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Stomach perforation-induced general occlusion/occlusion-like syndrome and stable gastric pentadecapeptide BpC 157 therapy effect

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World Journal of Gastroenterology 2023年第27期29卷 4289-4316页

作者： Luka Kalogjera Ivan Krezic Ivan Maria Smoday Hrvoje Vranes Helena Zizek Haidi Yago Katarina Oroz Vlasta Vukovic Ivana Kavelj Luka Novosel Slavica Zubcic Ivan Barisic Lidija Beketic Oreskovic Sanja Strbe marko Sever Ivica Sjekavica Anita Skrtic Alenka Boban Blagaic Sven Seiwerth predrag Sikiric Department of pharmacology School of MedicineZagreb 10000Croatia Division of Oncology and Radiotherapy University Hospital for TumorsSestre milosrdnice University Hospital CentreZagreb 10000Croatia Department of pathology School of MedicineZagreb 10000Croatia

BACKGROUND Using rat stomach perforation as a prototypic direct lesion applied in cytoprotection research,we focused on the first demonstration of the severe occlusion/occlusion-like syndrome induced by stomach *** revealed stomachinduced occlusion/occlusion-like syndrome corresponds to the previously described occlusion/occlusion-like syndromes in rats suffering multicausal pathology and shared severe vascular and multiorgan *** general point was particularly *** in all the described occlusion/occlusion-like syndromes with permanent occlusion of major vessels,peripheral and central,and other similar noxious procedures that severely affect endothelium function,the stable gastric pentadecapeptide BpC 157 was resolving *** To reveal the stomach perforation-induced general occlusion/occlusion-like syndrome and BpC 157 therapy *** The procedure included deeply anesthetized rats,complete calvariectomy,laparotomy at 15 min thereafter,and stomach perforation to rapidly induce vascular and multiorgan failure occlusion/occlusion-like *** 5 min post-perforation time,rats received therapy[BpC 157(10μg or 10 ng/kg)or saline(5 mL/kg,1 mL/rat)(controls)]into the perforated defect in the stomach).Sacrifice was at 15 min or 60 min post-perforation ***(gross and microscopy;volume)included:Brain swelling,peripheral vessels(azygos vein,superior mesenteric vein,portal vein,inferior caval vein)and heart,other organs lesions(i.e.,stomach,defect closing or widening);superior sagittal sinus,and peripherally the portal vein,inferior caval vein,and abdominal aorta blood pressures and clots;electrocardiograms;and bleeding time from the perforation(s).RESULTS BpC 157 beneficial effects accord with those noted before in the healing of the perforated defect(raised vessel presentation;less bleeding,defect contraction)and occlusion/occlusion-like syndromes *** 157 therapy(into the perforated defect),induced immediate

关键词： Stomach perforation General occlusion/occlusion-like syndrome Stable gastric pentadecapeptide BpC 157 Cytoprotection Therapy Rats

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Antibiotic Resistance Genes in the Human-Impacted Environment:A One Health perspective

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pedosphere 2019年第3期29卷 273-282页

作者： James M. TIEDJE WANG Fang Celia M. MANAIA marko VIRTA SHENG Hongjie MA Liping ZHANG Tong Edward TOpp Key Laboratory of Soil Environment and pollution Remediation Institute of Soil Science Chinese Academy of Sciences Nanjing 210008 (China) Center for Microbial Ecology Department of Plant Soil and Microbial Sciences Michigan State University East Lansing MI 48824 (USA) University of Chinese Academy of Sciences Beijing 100049 (China) Universidade Catolica portuguesa CBQF-Centro de Biotecnologia e Quimica Fina一Laboratorio Associado Escola Superior de Biotecnologia Porto 4200-374 (Portugal) Department of Microbiology University of Helsinki Helsinki 00014 (Finland) Environmental Biotechnology Lab The University of Hong Kong Hong Kong (China) London Research and Development Centre Agriculture and Agri-Food Canada and University of Western Ontario London ON N6G 0J3 (Canada)

Antibiotic resistance and its environmental component are gaining more attention as part of combating the growing healthcare crisis. The One Health framework, promulgated by many global health agencies, recognizes that antimicrobial resistance is a truly inter-domain problem in which human health, animal agriculture, and the environment are the core and interrelated *** prospectus presents the status and issues relevant to the environmental component of antibiotic resistance, namely, the needs for advancing surveillance methodology: the environmental reservoirs and sources of resistance, namely, urban wastewater treatment plants, aquaculture production systems, soil receiving manure and biosolid, and the atmosphere which includes longer range ***, much work has been done describing antibiotic resistance genes in various environments;now quantitative, mechanistic,and hypothesis-driven studies are needed to identify practices that reduce real risks and maintain the effectiveness of our current antibiotics as long as possible. Advanced deployable detection methods for antibiotic resistance in diverse environmental samples are needed in order to provide the surveillance information to identify risks and define barriers that can reduce risks. Also needed are practices that reduce antibiotic use and thereby reduce selection for resistance, as well as practices that limit the dispersal of or destroy antibiotic-resistant bacteria or their resistance genes that are feasible for these varied environmental domains.

关键词： animal agriculture antibiotic-resistant bacteria antimicrobial resistance aquaculture human health One Health framework soil contamination wastewater and sludge

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phase Structures of Nascent polyethylene powder Studied by Wideline proton NMR

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Chinese Journal of Chemistry 2007年第6期25卷 863-868页

作者：严小伟王靖岱任晓红阳永荣蒋斌波 VODA, Mihai Adrian BERTMER, marko STApF, Siegfried College of Material Science and Chemical Engineering Zhejiang University Hangzhou Zhejiang 310027 China Institute of Technical and Macromolecular Chemistry RWTH Aachen University Worringerweg 1 52074 Aachen Germany

The wideline proton NMR spectra of polyethylene powder samples were analyzed in terms of contributions from three components：（1） a rigid part with immobile chains, （2） a soft region with liquid-like character which produces a Lorentzian contribution to the spectrum, and （3） an intermediate region in which the rotation of methylene groups about C-C bonds is partially hindered. The relative mass fractions as well as chain mobilities varied greatly among samples produced by different polymerization techniques. The NMR crystallinity agreed well with that estimated by WAXD and was much higher than DSC crystallinity, indicating an inclusion of the contribution from a crystalline-amorphous interphase. The crystalline defects in the rigid part could be significantly affected by processing parameters when employing the same type of polymerization technique. The intermediate region in the NMR spectra was analyzed according to the comparison between bimodal high density polyethylene and corresponding linear unimodal one. It was found that the mass fraction of the NMR interphase could be an indication of the percentage of tie molecules between crystalline lamellae and thus may significantly affect the mechanical properties of polymeric material.

关键词： polyethylene powder wideline NMR phase structure

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Reasoning about Epistemic Actions and Knowledge in Multi-Agent Systems Using Coq

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Computer Technology and Application 2011年第8期2卷 616-627页

作者： marko Malikovic Mirko Cubrilo Faculty of Itumanities and Social Sciences University of Rijeka Rijeka Croatia Faculty of Organization and Informatics University of Zagreb Varazdin Croatia

In this paper, the authors outline a formal system for reasoning about agents’ knowledge in knowledge games—-a special type of multi-agent system. Knowledge games are card games where the agents’ actions involve an exchange of information with other agents in the game. The authors’ system is modeled using Coq—-a formal proof management system. To the best of the authors’ knowledge, there are no papers in which knowledge games are considered using a Coq proof assistant. The authors use the dynamic logic of common knowledge, where they particularly focus on the epistemic consequences of epistemic actions carried out by agents. The authors observe the changes in the system that result from such actions. Those changes that can occur in such a system that are of interest to the authors take the form of agents’ knowledge about the state of the system, knowledge about other agents’ knowledge, higher-order agents’ knowledge and so on, up to common knowledge. Besides an axiomatic of epistemic logic, the authors use a known axiomatization of card games that is extended with some new axioms that are required for the authors’ approach. Due to a deficit in implementations grounded in theory that enable players to compute their knowledge in any state of the game, the authors show how the authors’ approach can be used for these purposes.

关键词：多Agent系统知识推理操作动态逻辑游戏卡多代理系统代理商代理人

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Words apart:Standardizing forestry terms and definitions across European biodiversity studies

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森林生态系统:英文版 2023年第4期10卷 459-471页

作者： Giovanni Trentanovi Thomas Campagnaro Tommaso Sitzia Francesco Chianucci Giorgio Vacchiano Christian Ammer MichałCiach Thomas ANagel Miren del Río Yoan paillet Silvana Munzi Kris Vandekerkhove Andrés Bravo-Oviedo Andrea Cutini Ettore D'Andrea pallieter De Smedt Inken Doerfler Dimitris Fotakis Jacob Heilmann-Clausen Jeňýk Hofmeister Jan Hošek philippe Janssen Sebastian Kepfer-Rojas Nathalie Korboulewsky Bence Kovács Daniel Kozák Thibault Lachat Anders Mårell Radim Matula Martin Mikoláš Björn Nordén péterÓdor x marko perović Elisabeth pötzelsberger peter Schall Miroslav Svoboda Flóra Tinya Mariana Ujházyová Sabina Burrascano Research Institute on Terrestrial Ecosystems-National Research Council(IRET-CNR) Via Madonna Del Piano 1950019Sesto FiorentinoFIItaly Department of Land EnvironmentAgriculture and ForestryUniversitàdegli Studi di PadovaViale Dell’Università1635020LegnaroPDItaly National Biodiversity Future Center Piazza Marina 6190133PalermoItaly CREA Research Centre for Forestry and Wood Viale S.Margherita 8052100ArezzoItaly Department of Agricultural and Environmental Sciences(DISAA) University of MilanVia Celoria 220133MilanItaly Silviculture and Forest Ecology of the Temperate Zones University of GöttingenGermany Department of Forest Biodiversity Faculty of ForestryUniversity of Agricultureal.29 Listopada 4631-425KrakówPoland Department of Forestry and Renewable Forest Resources Biotechnical FacultyUniversity of LjubljanaVecna pot 831000LjubljanaSlovenia Instituto de Ciencias Forestales(ICIFOR-INIA) CSICCtra.de la Coruña Km 7.528040MadridSpain University Grenoble Alpes LessemINRAE2 Rue de la Papeterie38402 Saint-Martin-d'HèresFrance Centro Interuniversitário de História Das Ciências e da Tecnologia Faculdade de CiênciasUniversidade de LisboaPortugal Centre for Ecology Evolution and Environmental ChangesFaculdade de Ciências&CHANGE-Global Change and Sustainability InstituteUniversidade de LisboaPortugal Research Institute for Nature and Forest(INBO) Havenlaan 88 Bus 731000BrusselBelgium Department of Biogeography and Global Change National Museum of Natural Sciences-CSICC/Serrano 115bis28006MadridSpain Research Institute on Terrestrial Ecosystems-National Research Council(IRET-CNR) Via G.Marconi N.205010PoranoTRItaly Forest&Nature Lab Department of EnvironmentGhent UniversityGeraardsbergsesteenweg 2679090GontrodeBelgium Institute of Biology and Environmental Science Vegetation Science&Nature ConservationUniversity of OldenburgAmmerländer Heerstraße 114-11826129OldenburgGermany Forest Research Institute Hellenic Agricultural Organization DimitraVassilikaThessal

Forest biodiversity studies conducted across Europe use a multitude of forestry terms,often *** hinders the comparability across studies and makes the assessment of the impacts of forest management on biodiversity highly *** attempts to standardize forestry and stand description terminology mostly used a top-down approach that did not account for the perspectives and approaches of forest biodiversity *** work aims to establish common standards for silvicultural and vegetation definitions,creating a shared conceptual framework for a consistent study on the effects of forest management on *** have identified both strengths and weaknesses of the silvicultural and vegetation information provided in forest biodiversity *** quantitative data on forest biomass and dominant tree species are frequently included,information on silvicultural activities and vegetation composition is often lacking,shallow,or based on broad and heterogeneous *** discuss the existing classifications and their use in European forest biodiversity studies through a novel bottom-up and top-driven review process,and ultimately propose a common *** will enhance the comparability of forest biodiversity studies in Europe,and puts the basis for effective implementation and monitoring of sustainable forest management *** standards here proposed are potentially adaptable and applicable to other geographical areas and could be extended to other forest interventions.

关键词： Forest management Multi-taxon Terminology Silviculture Data harmonization

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基于脑机接口的机器人辅助脑瘫康复面部表情训练系统设计

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高技术通讯 2023年第4期33卷 419-427页

作者：卢振利王乾王红沈玄霖 pENCIC marko 刘燕单长考赵宇 CAVIC Maja ROUMIANA Ilieva MARJAN Mernik 常熟理工学院电气与自动化工程学院常熟215500 盐城工学院机械工程学院盐城224000 中国矿业大学信息与控制工程学院徐州221116 常熟市第二人民医院康复医学科常熟215500 诺维萨德大学技术科学学院诺维萨德21000塞尔维亚常熟理工学院商学院常熟215500 索非亚技术大学管理学院索非亚1000保加利亚马里博尔大学电气工程和计算机科学学院马里博尔462000 斯洛文尼亚

本文针对脑瘫(Cp)患儿这一特殊群体,研究设计了基于脑机接口(BCI)技术的表情辅助训练系统。系统采用的脑机接口设备是Emotiv EpOC+,通过WebSocket通信协议获取和传递脑电信号,并且使用小波包变换对信号进行处理,获取信号的特征值;使用V-... 详细信息

本文针对脑瘫(Cp)患儿这一特殊群体,研究设计了基于脑机接口(BCI)技术的表情辅助训练系统。系统采用的脑机接口设备是Emotiv EpOC+,通过WebSocket通信协议获取和传递脑电信号,并且使用小波包变换对信号进行处理,获取信号的特征值;使用V-REp仿真软件设计仿真四轮小车,将获取到的特征值用于控制仿真小车实现不同方向的运动,以达到吸引患儿的注意力、提高训练效果的目的。设定了带有图片的人机交互界面增强引导患儿注意力。通过与医院康复师现场实验,验证了该技术的可行性,可为相关设备研发提供技术储备。

关键词：脑瘫(Cp) 脑机接口(BCI) Emotiv EpOC+

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基于CpG的六足机器人运动控制方法研究综述

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高技术通讯 2023年第7期33卷 762-771页

作者：刘天成卢振利陈勇单长考刘燕赵宇 pENCIC marko CAVIC Maja ROUMIANA Ilieva MARJAN Mernik 盐城工学院机械工程学院盐城224000 常熟理工学院电气与自动化工程学院常熟215500 常熟理工学院商学院常熟215500 诺维萨德大学技术科学学院诺维萨德21000塞尔维亚索非亚工业大学管理学院索非亚1000 保加利亚马里博尔大学电气工程和计算机科学学院马里博尔462000斯洛文尼亚

以六足机器人为研究对象,分析了中枢模式发生器(CpG)的国内外发展现状,揭示其主要是以振荡器作为控制器进行信号输出。针对如何搭建CpG模型,以Hopf振荡器为例进行模型搭建和改进,搭建六足机器人实验平台验证CpG模型控制六足机器人步态... 详细信息

以六足机器人为研究对象,分析了中枢模式发生器(CpG)的国内外发展现状,揭示其主要是以振荡器作为控制器进行信号输出。针对如何搭建CpG模型,以Hopf振荡器为例进行模型搭建和改进,搭建六足机器人实验平台验证CpG模型控制六足机器人步态运动是可行的。最后对基于CpG的六足机器人发展进行了展望。

关键词：中枢模式发生器(CpG) 六足机器人步态运动

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社交型脑瘫康复训练系统人机交互关键技术综述

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高技术通讯 2023年第5期33卷 537-549页

作者：王乾卢振利沈玄霖单长考刘燕陈勇赵宇 pENCIC marko CAVIC Maja ROUMIANA Ilieva MARJAN Mernik 盐城工学院机械工程学院盐城224000 常熟理工学院电气与自动化工程学院常熟215500 常熟市第二人民医院康复医学科常熟215500 常熟理工学院商学院常熟215500 诺维萨德大学技术科学学院诺维萨德21000塞尔维亚索非亚工业大学管理学院索非亚1000保加利亚马里博尔大学电气工程和计算机科学学院马里博尔462000斯洛文尼亚

脑瘫是一种常见的脑部发育不良疾病,国内外针对脑瘫康复主要是在幼儿期进行针对性康复诊治。步入成年后,社交型障碍是一种常见症状,为了更好地使脑瘫患者融入社会生活,有必要针对语言、动作和表情进行康复训练。本文针对社交障碍中的关... 详细信息

脑瘫是一种常见的脑部发育不良疾病,国内外针对脑瘫康复主要是在幼儿期进行针对性康复诊治。步入成年后,社交型障碍是一种常见症状,为了更好地使脑瘫患者融入社会生活,有必要针对语言、动作和表情进行康复训练。本文针对社交障碍中的关键环节,结合传统康复手段,对人机交互技术在以机器人研发辅助工具来优化提升相关康复训练系统中的应用进行综述分析,为脑瘫患者康复训练设备智能化升级改造和研发提供有益借鉴。

关键词：脑瘫(Cp) 社交障碍人机交互辅助系统

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Climate shapes the spatiotemporal variation in color morph diversity and composition across the distribution range of Chrysomela lapponica leaf beetle

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Insect Science 2022年第3期29卷 942-955页

作者： Mikhail V.Kozlov Zowi Oudendijk Anders Forsman Vojtech Lanta Maxwell V.L.Barclay Vladimir I.Gusarov Bert Gustafsson Zheng-Zhong Huang Oksana Y.Kruglova Yuri M.Marusik Yuri E.Mikhailov marko Mutanen Alexander Schneider Lukas Sekerka Maksim E.Sergeev Vitali Zverev Elena L.Zvereva Department of Biology University of TurkuTurkuFinland Department of Animal Ecology and physiology Radboud UniversityNijmegenThe Netherlands Department of Biology and Environmental Science Linnaeus UniversityKalmarSweden Institute of Botany The Czech Academy of SciencesDukelskaTrebohCzech Republic Department of Life Sciences Natural History MuseumLondonUnited Kingdom Natural History Museum University of OsloOsloNorway Departmant of Zoology Swedish Museum of Natural HistoryStockholmSweden elnsititute of Zoology Chinese Academy of SciencesBeijingChina Faculty of Biology Belarusian State UniversityMinskBelarus Department of Biocenology Institute for Biological Problems of the NorthFar East Branch of the Russian Academy of SciencesMagadanRussia Department of Zoology&Entomology University of the Free StateBloemfonteinSouth Africa Department of Ecology&Nature Management Ural State Forest Engineering UniversityYekaterinburgRussia Ecology and Genetics Research Unit University of OuluOuluFinland Department of Terrestrial Zoology Senckenberg Research Institute and Natural History MuseumFrankfurt am MainGermany Department of Entomology National MuseumPrague 9CirkusovaCzech Republic Federal Scientific Center of the East Asia Terrestrial Biodiversity Far East Branch of the Russian Academy of SciencesVladivostokRussia

Color polymorphism offers rich opportunities for studying the eco-evolutionary mechanisms that drive the adaptations of local populations to heterogeneous and changing *** explored the color morph diversity and composition in a Chrysomela lapponica leaf beetle across its entire distribution range to test the hypothesis that environmental and climatic variables shape spatiotemporal variation in the phenotypic structure of a polymorphic *** obtained information on 13617 specimens of this beetle from museums,private collections,and *** specimens(collected from 1830-2020)originated from 959 localities spanning 33°latitude,178°longitude,and 4200 m *** classified the beetles into five color morphs and searched for environmental factors that could explain the variation in the level of polymorphism(quantified by the Shannon diversity index)and in the relative frequencies of individual color *** highest level of polymorphism was found at high latitudes and *** color morphs differed in their climatic requirements;composition of colour morphs was independent of the geographic distance that separated populations but changed with collection year,longitude,mean July temperature and betweenyear temperature *** proportion of melanic beetles,in line with the thermal melanism hypothesis,increased with increasing latitude and altitude and decreased with increasing climate *** morph frequencies also declined during the past century,but only at high latitudes and altitudes where recent climate warming was especially *** observed patterns suggest that color polymorphism is especially advantageous for populations inhabiting unpredictable environments,presumably due to the different climatic requirements of coexisting color morphs.

关键词： adaptive polymorphism color morphs evolutionary dynamics geographic variation phenotypic diversity thermal melanism

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4'-三氟甲基尿苷修饰的寡核苷酸合成及修饰位点构象研究

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有机化学 2021年第10期41卷 4059-4065页

作者：郭丰敏 marko Trajkovski 李强 Janez plavec 席真周传政南开大学化学学院元素有机化学国家重点实验室天津300071 斯洛文尼亚国家化学研究所核磁中心卢布尔雅那大学化学和化工学院卢布尔雅那1000斯洛文尼亚

合成了4'-CF3修饰的尿苷亚磷酰胺单体,并通过固相合成将其引入了寡聚核苷酸链.分子动态模拟和NMR的结构研究,以及寡聚核苷酸的基本生化性质测定都表明4'-CF3修饰将该核苷酸的核糖锁定在不常见的South构象.

关键词：核酸 RNA结构氟化学

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