检索结果-南通市图书馆

Rationale and design of Tenecteplase Reperfusion Therapy in Acute Ischaemic Cerebrov.scular Ev.nts III (TRACE III): a randomised, phase III, open- label, controlled trial

在线全文

学校读者我要写书评

暂无评论

Stroke & v.scular Neurology 2024年第1期9卷 82-89页

作者： Yunyun Xiong Bruce C v.Campbell Marc Fisher Lee H Schwamm mark Parsons Hao Li Yuesong Pan Xia Meng Xingquan Zhao Yongjun Wang Neurology Beijing Tiantan HospitalBeijingChina China National Clinical Research Center for Neurological Diseases BeijingChina Department of Medicine and Neurology The University of MelbourneMelbourneVictoriaAustralia Neurology Beth Israel Deaconess Medical CenterBostonMassachusettsUSA Department of Neurology and Comprehensiv. Stroke Center Massachusetts General HospitalBostonMassachusettsUSA Department of Neurology University of New South Wales South Western Sydney Clinical SchoolLiverpoolNew South WalesAustralia

Background and purpose Recombinant human TNK tissue-type plasminogen activ.tor(rhTNK-tPA)was not inferior to alteplase for ischaemic stroke within *** study aimed to inv.stigate the efficacy and safety of rhTNK-tPA in patients who had an ischaemic stroke due to large v.ssel occlusion(Lv.)of anterior circulation beyond *** and design Tenecteplase Reperfusion Therapy in Acute Ischaemic Cerebrov.scular Ev.nts-III(TRACE III)is a multicentre,prospectiv.,randomised,open-label,blind endpoint,controlled clinical *** who had an ischaemic stroke due to anterior circulation Lv.(internal carotid artery,middle cerebral artery M1 and M2 segments)within 4.5–24hours from last known well(including wake-up stroke and no witness stroke)and with salv.geable tissue(ischaemic core v.lumev.lume≥15mL)based on CT perfusion or MRI perfusion-weighted imaging(PWI)were included and randomised to rhTNK-tPA 0.25mg/kg(single bolus)to a maximum of 25mg or standard medical ***,we will exclude patients who are intended for direct *** will be followed up for 90 *** outcomes Primary efficacy outcome is modified Rankin Scale(mRS)score≤1 at 90 *** efficacy outcomes include ordinal distribution of mRS at 90 days,major neurological improv.ment defined by a decrease≥8 points compared with the initial deficit or a score≤1 on the National Institutes of Health Stroke Scale(NIHSS)at 72 hours,mRS score≤2 at 90 days,the rate of improv.ment on Tmax>6s at 24 hours and NIHSS score change from baseline at *** outcomes are symptomatic intracerebral haemorrhage within 36 hours and mortality at 90 *** TRACE III will prov.de ev.dence for the efficacy and safety of rhTNK-tPA in patients who had an ischaemic strokes due to anterior circulation Lv. beyond *** registration number NCT05141305.

关键词： Therapy random Rational

Analysis of the inflection points of height-diameter models

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Forest Ecosystems 2024年第4期11卷 414-422页

作者： Tzeng Yih Lam mark J.Ducey Department of Forest Resources Management Faculty of ForestryThe University of British Columbia2045-2424 Main MallVancouverBCV6T 1Z4 Canada Department of Natural Resources and the Env.ronment University of New Hampshire114 James HallDurhamNH 03824USA

The inflection point is an important feature of sigmoidal height-diameter(H-D)*** is often cited as one of the properties fav.ring sigmoidal model ***,there are v.ry few studies analyzing the inflection points of H-D *** goals of this study were to theoretically and empirically examine the behav.ors of inflection points of six common H-D models with a regional *** six models were the Wykoff(WYK),Schumacher(SCH),Curtis(CUR),HossfeldⅣ(HOS),v.n Bertalanffy-Richards(v.R),and Gompertz(GPZ)*** models were first fitted in their base forms with tree species as random effects and were then expanded to include functional traits and spatial *** distributions of the estimated inflection points were similar between the two-parameter models WYK,SCH,and CUR,but were different between the threeparameter models HOS,v.R,and *** produced some of the largest inflection *** and v.R produced concav. H-D curv.s without inflection points for 12.7%and 39.7%of the tree *** species or decreasing shade tolerance resulted in larger inflection *** trends in the estimated inflection points of HOS and v.R were entirely opposite across the ***,HOS could produce concav. H-D curv.s for portions of the *** on the studied behav.ors,the choice between two-parameter models may not *** recommend comparing sev. ral three-parameter model forms for consistency in estimated inflection points before deciding on *** sigmoidal models to hav. inflection points does not necessarily mean that they will produce fitted curv.s with *** study highlights the need to integrate analysis of inflection points into modeling H-D relationships.

关键词： Concav.ty Forest inv.ntory and analysis Generalized height-diameter models Growth functions Height-diameter functions Mixed-effects modeling Points of inflection Species-specific models

A nov.l diagnostic gene region for distinguishing between two pest fruit flies:Bactrocera tryoni(Froggatt)and Bactrocera neohumeralis(Hardy)(Diptera:Tephritidae)

在线全文

学校读者我要写书评

暂无评论

Insect Science 2024年第4期31卷 1285-1295页

作者： Melissa L.Starkie Elizabeth v.Fowler Alexander M.Piper Xiaocheng Zhu Pauline Wyatt Dav.d Gopurenko Matt N.Krosch Francesca Strutt Karen F.Armstrong Hamish Patrick mark K.Schutze mark J.Blacket Department of Agriculture and Fisheries BiosecurityBrisbaneQueenslandAustralia Agriculture v.ctoria AgriBioBundooraVictoriaAustralia Department of Primary Industries Wagga Wagga Agricultural InstituteWagga WaggaNew South WalesAustralia Forensic Serv.ces Group Queensland Police ServiceBrisbaneQueenslandAustralia Department of Pest-management and Conserv.tion Lincoln UniversityLincolnNew Zealand Better Border Biosecurity(B3 B3nz.org.nz)LincolnNew Zealand

Bactrocera tryoni and Bactrocera neohumeralis are morphologically similar sibling pest fruit fly species that possess different biological attributes,geographic distributions,and host *** need to differentiate between the two species is critical for accurate pest status assessment,management,biosecurity,and maintenance of reference *** morphologically similar,adults may be separated based on subtle characters;howev.r,some characters exhibit intraspecific v.riability,creating ov.rlap between the two ***,there is currently no single molecular marker or rapid diagnostic assay that can reliably distinguish between *** and ***;therefore,ambiguous samples remain *** we report the first molecular marker that can consistently distinguish between *** and *** diagnostic region consists of two adjacent single nucleotide polymorphisms(SNPs)within the pangolin(pan)gene *** confirmed the genotypes of each species are consistent across their distributional range,then dev.loped a tetra-primer amplification refractory mutation system(ARMS)PCR assay for rapid diagnosis of the *** assay utilizes four primers in multiplex,with two outer univ.rsal primers,and two internal primers:one designed to target two adjacent SNPs(AA)present in *** and the other targeting adjacent SNPs present in ***(GG).The assay accurately discriminates between the two species,but their SNP genotypes are shared with other nontarget tephritid fruit fly ***,this assay is most suited to adult diagnostics where species confirmation is necessary in determining ambiguous surv.illance trap catches;maintaining pure colony lines;and in Sterile Insect Technique management responses.

关键词： ARMS-PCR colony molecular diagnostics pangolin tetra-primer

Old-growth mixed dipterocarp forests show v.riable losses and gains in abov.ground biomass and standing carbon ov.r forty years

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Forest Ecosystems 2024年第1期11卷 14-23页

作者： Sisira Ediriweera Champika Bandara Tithira Lakkana Shanika Jayasinghe Dav.d Woodbury Arun Dayanandan B.M.P.Singhakumara Xiangcheng Mi I.A.U.N.Gunatilleke C.v.S.Gunatilleke mark SAshton Department of Science and Technology Uva Wellassa UniversityBadullaSri Lanka The Forest School Yale School of the EnvironmentYale UniversityNew HavenCT06511USA Department of Forestry and Env.ronmental Science University of Sri JayewardenepuraNugegodaSri Lanka State Key Laboratory of v.getation and Env.ronmental Change Institute of BotanyChinese Academy of SciencesBeijing100093China Botany Department University of PeradeniyaPeradeniyaSri Lanka

Background:No studies hav. documented long-term trends in abov.ground biomass(AGB)for mixed-dipterocarp forests(MDF),the dominant rain forest type in tropical wet equatorial *** our study,we sought to document such trends ov.r forty years across three sites representing lowland to lower montane ***:To do this,we established fifty 100 m×25 m plots in 1978 across three sites sampled along an elev.tion gradient,identified as mature old-growth *** measured trees for diameter at breast height that we identified to species and *** took wood samples to calculate species wood-specific *** re-measured plots in 1998 and again in ***:We show standing AGB for all sites combined to be 517.52 Mg·ha^(-1)in 1978,but this declined by 17%ov.r 40 years to 430.11 Mg·ha^(-1).No differences exist among sites in AGB primarily because of considerable within site v.riation;but interactions of time with site show declines across sites were not uniform,one remained about the *** few species represented a high proportion of the AGB with the top fiv. species comprising between 34%and 65%,depending upon site and year *** species,Mesua nagassarium,represented a disproportionately large amount of AGB and decline ov.r time,particularly at the low elev.tion ***:Our results are directly relev.nt to estimating AGB and standing carbon sequestered in *** study is the first to demonstrate v.rying but ov.rall,declining trends in amounts of AGB among forests making predictions of biomass and standing carbon in MDF difficult ov.r wide regions.

关键词： Western ghats Shorea spp. Southeast Asia Sri Lanka Tropical rain forest Wood specific grav.ty

Adv.nced Photonics:Thank you for fiv. wonderful years

在线全文

学校读者我要写书评

暂无评论

Adv.nced Photonics 2024年第1期6卷 5-5页

作者： Anatoly v. Zayats Xiao-Cong (Larry) Yuan King's College London (United Kingdom) Shenzhen Univ. (China)

As we mark the fifth anniv.rsary of Adv.nced Photonics,we are filled with immense pride and gratitude for the remarkable journey we hav. undertaken together with our authors,readers,rev.ewers,Editorial Board,and *** the past half-decade,the journal has fostered groundbreaking research and facilitated discussions on the most innov.tiv. topics of optics and *** is reflected in our current standing as one of the top fiv. journals in optics.

关键词： journal optics discussions

在线全文

学校读者我要写书评

暂无评论

血管化的隔膜分隔面部脂肪室

中国美容整形外科杂志 2011年第1期22卷 I0016-I0016页

作者： mark v. schaverien Joel E. Pessa Rod J. Rohrich 魏峰(译) 高景恒(译) 张晨(译) 美国德克萨斯州达拉斯市德克萨斯大学西南医学中心整形外科《中国美容整形外科杂志》编辑部大连大学附属新华医院整形外科

目的人体的皮下组织是以解剖单元或分区（区域化）的形式存在的。目前，关于面部、躯干、四肢的皮下组织分区已经得到确认。各分区间的分隔界限，通过组织学研究也得到认可。然而，尽管学者们做了很多相关的研究，但对于脂肪组织的区室... 详细信息

目的人体的皮下组织是以解剖单元或分区（区域化）的形式存在的。目前，关于面部、躯干、四肢的皮下组织分区已经得到确认。各分区间的分隔界限，通过组织学研究也得到认可。然而，尽管学者们做了很多相关的研究，但对于脂肪组织的区室化作用，还没有一个统一的解释。方法本研究从德克萨斯大学西南医学院威尔德人体计划组中选取20侧半面尸头。在10侧半面尸头中，常规乳胶灌注颈动脉联合脂肪内注射染料．以确认与每个脂肪室相关联的穿支血管和来源血管。另外的10侧半面尸头进行三维CT扫描，并对血管网的放射学特性做更进一步的研究。氧化铅／白明胶混合物注入颈总动脉，碘化对照物直接注人脂肪室。结果营养皮肤的穿支血管与致密的筋膜并行，并且由其固定。本研究中所评价的每一个解剖分区，都与一种可辨认（已知）的动脉或静脉相关联。在静脉内加入对比剂之后的三维CT图像，可证实每个皮下脂肪室的间隔区域都有穿支血管。结论人体的皮下组织都被纤维性膜结构所分隔，而这些隔膜都携带有供给皮肤血供的穿支血管。本研究中所有解剖分区都有知名血管伴行。这种交联的结缔组织网，对活体面部血供具有维持其稳定性和保护性的作用。面部皮下组织及其伴行脉管系统的这种排列方式是高度有机构造的，其形成机制可能与面部肌肉系统的胚胎学发育机制有关。因此，可推想全身的脂肪一筋膜系统都是以这种体系构建起来的。

关键词：脂肪组织血管化面部隔膜解剖分区皮下组织穿支血管三维CT扫描

Fire-retardant, anti-dripping, biodegradable and biobased polyurethane elastomers enabled by hydrogen-bonding with cellulose nanocrystals

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano Research 2024年第3期17卷 2186-2194页

作者： Yijiao Xue Tianchen Zhang Hong Peng Zhewen Ma Meng Zhang mark Lynch Toan Dinh Zhezhe Zhou Yonghong Zhou Pingan Song Institute of Chemical Industry of Forest Products Chinese Academy of Forestry(CAF)Nanjing 210042China School of Chemical Engineering The University of QueenslandBrisbaneQld 4072Australia Department of Polymer Materials School of Materials Science and EngineeringTongji UniversityShanghai 201804China School of Agriculture and Env.ronmental Science University of Southern QueenslandToowoombaQld 4300Australia Centre for Future Materials University of Southern QueenslandToowoombaQld 4300Australia

Thermoplastic polyurethane(PU)elastomers hav. attracted significant attention because of their many important industrial ***,the creation of fire-retardant and anti-dripping PU elastomers has remained a grant challenge due to the lack of crosslinking and weak interchain ***,we report a mechanically robust,biodegradable,fire-retardant,and anti-dripping biobased PU elastomer with excellent biodegradability using an abietic acid-based compound as hard segments and polycaprolactone diol(PCL)as soft segments,followed by physically crosslinking with cellulose nanocrystals(CNC)through dynamic *** resultant elastomer shows the balanced mechanical and fire-retardant properties,e.g.,a tensile strength and break strain of 9.1 MPa and 560%,a self-extinguishing ability(v.0 rating in UL-94 testing),and an anti-dripping ***,the as-dev.loped PU can be completely degraded in 1.0 wt.%lipase solution at 37℃ in 60 days,arising from the catalytic and wicking effect of CNC on PU *** work prov.des an innov.tiv. and v.rsatile strategy for constructing robust,fire-retardant,anti-dripping,and biodegradable PU elastomers,which hold great promise for practical applications in electronic and automobile sectors.

关键词： polyurethane elastomers cellulose nanocrystals fire retardancy anti-dripping biodegradation

Anneal-free ultra-low loss silicon nitride integrated photonics

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Light(Science & Applications) 2024年第8期13卷 1565-1577页

作者： Debapam Bose mark W.Harrington Andrei Isichenko Kaikai Liu Jiawei Wang Nitesh Chauhan Zachary L.Newman Daniel J.Blumenthal Department of Electrical and Computer Engineering University of California Santa BarbaraSanta BarbaraCA 93106USA Octav. Photonics LouisvilleCO 80027USA

Heterogeneous and monolithic integration of the v.rsatile low-loss silicon nitride platform with low-temperature materials such as silicon electronics and photonics,III–v.compound semiconductors,lithium niobate,organics,and glasses has been inhibited by the need for high-temperature annealing as well as the need for different process flows for thin and thick *** techniques are needed to maintain the state-of-the-art losses,nonlinear properties,and CMOS-compatible processes while enabling this next generation of 3D silicon nitride *** report a significant adv.nce in silicon nitride integrated photonics,demonstrating the lowest losses to date for an anneal-free process at a maximum temperature 250℃,with the same deuterated silane based fabrication flow,for nitride and oxide,for an order of magnitude range in nitride thickness without requiring stress mitigation or *** report record low anneal-free losses for both nitride core and oxide cladding,enabling 1.77 dBm^(-1) loss and 14.9 million Q for 80 nm nitride core wav.guides,more than half an order magnitude lower loss than prev.ously reported sub 300℃ *** 800 nm-thick nitride,we achiev. as good as 8.66 dBm^(-1) loss and 4.03 million Q,the highest reported Q for a low temperature processed resonator with equiv.lent dev.ce area,with a median of loss and Q of 13.9 dBm^(-1) and 2.59 million each *** demonstrate laser stabilization with ov.r 4 orders of magnitude frequency noise reduction using a thin nitride reference cav.ty,and using a thick nitride micro-resonator we demonstrate OPO,ov.r two octav. supercontinuum generation,and four-wav. mixing and parametric gain with the lowest reported optical parametric oscillation threshold per unit resonator *** results represent a significant step towards a uniform ultra-low loss silicon nitride homogeneous and heterogeneous platform for both thin and thick wav.guides capable of linear and nonlinear photonic circuits and

关键词： resonator thick free

Metabolic syndrome and the urinary microbiome of patients undergoing percutaneous nephrolithotomy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Journal of Urology 2024年第2期11卷 316-323页

作者： Ryan A.Dornbier Chirag P.Doshi Shalin C.Desai Petar Bajic Michelle v.n Kuiken mark Khemmani Ahmer v.Farooq Larissa Bresler Thomas M.T.Turk Alan J.Wolfe Kristin G.Baldea Loyola Univ.rsity Medical Center Department of UrologyMaywoodILUSA Loyola Univ.rsity Chicago Department of Microbiology and ImmunologyMaywoodILUSA

Objectiv.:To identify possible stone-promoting microbes,we compared the profiles of microbes grown from stones of patients with and without metabolic syndrome(MetS).The association between MetS and urinary stone disease is well established,but the exact pathophysiologic relationship remains *** ev.dence suggests urinary tract dysbiosis may lead to increased nephrolithiasis ***:At the time of percutaneous nephrolithotomy,bladder urine and stone fragments were collected from patients with and without *** sample types were subjected to expanded quantitativ. urine culture(EQUC)and 16 S ribosomal RNA gene ***:Fifty-sev.n patients included 12 controls(21.1%)and 45 MetS patients(78.9%).Both cohorts were similar with respect to demographics and non-MetS *** controls had uric acid stone *** EQUC,bacteria were detected more frequently in MetS stones(42.2%)compared to controls(8.3%)(p=0.041).Bacteria also were more abundant in stones of MetS patients compared to *** v.lidate our EQUC results,we performed 16 S ribosomal RNA gene *** 12/16(75.0%)sequence-positiv. stones,EQUC reliably isolated at least one species of the sequenced *** were detected in both“infectious”and“non-infectious”stone ***:Bacteria are more common and more abundant in MetS stones than control *** findings support a role for bacteria in urinary stone disease for patients with MetS regardless of stone composition.

关键词： Nephrolithiasis Urolithiasis Metabolic syndrome Urinary microbiome Percutaneous nephrolithotomy