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RNA m^(6)A reader YTHDF2 facilitates precursor miR-126 maturation to promote acute myeloid leukemia progression

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Genes & Diseases 2024年第1期11卷 382-396页

作者： Zheng Zhang Keren Zhou Li Han Andrew small Jianhuang Xue Huilin Huang Hengyou Weng Rui su Brandon Tan Chao shen Wei Li Zhicong Zhao Ying Qing Xi Qin Kitty Wang Keith Leung mark Boldin Chun-Wei Chen David Ann Zhijian Qian Xiaolan Deng Jianjun Chen Zhenhua Chen Department of systems Biology Beckman Research Institute of City of HopeMonroviaCA 91016USA Irell and Manella Graduate school of Biological sciences Beckman Research Institute of City of HopeDuarteCA 91010USA Gehr Family Center for Leukemia Research City of HopeDuarteCA 91010USA sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhouGuangdong 510060China Guangzhou Laboratory GuangzhouGuangdong 510005China Bioland Laboratory GuangzhouGuangdong 51005China Department of Liver surgery Renji HospitalShanghai Jiao Tong University School of MedicineShanghai 200127China Department of Diabetes Complications and Metabolism Beckman Research Institute of City of HopeDuarteCA 91010USA Department of Biochemistry and Molecular Biology University of FloridaGainesvilleFL 32603USA Tongji Hospital Affiliated to Tongji University Frontier Science Center for Stem Cell ResearchSchool of Life Sciences and TechnologyTongji UniversityShanghai 200092China school of Pharmacy China Medical UniversityShenyangLiaoning 110001China

As the most common internal modification of mRNA,Ne-methyladenosine(m^(6)A)and its regulators modulate gene expression and play critical roles in various biological and patholog-ical processes including *** was reported previously that m^(6)A methyltransferase(writer),methyltransferase-like 3(METTL3)adds m^(6)A in primary microRNAs(pri-miRNAs)and fa-cilitates its processing into precursor miRNAs(pre-miRNAs).However,it is unknown whether m^(6)A modification also plays a role in the maturation process of pre-miRNAs and(if so)whether such a function contributes to ***,we found that YTHDF2 is aberrantly overexpressed in acute myeloid leukemia(AML)patients,especially in relapsed patients,and plays an onco-genic role in ***,YTHDF2 promotes expression of miR-126-3p(also known as miR-126,as it is the main product of precursor miR-126(pre-miR-126)),a miRNA that was reported as an oncomiRNA in AML,through facilitating the processing of pre-miR-126 into mature ***,YTHDF2 recognizes m^(6)A modification in pre-miR-126 and recruits AGO2,a regulator of pre-miRNA processing,to promote the maturation of ***2 posi-tively and negatively correlates with miR-126 and miR-126's downstream target genes,respec-tively,in AML patients,and forced expression of miR-126 could largely rescue YTHDF2/Ythdf2 depletion-mediated suppression on AML cell growth/proliferation and leukemogenesis,indi-cating that miR-126 is a functionally important target of YTHDF2 in ***,our studies not only reveal a previously unappreciated YTHDF2/miR-126 axis in AML and highlight the ther-apeutic potential of targeting this axis for AML treatment,but also suggest that m^(6)A plays a role in pre-miRNA processing that contributes to tumorigenesis.

关键词： AML miR-126 N^(6)-methyladenosine Pre-miRNA maturation YTHDF2

Metabolic syndrome and the urinary microbiome of patients undergoing percutaneous nephrolithotomy

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Asian Journal of Urology 2024年第2期11卷 316-323页

作者： Ryan A.Dornbier Chirag P.Doshi shalin C.Desai Petar Bajic Michelle Van Kuiken mark Khemmani Ahmer V.Farooq Larissa Bresler Thomas M.T.Turk Alan J.Wolfe Kristin G.Baldea Loyola University Medical Center Department of UrologyMaywoodILUSA Loyola University Chicago Department of Microbiology and ImmunologyMaywoodILUSA

Objective:To identify possible stone-promoting microbes,we compared the profiles of microbes grown from stones of patients with and without metabolic syndrome(Mets).The association between Mets and urinary stone disease is well established,but the exact pathophysiologic relationship remains *** evidence suggests urinary tract dysbiosis may lead to increased nephrolithiasis ***:At the time of percutaneous nephrolithotomy,bladder urine and stone fragments were collected from patients with and without *** sample types were subjected to expanded quantitative urine culture(EQUC)and 16 s ribosomal RNA gene ***:Fifty-seven patients included 12 controls(21.1%)and 45 Mets patients(78.9%).Both cohorts were similar with respect to demographics and non-Mets *** controls had uric acid stone *** EQUC,bacteria were detected more frequently in Mets stones(42.2%)compared to controls(8.3%)(p=0.041).Bacteria also were more abundant in stones of Mets patients compared to *** validate our EQUC results,we performed 16 s ribosomal RNA gene *** 12/16(75.0%)sequence-positive stones,EQUC reliably isolated at least one species of the sequenced *** were detected in both“infectious”and“non-infectious”stone ***:Bacteria are more common and more abundant in Mets stones than control *** findings support a role for bacteria in urinary stone disease for patients with Mets regardless of stone composition.

关键词： Nephrolithiasis Urolithiasis Metabolic syndrome Urinary microbiome Percutaneous nephrolithotomy

Treatment and prevention of epilepsy in onchocerciasis-endemic areas is urgently needed

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Infectious Diseases of Poverty 2024年第1期13卷 85-89页

作者： Robert Colebunders Joseph Nelson siewe Fodjo Olivia Kamoen Luis-Jorge Amaral Amber Hadermann Chiara Trevisan mark J.Taylor Julia Gauglitz Achim Hoerauf Yasuaki sato Katja Polman Maria-Gloria Basanez Dan Bhwana Thomson Lakwo Gasim Abd-Elfarag sebastien D.Pion Global Health Institute University of AntwerpAntwerpBelgium Department of Neurology Heilig Hart ZiekenhuisLierBelgium Department of Public Health Institute of Tropical MedicineAntwerpBelgium Liverpool school of Tropical Medicine LiverpoolUK Department of Computer science University of AntwerpAntwerpBelgium Institute of Medical Microbiology Immunology and ParasitologyUniversity Hospital BonnBonnGermany German Center for Infection Research(DZIF) Partner Site Bonn-CologneBonnGermany school of Global Humanities and social sciences Nagasaki UniversityNagasakiJapan MRC Centre for Global Infectious Disease Analysis and London Centre for Neglected TropicalDisease Research Department of Infectious Disease EpidemiologySchool of Public HealthImperial College LondonLondonUK National Institute for Medical Research TangaTanzania Vector Control Division Ministry of HealthKampalaUganda school of Public Health University of JubaJubaSouth Sudan Access for Humanity JubaSouth Sudan French National Research Institute for sustainable Development MontpellierFrance

Background There is increasing epidemiological evidence supporting the association between onchocerciasis and seizures, reinforcing the concept of onchocerciasis-associated epilepsy (OAE). The aim of this paper is to provide an update on the new knowledge about OAE and to propose recommendations to the World Health Organization how to address this public health *** text During the 2nd International Workshop on OAE held on 19-21 september, 2023, in Antwerp, Belgium, participants recognised OAE as a substantial yet neglected public health problem, particularly in areas of sub-saharan Africa where onchocerciasis remains hyperendemic. Evidence from prospective population-based studies suggest that strengthening onchocerciasis elimination efforts leads to a significant reduction of OAE incidence. There is a need to validate an OAE case definition to estimate the burden of disease and identify onchocerciasis-endemic areas requiring intensification of onchocerciasis elimination programmes and integration of epilepsy care. It is expected that raising awareness about OAE will boost the population uptake of ivermectin. The implementation of a community-based epilepsy treatment programme offering free anti-seizure medications (AsMs) has shown high effectiveness in reducing the frequency of seizures and improving the overall quality of life of people with *** To reduce OAE burden, enhanced collaboration between onchocerciasis and mental health programmes at community, national, and international levels is required. Urgent efforts are needed to ensure the uninterrupted provision of free AsMs in onchocerciasis-endemic areas. Furthermore, OAE should be included in the quantification of the onchocerciasis disease burden.

关键词： Onchocerciasis Morbidity Burden of disease Prevention Ivermectin Epilepsy Nodding syndrome Treatment Children Policy

An assessment of interspecific competition between two introduced parasitoids of Diaphorina citri (Hemiptera: Liviidae)on caged citrus plants

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Insect science 2019年第1期26卷 119-127页

作者： Meghan A.Vankosky mark s.Hoddle Department of Entomology University of CalifomiaRiversideCalifomiaUSA Center for Invasive species Research University of CaliforniaRiversideCaliforniaUSA

Two parasitoids attacking nymphs of Asian citrus psyllid,Diaphorina citri Kuwayama (Hemiptera:Liviidae),Tamarixia radiata (Waterston)(Hymenoptera:Eulophi- dae)and Diaphoreneyrtus aligarhensis (shafee,Alam &Agarwal)(Hymenoptera:Encyrtidae)are being released in California,UsA in a classical biological control program. To evaluate the effect of multiple parasitoid species on *** mortality,we conducted mesocosm experiments under controlled conditions using a complete block design with 6 treatments (*** nymphs exposed to:no parasitoids;*** or *** alone;*** or *** released first (by 48 h);and both species released simultaneously).Parasitism of *** nymphs by *** exceeded 60%and was unchanged when *** were *** by *** was greatest when T. radiata was absent (-28%)and was reduced in all treatments with *** present (sitoid-related mortality *** was consistent across parasitoid *** results suggest that competition between *** and *** is asymmetric and favors *** may be difficult for *** to contribute significantly to *** biological control where *** is ***, results reported here suggest that competition between *** and *** is not likely to reduce parasitism by *** or reduce parasitoid-induced mortality of ***.

关键词： Asian citrus psyllid classical biological control competition Diaphorencyrtus aligarhensis Tamarixia radiata

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被拜登遗忘的美国铁锈带

商业周刊（中文版） 2024年第6期 26-30页

作者： shawn Donnan with mark Niquette 汪泽(译) 不详

就业人数大幅减少,拜登制造业复兴政策略过了美国铁锈带的摇摆州在密尔沃基的Master Lock Co.工厂,仅仅十年前,工人们每年的薪水至少达到10万美元,他们制造的挂锁确保了美国学校仓库和后院小屋的安全。然而现在,这座工厂显示出了美国总... 详细信息

就业人数大幅减少,拜登制造业复兴政策略过了美国铁锈带的摇摆州在密尔沃基的Master Lock Co.工厂,仅仅十年前,工人们每年的薪水至少达到10万美元,他们制造的挂锁确保了美国学校仓库和后院小屋的安全。然而现在,这座工厂显示出了美国总统乔·拜登(Joe Biden)竞选连任的经济宣传的一个弱点。

关键词：密尔沃基就业人数制造业复兴铁锈薪水

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华盛顿地铁设计风格和导引系统的时代变迁

商业周刊（中文版） 2024年第6期 41-43页

作者： mark Byrnes 孟洁冰(译) 程玺(译) 不详

华盛顿地铁的新标识旨在帮助人们更方便地出行,从而提高客流,但地铁系统最初的设计者可能不会赞同这种改变。在建筑师哈里·威斯(Harry Weese)设计的华盛顿特区地铁网络中,车站采用了野兽派(Brutalist)风格的高笃混凝土拱顶,像快捷的地... 详细信息

华盛顿地铁的新标识旨在帮助人们更方便地出行,从而提高客流,但地铁系统最初的设计者可能不会赞同这种改变。在建筑师哈里·威斯(Harry Weese)设计的华盛顿特区地铁网络中,车站采用了野兽派(Brutalist)风格的高笃混凝土拱顶,像快捷的地铁系统每天运送乘客往返的旅游景点一样,这些拱顶也具有重大的意义。

关键词：地铁系统地铁设计华盛顿特区地铁网络导引系统野兽派时代变迁旅游景点

André Weil“有限域上方程的解数”的评论

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数学译林 2024年第2期43卷 165-166,104页

作者： mark Goresky 王弈阳(译) 林开亮(校) 不详

André Weil(韦伊)的论文“有限域上方程的解数(Numbers of solutions of equations in finite fields)”[W1]是过去100年间最具影响力的数学文章之一。在该文的最后一页Weil提出了一组精确的猜想,这些猜想引发了数学的巨大进展。

关键词：有限域 Weil 数学

BAs-PsO算法优化的无传感器轮毂电机转速控制

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江苏理工学院学报 2024年第4期30卷 16-27页

作者：彭倩吴浪徐笑韩锋钢 mark Robinson 厦门理工学院机械与汽车工程学院福建厦门361024 福建省客车先进设计与制造重点实验室福建厦门361024 纽卡斯尔大学工程学院纽卡斯尔英国NE17RU

针对无位置传感器轮毂电机比例积分(Proportion Integration,PI)控制中常见的抗干扰能力差、计算量大、控制精度不高等问题,提出一种粒子群-天牛须(Beetle Antennae search-Particle swarm Optimization,BAs-PsO)算法,在模型参考自适应... 详细信息

针对无位置传感器轮毂电机比例积分(Proportion Integration,PI)控制中常见的抗干扰能力差、计算量大、控制精度不高等问题,提出一种粒子群-天牛须(Beetle Antennae search-Particle swarm Optimization,BAs-PsO)算法,在模型参考自适应系统(Model Reference Adaptive system,MRAs)观测电机转速与位置的基础上,实现转速控制器的PI参数自整定。建立永磁同步轮毂电机(Permanent Magnet synchronous Motor,PMsM)的数学模型,以转速环传递函数的时间绝对误差积分指标(Integrated Time Absolute Error,ITAE)作为适应度函数,通过BAs-PsO算法优化转速控制器的PI参数;MRAs将电机本身作为参考模型,将含有待估计参数的定子电流方程作为可调模型,基于Popov超稳定理论,设计合适的自适应律,估计电机的转速与位置;利用Matlab/simulink进行仿真对比,并在HIL平台进行硬件测试验证。结果表明:与传统方法相比,BAs-PsO算法能够提高电机的运行响应速度,降低转速超调量,提高系统的鲁棒性。

关键词：轮毂电机模型参考自适应系统 BAs-PsO算法无位置传感器

Assessment of strain bursting in deep tunnelling by using the finite-discrete element method

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Journal of Rock Mechanics and Geotechnical Engineering 2019年第1期11卷 12-37页

作者： Ioannis Vazaios mark s.Diederichs Nicholas Vlachopoulos Department of Ceological saences and Ceological Engineering Queen's UniversityKingstonCanada

Rockbursting in deep tunnelling is a complex phenomenon posing significant challenges both at the design and construction stages of an underground excavation within hard rock masses and under high in situ stresses. While local experience, field monitoring, and informed data-rich analysis are some of the tools commonly used to manage the hazards and the associated risks, advanced numerical techniques based on discontinuum modelling have also shown potential in assisting in the assessment of rockbursting. In this study, the hybrid finite-discrete element method(FDEM) is employed to investigate the failure and fracturing processes, and the mechanisms of energy storage and rapid release resulting in bursting, as well as to assess its utility as part of the design process of underground *** the calibration of the numerical model to simulate a deep excavation in a hard, massive rock mass, discrete fracture network(DFN) geometries are integrated into the model in order to examine the impact of rock structure on rockbursting under high in situ stresses. The obtained analysis results not only highlight the importance of explicitly simulating pre-existing joints within the model, as they affect the mobilised failure mechanisms and the intensity of strain bursting phenomena, but also show how the employed joint network geometry, the field stress conditions, and their interaction influence the extent and depth of the excavation induced damage. Furthermore, a rigorous analysis of the mass and velocity of the ejected rock blocks and comparison of the obtained data with well-established semi-empirical approaches demonstrate the potential of the method to provide realistic estimates of the kinetic energy released during bursting for determining the energy support demand.

关键词： Rockburst Finite-discrete element method(FDEM) Deep tunnelling Hard rock excavations Brittle fracturing Discrete fracture network(DFN)