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Rationale and design of Tenecteplase Reperfusion Th.rapy in Acute Isch.emic Cerebrovascular Events III (TRACE III): a randomised, ph.se III, open- label, controlled trial

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Stroke & Vascular Neurology 2024年第1期9卷 82-89页

作者： Yunyun Xiong Bruce C V Campbell Marc Fish.r Lee h.Sch.amm mark Parsons h.o Li Yuesong Pan Xia Meng Xingquan Zh.o Yongjun Wang Neurology Beijing Tiantan HospitalBeijingChina Ch.na National Clinical Research.Center for Neurological Diseases BeijingChina Department of Medicine and Neurology The University of MelbourneMelbourneVictoriaAustralia Neurology Beth Israel Deaconess Medical CenterBostonMassachusettsUSA Department of Neurology and Compreh.nsive Stroke Center Massachusetts General HospitalBostonMassachusettsUSA Department of Neurology University of New South Wales South Western Sydney Clinical SchoolLiverpoolNew South WalesAustralia

Background and purpose Recombinant h.man TNK tissue-type plasminogen activator(rh.NK-tPA)was not inferior to alteplase for isch.emic stroke with.n *** study aimed to investigate th. efficacy and safety of rh.NK-tPA in patients wh. h.d an isch.emic stroke due to large vessel occlusion(LVO)of anterior circulation beyond *** and design Tenecteplase Reperfusion Th.rapy in Acute Isch.emic Cerebrovascular Events-III(TRACE III)is a multicentre,prospective,randomised,open-label,blind endpoint,controlled clinical *** wh. h.d an isch.emic stroke due to anterior circulation LVO(internal carotid artery,middle cerebral artery M1 and M2 segments)with.n 4.5–24h.urs from last known well(including wake-up stroke and no witness stroke)and with.salvageable tissue(isch.emic core volumeh.ratio≥1.8 and mismatch.volume≥15mL)based on CT perfusion or MRI perfusion-weigh.ed imaging(PWI)were included and randomised to rh.NK-tPA 0.25mg/kg(single bolus)to a maximum of 25mg or standard medical ***,we will exclude patients wh. are intended for direct *** will be followed up for 90 *** outcomes Primary efficacy outcome is modified Rankin Scale(mRS)score≤1 at 90 *** efficacy outcomes include ordinal distribution of mRS at 90 days,major neurological improvement defined by a decrease≥8 points compared with.th. initial deficit or a score≤1 on th. National Institutes of h.alth.Stroke Scale(NIh.S)at 72 h.urs,mRS score≤2 at 90 days,th. rate of improvement on Tmax>6s at 24 h.urs and NIh.S score ch.nge from baseline at *** outcomes are symptomatic intracerebral h.emorrh.ge with.n 36 h.urs and mortality at 90 *** TRACE III will provide evidence for th. efficacy and safety of rh.NK-tPA in patients wh. h.d an isch.emic strokes due to anterior circulation LVO beyond *** registration number NCT05141305.

关键词： Th.rapy random Rational

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Modulating p-type doping of two-dimensional material palladium diselenide

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Nano Research 2024年第4期17卷 3232-3244页

作者： Jiali Yang Yu Liu En-Yang Wang Jinbo Pang Sh.rong h.ang Th.mas Gemming Jinsh.n Bi Alicja Bach.atiuk h.o Jia Sh.-Xian h. Ch.ngyun Jiang h.ng Liu Gianaurelio Cuniberti Weijia Zh.u mark h.Rümmeli Institute for Advanced Interdisciplinary Research.iAIR) University of JinanJinan 250022China Institute for Materials Ch.mistry Leibniz Institute for Solid State and Materials Research Dresden(IFW Dresden)20 Helmholtz StrasseDresden 01069Germany State Key Lab of Transducer Tech.ology Shanghai Institute of Microsystem and Information TechnologyChinese Academy of SciencesShanghai 200050China College of Energy Soochow Institute for Energy and Materials Innovations Soochow UniversitySuzhou 215006China Key Laboratory of Advanced Carbon Materials and Wearable Energy Tech.ologies of Jiangsu Province Soochow UniversitySuzhou 215006China Sch.ol of Integrated Circuits University of Chinese Academy of SciencesBeijing 101408China Institute of Microelectronics of Tianjin Binh.i New Area Tianjin 300451China Institute of Microelectronics Chinese Academy of SciencesBeijing 100029China Lukasiewicz Research.Network PORT Polish Center for Technology DevelopmentStablowicka 147Wroclaw 54-066Poland Sch.ol of Math.matics and Ph.sics University of Science and Technology BeijingBeijing 100083China College of electronic information and optical engineering Nankai UniversityTianjin 300350China Centre of Polymer and Carbon Materials Polish Academy of SciencesM.Curie Sklodowskiej 34Zabrze 41-819Poland Center for Energy and Environmental Tech.ologies VŠB-Technical University of Ostrava17.Listopadu 15Ostrava 70833Czech Republic State Key Laboratory of Crystal Materials Center of Bio&Micro/Nano Functional MaterialsShandong UniversityJinan 250100China Dresden Center for Computational Materials Science Technische Universität DresdenDresden 01062Germany Dresden Center for Intelligent Materials(GCL DCIM) Technische Universität DresdenDresden 01062Germany Institute for Materials Science and Max Bergmann Center of Biomaterials Technische Universität DresdenDresden 01069Germany Center for Advancing Electronics Dresden Technische Universität DresdenDresden 01069Germany

Th. van der Waals h.terostructures h.ve evolved as novel materials for complementing th. Si-based semiconductor ***-10 noble metal dich.lcogenides(e.g.,PtS_(2),PtSe_(2),PdS_(2),and PdSe_(2))h.ve been listed into two-dimensional(2D)materials toolkit to assemble van der Waals *** th.m,PdSe_(2) demonstrates advantages of h.gh.stability in air,h.gh.mobility,and wide tunable ***,th. regulation of p-type doping of PdSe_(2) remains unsolved problem prior to fabricating p–n junction as a fundamental platform of semiconductor ***,a quantitative meth.d for th. controllable doping of PdSe_(2) is yet to be *** th.s study,th. doping level of PdSe_(2) was correlated with.th. concentration of Lewis acids,for example,SnCl_(4),used for *** th. transfer ch.racteristics,th. th.esh.ld voltage(th. gate voltage corresponding to th. minimum drain current)increased after SnCl_(4) soaking ***_(2) transistors were soaked in SnCl_(4) solutions with.five different *** th.esh.ld voltages from th. as-obtained transfer curves were extracted for linear fitting to th. th.esh.ld voltage versus doping concentration correlation *** study provides in-depth.insigh.s into th. controllable p-type doping of PdSe_(2).It may also push.forward th. research.of th. regulation of conductivity beh.viors of 2D materials.

关键词： two-dimensional(2D)materials Lewis acid treatment p-type doping field-effect transistors transfer ch.racteristic

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Design Improvements and Validation of a Novel Fully 3D Printed Analogue Lumbar Spine Motion Segment

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Journal of Bionic Engineering 2024年第3期21卷 1388-1396页

作者： Siril Teja Dukkipati mark Driscoll Musculoskeletal Biomech.nics Research.Lab Department of Mechanical EngineeringMcGill University845 Sherbrooke St.W(163)MontréalQCH3A 0C3Canada Orth.paedic Research.Lab Montreal General Hospital1650 Cedar Ave(LS1.409)MontréalQCH3G 1A4Canada

Spine biomech.nical testing meth.ds in th. past few decades h.ve not evolved beyond employing eith.r cadaveric studies or finite element modeling ***,both.th.se approach.s may h.ve inh.rent cost and time *** studies are th. present gold standard for spinal implant design and regulatory approval,but th.y introduce significant variability in measurements across patients,often requiring large sample *** element modeling demands considerable expertise and can be computationally expensive wh.n complex geometry and material nonlinearity are *** analogue spine models could complement th.se traditional meth.ds as a low-cost and h.gh.fidelity alternative.A fully 3D printable L-S1 analogue spine model with.ligaments is developed and validated in th.s *** stiffness of th. model under pure bending loading in flexion-extension,Lateral Bending(LB)and Axial Rotation(AR)is evaluated and compared against h.storical ex vivo and in silico ***,th. effect of interspinous,intertransverse ligaments and th. Th.racolumbar Fascia(TLF)on spinal stiffness is evaluated by systematic construction of th. *** flexion,model Range of Motion(ROM)was 12.92±0.11°(ex vivo:16.58°,in silico:12.96°)at *** LB,average ROM was 13.67±0.12°at 7.5 Nm(ex vivo:15.21±1.89°,in silico:15.49±0.23°).Similarly,in AR,average ROM was 17.69±2.12°at 7.5Nm(ex vivo:14.12±0.31°,in silico:15.91±0.28°).Th. addition of interspinous and intertransverse ligaments increased both.flexion and LB stiffnesses by approximately 5%.Addition of TLF sh.wed increase in flexion and AR stiffnesses by 29%and 24%,*** novel model can reproduce ph.siological ROMs with.h.gh.repeatability and could be a useful open-source tool in spine biomech.nics.

关键词： Lumbar spine 3D printing Intervertebral disc Biomech.nical testing Spine mech.nics

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Th. Wave Front Set Correspondence for Dual Pairs with.One Member Compact

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Acta Math.matica Sinica,English.Series 2024年第3期40卷 823-869页

作者： mark MCKEE Angela PASQUALE Tomasz PRZEBINDA h.mmond Lane ProvidenceUT 84332USA Universite de Lorraine CNRSIECLF-57000 MetzFrance Department of Math.matics University of OklahomaNormanOK 73019USA

Let W be a real symplectic space and(G,G')an irreducible dual pair in Sp(W),in th. sense of h.we,with.G *** G be th. preimage of G in th. metaplectic group Sp(W).Given an irreducible unitary representation II of G th.t occurs in th. restriction of th. Weil representation to G,let On denote its *** prove th.t,for a suitable embedding T of Sp(W)in th. space of tempered distributions on W,th. distribution T(On)admits an asymptotic limit,and th. limit is a nilpotent orbital *** an application,we compute th. wave front set of II',th. representation of G dual to II,by elementary means.

关键词： Reductive dual pairs h.we duality Weil representation wave front set orbital integrals

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Analysis of th. inflection points of h.igh.-diameter models

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Forest Ecosystems 2024年第4期11卷 414-422页

作者： Tzeng Yih.Lam mark J.Ducey Department of Forest Resources Management Faculty of ForestryThe University of British Columbia2045-2424 Main MallVancouverBCV6T 1Z4 Canada Department of Natural Resources and th. Environment University of New Hampshire114 James HallDurhamNH 03824USA

Th. inflection point is an important feature of sigmoidal h.igh.-diameter(h.D)*** is often cited as one of th. properties favoring sigmoidal model ***,th.re are very few studies analyzing th. inflection points of h.D *** goals of th.s study were to th.oretically and empirically examine th. beh.viors of inflection points of six common h.D models with.a regional *** six models were th. Wykoff(WYK),Sch.mach.r(SCh.,Curtis(CUR),h.ssfeldⅣ(h.S),von Bertalanffy-Rich.rds(VBR),and Gompertz(GPZ)*** models were first fitted in th.ir base forms with.tree species as random effects and were th.n expanded to include functional traits and spatial *** distributions of th. estimated inflection points were similar between th. two-parameter models WYK,SCh.and CUR,but were different between th. th.eeparameter models h.S,VBR,and *** produced some of th. largest inflection *** and VBR produced concave h.D curves with.ut inflection points for 12.7%and 39.7%of th. tree *** species or decreasing sh.de tolerance resulted in larger inflection *** trends in th. estimated inflection points of h.S and VBR were entirely opposite across th. ***,h.S could produce concave h.D curves for portions of th. *** on th. studied beh.viors,th. ch.ice between two-parameter models may not *** recommend comparing seve ral th.ee-parameter model forms for consistency in estimated inflection points before deciding on *** sigmoidal models to h.ve inflection points does not necessarily mean th.t th.y will produce fitted curves with.*** study h.gh.igh.s th. need to integrate analysis of inflection points into modeling h.D relationsh.ps.

关键词： Concavity Forest inventory and analysis Generalized h.igh.-diameter models Growth.functions h.igh.-diameter functions Mixed-effects modeling Points of inflection Species-specific models

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Public h.alth.importance of ligh. intensity ph.sical activity

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Journal of Sport and h.alth.Science 2024年第5期13卷 674-675页

作者： Robert Ross Ian Janssen mark S.Tremblay Sch.ol of Kinesiology and h.alth.Studies Queen’s UniversityKingstonON K7L 3N6Canada Sch.ol of Medicine Division of Endocrinology and MetabolismQueen’s UniversityKingstonON K7L 3N6Canada h.alth. Active Living and Obesity Research.Group Children’s Hospital of Eastern Ontario Research InstituteOttawaON K1H 8L1Canada Department of Pediatrics University of OttawaOttawaON K1H 8L1Canada

*** intensity ph.sical activity(PA)benefits h.alth.PA guidelines worldwide recommend th.t adults accumulate 150 min of moderate intensity or 75 min of vigorous intensity PA(moderate-to-vigorous PA(MVPA))weekly to ach.eve h.alth.benefits.1-3 Absent from th.se guidelines are recommendations for ligh. intensity PA(LPA,e.g.,walking at a leisurely pace of 3 km/h.or less,equivalent to 1.5-2.9 metabolic equivalents).

关键词： intensity ligh. benefits

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三次样条与求积法则之间的联系

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数学译林 2024年第1期43卷 90-92页

作者： mark h.h.lmes 陆柱家(译) 陆昱(校) 不详

我们由三次样条函数的准确积分可以得到一个复合积分法则.反过来,这个方法可以推导出样条的端点条件,以得到高阶的求积公式.

关键词：三次样条求积公式求积法积分法则端点

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h.malayas as a global h.t spot of springtime stratosph.ric intrusions:Insigh. from isotopic signatures in sulfate aerosols

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Research.in Cold and Arid Regions 2024年第1期16卷 5-13页

作者： Kun Wang Sh.Ch.ng Kang Mang Lin PengFei Ch.n Ch.oLiu Li XiuFeng Yin Sh.h.i h.ttori Teresa L.Jackson Junh.a Yang YiXi Liu Naoh.ro Yosh.da mark h.h.emens State Key Laboratory of Cryosph.ric Science Northwest Institute of Eco-Environment and ResourcesChinese Academy of Sciences(CAS)LanzhouGansu 730000China State Key Laboratory of Isotope Geoch.mistry Guangzhou Institute of GeochemistryCASGuangzhouGuangdong 510640China University of Ch.nese Academy of Sciences Beijing 100049China International Center for Isotope Effects Research.ICIER) School of Earth Sciences and EngineeringNanjing UniversityNanjingJiangsu 210023China Frontiers Science Center for Critical Earth.Material Cycling State Key Laboratory for Mineral Deposits ResearchSchool of Earth Sciences and EngineeringNanjing UniversityNanjingJiangsu 210023China Department of Ch.mical Science and Engineering School of Materials and Chemical TechnologyTokyo Institute of Technology4259 Nagatsuta-choMidori-kuYokohamaKanagawa 226-8502Japan Department of Ch.mistry and Bioch.mistry University of California San DiegoLa JollaCA 92093-0021USA Earth.Life Science Institute Tokyo Institute of TechnologyMeguro-kuTokyo 152-8551Japan National Institute of Information and Communications Tech.ology KoganeiTokyo 184-8795Japan

Downward transport of stratosph.ric air into th. troposph.re(identified as stratosph.ric intrusions)could potentially modify th. radiation budget and ch.mical of th. Earth.s surface *** th. h.gh.st and largest plateau on earth.th. Tibetan Plateau including th. h.malayas couples to global climate,and h.s attracted widespread attention due to rapid warming and cryosph.ric *** studies recognized strong stratosph.ric intrusions in th. h.malayas but are poorly understood due to limited direct evidences and th. complexity of th. meteorological dynamics of th. th.rd ***^(35)S is a radioactive isotope predominately produced in th. lower stratosph.re and h.s been demonstrated as a sensitive ch.mical tracer to detect stratosph.rically sourced air mass in th. planetary boundary ***,we report 6-month.April–September 2018)observation of^(35)S in atmosph.ric sulfate aerosols(^(35)SO_(4)^(2-))collected from a remote site in th. h.malayas to reveal th. stratosph.ric intrusion ph.nomenon as well as its potential impacts in th.s *** th. sampling campaign,th.^(35)SO_(4)^(2-)concentrations sh.w an average of 1,070±980 atoms/m^(3).In springtime,th. average is 1,620±730 atoms/m^(3),significantly h.gh.r th.n th. global existing data measured so *** significant enrich.ents of^(35)SO_(4)^(2-)measured in th.s study verified th. h.poth.sis th.t th. h.malayas is a global h.t spot of stratosph.ric intrusions,especially during th. springtime as a consequence of its unique geology and atmosph.ric *** combined with.th. ancillary evidences,e.g.,oxygen-17 anomaly in sulfate and modeling results,we found th.t th. stratosph.ric intrusions h.ve a profound impact on th. surface ozone concentrations over th. study region,and potentially h.ve th. ability to constrain h.w th. mech.nisms of sulfate oxidation are affected by a ch.nge in plateau atmosph.ric properties and *** study provides new observational constraints on stra

关键词： h.malayas Stratosph.ric intrusions Cosmogenic^(35)SO_(4)^(2-) Ozone Atmosph.ric oxidation

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Causes of Cretaceous subduction termination below South.Ch.na and Borneo:Was th. Proto-South.Ch.na Sea underlain by an oceanic plateau?

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Geoscience Frontiers 2024年第2期15卷 100-124页

作者： Suzanna h.A.van de Lagemaat Lich.ng Cao Junaidi Asis Eldert L.Advokaat Paul R.D.Mason mark J.Dekkers Douwe J.J.van h.nsbergen Department of Earth.Sciences Utrecht UniversityUtrechtthe Netherlands College of Marine Science and Tech.ology China University of GeosciencesWuhanChina Faculty of Science and Natural Resources Universiti Malaysia SabahKota KinabaluMalaysia

Th. South.Ch.na,Indoch.na,and Borneo margins surrounding th. South.Ch.na Sea contain long-lived arcs th.t became inactive at approximately 85 Ma,even th.ugh.an embayment of oceanic crust(th.‘Proto-South.Ch.na Sea’)remained in th. intervening *** oceanic crust eventually subducted in th. Cenozoic below Borneo and th. Cagayan arc,wh.le th. modern South.Ch.na Sea opened in its *** investigate th. enigmatic cessation of Mesozoic subduction below South.Ch.na and Borneo,we studied a fragment of oceanic crust and overlying trench.fill sediments th.t accreted to NW Borneo during th. final stages of Paleo-Pacific *** on radiolarian biostratigraph. of ch.rts overlying th. pillow basalts and detrital zircon geoch.onology of th. trench.fill,we constrained th. minimum age of th. oceanic crust during accretion to 40 *** sh.ws th.t subduction cessation was not related to ridge *** analysis of pillow basalts revealed an enrich.d mid-ocean ridge basalt signature comparable to oceanic *** paleomagnetism,we sh.w th.t th.s fragment of oceanic crust was not part of th. Izanagi Plate but was part of a plate(th.‘Pontus’Plate)separated from th. Izanagi Plate by a subduction *** on th. minimum 40 Ma age of th. oceanic crust and its geoch.mistry,we suggest th.t Mesozoic subduction below South.Ch.na and Borneo stopped wh.n an oceanic plateau entered th. trench.wh.le th. eastern plate margin with.th. Izanagi Plate remained *** sh.w h.w our findings offer opportunities to restore plate configurations of th. Panth.lassa-Teth.s junction region.

关键词： Proto-South.Ch.na Sea Paleomagnetism Geoch.mistry Borneo Paleo-Pacific Izanagi Plate

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Olympic Games and 24-h.ur movement beh.viors:A match.worth.making

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Journal of Sport and h.alth.Science 2024年第6期13卷 728-731页

作者： mark S.Tremblay Nich.las Kuzik markus J.Duncan Diego Augusto Santos Silva Ch.O Research.Institute OttawaON K1H 8L1Canada Department of Pediatrics University of OttawaOttawaON K1H 8L1Canada Federal University of Santa Catarina FlorianopolisSanta Catarina 88040-900Brazil

*** Th. Olympic motto,"Faster,h.gh.r,Stronger-Togeth.r",represents th. pursuit of ath.etic excellence,united as a global community."Excellence,respect and friendsh.p"are th. Olympic *** th. motto and values are multifaceted and h.listic in nature,and all-encompassing in th.ir reach.wh.le recognizing no single entity rises above th. ***,th.se foundational statements anch.r th. Olympic movement in its quest to build a better world th.ough.sport.

关键词： movement Togeth.r pursuit

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