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Coordinated peak expression of MMP-26 and TIMP-4 in preinvasive human prostate tumor

Cell Research 2006年第9期16卷 750-758页

作者： SeakwooLee KevinKDesai Kenneth A Iczkowski Robert G Newcomer Kevin J Wu Winston W Tan markdroycik Qing-XiangAmySang Department of Chemistry and Biochemistry and Institute of Molecular Biophysics Florida State UniversityTallahasseeFL 32306USA Department of Pathology and Laboratory Medicine Veterans Affairs Medical CenterGainesvilleFL 32608USA Department of PathologyImmunologyand Laboratory of MedicineUniversity of Florida College of MedicineGainesvilleFL 32610USA Department of Pathology MedicineMayo ClinicJacksonvilleFL 32224USA Department of Internal Medicine Hematology/Oncology Mayo ClinicJacksonvilleFL 32224USA

The identification of novel biomarkers for early prostate cancer diagnosis is highly important because early detectionand treatment are critical for the medical management of *** in the continuity of both the basal celllayer and basement membrane is essential for the progression of high-grade prostatic intraepithelial neoplasia (HGPIN)to invasive adenocarcinoma in human *** molecules involved in the conversion to an invasive phenotype arethe subject of intense *** have previously reported that matrix metalloproteinase-26 (MMP-26) promotes theinvasion of human prostate cancer cells via the cleavage of basement membrane proteins and by activating the zymogenform of ***,we have found that tissue inhibitor of metalloproteinases-4 (TIMP-4) is the most potentendogenous inhibitor of *** we demonstrate higher (p<0.0001) MMP-26 and TIMP-4 expression in HGPINand cancer,compared to non-neoplastic *** expression levels are highest in HGP1N,but decline in invasive cancer(p<0.001 for each) in the same *** staining of serial prostate cancer tissue sections suggestscolocalization of MMP-26 and *** present study indicates that MMP-26 and TIMP-4 may play an integral roleduring the conversion of HGPIN to invasive cancer and may also serve as markers for early prostate cancer diagnosis.

关键词： matrix metalloproteinase-26 tissue inhibitor of metalloproteinases-4 high-grade prostatic intraepithelial neoplasia prostate cancer biomarkers early diagnosis immunohistochemistry co-immunoprecipitation

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