检索结果-南通市图书馆

Plasma lipidomics reveal systemic changes persistent throughout early life following a childhood burn injury

Burns & Trauma 2023年第1期11卷 814-824页

作者： Eva Kierath Monique Ryan Elaine holmes Jeremy K.Nicholson mark W.Fear Fiona M.Wood Luke Whiley Nicola Gray 无 Australian National Phenome Centre Health Futures InstituteMurdoch UniversityHarry Perkins Institute5 Robin Warren DriveMurdochPerthWA 6150Australia Fiona Wood Foundation Fiona Stanley HospitalFiona Wood FoundationFiona Stanley HospitalLevel 411 Robin Warren DriveMurdochWA 6150Australia Burn injury research unit School of Biomedical SciencesUniversity of Western Australia6 Verdun streetNedlandsWA 6009 Australia Department of Metabolism Digestion and ReproductionFaculty of MedicineImperial College LondonSir Alexander Fleming BuildingSouth KensingtonLondon SW72AZUK Centre for Computational Medicine Health Futures InstituteMurdoch University5 Robin Warren DriveMurdochPerthWA 6150Australia Medical School University of Western AustraliaHarry Perkins InstituteMurdochPerthWA 6150Australia Faculty of Medicine Institute of Global Health InnovationImperial College LondonLevel 1Faculty Building South Kensington CampusLondon SW72AZUK Burns Service of Western Australia WA Department of Health11 Robin Warren driveMurdochWA 6150Australia Perron Institute for Neurological and Translational Science NedlandsWAAustralia

Background:Non-severe paediatric burns can result in poor long-term health *** occurs even in cases with good acute burn-related outcomes,including minimal *** mechanisms that underpin the transition from non-severe burn to sustained negative long-term health impacts are currently ***,sustained metabolic and immune changes have been observed in paediatric burn studies,suggesting these changes may be *** plasma lipidome consists of a rich pool of bioactive metabolites that play critical roles in systemic processes including molecular signalling and *** hypothesised that changes in the plasma lipidome may reflect underlying changes in health status and be linked to long-term health after burn ***:This study analysed the lipidome in children who had previously experienced a non-severe burn,compared to non-injured ***-three participants were recruited between the ages of 5 and 8 years who had experienced a non-severe burn between the ages of 1 and 3 *** samples were also collected from a non-injured,healthy,age and gender matched control group(n=21).Plasma lipids were measured using reversed-phase liquid chromatographymass spectrometery(LC-MS).Results:In total 838 reproducible lipid species from 19 sub-classes passed quality control procedures and progressed to statistical *** of individual lipid metabolites showed significantly higher concentrations of lysophosphatidylethanolamines and phosphatidylethanolamines,and significantly lower concentrations in myristic,palmitic and palmitoleic acids in the plasma of those who had experienced burn injury compared to ***:Long-term changes in the lipid profile may give insight into the mechanisms underlying poor long-term health subsequent to non-severe burn *** work to investigate the relationship between long-term pathology and lipidomic changes may lead to a better understanding of the causes of seconda

关键词： Lipidomics Lipids Burns Trauma Paediatric Children Mass spectrometry

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Multi-proxy evidence for late Pleistocene-Holocene environ-mental change in arid Central Asia:An overview of the RACHAD 2001 symposium

引用

Chinese Science Bulletin 2003年第14期48卷 1397-1400页

作者： CHENFahu J.A.holmes KeyLaboratoryofDesertandDesertification ColdandAridRegionsEnvironmentalandEngineeringResearchInstituteChineseAcademyofSciencesLanzhou730000China EnvironmentalchangeResearchCentre UniversityCollegeLondon26BedfordWayLondonWC1H0APUK

This special issue of Chinese Science Bulletin arose from a symposium entitled 'Abrupt Environmental Changes in Arid Asia--History and Mechanisms' (RACHAD 2001) held at Lanzhou University in October 2001. This international event was attended by over 70 scientists from Australia, China, Germany, India, Mongolia, Russia, the UK and the USA. More than fifty papers were given over a three-dayperiod on all aspects of the mechanisms and history of environmental change in Asia's drylands. Most of the papers presented in the symposium are the preliminary results of the INQUA working group called 'Rapid Climatic Changes in the Central-Asia's Drylands' (RACHAD).

关键词：晚更新世全新世环境变化中亚干旱地区古气候

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Investigating neurogenic bowel in experimental spinal cord injury: where to begin?

引用

Neural Regeneration Research 2019年第2期14卷 222-226页

作者： Amanda R.White Gregory M.holmes Department of Neural & Behavioral Sciences Penn State University College of Medicine

The devastating losses following traumatic spinal cord injury(SCI) encompass the motor, sensory and autonomic nervous systems. Neurogenic bowel is a slow transit colonic dysfunction marked by constipation, rectal evacuation difficulties, decreased anorectal sensation, fecal incontinence or some combination thereof. Furthermore, neurogenic bowel is one of the most prevalent comorbidities of SCI and is recognized by afflicted individuals and caregivers as a lifelong physical and psychological challenge that profoundly affects quality of life. The restoration of post-injury control of movement has received considerable scientific scrutiny yet the daily necessity of voiding the bowel and bladder remains critically under-investigated. Subsequently, physicians and caregivers are rarely presented with consistent, evidence-based strategies to successfully address the consequences of dysregulated voiding reflexes. Neurogenic bowel is commonly believed to result from the interruption of the supraspinal control of the spinal autonomic circuits regulating the colon. In this mini-review, we discuss the clinical challenges presented by neurogenic bowel and emerging pre-clinical evidence that is revealing that SCI also initiates functional remodeling of the colonic wall concurrent with a decrease in local enteric neurons. Since the enteric input to the colonic smooth muscle is the final common pathway for functional contractions of the colon, changes to the neuromuscular interface must first be understood in order to maximize the efficacy of therapeutic interventions targeting colonic dysfunction following SCI.

关键词： colon enteric nervous system parasympathetic sympathetic autonomic nervous system defecationreflexes gastrointestinal inflammation constipation incontinence

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Geriatric assessment for oncologists

引用

Cancer Biology & Medicine 2015年第4期12卷 261-274页

作者： Beatriz Korc-Grodzicki Holly M.holmes Armin Shahrokni Memorial Sloan Kettering Cancer Center Weill Cornell Medical CollegeNew York Division of Geriatric and Palliative Medicine The University of Texas Health Science Center at Houston

The world is experiencing aging of its population. Age-specific incidence rates of cancer are higher and cancer is now recognized as a part of aging. Treating older patients can be challenging. The clinical behavior of some tumors changes with age and the aging process itself brings physiological changes leading to decline in the function of organs. It is essential to identify those patients with longer life expectancy, potentially more likely to benefit from aggressive treatment vs. those that are more vulnerable to adverse outcomes. A primary determination when considering therapy for an older cancer patient is a patient's physiologic, rather than chronologic age. In order to differentiate amongst patients of the same age, it is useful to determine if a patient is fit or frail. Frail older adults have multiple chronic conditions and difficulties maintaining independence. They may be more vulnerable to therapy toxicities, and may not have substantial lasting benefits from therapy. Geriatric assessment(GA) may be used as a tool to determine reversible deficits and devise treatment strategies to mitigate such deficits. GA is also used in treatment decision making by clinicians, helping to risk stratify patients prior to potentially high-risk therapy. An important practical aspect of GA is the feasibility of incorporating it into a busy oncology practice. Key considerations in performing the GA include: available resources, patient population, GA tools to use, and who will be responsible for using the GA results and develop care plans. Challenges in implementing GA in clinical practice will be discussed.

关键词： Geriatric oncology geriatric assessment(GA) frailty

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Mental health service users'progression from illicit drug use to schizophrenia in New Zealand

引用

General Psychiatry 2019年第5期32卷 257-260页

作者： Graham Mellsop Rees Tapsell Pragya holmes Research Contractor AucklandNew Zealand University of Auckland Waikato Clinical School HamiltonNew Zealand

Background Recently,publications have hypothesised that the demonstrated increase in the incidence of schizophrenia in New Zealand is a side effect of the increased strength of available cannabis derivatives over the last 25+years and the much more recent increase in the population's use of *** To compare the rates of later schizophrenia between age-matched mental health service users with initial diagnoses as alcohol abusers or illicit drug *** From the PRIMHD comprehensive national database,all users of the mental health services over a 5-year period who received an ICD-10 presenting diagnosis of alcohol or substance use/abuse were *** each person identified,the database was examined for the following 3 years to determine the numbers later diagnosed with *** For the initial alcohol problem people in their twenties,1.7%were diagnosed as suffering from schizophrenia in the subsequent 3 *** the initial drug problem people,the rate was 10.9%.Within that drug-using population,the indigenous Maori developed schizophrenia at a higher rate than did the remainder of the *** These findings in New Zealand require further research into their generalisability,context and explanation.

关键词： schizophrenia alcohol service

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Preliminary assessment of the solar resource in the United Kingdom

引用

Clean Energy 2018年第2期2卷 112-125页

作者： Mahmoud Dhimish Violeta holmes Peter Mather Martin Sibley Laboratory of Photovoltaics School of Computing and EngineeringUniversity of HuddersfieldUnited Kingdom

Solar radiation resources data are the foundation of knowledge for programs of large-scale deployment of solar energy *** article summarizes the analysis of a new weather stations network in the United *** analysis used three years(January 2015-December 2017)of data from 27 weather stations distributed across the *** data comprises global horizontal irradiance(GHI),diffuse horizontal irradiance,direct normal irradiance and the ambient *** design,implementation and data quality assurance are described to document the network extent and *** all observed datasets,we found that Plymouth(located in southwest England)has the dominant GHI and ambient temperature among all other 26 *** least GHI is observed for Aberdeen(located in northeast Scotland)estimated at 77.3 kWh/*** least average ambient temperature is equal to 9.1℃;the data were detected by the weather station located in the capital of Scotland(Edinburgh).Although continued measurements are needed to understand the interannual resource variability,the current study should have significant applications for preliminary technology selection,power plant modeling and resource forecasting.

关键词： solar resources GHI ambient temperature United Kingdom

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effect of the Laser Heating of Nanotube Nuclei on the Nanotube Type Population

引用

Nano Research 2009年第10期2卷 818-827页

作者： Pavel Nikolaev William holmes Edward Sosa Peter Boul Sivaram Arepalli Department of Energy Science Sungkyunkwan University300 Cheoncheon-dongJangan-guSuwon 440-746Korea Alan G.MacDiarmid NanoT ech Institute The University of Texas at Dallas800 West Campbell RoadRichardsonTX 75080USA ERC Inc./NASA Johnson Space Center Mail Stop ES-4P.O.Box 58561HoustonTX 77258USA

Many potential applications of carbon nanotubes are expected to benet from the availability of single-walled carbon nanotube materials enriched in metallic species,and specifically armchair *** present work focuses on the modification of the pulsed laser vaporization(PLV)technique to selectively produce certain carbon nanotube *** nuclei were“warmed-up”with an additional laser pulse,timed to coincide approximately with the nucleation *** effect of the second laser on the carbon vapor temperature was studied by emission *** type populations with and without warm-up were compared by means of absorption,photoluminescence,and Raman *** was found that the warm-up of nanotube nuclei with a laser pulse has a noticeable,albeit small,effect on the nanotube *** intensity of spectral features associated with(9,7)nanotube and its large chiral angle neighbors increased,while small chiral angle nanotubes decreased,with exception of the(15,0)*** experiment demonstrates that nanotube population during PLV synthesis can be manipulated in a controlled fashion.

关键词： Nanotube synthesis pulsed laser vaporization nanotube population

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Recent advances in phosphoric acid-based membranes for high-temperature proton exchange membrane fuel cells

引用

Journal of Energy Chemistry 2021年第12期30卷 393-429,I0010页

作者： Zunmin Guo Maria Perez-Page Jianuo Chen Zhaoqi Ji Stuart M.holmes Department of Chemical Engineering and Analytical Science The University of Manchester.Ml39PLUnited Kingdom

High-temperature proton exchange membrane fuel cells(HT-PEMFCs)are pursued worldwide as efficient energy conversion *** efforts have been made in the area of designing and developing phosphoric acid(PA)-based proton exchange membrane(PEM)of *** review focuses on recent advances in the limitations of acid-based PEM(acid leaching,oxidative degradation,and mechanical degradation)and the approaches mitigating the membrane *** multilayer or polymers with continuous network,adding hygroscopic inorganic materials,and introducing PA doping sites or covalent interactions with PA can effectively reduce acid *** oxidative degradation can be alleviated by synthesizing crosslinked or branched polymers,and introducing antioxidative groups or highly oxidative stable *** to get a compact structure,blending with stable polymers and inorganic materials,preparing polymer with high molecular weight,and fabricating the polymer with PA doping sites away from backbones,are recommended to improve the membrane mechanical ***,by comparing the running hours and decay rate,three current approaches,*** via thermally curing or polymeric crosslinker,*** hygroscopic inorganic materials,*** membrane layers or introducing strong basic groups and electron-withdrawing groups,have been concluded to be promising approaches to improve the durability of *** overall aim of this review is to explore the existing degradation challenges and opportunities to serve as a solid basis for the deployment in the fuel cell market.

关键词： High-temperature proton exchange membrane fuel cells Acid leaching Oxidative degradation Mechanical degradation Durability

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Transporting droplets through surface anisotropy

引用

Microsystems & Nanoengineering 2015年第1期1卷 74-81页

作者： Hal R.holmes Karl F.Böhringer Department of Bioengineering University of WashingtonSeattleWA 98195USA Department of Electrical Engineering University of WashingtonSeattleWA 98195USA

This review article examines digital microfluidic systems that manipulate droplets through surface *** systems are categorized as surface tension driven or contact line *** tension driven systems include electrowetting on dielectric,Marangoni flow on microheater arrays,and chemical gradient surfaces,whereas contact line driven systems include anisotropic ratchet conveyors,nanostructured Parylene ratchets,and tilted pillar *** article describes the operating principles and outlines the fabrication procedures for each *** also present new equations that unify several previous models of contact line driven *** strengths and weaknesses of each system are compared,with a focus on their ability to perform the generation,switching,fusion,and fission of ***,we discuss current and potential future applications of these systems.

关键词： droplets digital microfluidics electrowetting thermocapillary forces contact line oscillation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Mechanistic links between gut microbial community dynamics, microbial functions and metabolic health

引用

World Journal of Gastroenterology 2014年第44期20卷 16498-16517页

作者： Connie WY Ha Yan Y Lam Andrew J holmes School of Molecular Bio-science and Charles Perkins Centre The University of Sydney Pennington Biomedical Research Center

Gut microbes comprise a high density, biologically active community that lies at the interface of an animal with its nutritional environment. Consequently their activity profoundly influences many aspects of the physiology and metabolism of the host animal. A range of microbial structural components and metabolites directly interact with host intestinal cells and tissues to influence nutrient uptake and epithelial health. Endocrine, neuronal and lymphoid cells in the gut also integrate signals from these microbial factors to influence systemic responses. Dysregulation of these host-microbe interactions is now recognised as a major risk factor in the development of metabolic dysfunction. This is a two-way process and understanding the factors that tip host-microbiome homeostasis over to dysbiosis requires greater appreciation of the host feedbacks that contribute to regulation of microbial community composition. To date, numerous studies have employed taxonomic profiling approaches to explore the links between microbial composition and host outcomes(especially obesity and its comorbidities), but inconsistent host-microbe associations have been reported. Available data indicates multiple factors have contributed to discrepancies between studies. These include the high level of functional redundancy in host-microbiome interactions combined with individual variation in microbiome composition; differences in study design, diet composition and host system between studies; and inherent limitations to the resolution of r RNA-based community profiling. Accounting for these factors allows for recognition of the common microbial and host factors driving community composition and development of dysbiosis on high fat diets. New therapeutic intervention options are now emerging.

关键词： Microbiome Dysbiosis High fat diet Bile Intestinal mucosa Microbe-associated molecular patterns Short chain fatty acids Immunomodulation Enteroendocrine cells

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：