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Canadian children’s.and youth’s.adherence to the 24-h movement guidelines.during the COVID-19 pandemic: A decis.on tree analys.s

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Journal of s.ort and Health s.ience 2020年第4期9卷 313-321页

作者： Michelle D.Guerrero Leigh M.Vanderloo Ryan E.Rhodes.Guy Faulkner s.rah A.Moore mark s.Tremblay Children’s.Hos.ital of Eas.ern Ontario Res.arch Ins.itute OttawaON K1H 8L1Canada ParticipACTION TorontoON M5S 1M2Canada Child Health and Evaluative s.iences Hospital for Sick ChildrenTorontoON M5G 0A4Canada Behavioral Medicine Laboratory School of Exercise SciencePhysical and Health EducationUniversity of VictoriaVictoriaBC V8W 2Y2Canada s.hool of Kines.ology University of British ColumbiaVancouverBC V6T 1Z1Canada Department of Therapeutic Recreation Faculty of ChildFamilyand Community StudiesDouglas CollegeCoquitlamBC V3B 7X3Canada s.hool of Health and Human Performance Dalhousie UniversityHalifaxNS B3H 4R2Canada Department of Pediatrics University of OttawaOttawaON K1H 8L1Canada

Purpos.:The purpos. of this.s.udy was.to us. decis.on tree modeling to generate profiles.of children and youth who were more and les. likely to meet the Canadian 24-h movement guidelines.during the coronavirus.dis.as.-2019(COVID-19)***:Data for this.s.udy were from a nationally repres.ntative s.mple of 1472 Canadian parents.Meanage=45.12,s.=7.55)of children(511 years.old)or youth(1217 years.old).Data were collected in April 2020 via an online *** items.as.es.ed demographic,behavioral,s.cial,micro-environmental,and macro-environmental *** decis.on trees.of adherence and non-adherence to all movement recommendations.combined and each individual movement recommendation(phys.cal activity(PA),s.reen time,and s.eep)were ***:Res.lts.revealed s.ecific combinations.of adherence and non-adherence *** as.ociated with adherence to the recommendation(s.included high parental perceived capability to res.rict s.reen time,annual hous.hold income ofCAD 100,000,increas.s.in children’s.and youth’s.outdoor PA/s.ort s.nce the COVID-19 outbreak began,being a boy,having parents.younger than 43 years.old,and s.all increas.s.in children’s.and youth’s.s.eep duration s.nce the COVID-19 outbreak *** as.ociated with non-adherence to the recommendation(s.included low parental perceived capability to res.rict s.reen time,youth aged 1217 years.decreas.s.in children’s.and youth’s.outdoor PA/s.ort s.nce the COVID-19 outbreak began,primary res.dences.located in all provinces.except Quebec,low parental perceived capability to s.pport children’s.and youth’s.s.eep and PA,and annual hous.hold income ofCAD 99,***:Our res.lts.s.ow that s.ecific characteris.ics.interact to contribute to(non)adherence to the movement behavior *** highlight the importance of targeting parents.perceived capability for the promotion of children’s.and youth’s.movement behaviors.during challengin

关键词： Decis.on tree analys.s Parental perceived capability Phys.cal activity s.reen time s.eep

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Maximizing Performance under a Power Cons.raint on Modern Multicore s.s.ems

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Journal of Computer and Communications 2019年第7期7卷 252-266页

作者： Vaibhav s.ndriyal Mas.a s.s.nkina Bryce Wes.heimer mark s. Gordon Old Dominion Univers.ty Norfolk Virginia USA Iowa s.ate Univers.ty and Ames.Laboratory Ames IA USA

Energy efficiency and energy-proportional computing have become a central focus.in modern s.percomputers. Thes. s.percomputers.s.ould provide high throughput per unit of power to be s.s.ainable in terms.of operating cos. and failure rates. In this.paper, a power-bounded s.rategy is.propos.d that maximizes.parallel application performance under a given power cons.raint. The s.rategy dynamically allocates.power to core, uncore, and memory power domains.within a node to maximize performance under a given power budget. Experiments.on a 20-core Has.ell-EP platform for a real-world parallel application GAMEs. demons.rate that the propos.d s.rategy delivers.performance within 4% of the bes. pos.ible performance for as.much as.25% reduction in the minimum power budget required for maximum performance.

关键词： Uncore Frequency s.aling (UFs. Dynamic Voltage and Frequency s.aling (DVFs. Power Budget GAMEs.

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The Effects.of Zinc and Other Divalent Cations.on M-Current in Ventral Tegmental Area Dopamine Neurons

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Journal of Biomedical s.ience and Engineering 2014年第14期7卷 1075-1087页

作者： s.s.mu Koyama Munechika Enjoji mark s. Brodie s.rah B. Appel Department of Phys.ology and Biophys.cs University of Illinois at Chicago College of Medicine Chicago USA Department of Phys.ology and Biophys.cs University of Illinois at Chicago College of Medicine Chicago USA Department of Clinical Pharmacology Faculty of Pharmaceutical Sciences Fukuoka University Fukuoka Japan

Ventral tegmental area dopamine (DA VTA) neurons.are important for the reinforcing effects.of drugs.of abus. s.ch as.ethanol and nicotine. We have previous.y s.own that M-current (IM) regulates.the excitability of DA VTA neurons. Zinc (Zn2+) contributes.to the regulation of neuronal excitation as.a neuromodulator. In the pres.nt s.udy, we inves.igated zinc effect on the properties.of IM and the s.ontaneous.firing frequency of DA VTA neurons. The s.andard deactivation protocol was.us.d to meas.re IM during voltage-clamp recording with a hyperpolarizing voltage s.ep to ﹣40 mV from a holding potential (VH) of ﹣25 mV. Zn2+ (100 μM) inhibited IM amplitude and IM recovered completely from the inhibition after the was.out of Zn2+. Zn2+ inhibited IM in a concentration-dependent manner (IC50: 5.8 μM). When hyperpolarizing voltage s.eps.were given to ﹣65 mV (in 10 mV increments. from a VH of ﹣25 mV, Zn2+ (100 μM) reduced IM amplitude at each voltage and zinc inhibition of IM was.not voltage-dependent. Zn2+ increas.d the s.ontaneous.firing frequency of DA VTA neurons.in a concentration-dependent manner, s.gges.ing that Zn2+ caus.s.excitation of DA VTA neurons.through an action on IM. IM of DA VTA neurons.was.inhibited by 100 μM divalent cations.in increas.ng order of potency: Ba2+ (16%) 2+ (25%) 2+ (40%) 2+ (59%) 2+ (67%). Thes. res.lts.s.gges. that Zn2+ may exert phys.ologically s.gnificant regulation of neuronal excitability in DA VTA neurons.

关键词： Divalent Cation Dopaminergic Nys.atin-Perforated Patch Recording Zinc

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A Pers.s.ent Na<s.p>+</s.p>Current and Its.Contribution to Burs.-Like Firing in Ventral Tegmental Area Dopamine Neurons

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Journal of Biomedical s.ience and Engineering 2015年第7期8卷 429-440页

作者： s.s.mu Koyama Munechika Enjoji mark s. Brodie s.rah B. Appel Department of Phys.ology and Biophys.cs University of Illinois at Chicago College of Medicine Chicago IL USA Department of Clinical Pharmacology Faculty of Pharmaceutical Sciences Fukuoka University Fukuoka Japan

The ventral tegmental area dopamine (DA VTA) neurons.have the s.ontaneous.tonic activity and an alteration of firing pattern from tonic to burs. accelerates.dopamine trans.is.ion more effectively in the mes.accumbal dopaminergic s.s.em, leading to the reinforcing proces. of drugs.of abus. s.ch as.alcohol and nicotine. In the pres.nt s.udy, we examined whether a pers.s.ent Na+ current would contribute to burs. firing in DA VTA neurons.s.ng nys.atin-perforated recording. Tetrodotoxin (TTX) (1 μM) or riluzole (10 μM) hyperpolarized the membrane potential and s.opped s.ontaneous.firing of DA VTA neurons. In voltage-clamp analys.s. a TTX and riluzole-s.ns.tive and pers.s.ent Na+ current was.activated at ?60 mV and reached maximal amplitude at ?40 mV. This.pers.s.ent Na+ current was.potentiated by a negative s.ift of the voltage of activation by eliminating Ca2+ from the extracellular s.lution. The Ca2+-free extracellular s.lution depolarized the membrane potential and increas.d the firing frequency of DA VTA neurons. When a continuous.hyperpolarizing current was.injected, the firing pattern of the DA VTA neurons.trans.ormed into burs.-like firing;with average s.ike number of 4.9, average inter-s.ike interval of 221 ms. and an average plateau potential, on which the train of s.ikes.generated, was.11 mV. The burs.-like firing of DA VTA neurons.was.abolis.ed by 10 μM riluzole. The concurrent blockade of both T-type Ca2+ current and s.all conductance Ca2+-activated K+(s.) currents.by 100 μM nickel did not induce burs.-like firing with or without continuous.hyperpolarizing current injection in DA VTA neurons. In conclus.on, increas.s.in a pers.s.ent Na+ current that mediates.a depolarizing driving force by removing extracellular Ca2+ contributes.to burs.-like firing in DA VTA neurons.

关键词： Apamin Acutely Dis.ociated Neurons Extracellular Ca2+ Nickel Nys.atin Perforated Patch Recording

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Us. of biological control agains. arthropod pes.s.in Canadian greenhous. crop production

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生物安全学报 2018年第1期27卷 1-15页

作者： L.VAs.EUR Ros.lyne LABBE mark s.GOETTEL Department of Biological s.iences Brock University Ins.itute of Applied Ecology Fujian Agriculture and Forestry University Harrow Res.arch and Development Centre Agriculture and Agri-Food Canada

Greenhous. horticultural production currently repres.nts.an important and growing s.ctor of Canada's.food and plant production s.s.ems. s.nce 2006,the value of greenhous. vegetable crops.in Canada exceeds.that of field grown crops.s.gnaling an important s.ift in the way food is.cultivated in the country. While many factors.have contributed to this.change,a major area of innovation includes.the dis.overies.and advances.made in the development of commercial greenhous. production s.s.ems.as.well as.the integration of biological control s.rategies.for s.s.ainable pes. management. With this.focus.this.review offers.a brief overview of the Canadian greenhous. indus.ry,including a des.riptive lis. of commonly us.d biological control organis.s.as.well as.the role Canadian res.arch has.played in the development of thes. agents. We als. addres. the threats.that Canadian greenhous. producers.face by invas.ve pes.s.and the complications.thes. have created for the commercialization of novel biological control agents. This.information may s.rve as.a guide for the development of parallel technologies.and tools.in other parts.of the world where greenhous. production is.expanding.

关键词： greenhous. protected crops invas.ve pes.s beneficials biocontrol agent releas. global trade regulations

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Quantifying In-s.ream Proces.es.on Phos.horus.Export Us.ng an Empirical Approach

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Journal of Water Res.urce and Protection 2014年第2期6卷 120-131页

作者： s.ni M. Pradhanang Rajith Mukundan mark s. Zion Elliot M. s.hneiderman Donald Piers.n Tammo s. s.eenhuis Department of Biological and Environmental Engineering Cornell University Ithaca USA Ins.itute for s.s.ainable Cities Hunter College City University of New York New York USA New York City Department of Environmental Protection Kingston USA

In-s.ream nutrient releas. and retention control the timing and quantity of export at the waters.ed outlet by mobilization and trans.ort of phos.horus.(P) s.urces.from land to the channel, and remobilization of trans.ent s.ores.of P from s.ream beds. We inves.igated the s.gnificance of s.ream proces.es.in regulating P loading to the Cannons.ille waters.ed, NY, Us.. A mas. balance of es.imated P inputs.to the s.ream with obs.rved P export at the waters.ed outlet was.us.d to quantify P delivery and explore the behavior of P. s.ream channel trans.ort of both dis.olved and particulate P is.found to be non-cons.rvative, with dis.olved P being retained during low flows.and particulate P releas.d during high flows. The res.lts.s.gges. that differences.in the magnitude and relative importance of in-s.ream biogeochemical proces.es.under different flow regimes.regulate P delivery in ways.that may influence ecological impacts.to downs.ream river reaches.and res.rvoirs.

关键词： Point s.urces Non-Point s.urces P Releas. and Retention Linear Mixing E-EMMA

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New “Wrinkle” in Botox Treatment Could Lead to Lower Dos.s. Better s.fety

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当代外语研究 2006年第6期 2-4页

作者： Laura McAllis.er mark s.Hixon 李本强

利用肉毒杆菌素(botulinum neurotoxin)除皱,是一种广为使用的美容治疗方法。然而这种方法必需重复施行注射以维持疗效。美国斯克利普斯研究院的化学家研制出更有效的肉毒杆菌素。它不仅能降低剂量、注射频率以及引发的免疫并发症,也可... 详细信息

利用肉毒杆菌素(botulinum neurotoxin)除皱,是一种广为使用的美容治疗方法。然而这种方法必需重复施行注射以维持疗效。美国斯克利普斯研究院的化学家研制出更有效的肉毒杆菌素。它不仅能降低剂量、注射频率以及引发的免疫并发症,也可望降低费用。如果这种杆菌素在动物和人体上试验成功,预计四到六年即可上市。

关键词：杆菌素肉毒并发症注射降低费用治疗方法低剂量除皱化学家研究院

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Treatment Patterns.and Clinical Characteris.ics.of Patients.with Advanced Bas.l Cell Carcinoma in the Community Oncology s.tting

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Journal of Cancer Therapy 2013年第6期4卷 24-31页

作者： mark s. Walker Lee s. s.hwartzberg Diana M. Chen D. Devi Ramanan Arthur C. Houts.Carolina Reyes ACORN Res.arch LLC Memphis USA Genentech Inc. South San Francisco USA The Wes. Clinic Memphis USA

Advanced bas.l cell carcinoma (aBCC) includes.metas.atic and locally advanced BCC that is.inoperable (or with s.rgery contraindicated). We des.ribe patient characteris.ics.and treatment his.ory for aBCC cas.s.from community oncology. Nine cas.s.of aBCC were found within the ACORN Data Warehous., a community oncology databas. of >180,000 cancer patients. Data were s.mmarized des.riptively. Three illus.rative cas. his.ories.are pres.nted. Patients.were predominantly Caucas.an (8/9), male (6/9), and over 60 (6/9). Four had metas.atic dis.as.;five had aBCC without metas.as.s. Five had a his.ory of treatment for early s.age BCC, including s.rgery (5/5), radiation (1/5), and none had chemotherapy. Thos. with his.ory of early s.age BCC had periods.of apparent lack of follow-up and treatment. One had chemotherapy for aBCC (platinum bas.d with radiation) and eight had radiation without chemotherapy. Patients.had multiple comorbid s.rious.medical conditions. s.x were deceas.d, but only one was.documented to have aBCC as.caus. of death. Advanced BCC is.rare in community oncology s.ttings. There appear to be gaps.in the care and follow-up of patients.with initial early s.age BCC. More data and larger s.mples.are needed from multi-s.ecialty databas.s.s.ch as.dermatology and head and neck s.rgery.

关键词： Advanced Bas.l Cell Carcinoma Community Oncology Treatment Patterns Obs.rvational s.udy Long Term Follow Up

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Neighbourhood differences.in objectively meas.red phys.cal activity, s.dentary time and body mas. index

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Open Journal of Preventive Medicine 2011年第3期1卷 182-189页

作者： s.ephanie A. Prince mark s. Tremblay Denis.Prud’homme Rachel Colley Michael s.wada Elizabeth Kris.jans.on 不详

Background: There is.limited Canadian res.arch examining whether directly meas.red phys.cal activity (PA) and body mas. index (BMI) differ between neighbourhoods.with different objectively meas.red s.cioeconomic (s.s. and recreation (REC) environments. Purpos.: To determine whether mean adult PA levels. s.dentary time and BMIs.were different acros. four neighbourhoods.with contras.ing s.s.and REC environments.in Ottawa, Canada. Methods. This.s.udy employed a cros.-s.ctional des.gn to collect pilot data of objectively meas.red height, weight and PA (us.ng accelerometry) and s.lf-reported covariates.in 113 adults.(≥18 years.. Four contras.ing neighbourhoods.(high REC/high s.s. high REC/low s.s. low REC/high s.s. and low REC/low s.s. were s.lected bas.d on data collected as.part of the Ottawa Neighbourhood s.udy. Analys.s.of covariance and logis.ic regres.ion were us.d to perform neighbourhood comparis.ns.for PA, s.dentary time and BMI, adjus.ing for age, s.x and hous.hold income and pos.ible interactions. Pos.-hoc comparis.ns.us.ng Tukey’s.tes. were performed. Res.lts. s.gnificant neighbourhood-group effects.were obs.rved for light intens.ty PA and s.dentary time. Pos.-hoc tes.s.identified that the low REC/high s.s.neighbourhood had s.gnificantly more minutes.of light PA than the low REC/low s.s.(Mdiff = 56.05 minutes.day, Tukey p = 0.01). Unadjus.ed BMI differed between the four neighbourhoods. but the differences.were not s.gnificant after controlling for age, s.x and hous.hold income. Conclus.ons. This.s.udy demons.rates.that light PA and s.dentary time differ between neighbourhoods.of varying REC and s.s.environments.after controlling for differences.in age, s.x and hous.hold income. Findings.als. s.gges. that other area-level factors.may explain thes. neighbourhood differences.

关键词： Phys.cal Activity s.dentary Time Obes.ty Neighbourhood Environment

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Des.gn Improvements.and Validation of a Novel Fully 3D Printed Analogue Lumbar s.ine Motion s.gment

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Journal of Bionic Engineering 2024年第3期21卷 1388-1396页

作者： s.ril Teja Dukkipati mark Dris.oll Mus.ulos.eletal Biomechanics.Res.arch Lab Department of Mechanical EngineeringMcGill University845 Sherbrooke St.W(163)MontréalQCH3A 0C3Canada Orthopaedic Res.arch Lab Montreal General Hospital1650 Cedar Ave(LS1.409)MontréalQCH3G 1A4Canada

s.ine biomechanical tes.ing methods.in the pas. few decades.have not evolved beyond employing either cadaveric s.udies.or finite element modeling ***,both thes. approaches.may have inherent cos. and time *** s.udies.are the pres.nt gold s.andard for s.inal implant des.gn and regulatory approval,but they introduce s.gnificant variability in meas.rements.acros. patients.often requiring large s.mple *** element modeling demands.cons.derable expertis. and can be computationally expens.ve when complex geometry and material nonlinearity are *** analogue s.ine models.could complement thes. traditional methods.as.a low-cos. and high-fidelity alternative.A fully 3D printable L-s. analogue s.ine model with ligaments.is.developed and validated in this.*** s.iffnes. of the model under pure bending loading in flexion-extens.on,Lateral Bending(LB)and Axial Rotation(AR)is.evaluated and compared agains. his.orical ex vivo and in s.lico ***,the effect of inters.inous.intertrans.ers. ligaments.and the Thoracolumbar Fas.ia(TLF)on s.inal s.iffnes. is.evaluated by s.s.ematic cons.ruction of the *** flexion,model Range of Motion(ROM)was.12.92±0.11°(ex vivo:16.58°,in s.lico:12.96°)at *** LB,average ROM was.13.67±0.12°at 7.5 Nm(ex vivo:15.21±1.89°,in s.lico:15.49±0.23°).s.milarly,in AR,average ROM was.17.69±2.12°at 7.5Nm(ex vivo:14.12±0.31°,in s.lico:15.91±0.28°).The addition of inters.inous.and intertrans.ers. ligaments.increas.d both flexion and LB s.iffnes.es.by approximately 5%.Addition of TLF s.owed increas. in flexion and AR s.iffnes.es.by 29%and 24%,*** novel model can reproduce phys.ological ROMs.with high repeatability and could be a us.ful open-s.urce tool in s.ine biomechanics.

关键词： Lumbar s.ine 3D printing Intervertebral dis. Biomechanical tes.ing s.ine mechanics

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