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自动驾驶仪的要求如何制约寻的导弹的气动力设计(续)

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航空兵器 1995年第4期2卷 36-40页

作者： F.Williamnesline markl.nesline 苏身榜雷锡恩公司导弹系统部航空工业总公司○一四中心

穿越频率选择及其对自动驾驶仪约束的影响如果开环穿越频率ω_(CR)为44弧度/秒太低,控制工程师应提高它。随着ω_(CR)的增大,高频动特性更加重要。三阶模型难以把执行机构引起的出现在88弧度/秒附近的较快的一对根考虑进去。对于较大的... 详细信息

穿越频率选择及其对自动驾驶仪约束的影响如果开环穿越频率ω_(CR)为44弧度/秒太低,控制工程师应提高它。随着ω_(CR)的增大,高频动特性更加重要。三阶模型难以把执行机构引起的出现在88弧度/秒附近的较快的一对根考虑进去。对于较大的ω_(CR),这些根变得欠阻尼。

关键词：自动驾驶仪导弹气动力设计

4-1BB transcriptomic expression patterns across malignancies:Implications for clinical trials of 4-1BB agonists

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Cancer Communications 2024年第10期44卷 1168-1172页

作者： Yuji Uehara Shumei Kato Daisuke Nishizaki Hirotaka Miyashita Suzanna Lee Mary K.nesline Sarabjot Pabla Jeffrey M.Conroy Paul DePietro Heidi Ko Jason K.Sicklick Razelle Kurzrock Department of Thoracic Oncology and Respiratory Medicine Tokyo Metropolitan Cancer and Infectious Diseases CenterKomagome HospitalTokyoJapan Department of Precision Cancer Medicine Center for Innovative Cancer TreatmentTokyo Medical and Dental UniversityTokyoJapan Center for Personalized Cancer Therapy and Division of Hematology and Oncology Department of MedicineUniversity of California San DiegoMoores Cancer CenterLa JollaCaliforniaUnited States Dartmouth Cancer Center Hematology and Medical OncologyLebanonNew HampshireUnited States Labcorp Oncology DurhamNorth CarolinaUnited States OmniSeq Incorporation BuffaloNew YorkUnited States Division of Surgical Oncology Department of SurgeryCenter for Personalized Cancer TherapyUniversity of California San DiegoLa JollaCaliforniaUnited States Medical College of Wisconsin Cancer Center and Genomic Sciences and Precision Medicine Center Medical College of WisconsinMilwaukeeWisconsinUnited States Department of Oncology Medical College of Wisconsin Cancer CenterMilwaukeeWisconsinUnited States Department of Oncology University of NebraskaOmahaNebraskaUnited States

4-1BB,a member of the tumor necrosis factor receptor superfamily,is an important co-stimulatory molecule regulating the activity of immune cells across a range of physiological and pathological processes,which culminates in a potent immune response(Figure 1A and B)[1,2].Numerous clinical trials have been conducted utilizing 4–1BB agonists(Supplemental Table S1);however,previous and ongoing 4-1BB agonist trials are being conducted without biomarker selection,which potentially explains their modest ***,several studies suggest the potential value of utilizing transcriptomics in addition to genomics to identify the unique immunologic signature of individual tumors[3–7].

关键词： clinical utilizing Figure

A　DIAGNOSTIC　PRACTICE　STUDY　USING　INTERNATIONAL　CLASSIFICATION　OF　EPILEPSIES　AND　EPILEPTIC　SYNDROMES　IN　302　CASES

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Chinese Medical Sciences Journal 1995年第4期10卷 204-209页

作者：吴立文 markl,Scheuer DepartmentofNeurology PekingUnionMedicalCollegeHospitalCAMS＆PUMCBeiiing100730 ComprehensiveEpilepsyCenter Columbia-PresbyterianMed-icalCenterNewYorkUSA

We attempted to classify, according to the International Classification of Epilepsies and Epileptic Syndromes (1989), 302 patients at a tertiary epilepsy referral center. Proportion in categories as defined by the international League Against Epilepsy (ILAE) were as follows: localization-related epilepsies: 62. 9 %,generalized epilepsies: 22. 2%,epilepsies undetermined whether focal or generalized: 14. 2%, special syndromes: 0. 7%. Only 26. 8 % cases were definitely classified in single diagnostic ILAE categories based on ictal CCTV/EEG recordings. The distribution of epileptic syndromes was different from the previous reports due to various methods of case ascertainment and inclusion criteria. Use of specific criteria for the reliability study of international classification has been proposed.

关键词： epilepsies epileptic syndrome classification

Frequency, localization, and types of gastrointestinal stromal tumor-associated neoplasia

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World Journal of Gastroenterology 2019年第30期25卷 4261-4277页

作者： Johanna Waidhauser Anne Bornemann Martin Trepel Bruno markl Institute of Pathology and Molecular Diagnostics University Medical Center AugsburgAugsburg 86156Germany Department of Hematology and Clinical Oncology University Medical Center AugsburgAugsburg 86156Germany

BACKGROUND In recent years,increasing evidence of second neoplasms associated with gastrointestinal stromal tumors(GIST)has been *** case reports,mostly retrospective studies and a few reviews,have been *** our knowledge,however,no systematic review or meta-analysis of the existing data has been performed so *** To prepare a compilation,as complete as possible,of all reported second tumor entities that have been described in association with GIST and to systematically analyze the published studies with regard to frequency,localization,and types of GIST-associated *** The MEDLINE and EBSCO databases were searched for a combination of the keywords GIST/secondary,synchronous,coincident/tumor,neoplasm,and relevant publications were selected by two independent *** Initially,3042 publications were *** deletion of duplicates,1631 remained,and 130 papers were selected;22 of these were original studies with a minimum of 20 patients,and 108 were case *** the 22 selected studies,comprising a total number of 12050 patients,an overall rate of GIST-associated neoplasias of 20%could be *** second neoplasias were found in the gastrointestinal tract(32%)and in the male and female urogenital tract(30%).The specific risk scores of GISTs associated with other tumors were significantly lower than those without associated *** In this first systematic review,we could confirm previously reported findings of a more than coincidental association between GIST and other *** question whether there is an underlying causal association will need further *** data suggest that even GIST with a very low risk of disease progression should prompt screening for second neoplasia and subsequent frequent controls or extended staging.

关键词： Gastrointestinal stromal tumor Associated Secondary Neoplasia Tumor

Value of histomorphometric tumour thickness and smoothelin for conventional m-classification in early oesophageal adenocarcinoma

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World Journal of Gastrointestinal Oncology 2017年第11期9卷 444-451页

作者： Katharina Endhardt Bruno markl Andreas Probst Tina Schaller Daniela Aust Institute of Pathology Klinikum Augsburg Department of Gastroenterology Klinikum Augsburg Institute of Pathology Universitatsklinikum Dresden

AIM To test the validity of tumour thickness measurement in distinguishing between the different infiltration depths, especially when the duplication of muscularis mucosae cannot be demarcated clearly. METHODS We re-evaluated 100 completely embedded Barrett's adenocarcinomas regarding m-classification, maximum tumour thickness, and muscularis mucosae duplication. For validation, smoothelin staining was performed on a subset of cases. RESULTS The m1-, m2-and m3-classified adenocarcinomasshowed a significant lower tumour thickness compared to the m4-and sm1-classified lesions(P < 0.001). Smoothelin staining determined a clear muscularis mucosae duplication in 64% of the tested samples and enabled the differentiation of the two layers in diffuse and merged splits. CONCLUSION Tumour thickness in early oesophageal adenocarcinoma significantly correlates with the depth of infiltration and demonstrates its worth as an accurate p T classification in non-polypoid lesions. We created a new algorithm, which combines histomorphology with morphometric analyses. It is noteworthy that it facilitates the assessment of mucosal vs submucosal infiltration depth. The smoothelin staining strengthened our results of the tumour thickness evaluation and can be used in cases of doubt.

关键词： Smoothelin Endoscopic submucosal dissection Muscularis mucosae Barrett's carcinoma

THE　PEAK　LATENCY　OF　ORBITAL　PRESACCADIC　SPIKE　POTENTIAL　WITH　HORIZONTAL　EYE　MOVEMENTS

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Chinese Medical Sciences Journal 1996年第2期11卷 69-72页

作者：单扬 markl.Moster RichardA.Roemer[ DepartmentofNeurosensorySciences AlbertEinsteinMedicalCenterPhiladelphiaUSA DepartmentofPsychiatryandBehaviorSciences TempleUniversityPhiladelphiaUSA

Purpose. To investigate the peak latency of the orbital presaccadic spike potential (SP) with horizontal eye movement in ***. Orbital SP was recorded in 28 normal subjects from 8 electrodes around the eyes with Pz as the reference while performing 5°, 10°, 20°, 30° and 40°horizontal saccades to visual targets. SP peak latency was measured from SP onset to SP peak on averaged data aligned on SP ***. Significant main effects on SP peak latency are found for saccade size (0. 05). SP peak latency increases with increasing saccade size from 5°to 40°. SP peak latency is longer with saccades back to center than away from center, and with abducting saccades than with adducting saccades. SP peak latency differs at the electrode sites with an order from shorter to longer as follows: inner canthus (IC); inferior orbit (IO): outer canthus (OC); superior orbit (SO).Conclusicos. The effects on the peak latency of orbital SP can be explained by the saccade dynamic property, volume conduction as well as physiologic and anatomic factors of the eyes and orbits. The peak latency of orbital SP can be used to reflect the temporal characteristics of ocular motor units controlling saccadic eye movement.

关键词： saccade spike potential latency

Stage migration vs immunology: The lymph node count story in colon cancer

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World Journal of Gastroenterology 2015年第43期21卷 12218-12233页

作者： Bruno markl Institute of Pathology Klinikum Augsburg86156 AugsburgGermany

Lymph node staging is of crucial importance for the therapy stratification and prognosis estimation in colon cancer. Beside the detection of metastases,the number of harvested lymph nodes itself has prognostic relevance in stage Ⅱ/Ⅲ cancers. A stage migration effect caused by missed lymph node metastases has been postulated as most likely explanation for that. In order to avoid false negative node staging reporting of at least 12 lymph nodes is recommended. However,this threshold is met only in a minority of cases in daily practice. Due to quality initiatives the situation has improved in the past. This,however,had no influence on staging in several studies. While the numbers of evaluated lymph nodes increased continuously during the last decades the rate of node positive cases remained relatively constant. This fact together with other indications raised doubts that understaging is indeed the correct explanation for the prognostic impact of lymph node harvest. Several authors assume that immune response could play a major role in this context influencing both the lymph node detectability and the tumor's behavior. Further studies addressing this issue are need. Based on the findings the recommendations concerning minimal lymph node numbers and adjuvant chemotherapy should be reconsidered.

关键词： Colon cancer Lymph node harvest Stage migration Understaging Will Rogers Immune response

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硅中层错带中空位的电子态

Journal of Semiconductors 1998年第3期19卷 161-165页

作者：王永良 markl.,S 中国科学院半导体研究所

计算了硅中带状层错中的空位电子态，所使用的Ｒｅｃｕｒｓｉｏｎ方法是建立在原子轨道线性组合法的基础上，考虑了ｓ－ｐ－，ｄ－型十个原子轨道．用Ｌａｎｃｚｏｓ法得到了带隙及带连续态中的电子态，局域态密度是用连续连分数来表示... 详细信息

计算了硅中带状层错中的空位电子态，所使用的Ｒｅｃｕｒｓｉｏｎ方法是建立在原子轨道线性组合法的基础上，考虑了ｓ－ｐ－，ｄ－型十个原子轨道．用Ｌａｎｃｚｏｓ法得到了带隙及带连续态中的电子态，局域态密度是用连续连分数来表示的．硅中理想空位的三重简并态分裂为三个能级．从价态顶算起，它们的能量分别为－０．３，０．３，１．７ｅＶ．价带顶之上０．３ｅＶ的带隙态同纯层错中发现的电子态相似，但局域态密度要高一些．价带顶之上１．７ｅＶ的在导带中的电子态是一个强共振态．价带顶之下０．

关键词：硅层错空位电子态位错

黄连素及其与BCNU联合应用治疗恶性脑肿瘤的实验研究

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中国神经精神疾病杂志 1993年第2期19卷 86-89页

作者：张荣勋 markl.Posenblum Dolores V.Dougherty 河北医学院第二附属医院神经外科 050000 美国旧金山加里福尼亚大学医学院神经外科脑肿瘤研究中心

本文对黄连素的抗脑肿瘤作用,以及与1,3-bis(2-chloroethyl)-l-nitrosourea(BC-NU)联合应用进行了实验研究。用集落生成率测定(CFE)对6个人类脑胶质瘤细胞株和大白鼠9L脑肿瘤细胞(胶质肉瘤)进行了离体研究。用姐妹染色体交换法(SCE),对9... 详细信息

本文对黄连素的抗脑肿瘤作用,以及与1,3-bis(2-chloroethyl)-l-nitrosourea(BC-NU)联合应用进行了实验研究。用集落生成率测定(CFE)对6个人类脑胶质瘤细胞株和大白鼠9L脑肿瘤细胞(胶质肉瘤)进行了离体研究。用姐妹染色体交换法(SCE),对9L脑肿瘤细胞进行了评价。同时,在活体实验中用集落生成率测定对脑内固体9L脑肿瘤的治疗进行了分析。在BCNU的浓度为23μm单独使用时,对6个人类脑胶质瘤细胞株可获得平均为43％的细胞杀灭作用(0.24Log Kill)。而在黄连素与23μmBCNV联合应用治疗中,则可见到平均为97％的细胞杀灭相加作用(1.55Log Kill)。在采用150μg/ml黄连素离体治疗中,9L细胞姐妹染色体相对数的增高超过底数的2.7倍。在活体实验中,黄连素与BCNU联合应用也显示出细胞毒性相加作用。

关键词：黄连素 BCNU 脑肿瘤联合用药