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Peptic ulcer and childhood adversities experienced by working-aged people

World journal of Gastroenterology 2009年第27期15卷 3405-3410页

作者： markku PT Sumanen markku j koskenvuo Lauri H Sillanmki Kari j Mattila Kangasala Health Center and Medical School University of TampereFI 33014 Finland Department of Public Health University of HelsinkiFI 00014 Finland Department of General Practice University of Tampere Medical School and Hospital District of PirkanmaaFI 33014 Finland

AIM: To study the association between self-reported peptic ulcer and childhood ***: The Health and Social Support Study (HeS-Sup) population consisted of a stratif ied random sample drawn from the Finnish Population Register in four age groups: 20-24, 30-34, 40-44 and 50-54. The survey was carried out by postal questionnaire during 1998, with a response rate of 40.0%. A follow-up questionnaire was sent during 2003 to all those who responded to the f irst. Altogether 19 626 individuals returned the follow-up questionnaire; a response rate of 75.8%. The subjects were asked whether a doctor had told them that they have or have had peptic ulcer. The analyses covered those who responded aff irmatively to both the baseline and the follow-up enquiries (n = 718). Those not re-porting a peptic ulcer in either of the two questionnaires (n = 17 677) were taken as controls. The subjects were further requested (through six questions) to think about their childhood ***: The most common adversities mentioned were long-lasting financial difficulties in the family, serious conflicts in the family, and a family member seriously or chronically ill. All the adversities reported, except parental divorce, were more common among peptic ulcer patients than among controls (P values varied between justed odds ratios (OR) of childhood adversities in the multivariate logistic analysis for self-reported pep-tic ulcer varied between 1.45 and 2.01. Adjusting for smoking, heavy drinking, stress and nonsteroidal anti-inflammatory drug use had no further influence (ORs between 1.22 and 1.73).CONCLUSION: Our findings suggest that childhood adversities maintain a connection with and have a predictive role in the development of peptic ulcer.

关键词： Peptic ulcer Working-aged Childhood adversities Stress factors Predictive role

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直肠手术前机械肠道准备加口服抗生素对比单独机械肠道准备(MOBILE2):一项多中心、双盲、随机对照试验研究方案

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结直肠肛门外科 2021年第5期27卷 497-497页

作者：厉琳杰孙凌宇 koskenvuo L LUNKKA P VARPE P 哈尔滨医科大学附属第四医院肿瘤外科黑龙江哈尔滨150000 不详

背景:机械肠道准备(MBP)被广泛应用于直肠手术前。基于回顾性研究数据,诸多指南推荐机械肠道准备加口服抗生素(MOABP)以减少术后并发症,特别是手术部位感染(SSIs)。本研究的主要目的是查验MOABP是否能减少直肠手术的并发症。方法:研究分... 详细信息

背景:机械肠道准备(MBP)被广泛应用于直肠手术前。基于回顾性研究数据,诸多指南推荐机械肠道准备加口服抗生素(MOABP)以减少术后并发症,特别是手术部位感染(SSIs)。本研究的主要目的是查验MOABP是否能减少直肠手术的并发症。方法:研究分为MOABP组(MBP加口服抗生素)和MBP组(MBP加口服安慰剂)。MBP具体操作:所有患者于手术前2天的15:00开始饮用2 L聚乙二醇(PEG)和1 L液体进行MBP,且在手术前1天的15:00之前须完成MBP。

关键词：直肠手术手术部位感染机械肠道准备安慰剂回顾性研究口服抗生素术后并发症查验

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