneumothorax detection through the process of artificial evolution-a feasibility study

Military Medical Research 2022年第1期9卷 12-20页

作者： Adir Sommer Noy MarkGavriel D.Kohlberg Rafi Gerasi Linn Wagnert Avraham Ruth Fan-marko Arik Eisenkraft Dean Nachman The Medical Corps Israel Defense Forces(IDF)Tel Hashomer5262000 Ramat GanIsrael Department of Otolaryngology-Head and Neck Surgery University of WashingtonSeattleWA 98195USA The Institute for Research in Military Medicine the Faculty of Medicinethe Hebrew University of Jerusalem and the IDF Medical Corps9112102 JerusalemIsrael The Hebrew University School of Medicine 9112102 JerusalemIsrael Department of Medicine Hadassah Medical Center9112102 JerusalemIsrael.

Background:Tension pneumothorax is one of the leading causes of preventable death on the *** prehospital diagnosis relies on a subjective clinical impression complemented by a manual thoracic and respiratory *** techniques are not fully applicable in field conditions and on the battlefield,where situational and environmental factors may impair clinical *** aimed to assemble a device able to sample,analyze,and classify the unique acoustic signatures of pneumothorax and ***:Acoustic data was obtained with simultaneous use of two sensitive digital stethoscopes from the chest wall of an ex-vivo porcine *** second samples of acoustic data were obtained from the in-house assembled digital stethoscope system during mechanical *** thoracic cavity was injected with increasing volumes of 200,400,600,800,and 1000 ml of air or saline to simulate pneumothorax and hemothorax,*** data was analyzed using a multi-objective genetic algorithm that was used to develop an optimal mathematical detector through the process of artificial evolution,a cutting-edge approach in the artificial intelligence ***:The in-house assembled dual digital stethoscope system and developed genetic algorithm achieved an accuracy,sensitivity and specificity ranging from 64%to 100%,63%to 100%,and 63%to 100%,respectively,in classifying acoustic signal as associated with pneumothorax or hemothorax at fluid injection levels of 400 ml or more,and regardless of background ***:We present a novel,objective device for rapid diagnosis of potentially lethal thoracic *** further optimization,such a device could provide real-time detection and monitoring of pneumothorax and hemothorax in battlefield conditions.

关键词： pneumothorax Hemothorax Trauma Battlefield Artificial evolution Machine learning

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On tempered and square integrable representations of classical p-adic groups

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Science China Mathematics 2013年第11期56卷 2273-2313页

作者： TADI marko Department of Mathematics University of Zagreb

This paper has two *** first is to give a description of irreducible tempered representations of classical p-adic groups which follows naturally the classification of irreducible square integrable representations modulo cuspidal data obtained by M glin and the author of this article(2002).The second aim of the paper is to give a description of an invariant(partially defined function)of irreducible square integrable representation of a classical p-adic group(defined by M glin using embeddings)in terms of subquotients of Jacquet *** an application,we describe behavior of partially defined function in one construction of square integrable representations of a bigger group from such representations of a smaller group(which is related to deformation of Jordan blocks of representations).

关键词：平方可积表示古典不可约表示锻炼点数据定义函数

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Abstract Volterra equations in locally convex spaces

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Science China Mathematics 2012年第9期55卷 1797-1825页

作者： KOSTIC marko Faculty of Technical Sciences University of Novi SadNovi Sad 21125Serbia

A general class of(a,k)-regularized C-resolvent families is one of efficient research tools for dealing with non-degenerate abstract Volterra equations of scalar *** main purpose of this expository paper is to provide... 详细信息

关键词： Volterra方程局部凸空间摘要非退化正规化标量

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Analysis of shock wave unsteadiness using space and time correlations applied to shadowgraph flow visualization data

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Advances in Aerodynamics 2019年第1期1卷 14-38页

作者： S.marko p.M.Ligrani propulsion Research Center Department of Mechanical and Aerospace EngineeringUniversity of Alabama in Huntsville5000 Technology DriveOlin B.King Technology Hall S236HuntsvilleAL 35899USA

Unsteady flow characteristics of a normal shock wave,a lambda foot,and a separated turbulent boundary layer are investigated within a unique test section with supersonic inlet *** supersonic wind tunnel facility,containing this test section,provides a Mach number of approximately 1.54 at the test section *** shadowgraph flow visualization data are employed to visualize shock wave structure within the test *** data are analyzed to determine shock wave unsteadiness characteristics,including grayscale spectral energy variations with frequency,as well as time and space correlations,which give coherence and time lag properties associated with perturbations associated with different flow *** illustrate the complexity and unsteadiness of shock-wave-boundary-layerinteractions,including event frequencies from grayscale spectral energy distributions determined using a Lagrangian approach applied to shock wave location,and by grayscale spectral energy distributions determined using ensemble-averaging applied to multiple closely-located stationary pixel ***-correlation function results and two-point correlation functions(in the form of magnitude squared coherence)quantify the time-scales of periodic events,as well as the coherence of flow perturbations associated with different locations,over a range of *** time lag data provide information on the originating location of perturbation events,as well as the propagation direction and event sequence associated with different flow *** insight into spatial variations of time lag and flow coherence is provided by application of magnitude squared coherence analysis to multiple locations,relative to a single location associated with the normal shock wave.

关键词： Shock wave Supersonic flow Time correlation Spatial correlation Autocorrelation Two-point correlation Frequency spectra Magnitude squared coherence Time lag Lagrangian flow analysis Unsteady flow analysis

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Artificial intelligence-based predictive model of nanoscale friction using experimental data

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Friction 2021年第6期9卷 1726-1748页

作者： marko pERČIĆ Saša ZELENIKA Igor MEZIĆ University of Rijeka Faculty of Engineering51000 RijekaCroatia University of Rijeka Centre for Micro-and Nanosciences and Technologies&Center for Artificial Intelligence and Cybersecurity51000 RijekaCroatia University of California Santa Barbara Department of Mechanical EngineeringSanta BarbaraCA 93105USA

A recent systematic experimental characterisation of technological thin films,based on elaborated design of experiments as well as probe calibration and correction procedures,allowed for the first time the determination of nanoscale friction under the concurrent influence of several process parameters,comprising normal forces,sliding velocities,and temperature,thus providing an indication of the intricate correlations induced by their interactions and mutual *** created the preconditions to undertake in this work an effort to model friction in the nanometric domain with the goal of overcoming the limitations of currently available models in ascertaining the effects of the physicochemical processes and phenomena involved in nanoscale *** to the stochastic nature of nanoscale friction and the relatively sparse available experimental data,meta-modelling tools fail,however,at predicting the factual *** on the acquired experimental data,data mining,incorporating various state-of-the-art machine learning(ML)numerical regression algorithms,is therefore *** results of the numerical analyses are assessed on an unseen test dataset via a comparative statistical *** is therefore shown that the black box ML methods provide effective predictions of the studied correlations with rather good accuracy levels,but the intrinsic nature of such algorithms prevents their usage in most practical *** programming-based artificial intelligence(AI)methods are consequently finally *** the marked complexity of the analysed phenomena and the inherent dispersion of the measurements,the developed AI-based symbolic regression models allow attaining an excellent predictive performance with the respective prediction accuracy,depending on the sample type,between 72%and 91%,allowing also to attain an extremely simple functional description of the multidimensional dependence of nanoscale friction on the studied variable process param

关键词： nanoscale friction thin films data mining machine learning(ML) predictive artificial intelligence(AI)-based model

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SecReT6 update:a comprehensive resource of bacterial TypeⅥSecretion Systems

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Science China(Life Sciences) 2023年第3期66卷 626-634页

作者： Jianfeng Zhang Jiahao Guan Meng Wang Gang Li marko Djordjevic Cui Tai Hui Wang Zixin Deng Zhaoyan Chen Hong-Yu Ou State Key Laboratory of Microbial Metabolism Shanghai-Islamabad-Belgrade Joint Innovation Center on Antibacterial ResistancesJoint International Laboratory on Metabolic&Developmental SciencesSchool of Life Sciences&BiotechnologyShanghai Jiao Tong UniversityShanghai 200240China Intensive Care Unit First Affiliated Hospital of Guangxi Medical UniversityNanning 530021China Department of Laboratory Medicine Jinshan HospitalShanghai Medical CollegeFudan UniversityShanghai 201500China Quantitative Biology Group Institute of Physiology and BiochemistryFaculty of BiologyUniversity of BelgradeBelgrade 11000Serbia State Key Laboratory of pathogens and Biosecurity Beijing Institute of Microbiology and EpidemiologyBeijing 100071China Shanghai Key Laboratory of Veterinary Biotechnology Shanghai Jiao Tong UniversityShanghai 200240China

TypeⅥSecretion System(T6SS)plays significant roles in microbial activities via injecting effectors into adjacent cells or environments.T6SS increasingly gained attention due to its important influence on pathogenesis,microbial competition,etc.T6SS-associated research is explosively expanding on numerous grounds that call for an efficient *** SecReT6 version3 provides comprehensive information on T6SS and the interactions between T6SS and T6SS-related proteins such as T6SS regulators and T6SS *** assist T6SS researches like microbial competition and regulatory mechanisms,SecReT6 v3developed online tools for detection and analysis of T6SS and T6SS-related proteins and estimation of T6SS-dependent killing *** have identified a novel T6SS regulator and T6SS-dependent killing capacity in Acinetobacter baumannii clinical isolates with the aid of SecReT6 v3.17,212 T6SSs and plentiful T6SS-related proteins in 26,573 bacterial complete genomes were also detected,analyzed and incorporated into the *** database is freely available at https://***/SecReT6/.

关键词： TypeⅥSecretion System T6SS-related protein database prediction Acinetobacter baumannii

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Epispadias:recent techniques

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plastic and Aesthetic Research 2022年第1期9卷 628-639页

作者： Marta R.Bizic Borko Stojanovic marko Bencic Ivana Joksic Miroslav L.Djordjevic Department of Urology University Children’s HospitalFaculty of MedicineUniversity of BelgradeBelgrade 11000Serbia Department of Urology Belgrade Center for Urogenital Reconstructive SurgeryBelgrade 11000Serbia Department of Genetics Gynecology and Obstetrics Clinic“Narodni Front”Belgrade 11000Serbia Department of Urology Icahn School for Medicine at Mount SinaiNew YorkNY 10075USA

Aim:This paper presents the latest surgical approaches for epispadias treatment in the pediatric population,as well as those for adolescent and adult populations after initial failed repair in ***:The retrospective study was conducted between March 2005 and May 2020 and included 18 patients with the mean age of 21 months(range 11-48 months)(Group A),who underwent primary epispadias repair and 15 patients with the mean age of 18 years(range 13-29 years)(Group B),who underwent redo surgery after failed epispadias repair in *** Group A,the surgery was performed as a one-stage procedure using complete penile disassembly technique,while,in Group B,the surgery was done as a two-stage procedure and included complete straightening and lengthening of the penis,followed by urethral *** straightening and lengthening were achieved by tunica albuginea incision and *** Group A,the urethral plate was mobilized,transposed ventrally,and tubularized and augmented with vascularized preputial skin flap where *** Group B,the urethra was reconstructed either using the buccal mucosa graft and genital skin flaps or with tubularization of genital skin *** treatment was defined as a functional and esthetically acceptable penis without ***:The mean follow-up was 88 months(range 15-197 months).Satisfactory results were achieved in 26/33 *** fistula occurred in 4/18 patients from Group A and in 3/15 patients in Group B and was surgically repaired after four *** dehiscence occurred in eight patients,five from Group A and three from Group *** penile curvature was observed in 2/18 patients from Group A and required surgical correction and in 2/15 patients from Group B and was mild and did not need surgical *** patients from Group B who filled out the International Index for Erectile Function reported satisfying erectile function,sexual desire,intercourse,and overall satisfa

关键词： Epispadias primary repair penile disassembly urethroplasty buccal mucosa graft genital reconstruction failed epispadias

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Default or profit scoring credit systems?Evidence from European and US peer-to-peer lending markets

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Financial Innovation 2022年第1期8卷 954-974页

作者： Štefan Lyócsa petra Vašaničová Branka Hadji Misheva marko Dávid Vateha Faculty of Management and Business University of PrešovPrešovSlovak Republic Institute of Economic Research Slovak Academy of SciencesBratislavaSlovak Republic ZHAW School of Engineering WinterthurSwitzerland Depart-ment of Banking and International Finance Faculty of National EconomyUniversity of Economics in BratislavaBratislavaSlovak Republic Faculty of Economics and Administration Masaryk UniversityLipová507/41a60200 BrnoCzech Republic

For the emerging peer-to-peer(p2p)lending markets to survive,they need to employ credit-risk management practices such that an investor base is profitable in the long ***,credit-risk management relies on credit scoring that predicts loans’probability of *** this paper,we use a profit scoring approach that is based on modeling the annualized adjusted internal rate of returns of *** validate our profit scoring models with traditional credit scoring models,we use data from a European p2p lending market,Bondora,and also a random sample of loans from the Lending Club p2p lending *** compare the out-of-sample accuracy and profitability of the credit and profit scoring models within several classes of statistical and machine learning models including the following:logistic and linear regression,lasso,ridge,elastic net,random forest,and neural *** found that our approach outperforms standard credit scoring models for Lending Club and Bondora *** specifically,as opposed to credit scoring models,returns across all loans are 24.0%(Bondora)and 15.5%(Lending Club)higher,whereas accuracy is 6.7%(Bondora)and 3.1%(Lending Club)higher for the proposed profit scoring ***,our results are not driven by manual selection as profit scoring models suggest investing in more ***,even if we consider data sampling bias,we found that the set of superior models consists almost exclusively of profit scoring ***,our results contribute to the literature by suggesting a paradigm shift in modeling credit-risk in the p2p market to prefer profit as opposed to credit-risk scoring models.

关键词： profit scoring Credit scoring Financial intermediation p2p Fintech

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N-acetyl cysteine alters the genotoxic and estrogenic properties of Alternaria toxins in naturally occurring mixtures

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Emerging Contaminants 2022年第1期8卷 30-38页

作者： Georg Aichinger Dino Grgic Julia Beisl Francesco Crudo Benedikt Warth Elisabeth Varga Doris marko Department of Food Chemistry and Toxicology University of ViennaAustria Department of Health Sciences and Technology ETH ZurichSwitzerland

It is unclear if complex mycotoxin mixtures produced by Alternaria *** estrogenic and/or genotoxic under physiological conditions,particularly considering the co-occurrence with antioxidants in ***,this study focused on enlightening the impact of N-acetyl cysteine(NAC),as a representative antioxidative SH-donor,on the mentioned toxicological endpoints of the signature Alternaria toxins alternariol(AOH),altertoxin-II(ATX-II)and a complex extract(CE)of an Alternaria alternata *** Ishikawa cells as an in vitro model,we monitored alterations in toxin concentrations by LC-MS/MS,estrogenicity by alkaline phosphatase assays,cytotoxicity by sulforhodamine B assays,genotoxicity by single-cell gel electrophoresis and the transcription of selected genes of interest by quantitative realtime *** results indicate that the strong genotoxic effects of epoxide-carrying perylene quinones such as ATX-II are erased in the presence of *** cellular effects of ATX-II/AOH mixtures are dominated by the genotoxicity of the perylene *** this mixture,AOH regained its estrogenicity when coincubated with *** contrast,NAC treatment of an AOH/CE mixture did not result in a recovery of estrogenicity,but in potentiated anti-estrogenic *** findings were in line with gene transcription data,that indicated the aryl hydrocarbon receptor(AhR)to be a prime mediator of Alternaria toxin e induced antagonistic effects towards estrogen receptor *** together,further studies on potential endocrine-disruptive properties of non-genotoxic perylene quinones should be a future research priority in the field of these emerging contaminants.

关键词： Mycotoxin DNA damage Xenoestrogen Combinatory toxicology Food contaminant Mixture effects

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Amplitude Factorization Method in the Atmospheric Gravity-Wave Equation

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Communications in Computational physics 2007年第5期2卷 993-1006页

作者： Rein Room marko Zirk Institute of Environmental physics Tartu UniversityUlikooli 18Tartu 50090Estonia.

A novel amplitude factorization method is applied to solve a discrete buoyancy wave equation with arbitrary wind and temperature height *** solution is given in the form of a cumulative product of complex factors,which are computed by a nonlinear,inhomogeneous,two-member recurrence formula,initiated from a radiative condition on *** of the wave equation due to evanescent winds are eliminated by turbulent *** method provides an estimation of the minimal vertical resolution,required to attain a stable accurate *** areas of application of the developed numerical scheme are high resolution modelling of orographic waves for arbitrary orography in general atmospheric stratification conditions,and testing of adiabatic kernels of numerical weather prediction models.

关键词： Atmospheric gravity waves linear buoyancy wave equation arbitrary stratification numerical solution amplitude factorization method.

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