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Modeling China's offshore production sharing contracts using meta analysis

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Petroleum Science 2010年第2期7卷 283-288页

作者： Hao Hong mark j. Kaiser School of Business Administration China University of Petroleum Beijing 102249 China Center for Energy Studies Louisiana State University Baton Rouge LA 70803 USA

Production sharing contracts have been used in the development of China’s offshore petroleum resources since 1982, but the mechanism in which the fiscal terms impact project economics is complicated and not well understood. The purpose of this paper is to model China’s offshore production sharing contracts using a probabilistic approach. Cash flows and economic indicators are used for a typical offshore oilfield development, and meta-models are constructed to analyze the basic features of the fiscal system. Applications of the models in contract negotiation are discussed.

关键词： Contract negotiation fiscal models multiple regression production sharing contract simulation

A Class Effect Network Meta-analysis of Lipid Modulation in Non-alcoholic Steatohepatitis for Dyslipidemia

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journal of Clinical and Translational Hepatology 2022年第6期10卷 1042-1049页

作者： jieling Xiao Cheng-Han Ng Yip-Han Chin Darren jun Hao Tan Wen-Hui Lim Grace Lim jingxuan Quek Ansel Shao Pin Tang Kai-En Chan Rou-Yi Soong Nicholas Chew Benjamin Tay Daniel Q.Huang Nobuharu Tamaki Roger Foo mark Y.Chan Mazen Noureddin Mohammad Shadab Siddiqui Arun j.Sanyaland mark D.Muthiah Yong Loo Lin School of Medicine National University of SingaporeSingapore Lee Kong Chian School of Medicine Nan-yang Technological UniversitySingapore Department of Cardiology National University Heart CenterNational University HospitalSingapore Division of Gastroenterology and Hepatology Department of MedicineNational University HospitalSingaporeSingapore National University Center for Organ Transplantation National University Health SystemSingapore NAFLD Research Center Division of Gastroenterology and HepatologyDepartment of MedicineUniversity of California at San DiegoLa JollaCAUSA Department of Gastroenterology and Hepatology Musashino Red Cross HospitalTokyoJapan Cedars-Sinai Fatty Liver Program Division of Digestive and Liver DiseasesDepartment of MedicineComprehen-sive Transplant CenterCedars-Sinai Medical CenterLos AngelesCAUSA Division of Gastroenterology Hepatology and NutritionDepartment of Internal MedicineVirginia Commonwealth UniversityRichmondVAUSA

Background and Aims:Pharmaceutical therapy for NASH is associated with lipid modulation,but the consensus on drug treatment is limited and lacks comparative analysis of effectiveness.A network meta-analysis was conducted to compare NASH drug classes in lipid ***:Online databases were searched for randomized controlled trails(RCTs)evaluating NASH treatments in biopsy-proven NASH *** were classified into four groups:(1)inflammation,(2)energy,(3)bile acids,and(4)fibro-sis based on the mechanism of action.A Bayesian network analysis was conducted with outcome measured by mean difference(MD)with credible intervals(Crl)and surface un-der the cumulative ranking curve(SUCRA).Results:Forty-four RCTs were included in the *** acid modulat-ing treatments(MD:0.05,Crl:0.03-0.07)were the best treatment for improvement in high-density lipid(HDL)cho-lesterol,followed by treatments modulating energy(MD:0.03,Crl:0.02-0.04)and fibrosis(MD:0.01,Crl:−0.12 to 0.14)compared with *** top three treatments for reduction in triglycerides were treatments modulating energy(MD:−0.46,Crl:−0.49 to−0.43),bile acids(MD:−0.22,Crl:−0.35 to−0.09),and inflammation(MD:−0.08,Crl:−0.13 to−0.03)compared with *** found treatment modulating fibrosis(MD:−1.27,Crl:−1.76 to−0.79)was the best treatment for reduction in low-density lipid(LDL)cholesterol followed by treatment modulating in-flammation(MD:−1.03,Crl:−1.09 to−0.97)and energy(MD:−0.37,Crl:−0.39 to−0.34)compared with placebo,but LDL cholesterol was worsened by treatments modulat-ing bile ***:Network analysis comparing the class effects of dyslipidemia modulation in NASH found that treatment targets can include optimization of athero-genic *** studies are required to evaluate the cardiovascular outcomes.

关键词： Lipid modulation NASH Dyslipidemia

Sedentary Behavior Research Network members support new Canadian 24-Hour Movement Guideline recommendations

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journal of Sport and Health Science 2020年第6期9卷 479-481页

作者： mark S.Tremblay Scott Rollo Travis j.Saunders Healthy Active Living and Obesity Research Group Children’s Hospital of Eastern Ontario Research InstituteOttawaONK1H 8L1Canada Department of Pediatrics Faculty of MedicineUniversity of OttawaOttawaONK1H 8M5Canada Department of Health Sciences Carleton UniversityOttawaONK1S 5B6Canada Department of Applied Human Sciences University of Prince Edward IslandCharlottetownPEIC1A 4P3Canada

A new paradigm employing 24-h movement guidelines that combines recommendations for movement behaviors across the whole day(physical activities of all intensities,sedentary behaviors,and sleep)is gaining momentum around the globe,and several jurisdictions are developing and releasing evidence-informed public health guidelines embracing this approach.1,2 The Sedentary Behavior Research Network(SBRN),the world’s largest network of researchers and health professionals focusing specifically on the health impact of sedentary behaviors,embraces this new paradigm and has worked to normalize the integration of sedentary behaviors into the movement-behavior paradigm.

关键词： movement den behavior

Oxidative stress and male reproductive health

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Asian journal of Andrology 2014年第1期16卷 31-38页

作者： Robert j Aitken Tegan B Smith Matthew S jobling mark A Baker Geoffry N De Iuliis Priority Research Centre in Reproductive Science Discipline of Biological Sciences Faculty of Science and IT University of Newcastle Callaghan NSW 2308 Australia

One of the major causes of defective sperm function is oxidative stress, which not only disrupts the integrity of sperm DNA but also limits the fertilizing potential of these cells as a result of collateral damage to proteins and lipids in the sperm plasma membrane. The origins of such oxidative stress appear to involve the sperm mitochondria, which have a tendency to generate high leve｜s of superoxide anion as a prelude to entering the intrinsic apoptotic cascade. Unfortunately, these cells have very little capacity to respond to such an attack because they only possess the first enzyme in the base excision repair （BER） pathway, 8-oxoguanine glycosylase 1 （OGG1）. The latter successfully creates an abasic site, but the spermatozoa cannot process the oxidative lesion further because they lack the downstream proteins （APE1, XRCC1） needed to complete the repair process. It is the responsibility of the oocyte to continue the BER pathway prior to initiation of S-phase of the first mitotic division. If a mistake is made by the oocyte at this stage of development, a mutation will be created that will be represented in every cell in the body. Such mechanisms may explain the increase in childhood cancers and other diseases observed in the offspring of males who have suffered oxidative stress in their germ line as a consequence of age, environmental or lifestyle factors. The high prevalence of oxidative DNA damage in the spermatozoa of male infertility patients may have implications for the health of children conceived in vitro and serves as a driver for current research into the origins of free radical generation in the germ line.

关键词： DNA damage oxidative stress oxoguanine glycosylase 1 oocyte spermatozoa

Claudin-11 and occludin are major contributors to Sertoli cell tight junction function, in vitro

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Asian journal of Andrology 2016年第4期18卷 620-626页

作者： mark j McCabe Caroline FH Foo Marcel E Dinger Peter M Smooker Peter G Stanton Male Fertility Regulation Laboratory Hudson Institute of Medical Research Monash Medical Centre Clayton Victoria 3168 Australia School of Applied Sciences Royal Melbourne Institute of Technology University Bundoora Victoria 3088 Australia Kinghorn Centre for Clinical Genomics Garvan Institute of Medical Research Darlinghurst New South Wales 2010 Australia St Vincent's Clinical School UNSW Sydney New South Wales 2052 Australia.

The Sertoli cell tight junction （T j） is the key component of the blood-testis barrier, where it sequesters developing germ cells undergoing spermatogenesis within the seminiferous tubules. Hormonally regulated claudin-11 is a critical transmembrane protein involved in barrier function and its murine knockout results in infertility. We aimed to assess quantitatively the significance of the contribution of claudin-11 to Tj function, in vitro, using siRNA-mediated gene silencing. We also conducted an analysis of the contribution of occludin, another intrinsic transmembrane protein of the Tj. Silencing of claudin-11 and/or occludin was conducted using siRNA in an immature rat Sertoli cell culture model. Transepithelial electrical resistance was used to assess quantitatively Tj function throughout the culture. Two days after siRNA treatment, cells were fixed for immunocytochemical localization of junction proteins or lyzed for RT-PCR assessment of mRNA expression. Silencing of claudin-11, occludin, or both resulted in significant decreases in Tj function of 55% （P 〈 0.01）, 51% （P 〈 0.01）, and 62% （P 〈 0.01）, respectively. Data were concomitant with significant decreases in mRNA expression and marked reductions in the localization of targeted proteins to the Sertoli cell Tj. We provide quantitative evidence that claudin-11 contributes significantly （P 〈 0.01） to Sertoli cell Tj function in vitro. Interestingly, occludin, which is hormonally regulated but not implicated in infertility until late adulthood, is also a significant （P 〈 0.01） contributor to barrier function. Our data are consistent with in vivo studies that clearly demonstrate a role for these proteins in maintaining normal Tj barrier structure and function.

关键词： blood-testis barrier claudin-11 occludin Sertoli cell tight junction siRNA

A note on the estimation of variance for big BAF sampling

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Forest Ecosystems 2020年第4期7卷 819-832页

作者： jeffrey H.Gove Timothy G.Gregoire mark j.Ducey Thomas B.Lynch USDA Forest Service Northern Research Station271 Mast RoadDurham NH03824USA. School of Forestry&Environmental Studies Yale University360 Prospect StNew Haven CT06511USA. Department of Natural Resources and the Environment University of New Hampshire114 James HallDurham NH03824USA. Professor Emeritus Department of Natural Resource Ecology and ManagementOklahoma State UniversityAg Hall Room 008CStillwater OK74078USA.

Background:The double sampling method known as“big BAF sampling”has been advocated as a way to reduce sampling effort while still maintaining a reasonably precise estimate of volume.A well-known method for variance determination,Bruce’s method,is customarily used because the volume estimator takes the form of a product of random ***,the genesis of Bruce’s method is not known to most foresters who use the method in ***:We establish that the Taylor series approximation known as the Delta method provides a plausible explanation for the origins of Bruce’s *** were conducted on two different tree populations to ascertain the similarities of the Delta method to the exact variance of a ***,two alternative estimators for the variance of individual tree volume-basal area ratios,which are part of the estimation process,were compared within the overall variance estimation ***:The simulation results demonstrate that Bruce’s method provides a robust method for estimating the variance of inventories conducted with the big BAF *** simulations also demonstrate that the variance of the mean volume-basal area ratios can be computed using either the usual sample variance of the mean or the ratio variance estimators with equal accuracy,which had not been shown previously for Big BAF ***:A plausible explanation for the origins of Bruce’s method has been set forth both historically and mathematically in the Delta *** most settings,there is evidently no practical difference between applying the exact variance of a product or the Delta method—either can be used.A caution is articulated concerning the aggregation of tree-wise attributes into point-wise summaries in order to test the correlation between the two as a possible indicator of the need for further covariance augmentation.

关键词： Bitterlich sampling Delta method Double sampling Forest inventory Horizontal point sampling Variance of a product

An approximate point-based alternative for the estimation of variance under big BAF sampling

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Forest Ecosystems 2021年第3期8卷 439-457页

作者： Thomas B.Lynch jeffrey H.Gove Timothy G.Gregoire mark j.Ducey Professor Emeritus Department of Natural Resource Ecology and ManagementOklahoma State UniversityAg Hall Room 008CStillwater 74078OKUSA USDA Forest Service Northern Research Station271 Mast RoadDurham 03824NHUSA Yale School of Environment Yale University360 Prospect StNew Haven 06511CTUSA Department of Natural Resources and the Environment University of New Hampshire114 James HallDurham 03824NHUSA

Background:A new variance estimator is derived and tested for big BAF(Basal Area Factor)sampling which is a forest inventory system that utilizes Bitterlich sampling(point sampling)with two BAF sizes,a small BAF for tree counts and a larger BAF on which tree measurements are made usually including DBHs and heights needed for volume ***:The new estimator is derived using the Delta method from an existing formulation of the big BAF estimator as consisting of three sample *** new formula is compared to existing big BAF estimators including a popular estimator based on Bruce’s ***:Several computer simulation studies were conducted comparing the new variance estimator to all known variance estimators for big BAF currently in the forest inventory *** simulations the new estimator performed well and comparably to existing variance ***:A possible advantage of the new estimator is that it does not require the assumption of negligible correlation between basal area counts on the small BAF factor and volume-basal area ratios based on the large BAF factor selection trees,an assumption required by all previous big BAF variance estimation *** this correlation was negligible on the simulation stands used in this study,it is conceivable that the correlation could be significant in some forest types,such as those in which the DBH-height relationship can be affected substantially by density perhaps through *** derived a formula that can be used to estimate the covariance between estimates of mean basal area and the ratio of estimates of mean volume and mean basal *** also mathematically derived expressions for bias in the big BAF estimator that can be used to show the bias approaches zero in large samples on the order of 1n where n is the number of sample points.

关键词： Bitterlich sampling Delta method Double sampling Estimator bias Forest inventory Horizontal point sampling Variance of a product Volume basal area ratio Covariance estimation

Validity of a noninvasive estimation of deep body temperature when wearing personal protective equipment during exercise and recovery

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Military Medical Research 2019年第4期6卷 328-339页

作者： Andrew P.Hunt mark j.Buller Matthew j.Maley joseph T.Costello Ian B.Stewart School of Exercise and Nutrition Sciences&Institute of Health and Biomedical Innovation Queensland University of TechnologyBrisbaneQLDAustralia United States Army Research Institute of Environmental Medicine NatickMAUSA Extreme Environments Laboratory Department of Sport and Exercise ScienceUniversity of PortsmouthPortsmouthUK

Background:Deep body temperature is a critical indicator of heat ***,direct measures are often invasive,costly,and difficult to implement in the *** study assessed the agreement between deep body temperature estimated from heart rate and that measured directly during repeated work bouts while wearing explosive ordnance disposal(EOD)protective clothing and during ***:Eight males completed three work and recovery periods across two separate *** consisted of treadmill walking on a 1%incline at 2.5,4.0,or 5.5 km/h,in a random order,wearing EOD protective *** temperature and relative humidity were maintained at 24℃and 50%[Wet bulb globe temperature(WBGT)(20.9±1.2)℃]or 32℃and 60%[WBGT(29.0±0.2)℃]on the separate days,*** rate and gastrointestinal temperature(TGI)were monitored continuously,and deep body temperature was also estimated from heart rate(ECTemp).Results:The overall systematic bias between TGI and ECTemp was 0.01℃with 95%limits of agreement(Lo A)of±0.64℃and a root mean square error of 0.32℃.The average error statistics among participants showed no significant differences in error between the exercise and recovery periods or the environmental *** TGI levels of(37.0–37.5)℃,(37.5–38.0)℃,(38.0–38.5)℃,and>38.5℃,the systematic bias and±95%Lo A were(0.08±0.58)℃,(–0.02±0.69)℃,(–0.07±0.63)℃,and(–0.32±0.56)℃,***:The findings demonstrate acceptable validity of the ECTemp up to 38.5℃.Conducting work within an ECTemp limit of 38.4℃,in conditions similar to the present study,would protect the majority of personnel from an excessive elevation in deep body temperature(>39.0℃).

关键词： Protective clothing Body core temperature Heat strain Heat stress Kalman filter Explosive ordnance disposal

Abnormal colonic cholinergic and nitrergic activities in relation to elastosis in uncomplicated diverticular disease

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World journal of Gastroenterology 2010年第36期16卷 4625-4626页

作者： mark Golder Center for Academic Surgery Institute of Cell and Molecular ScienceBarts and the London School of Medicine and DentistryQueen Mary UniversityLondon E11BBUnited Kingdom

I read with interest the review on the pathogenesis of diverticular disease by Commane et al in World j Gastroenterol 2009;15(20):***,I would like to discuss several important errors that the authors made whilst citin... 详细信息

关键词： Diverticular disease Neural Acetylcholine Nitric oxide Elastin Protein gene product