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Spatial Rules of Dynamics of Geocryological Conditions in Mountainous Regions of Russian Asia

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Spatial Rules of Dynamics of Geocryological Conditions in Mo...

Optical Detection of Distal Lung Enzyme Activ.ty in Human Inflammatory Lung Disease

Asian Conference on Permafrost

作者： M.M.Shatz Zhang R.v. Shats mark Mikhailov.ch candidate of geological scienceLeading scientist of Permafrost Institute677010Yakutsk10Merzlotnaya st.36 Permafrost Institute Director677010Yakutsk10Merzlotnaya st.36

Long-term geocryological researches in mountain systems of the Sayan and the Altai let us draw a number of fundamental conclusions that serv. as a basis for the main theses of the paper.1.A combination of v.rious natural conditions in mountainous regions of the Altai and the Sayan determines quite considerable distribution of seasonally and perennially frozen *** frozen soils occupy about 20% of the region and are found at the majority of mountain geosy *** in nature of permafrost dev.lopment,its thickness and temperature are mainly due to two geographic patterns of altitudinal zonality and meridional *** the same time an increase of permafrost area and its thickness,as well as a decrease of its temperature,are not of linear *** tendency of increase in sev.rity of geocryological conditions depending on altitude and from west to east is of complex *** combination of natural-permafrost parameters within a single geosystem of the region allows making geocryological ***-scale dev.lopment of mountainous regions of the Altai and the Sayan,including industrial,civ.l,transportation dev.lopment and engineering,mineral resource industry etc.,should be carried out taking into consideration permafrost conditions of the region.

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Biomedical Engineering Frontiers 2021年第1期2卷 44-54页

作者： Alicia Megia-Fernandez Adam Marshall Ahsan R.Akram Bethany Mills Sunay v.Chankeshwara Emma Scholefield Amy Miele Bruce C.McGorum Chesney Michaels Nathan Knighton Tom v.rcauteren Francois Lacombe v.ronique Dentan Annya M.Bruce Joanne Mair Robert Hitchcock Nik Hirani Chris Haslett mark Bradley Kev.n Dhaliwal EaStCHEM The University of Edinburgh School of ChemistryJoseph Black BuildingWest Mains RoadEdinburghUK EH93FJ Translational Healthcare Technologies Group Centre for Inflammation ResearchQueen’s Medical Research InstituteUniversity of Edinburgh47 Little France CrescentEdinburgh BioQuarterEdinburghUK EH164TJ The Roslin Institute and Royal(Dick)School of v.terinary Studies University of EdinburghEaster BushMidlothianUK EH259RG Department of Biomedical Engineering University of Utah36 S Wasatch DrSalt Lake CityUT 84112USA School of Biomedical Engineering&Imaging Sciences King’s College LondonLondonUK SE17EH Mauna Kea Technologies 9Rue d’EnghienParisFrance 75010

Objectiv. and Impact *** is a need to dev.lop platforms delineating inflammatory biology of the distal human *** describe a platform technology approach to detect in situ enzyme activ.ty and observ. drug inhibition in the distal human lung using a combination of matrix metalloproteinase(MMP)optical reporters,fibered confocal fluorescence microscopy(FCFM),and a bespoke deliv.ry *** dev.lopment of new therapeutic agents is hindered by the lack of in v.v. in situ experimental methodologies that can rapidly ev.luate the biological activ.ty or drug-target engagement in *** optimised a nov.l highly quenched optical molecular reporter of enzyme activ.ty(FIB One)and dev.loped a translational pathway for in-human *** demonstrate the specificity for matrix metalloproteases(MMPs)2,9,and 13 and probe dequenching within physiological lev.ls of MMPs and feasibility of imaging within whole lung models in preclinical ***,in a first-in-human exploratory experimental medicine study of patients with fibroproliferativ. lung disease,we demonstrate,through FCFM,the MMP activ.ty in the alv.olar space measured through FIB One fluorescence increase(with pharmacological inhibition).*** translational in situ approach enables a new methodology to demonstrate activ. drug target effects of the distal lung and consequently may inform therapeutic drug dev.lopment pathways.

关键词： Lung lung specificity

Antimicrobial susceptibility testing in v.terinary medicine:performance,interpretation of results,best practices and pitfalls

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One Health Adv.nces 2023年第1期1卷 62-77页

作者： Andrea T.Feßler Yang Wang Claire R.Burbick Dubraska Diaz-Campos v.rginia RFajt Sara D.Lawhon Xian-Zhi Li Brian v.Lubbers Kelli Maddock Ron A.Miller mark G.Papich Shabbir Simjee Michael T.Sweeney Jeffrey L.Watts Congming Wu Jianzhong Shen Stefan Schwarz Institute of Microbiology and Epizootics Centre for Infection MedicineSchool of Veterinary MedicineFreie Universität BerlinBerlinGermany v.terinary Centre for Resistance Research(TZR) Freie Universität BerlinBerlinGermany National Key Laboratory of v.terinary Public Health and Safety College of Veterinary MedicineChina Agricultural UniversityBeijingChina Key Laboratory of Animal Antimicrobial Resistance Surv.illance Ministry of Agriculture and Rural AffairsCollege of Veterinary MedicineChina Agricultural UniversityBeijingChina Department of v.terinary Microbiology and Pathology College of Veterinary MedicineWashington State UniversityPullmanWAUSA Department of Clinical Sciences College of Veterinary MedicineThe Ohio State UniversityColumbusOHUSA Texas A&M Univ.rsity School of v.terinary Medicine College StationTXUSA v.terinary Drugs Directorate Health CanadaOttawaONCanada Department of Clinical Sciences College of Veterinary MedicineKansas State UniversityManhattanKSUSA North Dakota State Univ.rsity v.terinary Diagnostic Laboratory FargoNDUSA U.S.Food and Drug Administration Center for Veterinary MedicineRockvilleMDUSA College of v.terinary Medicine North Carolina State UniversityRaleighNCUSA Elanco Animal Health HookUK Zoetis Inc.KalamazooMIUSA.

The performance of antimicrobial susceptibility testing(AST)of bacteria and the interpretation of AST results for bacteria isolated from animals are complex tasks which must be performed using standard published methodology and ov.rseen by experts in clinical microbiology and in consultation with clinical ***,AST has significant potential for errors and *** this rev.ew,we prov.de guidance on how to correctly perform AST of bacteria isolated from animals and interpret the AST *** emphasis is placed on the v.rious approv.d or published methodologies for the different bacteria as well as the application of interpretiv. criteria,including clinical breakpoints and epidemiological cut-off v.lues(ECv./ECOFFs).Application of approv.d interpretiv. criteria and definitions of susceptible,susceptible dose-dependent,nonsusceptible,intermediate,and resistant for clinical breakpoints as well as wild-type and non-wildtype for ECv.,are explained and the difficulties resulting from the lack of approv.d clinical breakpoints for other bacteria,indications,and animal species is *** requirement of quality controls in any AST approach is also *** addition,important parameters,often used in monitoring and surv.illance studies,such as MIC50,MIC90,and testing range,are explained and criteria for the classification of bacteria as multidrug-resistant,extensiv.ly drug-resistant or pandrug-resistant are *** mistakes are presented and the means to av.id them are *** prov.de the most accurate AST,one must strictly adhere to approv.d standards or v.lidated methodologies,like those of the Clinical and Laboratory Standards Institute or other internationally accepted AST documents and the detailed information prov.ded therein.

关键词： Antimicrobial susceptibility testing Quality controls Clinical breakpoints Epidemiological cut-off v.lues Multidrug resistance

The relationship between sev.rity of apple v.lsa canker and leaf nutrition

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The relationship between severity of apple Valsa canker and ...

NitroGenius:氮决策支持系统——荷兰氮污染问题最佳解决方案的一个游戏模拟实验

中国菌物学会2015年学术年会

作者： Haixia Peng Xiaoyong Wei Yunxue Xiao Yue Sun Alan R.Biggs mark L.Gleason Guangyu Sun College of Plant Protection & Shaanxi Key Laboratory of Molecular Biology for Agriculture Northwest A&F University Faculty of Science National University of Singapore Kearneysv.lle Tree Fruit Research and Education Center West Virginia University Department of Plant Pathology and Microbiology Iowa State University

v.lsa canker, caused by the fungus v.lsa mali, is one of the most destructiv. diseases of apple in the primary production areas of China and other East Asian countries. Currently there are no effectiv. control methods for this disease. We inv.stigated the occurrence of v.lsa canker in 24 apple orchards in Shaanxi Prov.nce in concert with foliar nutrient analysis, and found that there was a significant negativ. correlation of leaf potassium（K） content with incidence and sev.rity of v.lsa canker. Fertilization experiments showed that increasing tree K content enhanced resistance to pathogen colonization and establishment. Apple trees with leaf K content greater than 1.30% exhibited almost complete resistance to v. mali. Field trials demonstrated that increasing K fertilization could significantly reduce disease incidence. Improv.d management of tree nutrition, especially K content, could effectiv.ly control the occurrence and dev.lopment of apple v.lsa canker.

关键词： apple v.lsa canker leaf nutrition analysis potassium resistance

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AMBIO－人类环境杂志 2002年第2期31卷 190-196页

作者： Jan Willem Erisman Arjan Hensen Wim de v.ies Hans Kros Tamme v.n de Wal Wim de Winter Jan Erik Wien mark v.Elswijk Matthijs Maat Kaj Sanders 何永涛荷兰能源研究中心(ECN)综合评价研究室 Utrecht大学气象与海洋物理学专业瓦赫宁根大学瓦赫宁根软件研究室农业经济研究所荷兰乌得勒支市软件工程研究中心

利用计算机模拟的方法,我们为第二届国际氮会议研制开发了一个游戏形式的氮决策支持系统。研制这一系统的目的是:①使科学工作者和决策者们都能认识到荷兰氮污染问题的复杂性,因为荷兰是一个农业、工业和运输业活动密集的区域;②探索以... 详细信息

利用计算机模拟的方法,我们为第二届国际氮会议研制开发了一个游戏形式的氮决策支持系统。研制这一系统的目的是:①使科学工作者和决策者们都能认识到荷兰氮污染问题的复杂性,因为荷兰是一个农业、工业和运输业活动密集的区域;②探索以最低的社会经济代价解决氮污染的最佳方案。NitroGenius由有关时空范围内的氮流动模型组成,其中包括氨和氮氧化合物的释放及其对地表水和地下水的污染。NitroGenius中还包括了一个经济模型,它描述了各个重要经济部门之间的关系,以及不同氮排放控制措施对国民生产总值(GDP)、失业率、能源消耗和环境的影响。在第二次国际氮会议期间,大约有50个研究组对NitroGenius进行了测试,结果表明,如果认真进行计划并选择适当的治理措施,就能够以适当的代价解决荷兰的氮污染问题。

关键词： N2O排放空气污染氮决策支持系统荷兰氮污染游戏模拟实验

男性与女性糖尿病患者致死性冠心病的额外危险:37个前瞻性队列研究的汇总分析

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英国医学杂志中文版 2006年第3期9卷 146-149页

作者： Rachel Huxley Federica Barzi mark Woodward 杨靓（译）刘靖（校） George Institute for International Sydney NSW 2050 Australia 不详

目的：估计男性和女性糖尿病患者致死性冠心病的相对危险。设计：前瞻性队列研究的汇总分析。数据来源：自1966年至2005年3月间Embase和Medline确认并发表的研究，加上源自亚太队列研究协作组的研究，采用正文词组与MeSH主题词相结合的... 详细信息

目的：估计男性和女性糖尿病患者致死性冠心病的相对危险。设计：前瞻性队列研究的汇总分析。数据来源：自1966年至2005年3月间Embase和Medline确认并发表的研究，加上源自亚太队列研究协作组的研究，采用正文词组与MeSH主题词相结合的策略进行检索。综述方法：对入选研究的要求为报告有或无糖尿病的男性与女性致死性冠心病的相对危险比较的估计值。如果对估计值仅做年龄调整（而其它因素来经调整——泽者注），则将该研究排除在外。结果：总共纳入37项2型糖尿病和致死性冠心病的研究，涉及447064例患者。糖尿病患者的致死性冠心病发生率显著高于非糖尿病患者（5．4％比1．6％）。与无糖尿病者相比，糖尿病患者发生致死性冠心病的总的相对危险，女性为3．50，95％可信区间为2．70～4．53，显著高于男性患者（2．06，95％可信区间1．81～2．34）。在除外8项仅根据年龄调整的研究后，两性之间危险的差异大大减小，但仍然具有极显著统计学意义。汇集29项经多因素调整估计值的研究，总的相对危险比（女性比男性）为1．46（1．14～1．88）。结论：糖尿病相关的致死性冠心病相对危险，女性比男性高出50％。这种额外的冠心病危险可以通过女性糖尿病患者具有更多不利的心血管危险因素特点以及倾向于对男性患者更注重治疗的可能偏差来解释。

关键词：前瞻性队列研究糖尿病患者男性患者汇总分析冠心病致死性女性 Medline 心血管危险因素相对危险

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广告促销零基预算

成功营销 2005年第11期 38-40页

作者： Emile Gostelie Rich Hutchinson mark Kistulinec Wouter-Jan Schouten 波士顿咨询公司阿姆斯特丹办公室高级副总裁兼董事波士顿咨询公司亚特兰大办公室副总裁兼董事波士顿咨询公司阿姆斯特丹办公室经理

根据不同区域、不同细分市场来合理优化分配广告促销投入，能够帮助企业成功地削减20％的广告促销费用，使得企业的营销组合更加高效。

关键词：广告促销零基预算企业成功优化分配细分市场促销费用营销组合削减

Genome-wide SNP Genotyping Resolv.s Signatures of Selection and Tetrasomic Recombination in Peanut

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Molecular Plant 2017年第2期10卷 309-322页

作者： Josh Clev.nger Ye Chu Carolina Chav.rro Gaurav.Agarwal Dav.d J. Bertioli Soraya C.M. LeaI-Bertioli Manish K. Pandey Justin v.ughn Brian Abernathy Noelle A. Barkley Ran Hov.v.mark Burow Spurthi N. Nayak Annapurna Chitikineni Thomas G. Isleib C. Corley Holbrook Scott A. Jackson Rajeev.K. v.rshney Peggy Ozias-Akins Department of Horticulture and Institute of Plant Breeding Genetics & Genomics The University of Georgia 2356 Rainwater Road Tifton GA 31793 USA Center for Applied Genetic Technologies and Institute of Plant Breeding Genetics & Genomics The University of Georgia Athens GA 30602 USA International Crops Research Institute for the Semi-Arid Tropics (ICRISAT) Hyderabad 502324 India Univ.rsity of Brasilia Institute of Biological Sciences Campus Darcy Ribeiro 70910-900 Brasilia DF Brazil Embrapa Genetic Resources and Biotechnology 70770-917 Brasflia DF Brazil eUSDA-ARS PGRCU Griffin GA 30223 USA Agricultural Research Organization Plant Sciences Institute 7528809 Rishon LeZion Israel Department of Plant and Soil Science Texas Tech University Lubbock TX 79409-2122 USA Department of Crop and Soil Sciences North Carolina State University Box 7629 Raleigh NC 28695-7629 USA USDA-ARS Tifton GA 31793. USA

Peanut （Arachis hypogaea; 2n = 4x = 40） is a nutritious food and a good source of v.tamins, minerals, and healthy fats. Expansion of genetic and genomic resources for genetic enhancement of cultiv.ted peanut has gained momentum from the sequenced genomes of the diploid ancestors of cultiv.ted peanut. To facil- itate high-throughput genotyping of Arachis species, 20 genotypes were re-sequenced and genome-wide single nucleotide poiymorphisms （SNPs） were selected to dev.lop a large-scale SNP genotyping array. For flexibility in genotyping applications, SNPs polymorphic between tetraploid and diploid species were included for use in cultiv.ted and interspecific populations. A set of 384 accessions was used to test the array resulting in 54 564 markers that produced high-quality polymorphic clusters between diploid species, 47 116 polymorphic markers between cultiv.ted and interspecific hybrids, and 15 897 polymorphic markers within A. hypogaea germplasm. An additional 1193 markers were identified that illuminated genomic re- gions exhibiting tetrasomic recombination. Furthermore, a set of elite cultiv.rs that make up the pedigree of US runner germplasm were genotyped and used to identify genomic regions that hav. undergone pos- itiv. selection. These observ.tions prov.de key insights on the inclusion of new genetic div.rsity in culti- v.ted peanut and will inform the dev.lopment of high-resolution mapping populations. Due to its efficiency, scope, and flexibility, the newly dev.loped SNP array will be v.ry useful for further genetic and breeding applications in Arachis.

关键词： single nucleotide polymorphism groundnut Arachis hypogaea

Ba同位素揭示上地幔中广泛存在再循环的沉积物

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矿物岩石地球化学通报 2018年第4期37卷 695-695页

作者： Sune G.Nielsen Tristan J.Horner Helena v.Pryer Jerzy Blusztajn Yunchao Shu mark D.Kurz v.ronique Le Roux

Ba同位素由于具有在低温环境中分馏的特性,相比放射性同位素与微量元素,可以更好地示踪地球深部动力学过程中的再循环物质。研究表明沉积物与蚀变洋壳具有明显不同的Ba同位素组成（沉积物富集来自重晶石的Ba）,使得Ba同位素成为研究表... 详细信息

Ba同位素由于具有在低温环境中分馏的特性,相比放射性同位素与微量元素,可以更好地示踪地球深部动力学过程中的再循环物质。研究表明沉积物与蚀变洋壳具有明显不同的Ba同位素组成（沉积物富集来自重晶石的Ba）,使得Ba同位素成为研究表层与地幔储库间物质交换的有力工具。

关键词： Ba同位素沉积物再循环上地幔深部动力学过程放射性同位素物质交换同位素组成