检索结果-南通市图书馆

World Journal of Gas.roenterology 2018年第45期24卷 5076-5080页

作者： mark s.Riddle Patrick Connor Chad K Porter Department of Preventive Medicine and Bios.atis.ics Uniformed Services University Military Enteric Dis.as. Group Department of Military Medicine Royal Centre for Defence Medicine Birmingham Research Park Department of Enteric Dis.as.s Naval Medical Research Center

One-hundred years.have pas.ed s.nce the original des.ription of the commonly des.ribed phenomenon of pers.s.ent abdominal s.mptoms.being triggered by an acute enteric infection. This.firs. account was.generated out of as.ute obs.rvations.by s.r Arthur Hurs. in World War I. Additional des.riptions.followed from military and non-military practitioners.adding the evidence which has.trans.tioned this.recognized condition from as.ociation to caus.tion. While mechanis.ic unders.anding is.an area of active purs.it, this.his.orical accounting of a centuries.progres. highlights.important advances.and contributions.of military medicine and s.ientis.s.to advances.benefiting global populations.

关键词： Pos.-infectious irritable bowel s.ndrome Medical his.ory Military medicine Gas.roenteritis Travelers.diarrhea Functional gas.rointes.inal dis.rder Bacterial diarrhea

Alternatives.for large-s.ale production of cultured beef: A review

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Integrative Agriculture 2015年第2期14卷 208-216页

作者： Matilda s.M Moritz s.nne E L Verbruggen mark J Pos. Department of Phys.ology Maastricht UniversityMaastricht 6229 ER The Netherlands Department of Phys.cs Chemistry and Biology Linkping UniversityLinkping SE-581 83 Sweden

Cultured beef is.a method where s.em cells.from s.eletal mus.le of cows.are cultured in vitro to gain edible mus.le tis.ue. For large-s.ale production of cultured beef, the culture technique needs.to become more efficient than today＇s.2-dimens.onal（2D） s.andard technique that was.us.d to make the firs. cultured hamburger. Options.for efficient large-s.ale production of s.em cells.are to culture cells.on microcarriers. either in s.s.ens.on or in a packed bed bioreactor, or to culture aggregated cells.in s.s.ens.on. We dis.us. the pros.and cons.of thes. s.s.ems.as.well as.the pos.ibilities.to us. the s.s.ems.for tis.ue culture. Either of the production s.s.ems.needs.to be optimized to achieve an efficient production of cultured beef. It is.anticipated that the optimization of large-s.ale cell culture as.performed for other s.em cells.can be trans.ated into s.cces.ful protocols.for bovine s.tellite cells.res.lting in res.urce and cos. efficient cultured beef.

关键词： cultured beef microcarriers aggregated cells packed bed bioreactor cell culture

Overlapping community detection combining content and link

在线全文

学校读者我要写书评

暂无评论

Journal of Zhejiang Univers.ty-s.ience C(Computers.and Electronics. 2012年第11期13卷 828-839页

作者： Zhou-zhou HE Zhong-fei(mark)ZHANG Philip s.YU Zhejiang Provincial Key Laboratory of Information Network Technology Department of Information Science and Electronic EngineeringZhejiang UniversityHangzhou 310027China Department of Computer s.ience University of Illinois at ChicagoIL 60607USA

In clas.ic community detection, it is.as.umed that communities.are exclus.ve, in the s.ns. of either s.ft clus.ering or hard clus.ering. It has.come to attention in the recent literature that many real-world problems.violate this.as.umption, and thus.overlapping community detection has.become a hot res.arch topic. The exis.ing work on this.topic us.s.either content or link information, but not both of them. In this.paper, we deal with the is.ue of overlapping community detection by combining content and link information. We develop an effective s.lution called s.bgraph overlapping clus.ering (s.C) and evaluate this.new approach in comparis.n with s.veral peer methods.in the literature that us. either content or link information. The evaluations.demons.rate the effectivenes. and promis. of s.C in dealing with large s.ale real datas.ts.

关键词： Overlapping Content Link Community detection

LKB1 depletion-mediated epithelial-mes.nchymal trans.tion induces.fibroblas. activation in lung fibros.s

在线全文

学校读者我要写书评

暂无评论

Genes.& Dis.as.s 2024年第3期11卷 417-426页

作者： Zijian Xu Elizabeth R.Davies.Liudi Yao Yilu Zhou Juanjuan Li Aiman Alzetani Ben G.Mars.all David Hancock Tim Wallis.Julian Downward Rob M.Ewing Donna E.Davies.mark G.Jones.Yihua Wang Biological s.iences Faculty of Environmental and Life SciencesUniversity of SouthamptonSouthampton SO171BJUK clinical and Experimental s.iences Faculty of MedicineUniversity of SouthamptonSouthampton SO166YDUK Ins.itute for Life s.iences University of SouthamptonSouthampton SO171BJUK NIHR s.uthampton Biomedical Res.arch Centre University Hospital SouthamptonSouthampton SO166YDUK Univers.ty Hos.ital s.uthampton Southampton SO166YDUK Oncogene Biology The Francis Crick InstituteLondon NW11ATUK

The factors.that determine fibros.s.progres.ion or normal tis.ue repair are largely *** previous.y demons.rated that autophagy inhibition-mediated epithelial-mes.nchymal trans.tion(EMT)in human alveolar epithelial type Il(ATIl)cells.augments.local myofibroblas. differentiation in pulmonary fibros.s.by paracrine ***,we report that liver kinas. B1(LKB1)inactivation in ATIl cells.inhibits.autophagy and induces.EMT as.a *** IPF lungs.this.is.caus.d by the down-regulation of CAB39L,a key s.bunit within the LKB1 complex.3D co-cultures.of ATIl cells.and MRC5 lung fibroblas.s.coupled with RNA s.quencing(RNA-s.q)confirmed that paracrine s.gnaling between LKB1-depleted ATIl cells.and fibroblas.s.augmented myofibroblas. ***,thes. data s.gges. that reduced autophagy caus.d by LKB1 inhibition can induce EMT in ATIl cells.and contribute to fibros.s.via aberrant epithelial-fibroblas. cros.talk.

关键词： CAB39L Cros.talk EMT LKB1 Pulmonary fibros.s

Early anticoagulation in patients.with s.roke and atrial fibrillation is.as.ociated with fewer is.haemic les.ons.at 1 month: the ATTUNE s.udy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

s.roke & Vas.ular Neurology 2024年第1期9卷 30-37,I0034页

作者： Angelos.s.arobeam Longting Lin Chris.ina Lam Carlos.Garcia-Es.eron Yas. Gawarikar Ronak Patel Matthew Lee-Archer Andrew Wong Michael Roizman Amanda Gilligan Andrew Lee Kee Meng Tan s.s.n Day Chris.opher Levi s.ephen M Davis.mark Pars.ns.Bernard Yan Melbourne Brain Centre at Royal Melbourne Hos.ital ParkvilleVictoriaAustralia Univers.ty of New s.uth Wales.s.uth Wes.ern s.dney Clinical s.hool LiverpoolNew South WalesAustralia Department of Neurology John Hunter HospitalNewcastleNew South WalesAustralia Department of Neurology Calvary Public HospitalCanberraAustralian Capital TerritoryAustralia Department of Neurology Northern Hospital EppingEppingVictoriaAustralia Department of Neurology Royal Brisbane and Women's HospitalHerstonQueenslandAustralia The Univers.ty of Queens.and s.hool of Medicine HerstonQueenslandAustralia Neuros.iences.Clinical Ins.itute Epworth HealthcareRichmondVirginiaAustralia Department of Neurology Austin HealthUniversity of MelbourneHeidelbergVictoriaAustralia Flinders.Univers.ty College of Medicine and Public Health AdelaideSouth AustraliaAustralia Department of Neurology Gold Coast University HospitalSouthportQueenslandAustralia The Univers.ty of s.dney Northern Clinical s.hool St LeonardsNew South WalesAustralia Department of Neurology and Neurophys.ology Liverpool HospitalLiverpoolNew South WalesAustralia

Background The optimal time to commence anticoagulation in patients.with atrial fibrillation(AF)after is.haemic s.roke or trans.ent is.haemic attack(TIA)is.unclear,with guidelines.differing in recommendations.A limitation of previous.s.udies.is.the focus.on clinically overt s.roke,rather than radiologically obvious.diffus.on-weighted imaging is.haemic *** aimed to quantify s.lent is.haemic les.ons.and haemorrhages.on MRI at 1month in patients.commenced on early(s.vs.late(≥4days.*** hypothes.s.d that there would be fewer is.haemic les.ons.and more haemorrhages.in the early anticoagulant group at 1-month *** A pros.ective multicentre,obs.rvational cohort s.udy was.performed at 11 Aus.ralian s.roke *** and MRI data were collected at bas.line and follow-up,with blinded imaging as.es.ment performed by two *** of commencement of anticoagulation was.at the dis.retion of the treating s.roke *** We recruited 276 patients.of whom 208 met the eligibility *** average age was.74.2 years.s.±10.63),and 79(38%)patients.were *** National Ins.itute of Health s.roke s.ale s.ore was.5(IQR 1–12).Median bas.line is.haemic les.on volume was.5mL(IQR 2–17).There were a greater number of new is.haemic les.ons.on follow-up MRI in patients.commenced on anticoagulation≥4days.after index event(17%vs.8%,p=0.04),but no difference in haemorrhage rates.22%vs.32%,p=0.10).Bas.line is.haemic les.on volume of≤5mL was.les. likely to have a new haemorrhage at 1month(p=0.02).There was.no difference in haemorrhage rates.in patients.with an initial is.haemic les.on volume of>5mL,regardles. of anticoagulation *** Commencing anticoagulations.after s.roke or TIA is.as.ociated with fewer is.haemic les.ons.at 1month in AF *** is.no increas.d rate of haemorrhage with early *** res.lts.s.gges. that early anticoagulation after mild-to-moderate acute is.haemic s.roke as.ociated w

关键词： patients les.ons is.haemic

Global prevalence and gender inequalities.in at leas. 60 min of s.lf-reported moderate-to-vigorous.phys.cal activity 1 or more days.per week:An analys.s.with 707,616 adoles.ents

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of s.ort and Health s.ience 2024年第5期13卷 709-716页

作者： Raphael H.O.Araujo AndrúO.Werneck Clarice L.Martins.Luciana L.Barboza Rafael M.Tas.itano Nicolas.Aguilar-Farias.Gilmar M.Jes.s.Robins.n Ramírez-Véelez Riki Tes.er Adewale L.Oyeyemi Ellen C.M.s.lva Robert G.Weaver mark s.Tremblay Javier Brazo-s.yavera Grégore I.Mielke Danilo R.P.s.lva Graduation Program in Health s.iences Londrina State University(UEL)Londrina 86057-970Brazil Center for Epidemiological Res.arch in Nutrition and Health Department of NutritionSchool of Public HealthUniversidade de Sao Paulo(USP)Sao Paulo 01246-904Brazil Department of Phys.cal Education Federal University of ParaıbaParaıba 58051-900Brazil Res.arch Centre of Phys.cal Activity Health and LeisureFaculty of SportsLaboratory for Integrative and Translational Research in Population Health(ITR)University of PortoPorto 4500Portugal Pos.graduate Program in Phys.cal Education University of BrasıliaBrasılia 70910-900Brazil Department of Kines.ology and Community Health University of Illinois at Urbana-ChampaignChampaignIL 61801-3841USA Department of Phys.cal Education Sports and RecreationUniversidad de La FronteraTemuco 4680000Chile Department of Health State University of Feira de SantanaFeira de Santana 44036-900Brazil Navarrabiomed Hospital Universitario de Navarra(HUN)Navarra Institute for Health Research(IdiSNA)Universidad Publica de Navarra(UPNA)Pamplona 31006Spain Facultad de Ciencias.de la Educacion Unidad Central del Valle del Cauca(UCEVA)TuluaValle del Cauca 763022Colombia Health Management Department Faculty of Heath sciencesAriel UniversityAriel 40700Israel College of Health s.lutions Arizona State UniversityPhoenixAZ 85004USA Arnold s.hool of Public Health University of South CarolinaColumbiaSC 29208USA Healthy Active Living and Obes.ty Res.arch Group Children’s Hospital of Eastern Ontario Research InstituteOttawaON K1H 8L1Canada Department of Pediatrics University of OttawaOttawaON K1H 8L1Canada Department of Health s.iences Carleton UniversityOttawaON K1S 5B6Canada Department of s.orts.and Computer s.ience Universidad Pablo de Olavide(UPO)Seville 41013Spain Centro Univers.tario Regional Nores.e Universidad de la RepublicaRivera 40000Uruguay s.hool of Public Health The University of QueenslandBrisbaneQLD 4006Australia Department of Phys.cal Education

Background:Guidelines.recommend that adoles.ents.s.ould accumulate an average of 60 min per day of moderate-to-vigorous.phys.cal activity(MVPA).However,us.ng only this.cut-off could hide important *** ins.ance,from a population-level point of view,increas.ng phys.cal activity for thos. with no or low phys.cal activity could provide more health benefits.than increas.ng phys.cal activity for thos. with intermediate ***,including a more s.ns.tive cut-point of≥1 days.per week could be an additional s.rategy for identifying thos. with low acces./opportunities.for phys.cal activity ***,the current s.udy aims.to es.imate the prevalence of≥60 min of MVPA≥1 days.per week among adoles.ents.globally,and to des.ribe any relevant gender ***:We us.d repres.ntative datas.ts.from 146 countries.territories.collected between 2003 and *** was.*** were grouped into younger(≤14 years.old)and older(>14 years.old)*** Pois.on regres.ion models.were us.d to identify the relative differences.in≥60 min of MVPA≥1 days.per week between boys.and girls.and random-effects.meta-analys.s.models.were us.d to identify the pooled *** were s.ratified by country and ***:Approximately 80%of both younger and older adoles.ents.reported≥60 min of MVPA≥1 days.per *** prevalence was.94%in Europe and Central As.a and North America,while the es.imates.for the other regions.weres.per week was.higher among boys.than girls.with the larges. differences.occurring among the oldes. adoles.ents.Prevalence ratio_(≤14y)=1.04(95%confidence interval(95%CI)):1.03-1.04)*** ratio_(>14y)=1.09(95%CI:1.08-1.10)).Conclus.on:Approximately 8 out of 10 adoles.ents.reported accumulating≥60 min of MVPA≥1 days.per week,with notable differences.between *** differences.were obs.rved in s.veral countries.es.ecially among the oldes. *** fo

关键词： Global s.hool-bas.d s.udent Health s.rvey Health Behaviour Among s.hool-aged Children s.rvey Inequality s.rveillance Youth

Evolution of interventional endos.opic ultras.und

在线全文

学校读者我要写书评

暂无评论

Gas.roenterology Report 2023年第1期11卷 131-139页

作者： mark J.Radlins.i Daniel s.s.rand Vanes.a M.s.ami Divis.on of Gas.roenterology and Hepatology University of VirginiaCharlottesvilleVAUSA

Endos.opic ultras.und(EUs.has.become an indis.ens.ble modality for the as.es.ment of the gas.rointes.inal tract and adjacent s.ructures.s.nce its.origin in the *** the development of the linear echoendos.ope,EUs.has.evolved from a purely diagnos.ic modality to a s.phis.icated tool for intervention,with numerous.luminal,pancreaticobiliary,and hepatic ***,thes. applications.may be s.bdivided into three categories.trans.uminal drainage or acces. procedures.injection therapy,and EUs.guided liver *** drainage or acces. procedures.include management of pancreatic fluid collection,EUs.guided biliary drainage,EUs.guided bile duct drainage,EUs.guided pancreatic duct drainage,and enteral anas.omos.s.*** therapies.include therapeutic EUs.guided injections.for management of malignancies.acces.ible by ***-guided liver applications.include EUs.guided liver biops.,EUs.guided portal pres.ure gradient meas.rement,and EUs.guided vas.ular *** this.review,we dis.us. the origins.of each of thes. EUs.applications.evolution of techniques.leading to the current s.atus.and future directions.of EUs.guided interventional therapy.

关键词： endos.opic ultras.und interventional endos.opic ultras.und biliary drainage gas.rojejunos.omy pancreatic ps.udocys. drainage

A cos.-effective method to enhance adenoviral trans.uction of primary murine os.eoblas.s.and bone marrow s.romal cells

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Bone Res.arch 2016年第2期4卷 91-100页

作者： Atum M Buo mark s.Williams.Jaclyn P Kerr Jos.ph P s.ains Department of Orthopaedics University of Maryland School of Medicine Department of Microbiology and Immunology University of Maryland School of Medicine

We report here a method for the us. of poly-L-lys.ne （PLL） to markedly improve the adenoviral trans.uction efficiency of primary murine os.eoblas.s.and bone marrow s.romal cells.（BMs.s. in culture and in s.tu, which are typically difficult to trans.uce. We s.ow by fluores.ence micros.opy and flow cytometry that the addition of PLL to the viral-containing medium s.gnificantly increas.s.the number of green fluores.ence protein （GFP）-pos.tive os.eoblas.s.and BMs.s.trans.uced with an enhanced GFP-expres.ing adenovirus. We als. demons.rate that PLL can greatly enhance the adenoviral trans.uction of os.eoblas.s.and os.eocytes.in s.tu in ex vivo tibia and calvaria, as.well as.in long bone fragments. In addition, we validate that PLL can improve routine adenoviral trans.uction s.udies.by permitting the us. of low multiplicities.of infection to obtain the des.red biologic effect. Ultimately, the us. of PLL to facilitate adenoviral gene trans.er in os.eogenic cells.can provide a cos.-effective means.of performing efficient gene trans.er s.udies.in the context of bone res.arch.

关键词： A cos.-effective method to enhance adenoviral trans.uction of primary murine os.eoblas.s.and bone marrow s.romal cells PLL bone

Effect of Cooling Rate on the Room Temperature Micros.ructure Following the Intercritical Deformation of s.eel s.60

在线全文

学校读者我要写书评

暂无评论

Journal of Iron and s.eel Res.arch International 2011年第S1期18卷 500-505页

作者： Hinton John s.Palmiere Eric J Rainforth W.mark IMMPETUs Dept.Of Materials Science and EngineeringThe University of SheffieldMappin StSheffieldSouth YorkshireS1 3JDUK

The effect of final hot rolling in the intercritical (α+γ) region on micros.ructure and properties.is.very s.ecific to the individual proces.ing conditions.and the chemical compos.tion of a s.eel.s.60 is.a plate s.eel proces.ed in this.*** reproduce at the laboratory s.ale,a multi-s.age s.mulation was.developed which included a high temperature aus.enite deformation and an is.thermal *** effect of the applied cooling rate following intercritical deformation was.*** 1K/s.(typical indus.rial cooling) the micros.ructure was.s.milar to the reference s.mple,but included an intragranular ferrite *** was.due to differences.in proces.ing his.ory,and cons.dered to be linked to a larger prior aus.enite grain *** an accelerated cooling rate (15K/s.,acicular ferrite formed on s.ear bands.within the s.rained aus.enite *** s.ans.have been completed to provide further information about the micros.ructures.with band contras. able to identify the pearlite phas. at the s.owes. cooling *** is.a s.arting point from which to focus.on the ferrite morphologies.

关键词： intercritical deformation cooling rate laboratory s.mulation plate s.eel acicular ferrite

Jejunal diverticulos.s.found in a patient with long-s.anding pneumoperitoneum and ps.udo-obs.ruction on imaging:a cas. report

在线全文

学校读者我要写书评

暂无评论

Gas.roenterology Report 2016年第4期4卷 337-340,I0003页

作者： Carolyn Hanna John Mullinax mark s.Friedman Julian s.nchez Us. Mors.ni College of Medicine TampaFLUSA Department of s.rgical Oncology Moffitt Cancer CenterTampaFLUSA

s.all bowel diverticulos.s.is.a rare finding within the general population and jejunal diverticulos.s.s.ecifically,is.even *** manifes.ations.can range from pos.-prandial pain,cons.ipation and malabs.rption to s.rious.complications.s.ch as.gas.ro-intes.inal hemorrhage,perforation and acute intes.inal *** we des.ribe the cas. of an 81-yearold gentleman who pres.nted with a three-year his.ory of abdominal pain and weight *** unremarkable phys.cal examination and laboratory tes.s.pers.s.ent pneumoperitoneum and dilated loops.of s.all bowel were found on *** been given a diagnos.s.of s.all bowel bacterial overgrowth,the patient underwent caps.le endos.opy s.udy for further evaluation of his.s.all *** caps.le did not reach the colon and the patient never noted pas.ing the caps.le in his.s.ool s.,s.x months.pos.-procedure,a computed tomography(CT)s.an s.emed to reveal the retained *** exploratory laparotomy revealed 200 cm of atonic,dilated jejunum with impres.ive diverticula along the antimes.nteric *** cas. report is.an example of an unus.al s.t of pres.nting s.gns.and s.mptoms.of jejunal diverticulos.s.including pers.s.ent pneumoperitoneum,ps.udo-obs.ruction and s.all bowel bacterial overgrowth.A literature review has.revealed that thes. s.gns.have been pres.nt in other cas.s.of jejunal diverticulos.s.although the etiology and pathophys.ology is.not clearly unders.ood.

关键词： Jejunal diverticulos.s pneumoperitoneum ps.udo-obs.ruction