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First determination of the highly genotoxic fungal contaminant altertoxin II in a naturally infested apple sample

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Emerging Contaminants 2020年第1期6卷 82-86页

作者： Hannes Puntscher Doris marko Benedikt Warth Department of Food Chemistry and Toxicology Faculty of ChemistryUniversity of ViennaWahringer Str.381090ViennaAustria

Altertoxin II is an epoxide-holding perylene quinone and secondary metabolite produced by Alternaria *** genotoxic potential and the high concentrations determined in laboratory fungal cultures resulted in an increased scientific interest in this emerging ***,no natural occurrence in food has been reported to date to the best of our ***,we unambiguously identified altertoxin II in a naturally infected,unprocessed *** a validated LC-MS/MS method,fruit peel spots(approx.1 mm in diameter),typically associated with Alternaria infestation,were tested for 17 mycotoxins produced by this *** concentrations of tentoxin were determined 24 h after harvest,and the dibenzopyrones alternariol,alternariol monomethyl ether(AME)and AME-3-sulfate after six months of ***,these contamination patterns can be considered unlikely to be of toxicological concern for ***,an inconspicuous peel lesion(0.5×1 cm)separately sampled from a stored apple,exhibited considerably high concentrations of 14 Alternaria toxins,including dibenzopyrones,their barely studied modified forms(glucosides and sulfates),as well as genotoxic perylene quinones including altertoxin *** the toxicological potential of this compound,contaminations in such infected fruit parts should not be underestimated,*** the case of exposure through the consumption of fresh smoothies or fruit juices.

关键词： Alternaria alternata Emerging contaminants Genotoxicity Food safety Plant pathology Liquid chromatography tandem mass spectrometry

Role of novel biomarkers in diabetic cardiomyopathy

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World Journal of Diabetes 2021年第6期12卷 685-705页

作者： marko Kumric Tina Ticinovic Kurir Josip A Borovac Josko Bozic Department of Pathophysiology University of Split School of MedicineSplit 21000Croatia Department of Endocrinology University Hospital of SplitSplit 21000Croatia Emergency Medicine Institute of Emergency Medicine of Split-Dalmatia CountySplit 21000Croatia

Diabetic cardiomyopathy(DCM)is commonly defined as cardiomyopathy in patients with diabetes mellitus in the absence of coronary artery disease and *** DCM is now recognized as a cause of substantial morbidity and mortality among patients with diabetes mellitus and clinical diagnosis is still inappropriate,various expert groups struggled to identify a suitable biomarker that will help in the recognition and management of DCM,with little success so ***,we thought it important to address the role of biomarkers that have shown potential in either human or animal studies and which could eventually result in mitigating the poor outcomes of *** the array of biomarkers we thoroughly analyzed,long noncoding ribonucleic acids,soluble form of suppression of tumorigenicity 2 and galectin-3 seem to be most beneficial for DCM detection,as their plasma/serum levels accurately correlate with the early stages of *** combination of relatively inexpensive and accurate speckle tracking echocardiography with some of the highlighted biomarkers may be a promising screening method for newly diagnosed diabetes mellitus type 2 *** purpose of the screening test would be to direct affected patients to more specific confirmation *** perspective is in concordance with current guidelines that accentuate the importance of an interdisciplinary team-based approach.

关键词： Diabetic cardiomyopathy Heart failure Biomarkers Diabetes mellitus Cardiomyopathy

Analysis of shock wave unsteadiness using space and time correlations applied to shadowgraph flow visualization data

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Advances in Aerodynamics 2019年第1期1卷 14-38页

作者： S.marko P.M.Ligrani Propulsion Research Center Department of Mechanical and Aerospace EngineeringUniversity of Alabama in Huntsville5000 Technology DriveOlin B.King Technology Hall S236HuntsvilleAL 35899USA

Unsteady flow characteristics of a normal shock wave,a lambda foot,and a separated turbulent boundary layer are investigated within a unique test section with supersonic inlet *** supersonic wind tunnel facility,containing this test section,provides a Mach number of approximately 1.54 at the test section *** shadowgraph flow visualization data are employed to visualize shock wave structure within the test *** data are analyzed to determine shock wave unsteadiness characteristics,including grayscale spectral energy variations with frequency,as well as time and space correlations,which give coherence and time lag properties associated with perturbations associated with different flow *** illustrate the complexity and unsteadiness of shock-wave-boundary-layerinteractions,including event frequencies from grayscale spectral energy distributions determined using a Lagrangian approach applied to shock wave location,and by grayscale spectral energy distributions determined using ensemble-averaging applied to multiple closely-located stationary pixel ***-correlation function results and two-point correlation functions(in the form of magnitude squared coherence)quantify the time-scales of periodic events,as well as the coherence of flow perturbations associated with different locations,over a range of *** time lag data provide information on the originating location of perturbation events,as well as the propagation direction and event sequence associated with different flow *** insight into spatial variations of time lag and flow coherence is provided by application of magnitude squared coherence analysis to multiple locations,relative to a single location associated with the normal shock wave.

关键词： Shock wave Supersonic flow Time correlation Spatial correlation Autocorrelation Two-point correlation Frequency spectra Magnitude squared coherence Time lag Lagrangian flow analysis Unsteady flow analysis

Origins of high ductility exhibited by an extruded magnesium alloy Mg-1.8Zn-0.2Ca:Experiments and crystal plasticity modeling

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Journal of Materials Science & Technology 2021年第25期84卷 27-42页

作者： Jie Wang Gaoming Zhu Leyun Wang Evgenii Vasilev Jun-Sang Park Gang Sha Xiaoqin Zeng marko Knezevic National Engineering Research Center of Light Alloy Net Forming Shanghai Jiao Tong UniversityShanghai200240China Department of Mechanical Engineering University of New HampshireDurhamNH03824USA Advanced Photon Source Argonne National LaboratoryLemontIL60439USA School of Materials Science and Engineering Nanjing University of Science and TechnologyNanjing210094China State Key Laboratory of Metal Matrix Composites Shanghai Jiao Tong UniversityShanghai200240China

Low ductility and strength are major bottlenecks against Mg alloys’wide *** this work,we systematically design the composition and fabrication process for a low-alloyed Mg-Zn-Ca alloy,showing that it can be extruded at low temperatures(~250℃)and high speeds(~2 mm/s).After the extrusion,this alloy exhibits a substantially weakened basal texture,relatively small grain size,very high tensile elongation(~30%),and good *** origin of the considerably improved ductility was studied using a combination of three-dimensional atom probe tomography(3D-APT),transmission electron microscopy(TEM),electron backscattered diffraction(EBSD)in conjunction with surface slip trace analysis,in-situ synchrotron X-ray diffraction,and elasto-plastic self-consistent(EPSC)***-segregation of Zn and Ca atoms at a grain boundary is observed and associated with texture weakening and grain boundary mediated plasticity,both improving the *** basal slip and prismatic slip are identified as the dominant deformation systems in the alloy,the ratio between their slip resistances is substantially reduced relative to pure Mg and most other Mg alloys,significantly contributing to the improved ductility of the *** Mg-Zn-Ca alloy exhibiting excellent mechanical properties and low fabrication cost is a promising candidate for industrial productions.

关键词： Mg-Zn-Ca alloy Ductility Deformation mechanisms Crystal plasticity modeling Grain boundary mediated plasticity

Adherence to Mediterranean diet and advanced glycation endproducts in patients with diabetes

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World Journal of Diabetes 2021年第11期12卷 1942-1956页

作者： marko Grahovac marko Kumric Marino Vilovic Dinko Martinovic Ante Kreso Tina Ticinovic Kurir Josip Vrdoljak Karlo Prizmic Joško Božić Department of Pharmacology University of Split School of MedicineSplit 21000Croatia Department of Pathophysiology University of Split School of MedicineSplit 21000Croatia Department of Endocrinology University Hospital of SplitSplit 21000Croatia

BACKGROUND In recent years,American Diabetes Association started to strongly advocate the Mediterranean diet(MD)over other diets in patients with diabetes mellitus(DM)because of its beneficial effects on glycemic control and cardiovascular(CV)risk *** levels of advanced glycation endproducts(AGEs)emerged as an indicator of CV risk in *** biopsy being invasive,the use of AGE Reader has been shown to reflect tissue AGEs *** To examine the association between adherence to MD and AGEs in patients with DM type *** This cross-sectional study was conducted on 273 patients with DM type II.A survey questionnaire was composed of 3 separate *** first part of the questionnaire included general data and the habits of the *** second part aimed to assess the basic parameters of participants’diseases and associated *** third part of the questionnaire was the Croatian version of the 14-item MD service score(MDSS).AGEs levels and associated CV risk were measured using AGE Reader(DiagnOptics Technologies BV,Groningen,The Netherlands).RESULTS A total of 27(9.9%)patients fulfilled criteria for adherence to MD,with a median score of 8.0(6.0-10.0).Patients with none/limited CV risk had significantly higher percentage of MD adherence in comparison to patients with increased/definite CV risk(15.2%vs 6.9%,P=0.028),as well as better adherence to guidelines for nuts(23.2%vs 12.6%,P=0.023)and legumes(40.4%vs 25.9%,P=0.013)*** number of patients with glycated hemoglobin(HbA1c)7%(14.9%vs 7.3%,P=0.045).Moreover,those patients followed the MDSS guidelines for eggs(33.0%vs 46.8%,P=0.025)and wine(15.6%vs 29.8%,P=0.006)consumption more *** score had significant positive correlation with disease duration(r=0.179,P=0.003)and negative correlation with body mass index(BMI)values(r=-0.159,P=0.008).In the multiple linear regression model,BMI(β±SE,-0.09±0.04,P=0.037

关键词： Mediterranean diet Cardiovascular disease Diabetes mellitus Advanced glycation endproducts Dietary habits Atherosclerosis

Periodic Solutions in Unbounded Domains for the Boussinesq System

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Acta Mathematica Sinica,English Series 2010年第5期26卷 837-862页

作者： Elder Jesús VILLAMIZAR-ROA María ngeles RODRíGUEZ-BELLIDO marko Antonio ROJAS-MEDAR Escuela de Matemáticas Universidad Nacional de Colombia Dpto. Ecuaciones Diferenciales y Análisis Numérico Universidad de Sevilla Aptdo Dpto. de Ciencias Básicas Facultad de Ciencias Universidad del Bío BíoCampus Fernando May

Assuming that the external forces of the system are small enough, the reference temperature being a periodic function, we study the existence, the uniqueness and the regularity of time-periodic solutions for the Boussinesq equations in several classes of unbounded domains of Rn. Our analysis is based on the framework of weak-Lp spaces.

关键词： Boussinesq equations strong periodic solutions unbounded domains

Diabetes Prediction Algorithm Using Recursive Ridge Regression L2

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Computers, Materials & Continua 2022年第4期71卷 457-471页

作者： Milos Mravik T.Vetriselvi K.Venkatachalam marko Sarac Nebojsa Bacanin Sasa Adamovic Department of Computer Science Singidunum UniversityBelgrade11000Serbia Department of Computer science and Engineering K.Ramakrishnan College of TechnologyTrichy621112India Department of Applied Cybernetics Faculty of ScienceUniversity of Hradec Králové50003Hradec KrálovéCzech Republic

At present,the prevalence of diabetes is increasing because the human body cannot metabolize the glucose *** prediction of diabetes patients is an important research *** researchers have proposed techniques to predict this disease through data mining and machine learning *** prediction,feature selection is a key concept in ***,the features that are relevant to the disease are used for *** condition improves the prediction *** the right features in the whole feature set is a complicated process,and many researchers are concentrating on it to produce a predictive model with high *** this work,a wrapper-based feature selection method called recursive feature elimination is combined with ridge regression(L2)to form a hybrid L2 regulated feature selection algorithm for overcoming the overfitting problem of data *** is a major problem in feature selection,where the new data are unfit to the model because the training data are *** regression is mainly used to overcome the overfitting *** features are selected by using the proposed feature selection method,and random forest classifier is used to classify the data on the basis of the selected *** work uses the Pima Indians Diabetes data set,and the evaluated results are compared with the existing algorithms to prove the accuracy of the proposed *** accuracy of the proposed algorithm in predicting diabetes is 100%,and its area under the curve is 97%.The proposed algorithm outperforms existing algorithms.

关键词： Ridge regression recursive feature elimination random forest machine learning feature selection

Treatment options in stage I seminoma

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Oncology Research 2022年第3期30卷 117-128页

作者： UROS BUMBASIREVIC marko ZIVKOVIC MILOS PETROVIC VESNA CORIC NIKOLA LISICIC NEBOJSA BOJANIC Clinic of Urology University Clinical Center of SerbiaBelgrade11000Serbia Faculty of Medicine University of BelgradeBelgrade11000Serbia Institute of Medical and Clinical Biochemistry Faculty of MedicineUniversity of BelgradeBelgrade11000Serbia

Seminomas are most commonly diagnosed in clinical stage I(CSI).After orchiectomy,approximately 15%of patients in this stage have subclinical *** radiotherapy(ART)delivered to the retroperitoneum and ipsilateral pelvic lymph nodes has been the mainstay of treatment for many *** highly efﬁcient,with long-term cancer-speciﬁc survival(CSS)rates approaching almost 100%,ART is associated with considerable long-term consequences,particularly cardiovascular toxicity and increased risk of secondary malignancies(SMN).Therefore,active surveillance(AS)and adjuvant chemotherapy(ACT)were developed as alternative treatment *** AS prevents patient overtreatment,it is associated with strict follow-up regimens and increased radiation exposure due to repeated *** to equivalent CSS rates to ART,and lower toxicity,one course of adjuvant carboplatin presents the cornerstone of chemotherapy for CSI *** is almost 100%for patients with CSI seminoma,regardless of the chosen treatment ***,a personalized approach in treatment selection is ***,routine radiotherapy for CSI seminoma patients is no longer ***,it should be reserved for patients who are unﬁt or unwilling for AS or ***ﬁcation of prognostic factors for disease relapse allowed for the development of risk-adapted treatment strategy and stratiﬁcation of patients in low-risk and high-risk *** risk-adapted policy needs further validation,surveillance is currently recommended in low-risk patients,while ACT is reserved for patients with a higher risk of relapse.

关键词： Chemotherapy Radiotherapy Risk-adapted strategy Seminoma Surveillance

Impact of the COVID-19 pandemic on inflammatory bowel disease patients:A review of the current evidence

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World Journal of Gastroenterology 2021年第25期27卷 3748-3761页

作者： marko Kumric Tina Ticinovic Kurir Dinko Martinovic Piero Marin Zivkovic Josko Bozic Department of Pathophysiology University of Split School of MedicineSplit 21000Croatia Department of Endocrinology University Hospital of SplitSplit 21000Croatia Department of Gastroenterology University Hospital of SplitSplit 21000Croatia

Since the initial coronavirus disease 2019(COVID-19)outbreak in China in December 2019,the infection has now become the biggest medical issue of modern *** major contributors that amplified the impact of the disease and subsequently increased the burden on health care systems were high mortality among patients with multiple co-morbidities and overcapacity of intensive care *** the gastroenterology-related community,particular concern was raised with respect to patients with inflammatory bowel disease(IBD),as those patients are prone to opportunistic infections mainly owing to their immunosuppressive-based ***,we sought to summarize current knowledge regarding COVID-19 infection in patients with ***,it seems that IBD is not a comorbidity that poses an increased risk for COVID-19 acquisition,except in patients treated with ***,outcomes of the infected patients are largely dependent on therapeutic modality by which they are treated,as some worsen the clinical course of COVID-19 infection,whereas others seem to dampen the detrimental effects of ***,we discussed the present and the future impact of COVID-19 pandemic and concomitantly increased health care burden on IBD-management.

关键词： COVID-19 SARS-CoV-2 Inflammatory bowel disease Crohn’s disease Ulcerative colitis