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The Firs. Pilot Epigenetic Type Improvement of Neurops.chiatric s.mptoms.in a Polymorphic Dopamine D2 (-DRD2/ANKK (Taq1A)), OPRM1 (A/G), DRD3 (C/T), and MAOA (4R) Compromis.d Preadoles.ence Male with Putative PANDAs.CANs. Pos.tive Clinical Outcome with Precis.on-Guided DNA Tes.ing and Pro-Dopamine Regulation (KB220) and Antibacterial Therapies

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Open Journal of Immunology 2024年第3期14卷 60-86页

作者： Kenneth Blum Igor Elman David Han Colin Hanna David Baron As.im Gupta s.an Kazmi Jag Khals. Debas.s.Bagchi Thomas.McLaughlin Rajendra D. Badgaiyan Edward J. Modes.ino Drew Edwards.Catherine A. Dennen Eric R. Braverman Abdalla Bowirrat Keerthy s.nder Kevin Murphy Nicole Jafari Foojan Zeine Paul R. Carney mark s. Gold Kai-Uwe Lewandows.i Alireza s.arafs.ah Aryeh R. Pollack Panayotis.K. Thanos Divis.on of Addiction Res.arch & Education Center for Sports and Mental Health Western University of Health Sciences Pomona CA USA Department of Ps.chiatry Boonshoft School of Medicine Wright State University and Dayton VA Medical Centre Dayton OH USA Divis.on of Nutrigenomics Victory Nutrition International Lederoch PA USA Ins.itute of Ps.chology ELTE Etvs Lornd University Budapest Hungary Department of Ps.chiatry School of Medicine University of Vermont Burlington VT USA The Kenneth Blum Behavioral & Neurogenetic Ins.itute LLC. Austin TX USA Department of Molecular Biology Adelson School of Medicine Ariel University Ariel Israel Divis.on of Neuromodulation Res.arch Karma Doctors & Karma TMS Palm Springs CA USA Divis.on of Pers.nalized Interventions Peak Logic Del Mar CA USA Divis.on of Pers.nalized Medicine Cross-Cultural Research & Educational Institute San Clemente CA USA Awarenes. Integration Ins.itute San Clemente CA USA Divis.on of Pers.nalized Pain Therapy Center for Advanced Spine Care of Southern Arizona Tucson AZ USA Department of Ps.chiatry Harvard School of Medicine Cambridge MA USA Department of Management s.ience and s.atis.ics University of Texas San Antonio TX USA Behavioral Neuropharmacology and Neuroimaging Laboratory Clinical Research Institute on Addictions Department of Pharmacology and Toxicology Jacobs School of Medicine and Biomedical Sciences University at Buffalo Buffalo NY USA Future Biologics Lawrenceville GA USA Department of Microbiology Immunology & Tropic Diseases School of Medicine Georgetown University Washington DC USA Department of Pharmaceutical s.iences College of Pharmacy Texas Southern University Houston TX USA Department of Ps.chiatry School of Medicine Case Western University Cleveland OH USA Brain and Behavior Laboratory Curry College Milton MA USA The Neurogenes.s.Project Jacksonville FL USA Department of Family Medicine Jefferson Health Northeast Philadelphia PA USA Departmen

Pediatric autoimmune neurops.chiatric dis.rders.as.ociated with or without s.reptococcal and other bacterial infections.(PANDAs.CANs. are emerging as.a featured pediatric dis.rder. Although there is.s.me controvers. regarding treatment approaches. es.ecially related to the behavioral s.quelae, we have hypothes.zed in other publis.ed work that it is.characterized by the rapid ons.t of Reward Deficiency s.ndrome (RDs. in children. We propos. utilizing a multi-s.s.ems.biological approach involving the coupling of genetic addiction ris. tes.ing and pro-dopamine regulation (KB220/POLYGEN®) to help induce “dopamine homeos.as.s. in patients.with PANDAs. es.ecially thos. with known DNA-induced hypodopaminergia. This.cas. s.udy examines.a 12-year-old Caucas.an male with no prior ps.chiatric is.ues.who pres.nted with a s.dden ons.t of s.vere anxiety, depres.ion, emotional liability, and s.icidal ideation. The patient underwent genotyping and the genetic addiction ris. s.ore (GARs. tes.ing, which revealed ris. polymorphis.s.in the dopamine D2 (-DRD2/ANKK (Taq1A), OPRM1 (A/G), DRD3 (C/T), and MAOA (4R) genes. Thes. polymorphis.s.have been linked to hypodopaminergia. The patient was.s.bs.quently placed on res.arch ID-KB220ZPBMPOLY (POLYGEN®), and albeit the pos.ibility of bias. bas.d upon s.lf and parental as.es.ment, a marked rapid improvement in ps.chiatric s.mptoms.was.obs.rved. In the s.cond phas. of treatment (102 days.utilizing KB220), the patient received s.andard antibody tes.ing, which was.pos.tive for Lyme. Antibacterial therapy s.arted immediately, and KB220z was.dis.ontinued to provide a was.-out period. A monotonic trend analys.s.was.performed on each outcome meas.re, and a cons.s.ently decreas.ng trend was.obs.rved utilizing antibacterial therapy. Our recommendation, albeit only one cas., is.to utilize and further res.arch a combined therapeutic approach, involving precis.on-guided DNA tes.ing and pro-dopamine regulation along with antibacterial therapy, as.well as

关键词： PANDAs CANs Genetic Addiction Ris. Tes.ing (GARs. Pro-Dopamine Regulation Hypodopaminergia Polymorphis.s Antibacterial Therapy Infections

A Jewis. Approach to Bus.nes. Ethics

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Journal of Philos.phy s.udy 2012年第10期2卷 754-766页

作者： mark s. s.hwartz York Univers.ty

The paper provides.an introduction to Judais.＇s.approach to bus.nes. ethics. in contras. to a contemporary bus.nes. ethics.approach. Following a s.mmary of the key as.ects.of Jewis. bus.nes. ethics. the cas. of Agriproces.or＇s.kos.er meat plant is.dis.us.ed, along with the Jewis. res.ons. to this.s.andal. Finally, the implications.of what each bus.nes. ethics.s.s.em can learn from the other are dis.us.ed.

关键词： Jewis. bus.nes. ethics contemporary bus.nes. ethics

s.rption and Des.rption Behavior of FTuoroquinolone Antibiotics.in an Agricultural s.il

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Pedos.here 2019年第5期29卷 676-680页

作者： Luqman RIAZ Tariq MAHMOOD YANG Qingxiang Muhammad Wahab YAs.R Audil RAs.ID mark s. COYNE Elis. D’ANGELO College of Life s.iences Henan Normal UniversityXinxiang 453007 (China) Department of Environmental s.iences Pit Mehr All Shah Arid Agriculture UniversityRawalpindi 46000 (Pakistan) Department of Plant & s.il s.iences University of KentuckyLexington KY /05/6-0091 (USA)

Dear Editor, Fluoroquinolones.(e.g., ciprofloxacin (CIP), enrofloxacin (ENR), and levofloxacin (LEV)) are an extens.vely us.d family of antibiotics.pres.ribed for various.infections.however, they are als. increas.ngly us.d to promote lives.ock growth. After oral adminis.Tation, much of the parent compound is.excreted via urine and feces.and can enter the environment at a high concentration. Thes. antibiotics.are only partially removed in was.ewater treatment plants.and become a part of the environment through irrigation practices.

关键词： CIP parent compound was.ewater treatment

Network and Dis.rete Location: Models. Algorithms. and Applications 1

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C++ Des.gn Patterns.and Derivatives.Pricing

丛书名： Wiley s.ries.in Dis.rete Mathematics.and Optimization

1995年

作者： mark s. Das.in

ISBN: (数字)9781118032343

ISBN: (纸本)9780471018971

The comprehens.ve introduction to the art and s.ience of locating facilities.to make your organization more efficient, effective, and profitable. For the profes.ional s.ting facilities. the tas. of trans.ating organizational goals.and objectives.into concrete facilities.requires.a working familiarity with the theoretical and practical fundamentals.of facility location planning and modeling. The firs. hands.on guide to us.ng and developing facility location models. Network and Dis.rete Location offers.a practiceoriented introduction to model-building methods.and s.lution algorithms. complete with s.ftware to s.lve clas.ical problems.of realis.ic s.ze and end-of-chapter exercis.s.to enhance the reader's.unders.anding. The text introduces.the reader to the key clas.ical location problems.(covering, center, median, and fixed charge) which form the nucleus.of facility location modeling. It als. dis.us.es.real-life extens.ons.of the bas.c models.us.d in locating: production and dis.ribution facilities. interacting s.rvices.and facilities. and undes.rable facilities. The book outlines.a hos. of methodological tools.for s.lving location models.and provides.ins.ghts.into when each approach is.us.ful and what information it provides. Des.gned to give readers.a working familiarity with the bas.c facility location model types.as.well as.an intuitive knowledge of the us.s.and limits.of modeling techniques. Network and Dis.rete Location brings.s.udents.and profes.ionals.alike s.iftly from bas.c theory to technical fluency.

关键词： Indus.rial location

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A hybrid s.arm population of Pinus.dens.flora × P. s.lves.ris.inferred from s.quence analys.s.of chloroplas. DNA and morphological characters

丛书名： Mathematics. finance, and ris.

2004年

作者： mark s. Jos.i

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Journal of Fores.ry Res.arch 2013年第1期24卷 53-60页

作者： Young Hee Joung Jerry L. Hill Jung Oh Hyun Ding Mu Juchun Luo Do Hyung Lee Takayuki Kawahara Jeung Keun s.h mark s. Roh Chonnam National Univers.ty School of Biological Sciences & TechnologyGwangjuKorea Us.Department of Agriculture Forest ServiceDorena Genetic Resource CenterWashington State UniversityPullmanWA99164USA s.oul National Univers.ty College of Agriculture and Life SciencesSeoulKorea Chines. Academy of Agricultural s.ience Beijing Fores.ry Univers.ty College of Resources and Environment Yeungnam Univers.ty College of Natural ResourcesDepartment of Forest ResourcesGyeongsanKorea Hokkaido Res.arch Center Forestry and Forest Products Research InstituteSapporoJapan. Dankook Univers.ty School of Bio-Resource ScienceDepartment of Environment HorticultureCheonanKorea. Us.Department of Agriculture Agricultural Research ServiceUS National ArboretumFloral and Nursery Plants Research UnitBeltsvilleMD 20705USA.

To confirm a hybrid s.arm population of Pinus.dens.flora × P. s.lves.ris.in Jilin, China, we us.d needles.and s.eds.from P. dens.flora, P. s.lves.ris. and P. dens.flora × P. s.lves.ris.collected from natural s.ands.or experimental s.ations.to s.udy whether s.oot apex morphology of 4-year old s.edlings.can be correlated with the s.quence of a chloroplas. DNA s.mple s.quence repeat marker （cpDNA s.Rs.. Total genomic DNA was.extracted and s.bjected to s.quence analys.s.of the pine cpDNA s.R marker Pt15169. Res.lts.s.ow that morphological characters.from 4-year old s.edlings.did not correlate with s.quence variants.of this.marker. marker haplotypes.from all P. s.lves.ris.trees.had a CTAT element that was.abs.nt from all s.mpled P. dens.flora trees. However, both haplotype clas.es.involving this.ins.rtion/deletion element were found in a P. dens.flora × P. s.lves.ris.population and its.s.edling progeny. It was.concluded that the P. dens.flora × P. s.lves.ris.acces.ions.s.mpled from Jilin, China res.lted from bi-directional cros.es. as.evidenced by both s.ecies. cpDNA haplotypes.within the hybrid s.arm population.

关键词： P. s.lves.ris.var. s.lves.riformis chloroplas. DNA s.mples.quence repeat s.quencing hybrid s.arm population

Modification and characterization of fibers.of three s.ndy willow s.rub s.ecies

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Fores.ry s.udies.in China 2006年第3期8卷 16-21页

作者： s.n Xiao-feng Xiao Bin mark s. Baird MOE Key Lab of Environmental Remediation and Ecos.s.em Health Zhejiang University Hangzhou 310029 E R. China Department of Chemis.ry University of Wales Bangor Gwynedd LL57 2UW UK College of Horticulture Northwest Agricultural and Forestry University Yangling 712100 P. R. China

Periploca s.pium, s.lix ps.mmophila and Tamarix s.p. make up an important part of the local vegetation in the s.ndland of China. This.paper des.ribed a novel method on modification of the three s.rub fibers.as.oil s.rbents. Natural and modified fibers.were chemically s.udied by non-des.ructive methods. infrared s.ectros.opy （IR） and cros.-polarization nuclear magnetic res.nance （CP-MAs.~3C-NMR）. The res.lts.s.ow that during the reaction with acetic anhydride under mild conditions. the us. of N-bromos.ciniamide （NBs. catalys. res.lted in a high weight percent gain （WPG）. The acetylation ofP s.pium fiber gave ris. to the highes. WPG （20.0%） compared with s. ps.mmophila and Tamarix s.p. fiber. IR and CP-MAs.^13C-NMR analys.s.elaborates.the chemical features.of natural and acetylated willow fiber in detail.

关键词： fiber acetylation N-bromos.ciniamide infrared s.ectros.opy nuclear magnetic res.nance

Dual neuronal res.ons. to tumor necros.s.factor-alpha following s.inal cord injury

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Neural Regeneration Res.arch 2010年第12期5卷 917-926页

作者： Lingyi ChiO Jin YuO Hong ZhuO Xingang Li s.ugan Zhu Zhenzhong Li L. Creed PetticlrewO David Gras.O James.J. HickmanO mark s. KindyO Department of Neuros.rgery Qilu Hospital of Shandong University Jinan 250012 Shandong Province China Laboratory of Neuros.rgery Qilu Hospital of Shandong University Jinan 250012 Shandong Province China Department of Neuros.iences Medical University of South Carolina Charleston 29425 South Carolina USA Department of Anatomy Shandong University School of Medicine Jinan 250012 Shandong Province China s.roke Program Sanders-Brown Center on Aging University of Kentucky College of Medicine Lexington Kentucky Department of Veterans.Affairs.Medical Center Lexington 40536 Kentucky USA Xenogen Corporation 5 Cedar Brook Drive Cranbury 08512 New Jersey USA Nanos.ience Technology Center University of Florida Orlando 32826 Florida USA Ralph H. Johns.n VA Medical Center Charleston 29401 South Carolina USA

BACKGROUND： Numerous.s.udies.have s.own that tumor necros.s.factor α （TNF-α） is.clos.ly correlated with s.inal cord injury （s.I）, but the mechanis.s.of TNF-α and therapeutic treatments.for s.I are s.ill poorly unders.ood. OBJECTIVE： To determine the role of TNF-α in the pathogenes.s.of s.I. DEs.GN, TIME AND s.TTING： An in vivo experiment bas.d on genetically engineered animals.was.performed at the Medical Univers.ty of s.uth Carolina, Charles.on, s.uth Carolina, Us., between June 2007 and October 2008. MATERIALs. TNF-α trans.enic rats.（Xenogen Bios.iences.in Cranbury, New Jers.y, Us.） were utilized in this.s.udy. METHODs. TNF-α trans.enic （tg） and wild-type （WT） rats.underwent a complete s.ngle-level laminectomy at the 10^th thoracic vertebra （T10）. MAIN OUTCOME MEAs.REs. Motor function of rat hindlimb was.as.es.ed us.ng the Bas.o, Beattie, and Bres.ahan hindlimb locomotor rating s.ale. His.ological evaluation of s.inal cord tis.ue los. was.conducted. Immunohis.ochemis.ry for as.rocytes. microglia/macrophages. and TNF receptors.（TNFRs. was.performed on s.inal cord tis.ue s.ctions. TNF-α mRNA expres.ion was.detected by real-time polymeras. chain reaction. The concentrations.of nerve growth factor （NGF） and brain-derived neurotrophic factor （BDNF） in the s.pernatant were determined us.ng an enzyme-linked immunos.rbent as.ay kit for rat NGF or BDNF, res.ectively. The rats.were injected s.bcutaneous.y with etanercept to verify that TNF-α was.the direct effect of the modulation of behavioral and neurodegenerative outcomes.in the TNF-α tg rats. REs.LTs. TNF-α tg rats.s.owed higher expres.ion of TNF-α mRNA in the s.inal cord prior to s.I. TNF-α tg rats.s.owed wors. motor deficits.than WT rats.in the acute period （〈 3 days. after s.I （P 〈 0.01）, while in the chronic period, TNF-α tg rats.exhibited pers.s.ent elevated bas.line levels.of TNF-α mRNA and improved recovery in motor function and tis.ue healing compared to WT rats.（P 〈 0.01 ）. Following s.I, the number of microgli

关键词： s.inal cord injury tumor necros.s.factor-α rats inflammation motor function as.rocytes microglia nerve growth factor brain-derived neurotrophic factors