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国外医学（军事医学分册） 1989年第1期6卷 34-36页

作者： mark.,pb 周景春

维生素K状态,补充和血管疾病:系统评价和荟萃分析

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中华高血压杂志 2019年第3期27卷 216-216页

作者：刘莉(译) 叶鹏(摘、审校) Lees JS Chapman FA Witham MD Jardine AG mark pb 不详

血管硬度和血管钙化是与心血管事件相关的血管健康的替代标志物。维生素K依赖性蛋白(vitamin K-dependent proteins,VKDP)与血管硬度和血管钙化相关,需要维生素K存在才能发挥作用。研究人员对①补充维生素K对血管硬度和血管钙化的影响,... 详细信息

血管硬度和血管钙化是与心血管事件相关的血管健康的替代标志物。维生素K依赖性蛋白(vitamin K-dependent proteins,VKDP)与血管硬度和血管钙化相关,需要维生素K存在才能发挥作用。研究人员对①补充维生素K对血管硬度和血管钙化的影响,以及②失活的VKDP水平与心血管病和死亡率的关联进行了系统评价和荟萃分析。两位作者搜索了MEDLINE和Embase数据库以及Cochrane和ISRCTN登记处,收集测定维生素K对血管钙化、血管硬度或VKDP的影响,以及评估VKDP对心血管事件或死亡率影响的临床试验和纵向研究,研究者对资料进行了随机效应荟萃分析。

关键词：血管钙化系统评价维生素荟萃分析

Unraveling the hydrothermal history of the Xinshuijing Na-metasomatite uranium deposit in the Longshoushan metallogenic belt， Northwest China by coupled hydrothermal zircon U–pb and albite Ar–Ar dating

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Journal of Earth Science 2024年

作者： JUN ZHONG mark MIHALASKY MICHEL CUNEY SHENG HE JUN-JIE LI National Key Laboratory of Uranium Resource Exploration-Mining and Nuclear Remote Sensing， Beijing Research Institute of Uranium Geology International Atomic Energy Agency (IAEA)， Nuclear Fuel Cycle and Materials Section， Division of Nuclear Fuel Cycle and Waste Technology， Vienna International Center Université de Lorraine， GéoRessources CNRS State Key Laboratory of Lithospheric Evolution (SKLLE)， Institute of Geology and Geophysics， Chinese Academy of Sciences

Na-metasomatite uranium deposits are an important type of large-tonnage low-grade uranium deposit. They are characterized by an intimate association between uranium minerals and albite， and by the common development of syn-ore hydrothermal zircons. Similar to other types of uranium deposits， constraining an accurate age of mineralization remains a challenge for the Na-metasomatite type ones. In this study， we present for the first time， an approach that combines age dating results from the syn-ore albites (40Ar-39Ar) and hydrothermal zircons （U-pb） for a typical Na-metasomatite uranium deposit， the Xinshuijing deposit in the Longshoushan metallogenic belt of northwest China. The hydrothermal zircon U-pb and albite40Ar-39Ar ages are consistent with each other （378-366 Ma; within error）， but also identical to the previously reported uraninite chemical U-pb ages （approximately 370 Ma）. The coupled application of hydrothermal zircon U-pb and albite40Ar-39Ar age dating is thus regarded as a robust approach for constraining the age of mineralization for Na-metasomatite uranium deposits. An age gap of approximately 70 m.y. between uranium mineralization （～ 370 Ma） and host granitoid emplacement （about 440 Ma） suggests no direct genetic linkage between the two. Further exploration in the surrounding metamorphic units is therefore suggested， rather than only focusing on the host granitoids， especially where intensive wallrock alteration and structural features are pervasive. The varied hydrothermal zircon δ18O isotope compositions are attributed to the significant fluid-wallrock interaction during the uranium mineralization， which is consistent with our previous fluid inclusion and geochemical studies. Our study highlights the importance of selecting appropriate isotopic dating methods， which is informed by detailed paragenetic and geochemical analysis of dateable minerals formed before or coeval to the main-stage uranium mineralization. Moreover， it is underlined that the e

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无心血管病者尿钠排泄、血压与未来心血管病及死亡风险

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中华高血压杂志 2019年第6期27卷 599-599页

作者： Welsh CE Welsh P Jhund P Delles C Celis-Morales C Lewsey JD Gray S Lyall D Iliodromiti S Gill JMR Sattar N mark pb 赵狄练桂丽不详

高血压是心血管病的危险因素。代表膳食钠摄入的尿钠排泄增加与血压相关。但在一些观察性研究中,低钠摄入与死亡率增加相关。进一步研究应评估混杂相关性是否能解释钠摄入与预后的关系。研究者分析英国生物银行参加者(n=457484,平均年龄... 详细信息

高血压是心血管病的危险因素。代表膳食钠摄入的尿钠排泄增加与血压相关。但在一些观察性研究中,低钠摄入与死亡率增加相关。进一步研究应评估混杂相关性是否能解释钠摄入与预后的关系。研究者分析英国生物银行参加者(n=457484,平均年龄56.3岁,44.7%为男性)尿电解质与血压的数据。采用Kawasaki公式估算每日尿钠排泄量。研究者分析基线无心血管病、治疗的高血压或糖尿病者(n=322624)钠排泄与血压的关系,并评估钠排泄与致死性及非致死性心血管病、心力衰竭及死亡发生率的关系。

关键词：尿钠排泄量心血管病死亡风险高血压危险因素生物银行平均年龄尿电解质

常规脂蛋白检测和载脂蛋白在心血管病预测中的比较

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中华高血压杂志 2019年第7期27卷 699-699页

作者： Welsh C Celis-Morales CA Brown R Mackay DF Lewsey J mark pb Gray SR Ferguson LD Anderson JJ Lyall DM Cleland JG Jhund PS Gill J MR Pell JP Sattar N Welsh P 刘青(译) 叶鹏(摘、审校) 不详

总胆固醇和高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)测量值对于心血管病风险评估至关重要,但对于其他脂质用于风险预测的效用一直存在争议。该研究纳入来自英国生物银行(Biobank)的无基线心血管病、未服用他汀... 详细信息

总胆固醇和高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)测量值对于心血管病风险评估至关重要,但对于其他脂质用于风险预测的效用一直存在争议。该研究纳入来自英国生物银行(Biobank)的无基线心血管病、未服用他汀类药物、有相关的脂质指标(n=346 686)的受试者。

关键词：心血管病风险预测载脂蛋白高密度脂蛋白胆固醇检测他汀类药物总胆固醇风险评估

Structure-function studies of the influenza virus RNA polymerase PA subunit

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Science China(Life Sciences) 2009年第5期52卷 450-458页

作者： mark BARTLAM College of Life Sciences and Tianjin State Laboratory of Protein Science Nankai University

The influenza virus RNA-dependent RNA polymerase is a heterotrimeric complex (PA, pb1 and pb2) with multiple enzymatic activities for catalyzing viral RNA transcription and replication. The roles of pb1 and pb2 have been clearly defined, but PA is less well understood. The critical role of the polymerase complex in the influenza virus life cycle and high sequence conservation suggest it should be a major target for therapeutic intervention. However, until very recently, functional studies and drug discovery targeting the influenza polymerase have been hampered by the lack of three-dimensional structural information. We will review the recent progress in the structure and function of the PA subunit of influenza polymerase, and discuss prospects for the development of anti-influenza therapeutics based on available structures.

关键词： influenza polymerase PA subunit crystal structure endonuclease protein-protein interaction

Atmospheric deposition of 7Be,210pb and 210Po during typhoons and thunderstorm in Shanghai, China and global data synthesis

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Science China Earth Sciences 2020年第4期63卷 602-614页

作者： Juan DU mark BASKARAN Jinzhou DU State Key Laboratory of Estuarine and Coastal Research East China Normal UniversityShanghai 200241China Department of Geology Wayne State UniversityDetroit 48202USA

Atmospherically-delivered ~7Be,^(210)Po and ^(210)pb in bulk precipitation and air samples collected around the globe have provided valuable quantification on the rates of removal, as well as proportional mixing of attendant air masses;however, such studies during thunderstorm and typhoon events are limited. We report the first continuous time-series rainwater sampling and analysis of ~7Be,^(210)pb and ^(210)Po from two typhoons and one thunderstorm during 2015 summer in Shanghai. The depositional fluxes within individual rain events of typhoons and thunderstorms varied by a factor of 10 for ~7Be, 5.7 for ^(210)pb, 7.4 for ^(210)Po,and 7.0 for ~7Be/^(210)pb activity ratios(AR). Such large observed variations in the depositional fluxes of ~7Be,^(210)pb,^(210)Po and ~7Be/^(210)pb activity ratios were attributed to air masses injected from surrounding high pressure system adjoining the typhoon to low pressure system within the typhoon. Based on ~7Be/^(210)pb activity ratios, we estimated the variations in the fraction of maritime and continental air masses into the typhoon. Observed constancy in the ^(210)Po/^(210)pb AR indicates that the residence times of air masses contributing to the typhoon during heavy rain are similar. From a synthesis of global fallout of ~7Be and ^(210)pb during pulse events(precipitation≥50 mm from single rainout event), we quantify the importance of pulse events in the atmospheric fallout of these radionuclides.

关键词： 7Be 210pb 210Po Typhoon Thunderstorm Air masses intrusions

清醒狗与开胸麻醉狗心肌顿抑氧自由基作用的研究

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中国病理生理杂志 1995年第2期11卷 143-147页

作者：李小鹰 McCay pb 解放军总医院

本实验应用自旋捕捉剂ＰＢＮ证实了开胸麻醉狗与清醒狗心肌顿抑模型的主要区别。冠状动脉阻闭１５ｍｉｎ后再灌注头３小时ＰＢＮ加合物释放总量开胸麻醉狗明显高于清醒狗（约为５倍），而且心肌顿抑的恢复开胸狗明显差于清醒狗。这种区... 详细信息

本实验应用自旋捕捉剂ＰＢＮ证实了开胸麻醉狗与清醒狗心肌顿抑模型的主要区别。冠状动脉阻闭１５ｍｉｎ后再灌注头３小时ＰＢＮ加合物释放总量开胸麻醉狗明显高于清醒狗（约为５倍），而且心肌顿抑的恢复开胸狗明显差于清醒狗。这种区别的主要原因推测是开胸创伤本身以及肾上腺素能神经过度兴奋引起，从而提示在心肌顿抑氧自由基产生的研究中应用清醒动物模型的重要性。

关键词：狗氧自由基心肌顿抑心肌缺血

Cambro-Silurian magmatisms at the northern Gondwana margin(Penninic basement of the Ligurian Alps)

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Geoscience Frontiers 2019年第1期10卷 315-330页

作者： Matteo Maino Laura Gaggero Antonio Langone Silvio Seno mark Fanning Department of Earth and Environmental Sciences University of Pavia Department of Earth Environment and Life Sciences University of Genoa CNRd Institute of Geosciences and Earth Resources U.O.S. Research School of Earth Sciences The Australian National University

The Early Paleozoic evolution of the northern margin of Gondwana is characterized by several episodes of bimodal magmatism intruded or outpoured within thick sedimentary basins. These processes are well recorded in the Variscan blocks incorporated in the Ligurian Alps because they experienced low temperature Alpine metamorphism. During the Paleozoic, these blocks, together with the other Alpine basements, were placed between the Corsica-Sardinia and the Bohemian Massif along the northern margin of Gondwana. In this framework, they host several a variegated lithostratigraphy forming two main complexes(Complexs I and II) that can be distinguished by both the protoliths and their crosscutting relationships, which indicate that the acidic and mafic intrusives of Complex II cut an already folded sequence made of sediments, basalts and granitoids of Complex I. Both complexes were involved in the Variscan orogenic phases as highlighted by the pervasive eclogite-amphibolite facies schistosity(foliation II). However, rare relicts of a metamorphic foliation at amphibolite facies conditions(foliation I)is locally preserved only in the rocks of Complex I. It is debatable if this schistosity was produced during the early folding event e occurred between the emplacement of Complex I and II e rather than during an early stage of the Variscan metamorphic *** SHRIMP and LA ICP-MS Ue pb zircon dating integrated with literature data, provide emplacement ages of the several volcanic or intrusive bodies of both complexes. The igneous activity of Complex I is dated between 507 ± 15 Ma and 494 ± 5 Ma, while Complex II between 467 ± 12 Ma and 445.5 ± 12 *** folding event recorded only by the Complex I should therefore have occurred between 494 ± 5 Ma and 467 ± 12 Ma. The Variscan eclogite-amphibolite facies metamorphism is instead constrained between ~420 Ma and ~300 Ma. These ages and the geochemical signature of these rocks allow constraining the Early Paleozoic tectono-magmatic

关键词： U-pb zircon dating Early Paleozoic magmatism Pre-Alpine basements Gondwana margin Ligurian Alps

Provenance of the Permo-Carboniferous sediments in the northern Alxa and its tectonic implications for the southernmost Central Asian Orogenic Belt

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Geoscience Frontiers 2020年第4期11卷 1415-1429页

作者： Yan Chen Tairan Wu Zhicheng Zhang C.mark Fanning Mingming Zhang Mingming Zhang Institute for Peat and Mire Research State Environmental Protection Key Laboratory of Wetland Ecology and Vegetation RestorationNortheast Normal UniversityChangchun 130024China Key Laboratory of Geographical Processes and Ecological Security in Changbai Mountains Ministry of EducationSchool of Geographical SciencesNortheast Normal UniversityChangchun 130024China The Key Laboratory of Orogenic Belts and Crustal Evolution Ministry of EducationSchool of Earth and Space SciencesPeking UniversityBeijing 100871China Research School of Earth Sciences Australian National UniversityMills RoadCanberraACT0200Australia

As the southernmost segment of the Central Asian Orogenic Belt(CAOB),the northern Alxa orogenic belt(NAOB)connects the southeastern and southwestern segments of the *** NAOB amalgamated with the closure of the Paleo-Asian Ocean;however,the closure time of the Paleo-Asian Ocean is still on great *** this study,we reported new detrital zircon U-pb geochronology and Hf-O isotopes for the Permo-Carboniferous sediments in the northern Alxa to constrain the provenance and its tectonic *** Permo-Carbonifereous Amushan Formation is composed of volcanic-carbonite-clastic rocks and was deposited in a shallow marine *** on the zircon U-pb geochronology,the Amushan Formation was deposited in the late Carboniferous to early Permian,but some outcrops of volcanic and clastic rocks in the Quaganqulu area were likely formed in the middle to late *** integrated zircon age spectrum for the clastic rocks shows a wide range from late Archean to Paleoproterozoic,Mesoproterozoic(with a peak age at 1458 Ma),early Neoproterozoic(with peak ages of 988 Ma and 929 Ma),early Paleozoic(with a peak age at 447 Ma) and late Paleozoic(with a peak age at 294 Ma).Combined with the zircon Hf-O isotopes,the provenance was considered to be the Alxa Block,the Shalazhashan terrane and the Zhusileng-Hangwula block(and the southern Beishan orogenic belt).The multiple source regions to the south and north of the Paleo-Asian Ocean indicate the closure of this ocean before the late *** absence or small proportion of depositional age-approximated zircons in most samples makes their age spectra similar to extensional *** with the intra-plate volcanism,the deposits were considered to be formed in extensional ***,after the closure of the Paleo-Asian Ocean,the NAOB stepped into an extensional stage.

关键词： CAOB Alxa Provenance Permo-Carboniferous Detrital zircon